Ccr3 (C-C motif chemokine receptor 3)

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Gene: Ccr3 (C-C motif chemokine receptor 3) Ictidomys tridecemlineatus

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Symbol:

Ccr3

Name:

C-C motif chemokine receptor 3

RGD ID:

12728412

Description:

ENCODES a protein that exhibits C-C chemokine binding (inferred); C-C chemokine receptor activity (inferred); G protein-coupled receptor activity (inferred); INVOLVED IN angioblast cell migration (ortholog); chemotaxis (ortholog); eosinophil chemotaxis (ortholog); ASSOCIATED WITH allergic conjunctivitis (ortholog); allergic contact dermatitis (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN endosome (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-C chemokine receptor type 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	200,674,516 - 200,675,950 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	223,660 - 224,739 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	223,660 - 224,739 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic conjunctivitis (ISO)

allergic contact dermatitis (ISO)

Animal Mammary Neoplasms (ISO)

aspirin-induced respiratory disease (ISO)

asthma (ISO)

atopic dermatitis (ISO)

Choroidal Neovascularization (ISO)

chronic obstructive pulmonary disease (ISO)

corneal neovascularization (ISO)

COVID-19 (ISO)

cutaneous lupus erythematosus (ISO)

cystic fibrosis (ISO)

Eosinophilia (ISO)

eosinophilic esophagitis (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Mammary Neoplasms (ISO)

extrinsic allergic alveolitis (ISO)

Facial Nerve Injuries (ISO)

granulomatosis with polyangiitis (ISO)

hepatitis B (ISO)

human immunodeficiency virus infectious disease (ISO)

ileitis (ISO)

meningitis (ISO)

multiple sclerosis (ISO)

myocardial infarction (ISO)

obesity (ISO)

ovary epithelial cancer (ISO)

periapical granuloma (ISO)

pleurisy (ISO)

pneumonia (ISO)

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

pulmonary eosinophilia (ISO)

pulmonary fibrosis (ISO)

respiratory allergy (ISO)

rheumatoid arthritis (ISO)

rhinitis (ISO)

severe acute respiratory syndrome (ISO)

status epilepticus (ISO)

systemic lupus erythematosus (ISO)

ulcerative colitis (ISO)

urticaria (ISO)

visceral leishmaniasis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angioblast cell migration (ISO)

calcium-mediated signaling (IEA)

cell chemotaxis (IEA)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA,ISO)

eosinophil chemotaxis (ISO)

ERK1 and ERK2 cascade (ISO)

G protein-coupled receptor signaling pathway (IEA)

immune response (IEA)

inflammatory response (IEA)

mast cell chemotaxis (ISO)

positive regulation of angiogenesis (IEA)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of endothelial cell proliferation (IEA)

Cellular Component

cytoplasm (IEA)

endosome (ISO)

external side of plasma membrane (IEA)

extracellular space (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

C-C chemokine binding (IEA)

C-C chemokine receptor activity (IEA)

G protein-coupled receptor activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ccr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	200,674,516 - 200,675,950 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	223,660 - 224,739 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	223,660 - 224,739 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	46,210,696 - 46,266,706 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	46,130,890 - 46,266,706 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	46,283,872 - 46,308,197 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	46,258,692 - 46,283,166 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	46,258,691 - 46,283,166	NCBI
Celera	3	46,221,217 - 46,245,543 (+)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	46,327,575 - 46,351,905 (+)	NCBI		HuRef
CHM1_1	3	46,233,878 - 46,258,185 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	46,226,558 - 46,282,568 (+)	NCBI		T2T-CHM13v2.0

Ccr3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	123,817,799 - 123,831,729 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	123,822,009 - 123,831,726 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	124,017,825 - 124,031,692 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	124,021,972 - 124,031,689 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	123,936,703 - 123,946,421 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	123,870,898 - 123,879,738 (+)	NCBI		MGSCv36	mm8
Celera	9	124,968,286 - 124,978,018 (-)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	75.05	NCBI

Ccr3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	132,463,533 - 132,511,601 (+)	NCBI		GRCr8
mRatBN7.2	8	123,586,100 - 123,634,178 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	123,616,236 - 123,634,990 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	129,226,802 - 129,236,184 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	127,425,930 - 127,435,312 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	125,243,844 - 125,253,226 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	133,026,539 - 133,040,999 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	133,029,625 - 133,040,997 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	132,180,887 - 132,190,686 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	128,759,943 - 128,769,341 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	128,779,679 - 128,789,067 (+)	NCBI
Celera	8	122,724,521 - 122,733,919 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Ccr3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	25,701,407 - 25,723,353 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	25,702,917 - 25,723,269 (-)	NCBI	ChiLan1.0	ChiLan1.0

CCR3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	46,204,630 - 46,230,081 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	46,209,398 - 46,234,849 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	46,147,928 - 46,172,947 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	47,253,878 - 47,278,630 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	47,253,878 - 47,278,630 (+)	Ensembl	panpan1.1		panPan2

CCR3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	42,382,380 - 42,398,449 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	42,383,135 - 42,384,217 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	42,299,062 - 42,300,141 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	42,864,741 - 42,903,643 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	42,865,496 - 42,866,578 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	42,106,665 - 42,107,744 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	42,508,009 - 42,509,088 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	42,789,121 - 42,790,200 (-)	NCBI		UU_Cfam_GSD_1.0

CCR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	29,285,012 - 29,376,343 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	29,251,950 - 29,286,470 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	32,348,402 - 32,450,254 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCR3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	7,648,410 - 7,698,523 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	7,697,068 - 7,698,135 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	159,459,370 - 159,477,790 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ccr3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	74,768,668 - 74,769,798 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	74,768,668 - 74,769,749 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000006043 ⟹ ENSSTOP00000021316

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936596	223,660 - 224,739 (+)	Ensembl

RefSeq Acc Id:

XM_005332913 ⟹ XP_005332970

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	200,674,516 - 200,675,950 (+)	NCBI
SpeTri2.0	NW_004936596	223,660 - 224,739 (+)	NCBI

Sequence:

show sequence

ATGGCCACCTCCTTCCCCGAGACTGAGCTTGCCCTGGAGGCAGTTGGAACCACACCCTACGACT
ACGACTTGGCACCGCCCTGTGAAAAAGTCAATATCAAGGAGCTGGGGGCGAGGTTTCTGCCCCC
GCTGTACTCCCTGGTGCTCGTGGTGGGGCTCCTGGGCAACGTGGTGGTGGTGCTGATCCTCACC
AAGTACCGGAGGCTCAAGGTCATGACCAACATCTATCTGCTCAACCTGGCGATTTCTGACTTGC
TCTTTCTCTTCACTCTTCCCTTCTGGATCCACTACGTTGGGTGGAACGAGTGGGTTTTTGGTCC
TTTCATGTGCAAGCTCCTCTCGGGGTTTTATTACCTGGGCTTGTACAGCGAGATCTTTTTCATC
ATCCTGCTGACCATCGACAGGTACCTGGCCATCGTCCACGCCGTGTTTGCCCTTCGAGCCCGGA
CGGTGACTTTCGGTGTCAGCAGCAGCATCTTCACCTGGGTCCTGGCAGTGCTGGCGGCCCTCCC
CGAATTTATCTTTCACGAGTCCCAACAGGGCTCCGAAGAGTCTGTCTGCAGTCCTCTCTACCCA
GAGGACGAGGAAGACAGCTGGAAGCGTTTCCATGCTCTGAGAATGAACATCTTGGGTCTAGCGC
TCCCTCTGCTCATCATGGCCGTCTGCTACTCTGGGATCATCAAAACCCTGCTGAGATGCCCCAA
CAGAAAAAAGTACAAGGCCATCCGGCTCATTTTTATCATCATGGTGGTCTTTTTCGTTTTCTGG
ACCCCCTACAACCTGGTTCTCCTTCTCTCTGCTTTTCAAATGAACTTACTGGAGTACAGCTGTG
AGCGCAGTAGACATCTGGACCTGGCCATGCAGGTGACGGAGGTGATCGCCTATACCCACTGCTG
CGTCAACCCTGTCATCTACGCCTTCGTGGGCGAGAGGTTCCAGAAATACCTGCGCCACTTCTTC
CACAGGCACGTGGCCATCTACCTGGGCAAATACATCCCATTCCTTCCTACCGAGAAACTGGAAA
GAAGCAGTTCTGTCTCCCCATCTACTGGGGAGCCGGAACTGTCTGTGGTGTTTTAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005332970	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021316.1
GenBank Protein	KAG3279776	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005332970 ⟸ XM_005332913

- UniProtKB:

I3NAB9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATSFPETELALEAVGTTPYDYDLAPPCEKVNIKELGARFLPPLYSLVLVVGLLGNVVVVLILT
KYRRLKVMTNIYLLNLAISDLLFLFTLPFWIHYVGWNEWVFGPFMCKLLSGFYYLGLYSEIFFI
ILLTIDRYLAIVHAVFALRARTVTFGVSSSIFTWVLAVLAALPEFIFHESQQGSEESVCSPLYP
EDEEDSWKRFHALRMNILGLALPLLIMAVCYSGIIKTLLRCPNRKKYKAIRLIFIIMVVFFVFW
TPYNLVLLLSAFQMNLLEYSCERSRHLDLAMQVTEVIAYTHCCVNPVIYAFVGERFQKYLRHFF
HRHVAIYLGKYIPFLPTEKLERSSSVSPSTGEPELSVVF

hide sequence

Ensembl Acc Id:

ENSSTOP00000021316 ⟸ ENSSTOT00000006043

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006048	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006043.2	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Chemokine_CCR3	UniProtKB/TrEMBL
	Chemokine_rcpt	UniProtKB/TrEMBL
	GPCR1	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	Ccr3	ENTREZGENE
PANTHER	C-C CHEMOKINE RECEPTOR TYPE 3	UniProtKB/TrEMBL
	CELL ADHESION MOLECULE	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	CCCHEMOKINER	UniProtKB/TrEMBL
	CHEMOKINER3	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	I3NAB9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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