Tnfsf10 (TNF superfamily member 10) - Rat Genome Database

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Gene: Tnfsf10 (TNF superfamily member 10) Rattus norvegicus
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Symbol: Tnfsf10
Name: TNF superfamily member 10
RGD ID: 628734
Description: Predicted to enable several functions, including TRAIL binding activity; identical protein binding activity; and zinc ion binding activity. Involved in male gonad development; positive regulation of apoptotic process; and response to insulin. Predicted to be located in extracellular space. Biomarker of osteoarthritis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10); PARTICIPATES IN Trail mediated signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tnlg6a; Trail; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand 6a; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22110,199,835 - 110,227,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,863,492 - 116,880,479 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02114,976,052 - 114,993,034 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02109,691,219 - 109,708,034 (+)NCBIRnor_WKY
Rnor_6.02113,008,008 - 113,026,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,726,333 - 132,742,550 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,204,303 - 113,221,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12113,149,265 - 113,166,510 (+)NCBI
Celera2105,412,626 - 105,429,375 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
Auriculasin  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bepridil  (ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
bromoacetate  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
carmustine  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysene  (ISO)
chrysin  (ISO)
cibenzoline  (ISO)
cisplatin  (EXP,ISO)
cocaine  (EXP)
coformycin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dacarbazine  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dihydroxyacetone  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enniatin  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenoldopam  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
gadolinium trichloride  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gingerol  (ISO)
glucose  (ISO)
Glutathione ethyl ester  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
Ilimaquinone  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
masoprocol  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methyltestosterone  (ISO)
mifepristone  (ISO)
mithramycin  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
morphine  (ISO)
Myrtucommulone A  (ISO)
N,N-dimethylformamide  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
NS-398  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
Protolichesterinic acid  (ISO)
quartz  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
ribavirin  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP)
sanguinarine  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SM-164  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
styrene  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sumatriptan  (EXP)
Sunset Yellow FCF  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tranilast  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venom  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Effects of valsartan, mycophenolate mofetil and their combined application on TRAIL and nuclear factor-kappaB expression in the kidneys of diabetic rats] Chen B, etal., Zhonghua Yi Xue Za Zhi. 2008 Feb 26;88(8):540-5.
2. Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro. Corallini F, etal., J Cell Physiol. 2007 Jul;212(1):89-95.
3. Adenovirus-Mediated TRAIL Gene (Ad5hTRAIL) Delivery into Pancreatic Islets Prolongs Normoglycemia in Streptozotocin-Induced Diabetic Rats. Dirice E, etal., Hum Gene Ther. 2009 Aug 21.
4. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Expression of tumor necrosis factor-alpha-related apoptosis-inducing ligand and its receptors in rat testis during development. Grataroli R, etal., Biol Reprod 2002 Jun;66(6):1707-15.
7. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Lamhamedi-Cherradi SE, etal., Nat Immunol. 2003 Mar;4(3):255-60. Epub 2003 Feb 10.
8. TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. Lee SW, etal., Arthritis Rheum. 2004 Feb;50(2):534-42.
9. The death ligand TRAIL in diabetic nephropathy. Lorz C, etal., J Am Soc Nephrol. 2008 May;19(5):904-14. Epub 2008 Feb 20.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice. Mi QS, etal., Diabetes. 2003 Aug;52(8):1967-75.
12. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Increased expression of TRAIL and its receptors on peripheral T-cells in type 1 diabetic patients. Salehi E, etal., Iran J Immunol. 2007 Dec;4(4):197-205.
20. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Secchiero P, etal., Circulation. 2006 Oct 3;114(14):1522-30. Epub 2006 Sep 25.
21. Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis. Tang X, etal., Life Sci. 2009 Apr 10;84(15-16):552-7.
22. [Therapeutic effects of recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand on non-small lung cell cancer: an experimental with rats] Tang YM, etal., Zhonghua Yi Xue Za Zhi. 2005 Aug 3;85(29):2021-5.
23. Apoptosis and expression of protein TRAIL in granulosa cells of rats with polycystic ovarian syndrome. Zhang J, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Jun;27(3):311-4.
Additional References at PubMed
PMID:12466268   PMID:12573821   PMID:12761501   PMID:15632112   PMID:16178278   PMID:17627577   PMID:18362891   PMID:19199708   PMID:20097879   PMID:21459798   PMID:21525171   PMID:22266862  
PMID:22286051   PMID:22520731   PMID:23274391   PMID:24097299   PMID:25032854   PMID:26333348   PMID:26457518   PMID:26646413   PMID:26802603   PMID:28073079   PMID:28392572   PMID:29484366  
PMID:29635023   PMID:33875613  


Genomics

Comparative Map Data
Tnfsf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22110,199,835 - 110,227,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,863,492 - 116,880,479 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02114,976,052 - 114,993,034 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02109,691,219 - 109,708,034 (+)NCBIRnor_WKY
Rnor_6.02113,008,008 - 113,026,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,726,333 - 132,742,550 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,204,303 - 113,221,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12113,149,265 - 113,166,510 (+)NCBI
Celera2105,412,626 - 105,429,375 (+)NCBICelera
Cytogenetic Map2q24NCBI
TNFSF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383172,505,508 - 172,523,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3172,505,508 - 172,523,475 (-)EnsemblGRCh38hg38GRCh38
GRCh373172,223,298 - 172,241,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,706,158 - 173,723,963 (-)NCBINCBI36Build 36hg18NCBI36
Build 343173,706,166 - 173,723,971NCBI
Celera3170,621,889 - 170,639,888 (-)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3169,593,908 - 169,611,904 (-)NCBIHuRef
CHM1_13172,186,184 - 172,204,170 (-)NCBICHM1_1
T2T-CHM13v2.03175,290,584 - 175,308,501 (-)NCBIT2T-CHM13v2.0
Tnfsf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,371,226 - 27,393,814 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,371,177 - 27,396,576 (+)EnsemblGRCm39 Ensembl
GRCm38327,317,077 - 27,339,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,317,028 - 27,342,427 (+)EnsemblGRCm38mm10GRCm38
MGSCv37327,215,999 - 27,238,587 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36327,508,150 - 27,530,738 (+)NCBIMGSCv36mm8
Celera327,279,765 - 27,300,536 (+)NCBICelera
Cytogenetic Map3A3NCBI
Tnfsf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554202,549,142 - 2,566,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554202,550,392 - 2,566,448 (-)NCBIChiLan1.0ChiLan1.0
TNFSF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13177,693,860 - 177,712,137 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,694,021 - 177,712,137 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03169,512,491 - 169,530,706 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TNFSF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13436,719,249 - 36,734,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,670,849 - 36,735,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3445,731,787 - 45,747,520 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03436,803,929 - 36,819,723 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,802,389 - 36,820,029 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13436,742,701 - 36,758,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03436,711,390 - 36,727,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03436,969,308 - 36,985,009 (-)NCBIUU_Cfam_GSD_1.0
Tnfsf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602103,391,320 - 103,422,437 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936593212,642 - 230,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFSF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,983,298 - 111,038,324 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113111,021,952 - 111,103,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,874,763 - 119,882,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNFSF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11516,934,982 - 16,953,155 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1516,934,962 - 16,954,860 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606325,697,846 - 25,715,823 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfsf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473050,531,915 - 50,550,528 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473050,534,284 - 50,550,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Tnfsf10
150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000017758
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 9 17 7 12 7 13 8 11
Low 18 30 24 7 24 8 11 29 22 25 8
Below cutoff 6 6 6 6 22 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017758   ⟹   ENSRNOP00000017758
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118000   ⟹   ENSRNOP00000082857
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119330   ⟹   ENSRNOP00000076967
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)Ensembl
RefSeq Acc Id: NM_145681   ⟹   NP_663714
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,208,263 - 110,225,135 (+)NCBI
Rnor_6.02113,008,324 - 113,024,795 (+)NCBI
Rnor_5.02132,726,333 - 132,742,550 (+)NCBI
RGSC_v3.42113,204,303 - 113,221,550 (+)RGD
Celera2105,412,626 - 105,429,375 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590632   ⟹   XP_017446121
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,207,899 - 110,227,239 (+)NCBI
Rnor_6.02113,008,008 - 113,026,899 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590633   ⟹   XP_017446122
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,207,983 - 110,227,239 (+)NCBI
Rnor_6.02113,008,015 - 113,026,899 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590634   ⟹   XP_017446123
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,207,905 - 110,227,239 (+)NCBI
Rnor_6.02113,008,012 - 113,026,899 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101743   ⟹   XP_038957671
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,199,835 - 110,227,239 (+)NCBI
RefSeq Acc Id: XM_039101744   ⟹   XP_038957672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22110,207,963 - 110,227,239 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_663714   ⟸   NM_145681
- UniProtKB: E9PU84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446121   ⟸   XM_017590632
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446123   ⟸   XM_017590634
- Peptide Label: isoform X2
- UniProtKB: E9PU84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446122   ⟸   XM_017590633
- Peptide Label: isoform X2
- UniProtKB: E9PU84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017758   ⟸   ENSRNOT00000017758
RefSeq Acc Id: XP_038957671   ⟸   XM_039101743
- Peptide Label: isoform X2
- UniProtKB: E9PU84 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957672   ⟸   XM_039101744
- Peptide Label: isoform X2
- UniProtKB: E9PU84 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082857   ⟸   ENSRNOT00000118000
RefSeq Acc Id: ENSRNOP00000076967   ⟸   ENSRNOT00000119330
Protein Domains
TNF_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU84-F1-model_v2 AlphaFold E9PU84 1-291 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628734 AgrOrtholog
BioCyc Gene G2FUF-53508 BioCyc
Ensembl Genes ENSRNOG00000013269 Ensembl
  ENSRNOG00000067968 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000076967 ENTREZGENE
  ENSRNOP00000076967.1 UniProtKB/TrEMBL
  ENSRNOP00000082857.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000118000.1 UniProtKB/TrEMBL
  ENSRNOT00000119330 ENTREZGENE
  ENSRNOT00000119330.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro TNF_CS UniProtKB/TrEMBL
  TNF_family UniProtKB/TrEMBL
  TNF_ligand_10/11 UniProtKB/TrEMBL
  Tumour_necrosis_fac-like UniProtKB/TrEMBL
NCBI Gene 246775 ENTREZGENE
Pfam TNF UniProtKB/TrEMBL
PhenoGen Tnfsf10 PhenoGen
PIRSF TNF10_TNF11 UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A0A0U5J7B5_RAT UniProtKB/TrEMBL
  A0A8I5ZY27_RAT UniProtKB/TrEMBL
  E9PU84 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Tnfsf10  TNF superfamily member 10  Tnfsf10  tumor necrosis factor superfamily member 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Tnfsf10  tumor necrosis factor superfamily member 10  Tnfsf10  tumor necrosis factor (ligand) superfamily, member 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tnfsf10  tumor necrosis factor (ligand) superfamily, member 10      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Tnfsf10  tumor necrosis factor (ligand) superfamily, member 10      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis during development; present in the different germ cell types but its receptors predominantly found in the postmeiotic germ cells 634235