RGD Reference Report - Analysis of the expression profiles of cytokines and cytokine-related genes during the progression of breast cancer growth in mice. - Rat Genome Database

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Analysis of the expression profiles of cytokines and cytokine-related genes during the progression of breast cancer growth in mice.

Authors: Jung, MY  Kim, SH  Cho, D  Kim, TS 
Citation: Jung MY, etal., Oncol Rep. 2009 Nov;22(5):1141-7.
RGD ID: 6893387
Pubmed: PMID:19787232   (View Abstract at PubMed)

Cytokines are a protein family of regulatory factors derived from tumors and their environmental components that contribute to the growth, invasion and metastasis of breast cancer. However, the way in which tumor progression and cytokines regulate each other is not well understood. In this study, we used an oligoDNA microarray to assess the kinetic expression profile of cytokine genes in tumor tissues and lymph nodes during the progression of tumor growth in mice that had been subcutaneously challenged with breast adenocarcinoma SB5b cells. Our results demonstrated that IL-15, IL-17, IL-18 and IL-18 binding protein (IL-18bp), which are associated with inflammation, were increased in tumor tissues. Conversely, chemokines and their receptors, including CXCR4/CXCL12, CCR7/CCL21, CCL9, CXCL9 and CCL12, were overexpressed in lymph nodes during tumor growth. Furthermore, RT-PCR and Western blot analysis revealed that IL-18, a pro-angiogenic factor in tumors, was up-regulated in tumor tissues. Interestingly, CCR3, IL-1R2, SOCS and IL-20 were up-regulated in tumor tissues, but down-regulated in lymph nodes during tumor growth. This result suggests that the expression of cytokines and cytokine-related genes was differentially regulated, which resulted in a beneficial effect for tumor progression.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCR3HumanAnimal Mammary Neoplasms  ISOCcr3 (Mus musculus) RGD 
Ccr3RatAnimal Mammary Neoplasms  ISOCcr3 (Mus musculus) RGD 
Ccr3MouseAnimal Mammary Neoplasms  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr3  (C-C motif chemokine receptor 3)

Genes (Mus musculus)
Ccr3  (C-C motif chemokine receptor 3)

Genes (Homo sapiens)
CCR3  (C-C motif chemokine receptor 3)


Additional Information