Cyp8b1 (cytochrome P450 family 8 subfamily B member 1) - Rat Genome Database

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Gene: Cyp8b1 (cytochrome P450 family 8 subfamily B member 1) Rattus norvegicus
Analyze
Symbol: Cyp8b1
Name: cytochrome P450 family 8 subfamily B member 1
RGD ID: 71016
Description: Exhibits sterol 12-alpha-hydroxylase activity. Involved in bile acid signaling pathway; response to cholesterol; and response to nutrient levels. Predicted to localize to endoplasmic reticulum membrane. Biomarker of extrahepatic cholestasis; non-alcoholic fatty liver disease; and premature menopause. Orthologous to human CYP8B1 (cytochrome P450 family 8 subfamily B member 1); PARTICIPATES IN bile acid signaling pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH (+)-schisandrin B; 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; cytochrome P450 8b1 sterol 12 alpha-hydrolase; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; cytochrome P450, family 8, subfamily b, polypeptide 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28121,578,123 - 121,580,093 (-)NCBI
Rnor_6.0 Ensembl8130,548,418 - 130,550,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08130,548,418 - 130,550,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08129,723,896 - 129,725,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,018,908 - 127,020,878 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18127,038,644 - 127,040,615 (+)NCBI
Celera8120,702,850 - 120,704,820 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-amphetamine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
acadesine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cefalotin  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP)
cholic acid  (ISO)
choline  (ISO)
chrysophanol  (EXP)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
diclofenac  (ISO)
dieldrin  (EXP)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
fenofibrate  (EXP)
fipronil  (ISO)
fumonisin B1  (ISO)
ginsenoside Re  (EXP)
guggulsterone  (ISO)
GW 4064  (EXP)
Heliotrine  (ISO)
imipenem hydrate  (ISO)
kojic acid  (EXP)
L-methionine  (ISO)
lithocholic acid  (ISO)
melatonin  (ISO)
metacetamol  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methoxsalen  (EXP)
microcystin-LR  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
neomycin  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
oleanolic acid  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
physcion  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
resveratrol  (EXP)
rifampicin  (ISO)
ritodrine  (ISO)
ritonavir  (EXP,ISO)
rotenone  (EXP)
selenium atom  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
sulindac  (EXP)
tamoxifen  (EXP,ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thyroxine  (EXP)
toluene  (EXP)
triadimefon  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
Yangonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:29028359  


Genomics

Comparative Map Data
Cyp8b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28121,578,123 - 121,580,093 (-)NCBI
Rnor_6.0 Ensembl8130,548,418 - 130,550,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08130,548,418 - 130,550,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08129,723,896 - 129,725,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,018,908 - 127,020,878 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18127,038,644 - 127,040,615 (+)NCBI
Celera8120,702,850 - 120,704,820 (-)NCBICelera
Cytogenetic Map8q32NCBI
CYP8B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl342,856,005 - 42,875,898 (-)EnsemblGRCh38hg38GRCh38
GRCh38342,872,192 - 42,875,879 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37342,913,684 - 42,917,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36342,888,688 - 42,892,637 (-)NCBINCBI36hg18NCBI36
Build 34342,888,687 - 42,892,637NCBI
Celera342,851,598 - 42,855,548 (-)NCBI
Cytogenetic Map3p22.1NCBI
HuRef342,956,837 - 42,960,786 (-)NCBIHuRef
CHM1_1342,863,684 - 42,867,633 (-)NCBICHM1_1
Cyp8b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399121,743,422 - 121,745,371 (-)NCBIGRCm39mm39
GRCm39 Ensembl9121,743,422 - 121,745,371 (-)Ensembl
GRCm389121,914,356 - 121,916,305 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9121,914,356 - 121,916,305 (-)EnsemblGRCm38mm10GRCm38
MGSCv379121,823,474 - 121,825,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv369121,763,054 - 121,764,989 (-)NCBImm8
Celera9122,389,259 - 122,391,208 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map972.73NCBI
LOC102019604
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542027,988,067 - 27,990,637 (+)NCBIChiLan1.0ChiLan1.0
CYP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1343,838,315 - 43,842,260 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl343,824,423 - 43,842,716 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0342,775,679 - 42,779,440 (-)NCBIMhudiblu_PPA_v0panPan3
CYP8B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12311,965,685 - 11,968,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2311,967,341 - 11,968,846 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2311,939,545 - 11,942,820 (-)NCBI
ROS_Cfam_1.02312,255,398 - 12,258,673 (-)NCBI
UMICH_Zoey_3.12312,057,378 - 12,060,653 (-)NCBI
UNSW_CanFamBas_1.02312,199,554 - 12,202,829 (-)NCBI
UU_Cfam_GSD_1.02312,202,997 - 12,206,280 (-)NCBI
LOC101977223
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118199,911,411 - 199,913,713 (+)NCBI
SpeTri2.0NW_0049366952,263,868 - 2,265,373 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP8B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1326,330,171 - 26,337,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11326,330,233 - 26,331,738 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP8B1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1224,323,840 - 4,326,459 (-)NCBI
ChlSab1.1 Ensembl224,324,396 - 4,325,901 (-)Ensembl
Vero_WHO_p1.0NW_023666041162,874,321 - 162,895,194 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)889058229132243842Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102051964133307652Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8104682575133307652Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)8104682575133307652Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000026355
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23 1 1
Low 2 10 4 4 4 2 2 1 4 12 3 2
Below cutoff 7 18 8 15 8 6 8 13 11 13 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026355   ⟹   ENSRNOP00000026355
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8130,548,418 - 130,550,388 (-)Ensembl
RefSeq Acc Id: NM_031241   ⟹   NP_112520
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28121,578,123 - 121,580,093 (-)NCBI
Rnor_6.08130,548,418 - 130,550,388 (-)NCBI
Rnor_5.08129,723,896 - 129,725,866 (-)NCBI
RGSC_v3.48127,018,908 - 127,020,878 (+)RGD
Celera8120,702,850 - 120,704,820 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112520 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA76602 (Get FASTA)   NCBI Sequence Viewer  
  BAA82169 (Get FASTA)   NCBI Sequence Viewer  
  EDL76812 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_112520   ⟸   NM_031241
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000026355   ⟸   ENSRNOT00000026355

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696393
Promoter ID:EPDNEW_R6918
Type:initiation region
Name:Cyp8b1_1
Description:cytochrome P450 family 8 subfamily B member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08130,550,402 - 130,550,462EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71016 AgrOrtholog
Ensembl Genes ENSRNOG00000019481 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026355 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026355 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_CYP8B1 UniProtKB/TrEMBL
KEGG Report rno:81924 UniProtKB/TrEMBL
NCBI Gene 81924 ENTREZGENE
PANTHER PTHR24306:SF0 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp8b1 PhenoGen
PIRSF Cytochrome_CYP8B1 UniProtKB/TrEMBL
  Cytochrome_CYPVIIA1 UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/TrEMBL
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt G3V8J2_RAT UniProtKB/TrEMBL
  Q9WVT5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-13 Cyp8b1  cytochrome P450 family 8 subfamily B member 1  Cyp8b1  cytochrome P450, family 8, subfamily b, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cyp8b1  cytochrome P450, family 8, subfamily b, polypeptide 1    cytochrome P450, 8b1, sterol 12 alpha-hydrolase  Name updated 1299863 APPROVED
2002-07-09 Cyp8b1  cytochrome P450, 8b1, sterol 12 alpha-hydrolase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA highly expressed in streptozotocin-induced diabetic rats 70706
gene_expression expressed specifically in liver 70706
gene_regulation mRNA induced by clofibrate, dexamethasone and thyroxin; decreased by insulin 70706