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Gene: Tnfsf10 (TNF superfamily member 10) Rattus norvegicus
Symbol: Tnfsf10
Name: TNF superfamily member 10
RGD ID: 628734
Description: Predicted to have several functions, including TRAIL binding activity; identical protein binding activity; and zinc ion binding activity. Involved in male gonad development; positive regulation of apoptotic process; and response to insulin. Predicted to localize to extracellular space and integral component of membrane. Biomarker of osteoarthritis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10); PARTICIPATES IN Trail mediated signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Tnlg6a; Trail; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand 6a; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
Homo sapiens (human) : TNFSF10 (TNF superfamily member 10)  HGNC  Alliance
Mus musculus (house mouse) : Tnfsf10 (tumor necrosis factor (ligand) superfamily, member 10)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfsf10 (TNF superfamily member 10)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFSF10 (TNF superfamily member 10)
Canis lupus familiaris (dog) : TNFSF10 (TNF superfamily member 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfsf10 (TNF superfamily member 10)
Sus scrofa (pig) : TNFSF10 (TNF superfamily member 10)
Chlorocebus sabaeus (African green monkey) : TNFSF10 (TNF superfamily member 10)
Heterocephalus glaber (naked mole-rat) : Tnfsf10 (TNF superfamily member 10)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02113,008,008 - 113,026,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,726,333 - 132,742,550 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,204,303 - 113,221,550 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12113,149,265 - 113,166,510 (+)NCBI
Celera2105,412,626 - 105,429,375 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tnfsf10
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628734
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.