Gene: Cyp8b1 (cytochrome P450 family 8 subfamily B member 1) Rattus norvegicus
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Symbol: Cyp8b1
Name: cytochrome P450 family 8 subfamily B member 1
Description: ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity; INVOLVED IN oxidation-reduction process (inferred); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; cytochrome P450 8b1 sterol 12 alpha-hydrolase; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; cytochrome P450, family 8, subfamily b, polypeptide 1
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08130,548,418 - 130,550,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08129,723,896 - 129,725,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,018,908 - 127,020,878 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18127,038,644 - 127,040,615 (+)NCBI
Celera8120,702,850 - 120,704,820 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp8b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 71016
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-03-12
Status: ACTIVE