Ccr3 (chemokine (C-C motif) receptor 3) - Rat Genome Database
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Gene: Ccr3 (chemokine (C-C motif) receptor 3) Mus musculus
Analyze
Symbol: Ccr3
Name: chemokine (C-C motif) receptor 3
RGD ID: 733966
MGI Page MGI
Description: Exhibits C-C chemokine binding activity and C-C chemokine receptor activity. Involved in chemotaxis; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to localize to endosome; external side of plasma membrane; and extracellular space. Is expressed in embryo and yolk sac. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif chemokine receptor 3); INTERACTS WITH (+)-pilocarpine; 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-C CKR-3; CC chemokine receptor 3; CC-CKR; CC-CKR-3; CC-CKR3; CCR-3; chemokine (C-C) receptor 1,-like 2; chemokine (C-C) receptor 3; CKR; CKR3; Cmkbr; Cmkbr1l2; Cmkbr3; macrophage inflammatory protein 1-alpha receptor-like 2; MGC124265; MGC124266; MIP-1 alpha RL2; MIP-1 alphaRL2; probable C-C chemokine receptor type 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,817,799 - 123,831,729 (+)NCBIGRCm39mm39
GRCm389124,017,825 - 124,031,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,021,972 - 124,031,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv379123,936,703 - 123,946,421 (+)NCBIGRCm37mm9NCBIm37
MGSCv369123,870,898 - 123,879,738 (+)NCBImm8
Celera9124,968,286 - 124,978,018 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
1. Al-Abdulhadi SA and Al-Rabia MW, Ann Saudi Med. 2010 Mar-Apr;30(2):115-22.
2. Allakhverdi Z, etal., Ann N Y Acad Sci. 2006 Oct;1082:62-73.
3. Andalib A, etal., Iran J Immunol. 2011 Mar;8(1):1-10.
4. Arrington ER, etal., Clin Nucl Med. 1992 May;17(5):371-4.
5. Balding CE, etal., Clin Exp Immunol. 2001 Aug;125(2):332-9.
6. Ben S, etal., Allergy. 2008 Sep;63(9):1164-76.
7. Bonaros N, etal., J Thorac Cardiovasc Surg. 2008 Oct;136(4):1044-53. Epub 2008 Jul 7.
8. Caproni M, etal., Clin Immunol. 2005 Mar;114(3):284-92.
9. Chuang CC, etal., Acta Trop. 2010 Mar;113(3):209-13. Epub 2009 Nov 1.
10. D'Avila H, etal., Infect Immun. 2007 Mar;75(3):1507-11. Epub 2006 Dec 11.
11. Fattouh R, etal., Am J Respir Crit Care Med. 2010 Aug 23.
12. Fortin M, etal., Cytokine. 2010 Aug 7.
13. Fortin M, etal., Oligonucleotides. 2006 Fall;16(3):203-12.
14. Francis JN, etal., Allergy. 2007 Jan;62(1):59-65.
15. Freutel S, etal., Lupus. 2011 Oct;20(12):1300-4. Epub 2011 Aug 15.
16. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
17. Goode EL, etal., Clin Cancer Res. 2010 Feb 1;16(3):995-1007. Epub 2010 Jan 26.
18. Han NR, etal., Life Sci. 2012 Jan 16;90(3-4):147-53. Epub 2011 Oct 29.
19. Hartl D, etal., J Immunol. 2008 Dec 1;181(11):8053-67.
20. Huan J, etal., J Immunol. 2004 Apr 1;172(7):4556-66.
21. Huaux F, etal., Am J Pathol. 2005 Dec;167(6):1485-96.
22. Huber J, etal., J Clin Endocrinol Metab. 2008 Aug;93(8):3215-21. Epub 2008 May 20.
23. Humbles AA, etal., Proc Natl Acad Sci U S A 2002 Feb 5;99(3):1479-84.
24. Jung MY, etal., Oncol Rep. 2009 Nov;22(5):1141-7.
25. Kabashima H, etal., Cytokine. 2001 Oct 21;16(2):62-6.
26. Kato Y, etal., Int Arch Allergy Immunol. 2006;139(3):245-57. Epub 2006 Jan 30.
27. Kim SH, etal., Respir Med. 2010 May;104(5):626-32. Epub 2009 Dec 21.
28. Komai M, etal., J Pharmacol Sci. 2010 Feb;112(2):203-13. Epub 2010 Feb 4.
29. Komatsu N, etal., Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5307-13. Epub 2008 Jul 24.
30. Lamprecht P, etal., Arthritis Res Ther. 2003;5(1):R25-31. Epub 2002 Oct 24.
31. Lee JH, etal., J Allergy Clin Immunol. 2007 Nov;120(5):1110-7.
32. Li YM, etal., Chin Med Sci J. 2010 Sep;25(3):162-8.
33. Liclican EL, etal., Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6311-20. Epub 2010 Jul 7.
34. Manousou P, etal., Clin Exp Immunol. 2010 Nov;162(2):337-47.
35. Masterson JC, etal., Am J Pathol. 2011 Nov;179(5):2302-14. Epub 2011 Sep 23.
36. MGD data from the GO Consortium
37. MGD IEA
38. Nakamura H, etal., Int Arch Allergy Immunol. 2007;142(4):329-34. Epub 2006 Nov 28.
39. Ohnuma A, etal., Exp Toxicol Pathol. 2009 Sep 15.
40. Ok IS, etal., Mediators Inflamm. 2009;2009:413270. Epub 2009 Aug 2.
41. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
42. Owen JL, etal., Cell Immunol. 2011;270(2):172-82. Epub 2011 May 10.
43. Potestio M, etal., Immunology. 2004 Oct;113(2):260-8.
44. RGD automated import pipeline
45. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. RGD automated import pipeline for gene-chemical interactions
47. Sterclova M, etal., Exp Lung Res. 2009 Aug;35(6):514-23.
48. Takeda A, etal., Nature. 2009 Jul 9;460(7252):225-30. Epub 2009 Jun 14.
49. TrehanPati N, etal., Hepatology. 2009 Mar;49(3):781-90.
50. Wainwright DA, etal., ASN Neuro. 2009 Dec 11;1(5):e00024.
Additional References at PubMed
PMID:7542241   PMID:7594543   PMID:8530091   PMID:9139699   PMID:9365121   PMID:10349636   PMID:10479460   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11466387   PMID:11877470  
PMID:12079287   PMID:12080938   PMID:12083417   PMID:12118095   PMID:12461651   PMID:12477932   PMID:12496441   PMID:12538707   PMID:12673069   PMID:15705791   PMID:15802529   PMID:16102831  
PMID:16141072   PMID:16141073   PMID:16210640   PMID:16343433   PMID:16602821   PMID:17060636   PMID:17148674   PMID:17635911   PMID:17650182   PMID:17949991   PMID:18077323   PMID:18094012  
PMID:18287559   PMID:19147836   PMID:19302742   PMID:19490431   PMID:19734227   PMID:20050333   PMID:20223839   PMID:20541248   PMID:20875077   PMID:21267068   PMID:21358803   PMID:21677750  
PMID:21735070   PMID:21873635   PMID:22183343   PMID:22282655   PMID:22664873   PMID:23183094   PMID:23670593   PMID:24507645   PMID:24631157   PMID:24889202   PMID:25551463   PMID:25622543  
PMID:26075897   PMID:26147683   PMID:26756352   PMID:27309355   PMID:27621211   PMID:27822494   PMID:29186205   PMID:29467297   PMID:29778007   PMID:30106146   PMID:30784579   PMID:30977156  


Genomics

Comparative Map Data
Ccr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,817,799 - 123,831,729 (+)NCBIGRCm39mm39
GRCm389124,017,825 - 124,031,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,021,972 - 124,031,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv379123,936,703 - 123,946,421 (+)NCBIGRCm37mm9NCBIm37
MGSCv369123,870,898 - 123,879,738 (+)NCBImm8
Celera9124,968,286 - 124,978,018 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
CCR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,163,604 - 46,266,706 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,210,699 - 46,266,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,283,872 - 46,308,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,258,692 - 46,283,166 (+)NCBINCBI36hg18NCBI36
Build 34346,258,691 - 46,283,166NCBI
Celera346,221,217 - 46,245,543 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,327,575 - 46,351,905 (+)NCBIHuRef
CHM1_1346,233,878 - 46,258,185 (+)NCBICHM1_1
Ccr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08133,026,539 - 133,040,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,029,625 - 133,040,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,180,887 - 132,190,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,759,943 - 128,769,341 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,779,679 - 128,789,067 (+)NCBI
Celera8122,724,521 - 122,733,919 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ccr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,701,407 - 25,723,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,702,917 - 25,723,269 (-)NCBIChiLan1.0ChiLan1.0
CCR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,253,878 - 47,278,630 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,253,878 - 47,278,630 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,147,928 - 46,172,947 (+)NCBIMhudiblu_PPA_v0panPan3
CCR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2042,383,135 - 42,384,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12042,382,380 - 42,398,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ccr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936596223,660 - 224,739 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,251,959 - 29,376,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,251,950 - 29,286,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,348,402 - 32,450,254 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,648,410 - 7,698,523 (+)NCBI
ChlSab1.1 Ensembl227,697,068 - 7,698,135 (+)Ensembl
Ccr3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,768,668 - 74,769,749 (-)NCBI

Position Markers
PMC112554P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,028,670 - 124,029,594UniSTSGRCm38
MGSCv379123,943,402 - 123,944,326UniSTSGRCm37
Celera9124,970,395 - 124,971,319UniSTS
Cytogenetic Map9FUniSTS
cM Map971.8UniSTS
UniSTS:224204  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,029,760 - 124,029,834UniSTSGRCm38
MGSCv379123,944,492 - 123,944,566UniSTSGRCm37
Celera9124,970,155 - 124,970,229UniSTS
Cytogenetic Map9FUniSTS
cM Map971.8UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:487
Count of miRNA genes:361
Interacting mature miRNAs:397
Transcripts:ENSMUST00000039171
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039171   ⟹   ENSMUSP00000039107
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9124,021,972 - 124,031,689 (+)Ensembl
RefSeq Acc Id: NM_009914   ⟹   NP_034044
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,822,008 - 123,831,726 (+)NCBI
GRCm389124,021,971 - 124,031,689 (+)NCBI
MGSCv379123,936,703 - 123,946,421 (+)RGD
Celera9124,968,286 - 124,978,018 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313119   ⟹   XP_017168608
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,817,799 - 123,831,729 (+)NCBI
GRCm389124,017,825 - 124,031,692 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034044   ⟸   NM_009914
- UniProtKB: P51678 (UniProtKB/Swiss-Prot),   Q3U5L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168608   ⟸   XM_017313119
- Peptide Label: isoform X1
- UniProtKB: P51678 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000039107   ⟸   ENSMUST00000039171
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6844299
Promoter ID:MM_KWN:59289
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:NM_009914
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369123,936,416 - 123,936,916 (+)MPROMDB
RGD ID:8671364
Promoter ID:EPDNEW_M13713
Type:multiple initiation site
Name:Ccr3_1
Description:Mus musculus chemokine (C-C motif) receptor 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13714  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389124,021,971 - 124,022,031EPDNEW
RGD ID:8671366
Promoter ID:EPDNEW_M13714
Type:single initiation site
Name:Ccr3_2
Description:Mus musculus chemokine (C-C motif) receptor 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13713  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389124,022,411 - 124,022,471EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104616 AgrOrtholog
Ensembl Genes ENSMUSG00000035448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000039107 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000039171 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Chemokine_CCR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104616 ENTREZGENE
NCBI Gene 12771 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccr3 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.57050 ENTREZGENE
UniProt CCR3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U5L7 ENTREZGENE, UniProtKB/TrEMBL
  Q8BHB8_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8K3M7 UniProtKB/Swiss-Prot