CCR3 (C-C motif chemokine receptor 3) - Rat Genome Database

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Gene: CCR3 (C-C motif chemokine receptor 3) Homo sapiens
Analyze
Symbol: CCR3
Name: C-C motif chemokine receptor 3
RGD ID: 1345616
HGNC Page HGNC:1604
Description: Enables C-C chemokine binding activity. Involved in positive regulation of angiogenesis. Located in plasma membrane. Implicated in asthma; ovary epithelial cancer; and rhinitis. Biomarker of several diseases, including asthma (multiple); autoimmune disease (multiple); cystic fibrosis; hepatitis B; and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: b-chemokine receptor; C C CKR3; C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CC-CKR-3; CCR-3; CD193; chemokine (C-C motif) receptor 3; CKR 3; CKR3; CMKBR3; eosinophil CC chemokine receptor 3; eosinophil eotaxin receptor; MGC102841
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,210,696 - 46,266,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,130,890 - 46,266,706 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,283,872 - 46,308,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,258,692 - 46,283,166 (+)NCBINCBI36Build 36hg18NCBI36
Build 34346,258,691 - 46,283,166NCBI
Celera346,221,217 - 46,245,543 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,327,575 - 46,351,905 (+)NCBIHuRef
CHM1_1346,233,878 - 46,258,185 (+)NCBICHM1_1
T2T-CHM13v2.0346,226,558 - 46,282,568 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
9-cis-retinoic acid  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-amanitin  (ISO)
ammonium chloride  (ISO)
aripiprazole  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
asperentin  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
Dibutyl phosphate  (EXP)
Didecyldimethylammonium  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
emodin  (EXP)
epoxiconazole  (ISO)
fumaric acid  (ISO)
indometacin  (EXP)
lipopolysaccharide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylarsine oxide  (EXP)
phthalic anhydride  (ISO)
prednisolone  (ISO)
proanthocyanidin  (EXP)
propiconazole  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
TMC-120A  (ISO)
topotecan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
U-73122  (EXP)
wortmannin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy. Al-Abdulhadi SA and Al-Rabia MW, Ann Saudi Med. 2010 Mar-Apr;30(2):115-22.
2. Multitargeted approach using antisense oligonucleotides for the treatment of asthma. Allakhverdi Z, etal., Ann N Y Acad Sci. 2006 Oct;1082:62-73.
3. Expression of chemokine receptors on Th1/Th2 CD4+ lymphocytes in patients with multiple sclerosis. Andalib A, etal., Iran J Immunol. 2011 Mar;8(1):1-10.
4. The two-view radionuclide ventriculogram. Advantages of the LPO view. Arrington ER, etal., Clin Nucl Med. 1992 May;17(5):371-4.
5. Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis. Balding CE, etal., Clin Exp Immunol. 2001 Aug;125(2):332-9.
6. Treatment with anti-CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34 progenitor cells in an allergic mouse model. Ben S, etal., Allergy. 2008 Sep;63(9):1164-76.
7. CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair. Bonaros N, etal., J Thorac Cardiovasc Surg. 2008 Oct;136(4):1044-53. Epub 2008 Jul 7.
8. Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals. Caproni M, etal., Clin Immunol. 2005 Mar;114(3):284-92.
9. Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice. Chuang CC, etal., Acta Trop. 2010 Mar;113(3):209-13. Epub 2009 Nov 1.
10. Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy. D'Avila H, etal., Infect Immun. 2007 Mar;75(3):1507-11. Epub 2006 Dec 11.
11. Eosinophils are Dispensable for Allergic Remodeling and Immunity in a Model of House Dust Mite-Induced Airway Disease. Fattouh R, etal., Am J Respir Crit Care Med. 2010 Aug 23.
12. Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis. Fortin M, etal., Cytokine. 2010 Aug 7.
13. Effects of antisense oligodeoxynucleotides targeting CCR3 on the airway response to antigen in rats. Fortin M, etal., Oligonucleotides. 2006 Fall;16(3):203-12.
14. T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy. Francis JN, etal., Allergy. 2007 Jan;62(1):59-65.
15. Enhanced CCR5+/CCR3+ T helper cell ratio in patients with active cutaneous lupus erythematosus. Freutel S, etal., Lupus. 2011 Oct;20(12):1300-4. Epub 2011 Aug 15.
16. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
17. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
18. Inherited determinants of ovarian cancer survival. Goode EL, etal., Clin Cancer Res. 2010 Feb 1;16(3):995-1007. Epub 2010 Jan 26.
19. Effect of Pyeongwee-San (KMP6) on 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Han NR, etal., Life Sci. 2012 Jan 16;90(3-4):147-53. Epub 2011 Oct 29.
20. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. Hartl D, etal., J Immunol. 2008 Dec 1;181(11):8053-67.
21. Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch. Huan J, etal., J Immunol. 2004 Apr 1;172(7):4556-66.
22. Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Huaux F, etal., Am J Pathol. 2005 Dec;167(6):1485-96.
23. CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. Huber J, etal., J Clin Endocrinol Metab. 2008 Aug;93(8):3215-21. Epub 2008 May 20.
24. Analysis of the expression profiles of cytokines and cytokine-related genes during the progression of breast cancer growth in mice. Jung MY, etal., Oncol Rep. 2009 Nov;22(5):1141-7.
25. The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. Kabashima H, etal., Cytokine. 2001 Oct 21;16(2):62-6.
26. Increased expression of RANTES, CCR3 and CCR5 in the lesional skin of patients with atopic eczema. Kato Y, etal., Int Arch Allergy Immunol. 2006;139(3):245-57. Epub 2006 Jan 30.
27. Association of the CCR3 gene polymorphism with aspirin exacerbated respiratory disease. Kim SH, etal., Respir Med. 2010 May;104(5):626-32. Epub 2009 Dec 21.
28. A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice. Komai M, etal., J Pharmacol Sci. 2010 Feb;112(2):203-13. Epub 2010 Feb 4.
29. Transcriptional analyses before and after suppression of immediate hypersensitivity reactions by CCR3 blockade in eyes with experimental allergic conjunctivitis. Komatsu N, etal., Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5307-13. Epub 2008 Jul 24.
30. Heterogeneity of CD4 and CD8+ memory T cells in localized and generalized Wegener's granulomatosis. Lamprecht P, etal., Arthritis Res Ther. 2003;5(1):R25-31. Epub 2002 Oct 24.
31. Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients. Lee JH, etal., J Allergy Clin Immunol. 2007 Nov;120(5):1110-7.
32. mRNA expression of chemokine receptors on peripheral blood mononuclear cells and correlation with clinical features in systemic lupus erythematosus patients. Li YM, etal., Chin Med Sci J. 2010 Sep;25(3):162-8.
33. Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis. Liclican EL, etal., Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6311-20. Epub 2010 Jul 7.
34. Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies. Manousou P, etal., Clin Exp Immunol. 2010 Nov;162(2):337-47.
35. CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling. Masterson JC, etal., Am J Pathol. 2011 Nov;179(5):2302-14. Epub 2011 Sep 23.
36. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. Nakamura H, etal., Int Arch Allergy Immunol. 2007;142(4):329-34. Epub 2006 Nov 28.
37. Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice. Ohnuma A, etal., Exp Toxicol Pathol. 2009 Sep 15.
38. Pinellia ternata, Citrus reticulata, and their combinational prescription inhibit eosinophil infiltration and airway hyperresponsiveness by suppressing CCR3+ and Th2 cytokines production in the ovalbumin-induced asthma model. Ok IS, etal., Mediators Inflamm. 2009;2009:413270. Epub 2009 Aug 2.
39. Expression of the inflammatory chemokines CCL2, CCL5 and CXCL2 and the receptors CCR1-3 and CXCR2 in T lymphocytes from mammary tumor-bearing mice. Owen JL, etal., Cell Immunol. 2011;270(2):172-82. Epub 2011 May 10.
40. CD4+ CCR5+ and CD4+ CCR3+ lymphocyte subset and monocyte apoptosis in patients with acute visceral leishmaniasis. Potestio M, etal., Immunology. 2004 Oct;113(2):260-8.
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Chemokine receptors in a regulation of interstitial lung fibrosis and inflammation. Sterclova M, etal., Exp Lung Res. 2009 Aug;35(6):514-23.
44. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Takeda A, etal., Nature. 2009 Jul 9;460(7252):225-30. Epub 2009 Jun 14.
45. Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B infection. TrehanPati N, etal., Hepatology. 2009 Mar;49(3):781-90.
46. Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice. Wainwright DA, etal., ASN Neuro. 2009 Dec 11;1(5):e00024.
47. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:7594543   PMID:7622448   PMID:8609214   PMID:8631813   PMID:8631926   PMID:8642344   PMID:8674119   PMID:8676064   PMID:8884276   PMID:9005985   PMID:9024664   PMID:9143512  
PMID:9182688   PMID:9252350   PMID:9289016   PMID:9302298   PMID:9346309   PMID:9359702   PMID:9419219   PMID:9573273   PMID:9636210   PMID:9653051   PMID:9712872   PMID:9736741  
PMID:9765440   PMID:9789057   PMID:10094132   PMID:10201960   PMID:10415069   PMID:10488147   PMID:10514402   PMID:10527858   PMID:10590105   PMID:10642580   PMID:10666479   PMID:10713092  
PMID:10877489   PMID:10900353   PMID:10975800   PMID:11001881   PMID:11085751   PMID:11110785   PMID:11115360   PMID:11120849   PMID:11149986   PMID:11196669   PMID:11307756   PMID:11396683  
PMID:11425309   PMID:11449371   PMID:11832479   PMID:11920572   PMID:11991282   PMID:11994538   PMID:12023397   PMID:12079287   PMID:12149192   PMID:12218106   PMID:12393570   PMID:12397598  
PMID:12477932   PMID:12654630   PMID:12794150   PMID:12884299   PMID:12902471   PMID:14581140   PMID:14647058   PMID:14702039   PMID:14733956   PMID:15053339   PMID:15086398   PMID:15194768  
PMID:15219825   PMID:15476879   PMID:15489334   PMID:15507393   PMID:15580493   PMID:15607028   PMID:15807893   PMID:15857508   PMID:15992849   PMID:16081847   PMID:16174786   PMID:16470129  
PMID:16631222   PMID:16712896   PMID:16904155   PMID:16920975   PMID:17041228   PMID:17146638   PMID:17672867   PMID:17703412   PMID:17845580   PMID:18240029   PMID:18244953   PMID:18311140  
PMID:18379861   PMID:18577758   PMID:18636124   PMID:18676680   PMID:18805825   PMID:18974840   PMID:19028820   PMID:19131662   PMID:19170196   PMID:19218218   PMID:19247692   PMID:19258923  
PMID:19414538   PMID:19423540   PMID:19526283   PMID:19542083   PMID:19553323   PMID:19559392   PMID:19625176   PMID:19692168   PMID:19693089   PMID:19714638   PMID:19731977   PMID:20056178  
PMID:20144207   PMID:20190752   PMID:20237496   PMID:20306659   PMID:20364559   PMID:20380698   PMID:20406964   PMID:20438785   PMID:20503287   PMID:20505746   PMID:20603037   PMID:20647273  
PMID:20659406   PMID:20726325   PMID:20734064   PMID:20921899   PMID:20923436   PMID:21041734   PMID:21143381   PMID:21280323   PMID:21406396   PMID:21660963   PMID:21735070   PMID:21873635  
PMID:21917937   PMID:22086059   PMID:22217447   PMID:22702503   PMID:22829007   PMID:22842622   PMID:23017229   PMID:23054685   PMID:23183094   PMID:23251661   PMID:23291587   PMID:23566847  
PMID:23597562   PMID:23636060   PMID:23643185   PMID:23702389   PMID:23742077   PMID:23955446   PMID:24041034   PMID:24489825   PMID:24917456   PMID:24999842   PMID:25340798   PMID:25450766  
PMID:25986216   PMID:26289103   PMID:26409848   PMID:26756352   PMID:27086913   PMID:27119233   PMID:27250766   PMID:27275740   PMID:27495116   PMID:28387445   PMID:28994588   PMID:29457550  
PMID:30298073   PMID:31045236   PMID:32485201   PMID:32777727   PMID:33540982   PMID:33556295   PMID:33671469   PMID:33671956   PMID:33888907   PMID:33961781   PMID:34184200   PMID:35224516  
PMID:35809272   PMID:36123391   PMID:36131165   PMID:36971331   PMID:38636619  


Genomics

Comparative Map Data
CCR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,210,696 - 46,266,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,130,890 - 46,266,706 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,283,872 - 46,308,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,258,692 - 46,283,166 (+)NCBINCBI36Build 36hg18NCBI36
Build 34346,258,691 - 46,283,166NCBI
Celera346,221,217 - 46,245,543 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,327,575 - 46,351,905 (+)NCBIHuRef
CHM1_1346,233,878 - 46,258,185 (+)NCBICHM1_1
T2T-CHM13v2.0346,226,558 - 46,282,568 (+)NCBIT2T-CHM13v2.0
Ccr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,817,799 - 123,831,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,822,009 - 123,831,726 (+)EnsemblGRCm39 Ensembl
GRCm389124,017,825 - 124,031,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,021,972 - 124,031,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv379123,936,703 - 123,946,421 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,870,898 - 123,879,738 (+)NCBIMGSCv36mm8
Celera9124,968,286 - 124,978,018 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
Ccr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,463,533 - 132,511,601 (+)NCBIGRCr8
mRatBN7.28123,586,100 - 123,634,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,616,236 - 123,634,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,226,802 - 129,236,184 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,425,930 - 127,435,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,243,844 - 125,253,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,026,539 - 133,040,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,029,625 - 133,040,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,180,887 - 132,190,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,759,943 - 128,769,341 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,779,679 - 128,789,067 (+)NCBI
Celera8122,724,521 - 122,733,919 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ccr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,701,407 - 25,723,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,702,917 - 25,723,269 (-)NCBIChiLan1.0ChiLan1.0
CCR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,204,630 - 46,230,081 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,209,398 - 46,234,849 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,147,928 - 46,172,947 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,253,878 - 47,278,630 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,253,878 - 47,278,630 (+)Ensemblpanpan1.1panPan2
CCR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,382,380 - 42,398,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,383,135 - 42,384,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,299,062 - 42,300,141 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,864,741 - 42,903,643 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,865,496 - 42,866,578 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,106,665 - 42,107,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,508,009 - 42,509,088 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,789,121 - 42,790,200 (-)NCBIUU_Cfam_GSD_1.0
Ccr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,674,516 - 200,675,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596223,660 - 224,739 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936596223,660 - 224,739 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,285,012 - 29,376,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,251,950 - 29,286,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,348,402 - 32,450,254 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,648,410 - 7,698,523 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,697,068 - 7,698,135 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,459,370 - 159,477,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,768,668 - 74,769,798 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473074,768,668 - 74,769,749 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCR3
26 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001164680.1(CCR3):c.592G>A (p.Glu198Lys) single nucleotide variant Malignant melanoma [RCV000066087] Chr3:46265696 [GRCh38]
Chr3:46307187 [GRCh37]
Chr3:46282191 [NCBI36]
Chr3:3p21.31		 not provided
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2		 pathogenic
GRCh38/hg38 3p21.31(chr3:45691931-46277910)x3 copy number gain See cases [RCV000134890] Chr3:45691931..46277910 [GRCh38]
Chr3:45733423..46319401 [GRCh37]
Chr3:45708427..46294405 [NCBI36]
Chr3:3p21.31		 likely benign
GRCh37/hg19 3p22.2-21.31(chr3:37028313-49929220)x3 copy number gain See cases [RCV000240519] Chr3:37028313..49929220 [GRCh37]
Chr3:3p22.2-21.31		 likely pathogenic
GRCh37/hg19 3p21.31(chr3:46243839-46307968)x3 copy number gain See cases [RCV000446594] Chr3:46243839..46307968 [GRCh37]
Chr3:3p21.31		 likely benign
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1		 pathogenic
NC_000003.11:g.(?_45435946)_(49137751_?)dup duplication Diffuse cerebral and cerebellar atrophy - intractable seizures - progressive microcephaly syndrome [RCV003116297] Chr3:45435946..49137751 [GRCh37]
Chr3:3p21.31		 uncertain significance
GRCh37/hg19 3p21.31(chr3:44948482-49115809)x1 copy number loss not provided [RCV002279744] Chr3:44948482..49115809 [GRCh37]
Chr3:3p21.31		 pathogenic
NM_178329.3(CCR3):c.1028C>T (p.Ser343Phe) single nucleotide variant not specified [RCV004599573] Chr3:46266186 [GRCh38]
Chr3:46307677 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.157G>A (p.Val53Met) single nucleotide variant not specified [RCV004098667] Chr3:46265315 [GRCh38]
Chr3:46306806 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.1046C>T (p.Pro349Leu) single nucleotide variant not specified [RCV004138713] Chr3:46266204 [GRCh38]
Chr3:46307695 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.569A>G (p.Asp190Gly) single nucleotide variant not specified [RCV004155899] Chr3:46265727 [GRCh38]
Chr3:46307218 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.428G>A (p.Arg143Gln) single nucleotide variant not specified [RCV004240680] Chr3:46265586 [GRCh38]
Chr3:46307077 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.74A>T (p.Glu25Val) single nucleotide variant not specified [RCV004211104] Chr3:46265232 [GRCh38]
Chr3:46306723 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.440T>C (p.Val147Ala) single nucleotide variant not specified [RCV004093651] Chr3:46265598 [GRCh38]
Chr3:46307089 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.646G>A (p.Ala216Thr) single nucleotide variant not specified [RCV004103904] Chr3:46265804 [GRCh38]
Chr3:46307295 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.458C>T (p.Thr153Ile) single nucleotide variant not specified [RCV004238944] Chr3:46265616 [GRCh38]
Chr3:46307107 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.224A>G (p.Asn75Ser) single nucleotide variant not specified [RCV004101605] Chr3:46265382 [GRCh38]
Chr3:46306873 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.910G>T (p.Val304Phe) single nucleotide variant not specified [RCV004276889] Chr3:46266068 [GRCh38]
Chr3:46307559 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.926G>A (p.Arg309Gln) single nucleotide variant not specified [RCV004342739] Chr3:46266084 [GRCh38]
Chr3:46307575 [GRCh37]
Chr3:3p21.31		 likely benign
NM_178329.3(CCR3):c.766A>G (p.Asn256Asp) single nucleotide variant not specified [RCV004365717] Chr3:46265924 [GRCh38]
Chr3:46307415 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.237G>A (p.Ser79=) single nucleotide variant not provided [RCV004585371] Chr3:46265395 [GRCh38]
Chr3:46306886 [GRCh37]
Chr3:3p21.31		 likely benign
NM_178329.3(CCR3):c.921G>T (p.Arg307Ser) single nucleotide variant not specified [RCV004432973] Chr3:46266079 [GRCh38]
Chr3:46307570 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.315G>A (p.Met105Ile) single nucleotide variant not specified [RCV004432967] Chr3:46265473 [GRCh38]
Chr3:46306964 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.962T>G (p.Leu321Arg) single nucleotide variant not specified [RCV004432974] Chr3:46266120 [GRCh38]
Chr3:46307611 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.597C>A (p.His199Gln) single nucleotide variant not specified [RCV004432969] Chr3:46265755 [GRCh38]
Chr3:46307246 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.611C>T (p.Thr204Ile) single nucleotide variant not specified [RCV004432970] Chr3:46265769 [GRCh38]
Chr3:46307260 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.742T>G (p.Phe248Val) single nucleotide variant not specified [RCV004432972] Chr3:46265900 [GRCh38]
Chr3:46307391 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.412G>T (p.Ala138Ser) single nucleotide variant not specified [RCV004432968] Chr3:46265570 [GRCh38]
Chr3:46307061 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.736G>A (p.Ala246Thr) single nucleotide variant not specified [RCV004432971] Chr3:46265894 [GRCh38]
Chr3:46307385 [GRCh37]
Chr3:3p21.31		 uncertain significance
NM_178329.3(CCR3):c.305G>A (p.Gly102Asp) single nucleotide variant not specified [RCV004604911] Chr3:46265463 [GRCh38]
Chr3:46306954 [GRCh37]
Chr3:3p21.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1495
Count of miRNA genes:604
Interacting mature miRNAs:672
Transcripts:ENST00000357422, ENST00000395940, ENST00000395942, ENST00000452454, ENST00000457243, ENST00000475150, ENST00000484025, ENST00000541018, ENST00000545097
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406902083GWAS551059_HCOVID-19, mortality QTL GWAS551059 (human)0.000002COVID-19, mortalityratio of deaths to total study population during a period of time (CMO:0001023)34623765946237660Human
406950917GWAS599893_Hfemoral neck bone mineral density QTL GWAS599893 (human)0.000003femoral neck bone mineral densitybone mineral density (CMO:0001226)34626169346261694Human
406895878GWAS544854_Hsystemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis QTL GWAS544854 (human)0.0000002systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis34621215946212160Human
406964814GWAS613790_Hsystemic lupus erythematosus, COVID-19 QTL GWAS613790 (human)7e-44systemic lupus erythematosus, COVID-1934622523546225236Human
407061779GWAS710755_HCCL2 measurement QTL GWAS710755 (human)5e-20CCL2 measurement34623067146230672Human
407285974GWAS934950_Hbody height QTL GWAS934950 (human)8e-15body height (VT:0001253)body height (CMO:0000106)34623094946230950Human
407248343GWAS897319_Hpneumonia, COVID-19 QTL GWAS897319 (human)0.000006pneumonia, COVID-1934621232146212322Human
406972692GWAS621668_Heotaxin measurement QTL GWAS621668 (human)4e-10eotaxin measurement34626169346261694Human
407023323GWAS672299_HCCL2 measurement QTL GWAS672299 (human)7e-09CCL2 measurement34624090046240901Human
407335389GWAS984365_Hmean corpuscular hemoglobin QTL GWAS984365 (human)4e-08mean corpuscular hemoglobinmean corpuscular hemoglobin (CMO:0000290)34621377146213772Human
406982105GWAS631081_Hheel bone mineral density QTL GWAS631081 (human)4e-11heel bone mineral densitybone mineral density (CMO:0001226)34621741146217412Human
407248664GWAS897640_Hbasophil count QTL GWAS897640 (human)2e-09basophil quantity (VT:0002607)blood basophil count (CMO:0000034)34622312746223128Human
1298487BFD1_HBody fluid distribution QTL 1 (human)3.94Body fluid distributionimpedance ratio33638071262380712Human
406972708GWAS621684_Hmonocyte count QTL GWAS621684 (human)4e-25monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34625688246256883Human
406974950GWAS623926_Hceliac disease QTL GWAS623926 (human)4e-08celiac disease34624025346240254Human
407053796GWAS702772_Heosinophil count QTL GWAS702772 (human)1e-13eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)34626582246265823Human
406940456GWAS589432_Heosinophil percentage of leukocytes QTL GWAS589432 (human)3e-12eosinophil percentage of leukocytesblood eosinophil count to total leukocyte count ratio (CMO:0000369)34626582246265823Human
1298489RA4_HRheumatoid arthritis QTL 4 (human)0.0283Joint/bone inflammationrheumatoid arthritis33638071262380712Human
406885610GWAS534586_Hdaytime rest measurement QTL GWAS534586 (human)3e-08daytime rest measurement34622883546228836Human
407201199GWAS850175_Heosinophil count QTL GWAS850175 (human)2e-16eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)34626582246265823Human
406964394GWAS613370_Hrheumatoid arthritis, COVID-19 QTL GWAS613370 (human)6e-16rheumatoid arthritis, COVID-1934623346946233470Human
1643509BW293_HBody Weight QTL 293 (human)1.42Body weightBMI33638071262380712Human
407190953GWAS839929_HCOVID-19, osteoarthritis QTL GWAS839929 (human)7e-14COVID-19, osteoarthritis34623765946237660Human
407054830GWAS703806_HCOVID-19 QTL GWAS703806 (human)1e-35COVID-1934622728146227282Human
407203880GWAS852856_Hblood protein measurement QTL GWAS852856 (human)3e-11blood protein measurementblood protein measurement (CMO:0000028)34623846046238461Human
407062258GWAS711234_Hjuvenile idiopathic arthritis QTL GWAS711234 (human)3e-11juvenile idiopathic arthritis34623608646236087Human
406976249GWAS625225_Hmacrophage inflammatory protein 1b measurement QTL GWAS625225 (human)3e-126macrophage inflammatory protein 1b measurement34623608646236087Human
406952187GWAS601163_Hrheumatoid arthritis, celiac disease QTL GWAS601163 (human)2e-11rheumatoid arthritis, celiac disease34623276846232769Human
407340796GWAS989772_HC-C motif chemokine 3 measurement QTL GWAS989772 (human)2e-13C-C motif chemokine 3 measurement34623608646236087Human
406964797GWAS613773_Hsystemic lupus erythematosus, COVID-19 QTL GWAS613773 (human)6e-50systemic lupus erythematosus, COVID-1934622404446224045Human
2316061GLUCO194_HGlucose level QTL 194 (human)0.02Glucose level32338077449380774Human
2289308BW392_HBody weight QTL 392 (human)1.42Body weightBMI33638071262380712Human
407345848GWAS994824_Heosinophil count QTL GWAS994824 (human)9e-12eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)34626582246265823Human

Markers in Region
PMC109434P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,307,229 - 46,307,539UniSTSGRCh37
Build 36346,282,233 - 46,282,543RGDNCBI36
Celera346,244,575 - 46,244,885RGD
Cytogenetic Map3p21.3UniSTS
HuRef346,350,937 - 46,351,247UniSTS
PMC109444P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,306,651 - 46,307,189UniSTSGRCh37
Build 36346,281,655 - 46,282,193RGDNCBI36
Celera346,243,997 - 46,244,535RGD
Cytogenetic Map3p21.3UniSTS
HuRef346,350,359 - 46,350,897UniSTS
PMC110312P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,307,417 - 46,307,738UniSTSGRCh37
Build 36346,282,421 - 46,282,742RGDNCBI36
Celera346,244,763 - 46,245,084RGD
Cytogenetic Map3p21.3UniSTS
HuRef346,351,125 - 46,351,446UniSTS
PMC135988P6  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,307,077 - 46,307,486UniSTSGRCh37
Build 36346,282,081 - 46,282,490RGDNCBI36
Celera346,244,423 - 46,244,832RGD
Cytogenetic Map3p21.3UniSTS
HuRef346,350,785 - 46,351,194UniSTS
PMC155019P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,306,728 - 46,307,562UniSTSGRCh37
Build 36346,281,732 - 46,282,566RGDNCBI36
Celera346,244,074 - 46,244,908RGD
Cytogenetic Map3p21.3UniSTS
HuRef346,350,436 - 46,351,270UniSTS
CCR3_515  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,307,007 - 46,307,863UniSTSGRCh37
Build 36346,282,011 - 46,282,867RGDNCBI36
Celera346,244,353 - 46,245,209RGD
HuRef346,350,715 - 46,351,571UniSTS
D3S4503  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,306,753 - 46,307,397UniSTSGRCh37
Build 36346,281,757 - 46,282,401RGDNCBI36
Celera346,244,099 - 46,244,743RGD
Cytogenetic Map3p21.3UniSTS
HuRef346,350,461 - 46,351,105UniSTS
SHGC-76880  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,307,462 - 46,307,632UniSTSGRCh37
Build 36346,282,466 - 46,282,636RGDNCBI36
Celera346,244,808 - 46,244,978RGD
Cytogenetic Map3p21.3UniSTS
HuRef346,351,170 - 46,351,340UniSTS
TNG Radiation Hybrid Map329182.0UniSTS
GeneMap99-GB4 RH Map3143.37UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006712960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011533335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB023887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF026535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF224495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF247359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF247360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF247361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF262299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF262300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF262301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF262302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF262303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF262304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX705064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY221092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB584191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U28694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000357422   ⟹   ENSP00000350003
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,163,604 - 46,266,615 (+)Ensembl
Ensembl Acc Id: ENST00000395940   ⟹   ENSP00000379271
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,242,460 - 46,266,706 (+)Ensembl
Ensembl Acc Id: ENST00000395942   ⟹   ENSP00000379273
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,265,128 - 46,266,328 (+)Ensembl
Ensembl Acc Id: ENST00000452454   ⟹   ENSP00000389336
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,242,460 - 46,265,399 (+)Ensembl
Ensembl Acc Id: ENST00000457243   ⟹   ENSP00000401822
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,242,461 - 46,265,221 (+)Ensembl
Ensembl Acc Id: ENST00000475150
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,263,390 - 46,265,365 (+)Ensembl
Ensembl Acc Id: ENST00000484025
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,242,461 - 46,264,744 (+)Ensembl
Ensembl Acc Id: ENST00000545097   ⟹   ENSP00000441600
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,242,381 - 46,266,706 (+)Ensembl
Ensembl Acc Id: ENST00000682778
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,163,216 - 46,189,564 (+)Ensembl
Ensembl Acc Id: ENST00000684109
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,130,890 - 46,190,381 (+)Ensembl
RefSeq Acc Id: NM_001164680   ⟹   NP_001158152
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,242,460 - 46,266,706 (+)NCBI
GRCh37346,283,872 - 46,308,197 (+)ENTREZGENE
HuRef346,327,575 - 46,351,905 (+)ENTREZGENE
CHM1_1346,233,878 - 46,258,185 (+)NCBI
T2T-CHM13v2.0346,258,322 - 46,282,568 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001837   ⟹   NP_001828
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,242,460 - 46,266,706 (+)NCBI
GRCh37346,283,872 - 46,308,197 (+)ENTREZGENE
Build 36346,258,692 - 46,283,166 (+)NCBI Archive
HuRef346,327,575 - 46,351,905 (+)ENTREZGENE
CHM1_1346,233,878 - 46,258,185 (+)NCBI
T2T-CHM13v2.0346,258,322 - 46,282,568 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178328   ⟹   NP_847898
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,242,381 - 46,266,706 (+)NCBI
GRCh37346,283,872 - 46,308,197 (+)ENTREZGENE
HuRef346,327,575 - 46,351,905 (+)ENTREZGENE
CHM1_1346,233,878 - 46,258,185 (+)NCBI
T2T-CHM13v2.0346,258,243 - 46,282,568 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178329   ⟹   NP_847899
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,242,460 - 46,266,706 (+)NCBI
GRCh37346,283,872 - 46,308,197 (+)ENTREZGENE
Build 36346,258,692 - 46,283,166 (+)NCBI Archive
HuRef346,327,575 - 46,351,905 (+)ENTREZGENE
CHM1_1346,233,878 - 46,258,185 (+)NCBI
T2T-CHM13v2.0346,258,322 - 46,282,568 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006712960   ⟹   XP_006713023
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,210,696 - 46,266,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017005685   ⟹   XP_016861174
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,242,460 - 46,266,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054345168   ⟹   XP_054201143
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0346,258,322 - 46,282,568 (+)NCBI
RefSeq Acc Id: XM_054345169   ⟹   XP_054201144
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0346,226,558 - 46,282,568 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001158152 (Get FASTA)   NCBI Sequence Viewer  
  NP_001828 (Get FASTA)   NCBI Sequence Viewer  
  NP_847898 (Get FASTA)   NCBI Sequence Viewer  
  NP_847899 (Get FASTA)   NCBI Sequence Viewer  
  XP_006713023 (Get FASTA)   NCBI Sequence Viewer  
  XP_016861174 (Get FASTA)   NCBI Sequence Viewer  
  XP_054201143 (Get FASTA)   NCBI Sequence Viewer  
  XP_054201144 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB09726 (Get FASTA)   NCBI Sequence Viewer  
  AAB16831 (Get FASTA)   NCBI Sequence Viewer  
  AAB82589 (Get FASTA)   NCBI Sequence Viewer  
  AAC50469 (Get FASTA)   NCBI Sequence Viewer  
  AAI10298 (Get FASTA)   NCBI Sequence Viewer  
  AAI30319 (Get FASTA)   NCBI Sequence Viewer  
  AAI30321 (Get FASTA)   NCBI Sequence Viewer  
  AAK49027 (Get FASTA)   NCBI Sequence Viewer  
  AAK49028 (Get FASTA)   NCBI Sequence Viewer  
  AAL85154 (Get FASTA)   NCBI Sequence Viewer  
  AAL85628 (Get FASTA)   NCBI Sequence Viewer  
  AAL85629 (Get FASTA)   NCBI Sequence Viewer  
  AAL85630 (Get FASTA)   NCBI Sequence Viewer  
  AAL85631 (Get FASTA)   NCBI Sequence Viewer  
  AAL85632 (Get FASTA)   NCBI Sequence Viewer  
  AAO65970 (Get FASTA)   NCBI Sequence Viewer  
  ABK41943 (Get FASTA)   NCBI Sequence Viewer  
  BAA86964 (Get FASTA)   NCBI Sequence Viewer  
  CAD88095 (Get FASTA)   NCBI Sequence Viewer  
  CAR96700 (Get FASTA)   NCBI Sequence Viewer  
  EAW64758 (Get FASTA)   NCBI Sequence Viewer  
  EAW64759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000350003
  ENSP00000350003.2
  ENSP00000379271
  ENSP00000379271.2
  ENSP00000379273.2
  ENSP00000389336.1
  ENSP00000401822.1
  ENSP00000441600
  ENSP00000441600.1
GenBank Protein P51677 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001828   ⟸   NM_001837
- Peptide Label: isoform 1
- UniProtKB: Q8TDP6 (UniProtKB/Swiss-Prot),   Q86WD2 (UniProtKB/Swiss-Prot),   Q2YDB9 (UniProtKB/Swiss-Prot),   Q15748 (UniProtKB/Swiss-Prot),   F5GWL6 (UniProtKB/Swiss-Prot),   B3KVQ1 (UniProtKB/Swiss-Prot),   Q9ULY8 (UniProtKB/Swiss-Prot),   P51677 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_847898   ⟸   NM_178328
- Peptide Label: isoform 2
- UniProtKB: P51677 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001158152   ⟸   NM_001164680
- Peptide Label: isoform 3
- UniProtKB: Q8TDP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_847899   ⟸   NM_178329
- Peptide Label: isoform 1
- UniProtKB: Q8TDP6 (UniProtKB/Swiss-Prot),   Q86WD2 (UniProtKB/Swiss-Prot),   Q2YDB9 (UniProtKB/Swiss-Prot),   Q15748 (UniProtKB/Swiss-Prot),   F5GWL6 (UniProtKB/Swiss-Prot),   B3KVQ1 (UniProtKB/Swiss-Prot),   Q9ULY8 (UniProtKB/Swiss-Prot),   P51677 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006713023   ⟸   XM_006712960
- Peptide Label: isoform X2
- UniProtKB: Q8TDP6 (UniProtKB/Swiss-Prot),   Q86WD2 (UniProtKB/Swiss-Prot),   Q2YDB9 (UniProtKB/Swiss-Prot),   Q15748 (UniProtKB/Swiss-Prot),   F5GWL6 (UniProtKB/Swiss-Prot),   B3KVQ1 (UniProtKB/Swiss-Prot),   Q9ULY8 (UniProtKB/Swiss-Prot),   P51677 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016861174   ⟸   XM_017005685
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000389336   ⟸   ENST00000452454
Ensembl Acc Id: ENSP00000441600   ⟸   ENST00000545097
Ensembl Acc Id: ENSP00000401822   ⟸   ENST00000457243
Ensembl Acc Id: ENSP00000379273   ⟸   ENST00000395942
Ensembl Acc Id: ENSP00000379271   ⟸   ENST00000395940
Ensembl Acc Id: ENSP00000350003   ⟸   ENST00000357422
RefSeq Acc Id: XP_054201144   ⟸   XM_054345169
- Peptide Label: isoform X2
- UniProtKB: Q8TDP6 (UniProtKB/Swiss-Prot),   Q86WD2 (UniProtKB/Swiss-Prot),   Q2YDB9 (UniProtKB/Swiss-Prot),   Q15748 (UniProtKB/Swiss-Prot),   P51677 (UniProtKB/Swiss-Prot),   F5GWL6 (UniProtKB/Swiss-Prot),   B3KVQ1 (UniProtKB/Swiss-Prot),   Q9ULY8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054201143   ⟸   XM_054345168
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51677-F1-model_v2 AlphaFold P51677 1-355 view protein structure

Promoters
RGD ID:6864186
Promoter ID:EPDNEW_H5258
Type:initiation region
Name:CCR3_1
Description:C-C motif chemokine receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,242,460 - 46,242,520EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1604 AgrOrtholog
COSMIC CCR3 COSMIC
Ensembl Genes ENSG00000183625 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000357422 ENTREZGENE
  ENST00000357422.2 UniProtKB/Swiss-Prot
  ENST00000395940 ENTREZGENE
  ENST00000395940.3 UniProtKB/Swiss-Prot
  ENST00000395942.2 UniProtKB/Swiss-Prot
  ENST00000452454.1 UniProtKB/TrEMBL
  ENST00000457243.1 UniProtKB/TrEMBL
  ENST00000545097 ENTREZGENE
  ENST00000545097.1 UniProtKB/Swiss-Prot
Gene3D-CATH 6.20.400.20 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000183625 GTEx
HGNC ID HGNC:1604 ENTREZGENE
Human Proteome Map CCR3 Human Proteome Map
InterPro Chemokine_CCR3 UniProtKB/Swiss-Prot
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1232 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1232 ENTREZGENE
OMIM 601268 OMIM
PANTHER C-C CHEMOKINE RECEPTOR TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA26168 PharmGKB
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER3 UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3KVQ1 ENTREZGENE
  CCR3_HUMAN UniProtKB/Swiss-Prot
  F5GWL6 ENTREZGENE
  P51677 ENTREZGENE
  Q15748 ENTREZGENE
  Q2YDB9 ENTREZGENE
  Q86WD2 ENTREZGENE
  Q8TDP4 ENTREZGENE, UniProtKB/TrEMBL
  Q8TDP5_HUMAN UniProtKB/TrEMBL
  Q8TDP6 ENTREZGENE
  Q8TDP7_HUMAN UniProtKB/TrEMBL
  Q8TDP8_HUMAN UniProtKB/TrEMBL
  Q96T96_HUMAN UniProtKB/TrEMBL
  Q96T97_HUMAN UniProtKB/TrEMBL
  Q9ULY8 ENTREZGENE
UniProt Secondary B3KVQ1 UniProtKB/Swiss-Prot
  F5GWL6 UniProtKB/Swiss-Prot
  Q15748 UniProtKB/Swiss-Prot
  Q2YDB9 UniProtKB/Swiss-Prot
  Q86WD2 UniProtKB/Swiss-Prot
  Q8TDP6 UniProtKB/Swiss-Prot
  Q9ULY8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 CCR3  C-C motif chemokine receptor 3    chemokine (C-C motif) receptor 3  Symbol and/or name change 5135510 APPROVED