Gene: Rock1 (Rho-associated coiled-coil containing protein kinase 1) Rattus norvegicus
Analyze
Symbol:
Rock1
Name:
Rho-associated coiled-coil containing protein kinase 1
Description:
Exhibits GTP-Rho binding activity. Involved in several processes, including Rho protein signal transduction; cytoskeleton organization; and response to transforming growth factor beta. Predicted to colocalize with the amyloid-beta complex. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1); PARTICIPATES IN E-cadherin signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-(1,4-diazepane-1-sulfonyl)isoquinoline; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
liver regeneration-related protein LRRG199; p150 RhoA-binding kinase ROK beta; p160 ROCK-1; P160Rock; Rho-associated coiled-coil forming kinase 1; Rho-associated kinase beta; rho-associated protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I; ROCK-I
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ROCK1 (Rho associated coiled-coil containing protein kinase 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Rock1 (Rho-associated coiled-coil containing protein kinase 1) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Rock1 (Rho associated coiled-coil containing protein kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ROCK1 (Rho associated coiled-coil containing protein kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ROCK1 (Rho associated coiled-coil containing protein kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rock1 (Rho associated coiled-coil containing protein kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ROCK1 (Rho associated coiled-coil containing protein kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ROCK1 (Rho associated coiled-coil containing protein kinase 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Rock1 (Rho-associated coiled-coil containing protein kinase 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
rock1 (Rho-associated, coiled-coil containing protein kinase 1)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
let-502
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Rok
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 18 1,273,490 - 1,390,790 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 18 1,316,022 - 1,433,175 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 18 1,391,751 - 1,511,865 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 18 1,391,824 - 1,511,866 (-) NCBI Celera 18 1,001,677 - 1,120,847 (-) NCBI Celera Cytogenetic Map 18 p13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
breast cancer ISO RGD:733751 8554872 ClinVar Annotator: match by term: Breast cancer ClinVar PMID:20140017 Breast Neoplasms ISO RGD:733751 8554872 ClinVar Annotator: match by term: Breast cancer ClinVar PMID:20140017 lung cancer ISO RGD:733751 8554872 ClinVar Annotator: match by term: Lung cancer ClinVar PMID:20140017
Imported Annotations - CTD
Prenatal Injuries ISO RGD:733751 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18956198
17beta-estradiol multiple interactions ISO RGD:733751 6480464 Estradiol inhibits the reaction [TNF protein results in increased expression of ROCK1 mRNA] CTD PMID:24771768 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ROCK1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733752 6480464 Tetrachlorodibenzodioxin affects the expression of ROCK1 mRNA CTD PMID:18691609 , PMID:21570461 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:733752 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of ROCK1 mRNA CTD PMID:26251327 4-vinylcyclohexene dioxide affects expression ISO RGD:733752 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of ROCK1 mRNA CTD PMID:20829426 5-(1,4-diazepane-1-sulfonyl)isoquinoline decreases expression ISO RGD:733751 6480464 fasudil results in decreased expression of ROCK1 mRNA, fasudil results in decreased expression of ROCK1 protein CTD PMID:26172442 5-(1,4-diazepane-1-sulfonyl)isoquinoline multiple interactions EXP 6480464 fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA] more ... CTD PMID:20037814 more ... 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide decreases expression ISO RGD:733751 6480464 Niclosamide results in decreased expression of ROCK1 mRNA, Niclosamide results in decreased expression of ROCK1 protein CTD PMID:29251334 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ROCK1 mRNA CTD PMID:24780913 aflatoxin B1 increases expression ISO RGD:733752 6480464 Aflatoxin B1 results in increased expression of ROCK1 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:733751 6480464 Aflatoxin B1 results in decreased methylation of ROCK1 gene CTD PMID:27153756 aflatoxin M1 decreases expression ISO RGD:733751 6480464 Aflatoxin M1 results in decreased expression of ROCK1 mRNA CTD PMID:30928695 aldehydo-D-glucose multiple interactions EXP 6480464 [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein, notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 arsane affects methylation ISO RGD:733751 6480464 Arsenic affects the methylation of ROCK1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:733751 6480464 Arsenic affects the methylation of ROCK1 gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:733751 6480464 Arsenic affects the methylation of ROCK1 gene CTD PMID:25304211 benzo[a]pyrene decreases expression ISO RGD:733751 6480464 Benzo(a)pyrene results in decreased expression of ROCK1 mRNA CTD PMID:20064835 benzo[a]pyrene increases expression ISO RGD:733751 6480464 Benzo(a)pyrene metabolite results in increased expression of ROCK1 mRNA CTD PMID:26314263 benzo[a]pyrene increases expression ISO RGD:733752 6480464 Benzo(a)pyrene results in increased expression of ROCK1 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:733751 6480464 7 more ... CTD PMID:19150397 , PMID:26238291 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ROCK1 mRNA CTD PMID:25181051 Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of ROCK1 protein CTD PMID:28903499 bufalin decreases expression ISO RGD:733751 6480464 bufalin results in decreased expression of ROCK1 protein CTD PMID:23949904 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of ROCK1 promoter CTD PMID:22457795 cadmium dichloride decreases expression ISO RGD:733752 6480464 Cadmium Chloride results in decreased expression of ROCK1 mRNA CTD PMID:24982889 calciol increases expression ISO RGD:733752 6480464 Cholecalciferol results in increased expression of ROCK1 mRNA CTD PMID:17170073 carbamazepine affects expression ISO RGD:733751 6480464 Carbamazepine affects the expression of ROCK1 mRNA CTD PMID:24752500 carbon nanotube multiple interactions ISO RGD:733751 6480464 ROCK1 protein promotes the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein] CTD PMID:24760326 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of ROCK1 mRNA CTD PMID:23125180 chromium atom increases expression EXP 6480464 Chromium results in increased expression of ROCK1 mRNA CTD PMID:17692352 chromium(3+) increases expression EXP 6480464 Chromium results in increased expression of ROCK1 mRNA CTD PMID:17692352 clobetasol decreases expression ISO RGD:733752 6480464 Clobetasol results in decreased expression of ROCK1 mRNA CTD PMID:27462272 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNA CTD PMID:17602206 cobalt dichloride increases expression ISO RGD:733751 6480464 cobaltous chloride results in increased expression of ROCK1 mRNA CTD PMID:26314263 crocidolite asbestos multiple interactions ISO RGD:733751 6480464 ROCK1 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein] CTD PMID:24760326 cyclosporin A decreases expression ISO RGD:733752 6480464 Cyclosporine results in decreased expression of ROCK1 mRNA CTD PMID:19770486 D-glucose multiple interactions EXP 6480464 [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein, notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 daunorubicin affects expression EXP 6480464 Daunorubicin affects the expression of ROCK1 mRNA CTD PMID:20037814 daunorubicin multiple interactions EXP 6480464 fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA] CTD PMID:20037814 Deguelin decreases expression ISO RGD:733751 6480464 deguelin results in decreased expression of ROCK1 protein CTD PMID:25322282 , PMID:26884827 diclofenac affects expression ISO RGD:733751 6480464 Diclofenac affects the expression of ROCK1 mRNA CTD PMID:24752500 dicrotophos decreases expression ISO RGD:733751 6480464 dicrotophos results in decreased expression of ROCK1 mRNA CTD PMID:28302478 dimethylarsinic acid decreases expression EXP 6480464 Cacodylic Acid results in decreased expression of ROCK1 mRNA CTD PMID:17720352 dioxygen multiple interactions EXP 6480464 [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein, notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 dioxygen multiple interactions ISO RGD:733751 6480464 ROCK1 protein affects the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:30831131 disodium selenite increases expression ISO RGD:733751 6480464 Sodium Selenite results in increased expression of ROCK1 mRNA CTD PMID:18175754 doxorubicin decreases expression ISO RGD:733751 6480464 Doxorubicin results in decreased expression of ROCK1 mRNA CTD PMID:29803840 emodin decreases expression ISO RGD:733751 6480464 Emodin results in decreased expression of ROCK1 mRNA CTD PMID:16045814 endosulfan multiple interactions ISO RGD:733751 6480464 Endosulfan results in increased expression of and affects the localization of ROCK1 protein CTD PMID:22677888 ethanol decreases expression ISO RGD:733752 6480464 Ethanol results in decreased expression of ROCK1 mRNA CTD PMID:29018328 ethanol increases expression ISO RGD:733752 6480464 Ethanol results in increased expression of ROCK1 mRNA CTD PMID:30319688 fasudil hydrochloride decreases expression ISO RGD:733751 6480464 fasudil results in decreased expression of ROCK1 mRNA, fasudil results in decreased expression of ROCK1 protein CTD PMID:26172442 fasudil hydrochloride multiple interactions EXP 6480464 fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA] more ... CTD PMID:20037814 more ... glucose multiple interactions EXP 6480464 [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein, notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 glycyrrhetinate multiple interactions ISO RGD:733751 6480464 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA], 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein] CTD PMID:31325423 glycyrrhetinic acid multiple interactions ISO RGD:733751 6480464 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA], 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein] CTD PMID:31325423 hyaluronic acid increases phosphorylation ISO RGD:733751 6480464 Hyaluronic Acid results in increased phosphorylation of ROCK1 protein CTD PMID:16864594 hypochlorous acid increases expression ISO RGD:733752 6480464 Hypochlorous Acid results in increased expression of ROCK1 mRNA CTD PMID:19376150 lead diacetate decreases expression ISO RGD:733752 6480464 lead acetate results in decreased expression of ROCK1 mRNA CTD PMID:22609695 maneb multiple interactions ISO RGD:733752 6480464 [Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA CTD PMID:22563483 methoxychlor affects expression ISO RGD:733752 6480464 Methoxychlor affects the expression of ROCK1 mRNA CTD PMID:20829426 methylmercury(1+) increases expression ISO RGD:733751 6480464 methylmercury II results in increased expression of ROCK1 mRNA CTD PMID:26314263 miconazole decreases expression ISO RGD:733752 6480464 Miconazole results in decreased expression of ROCK1 mRNA CTD PMID:27462272 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNA CTD PMID:17602206 notoginsenoside R1 multiple interactions EXP 6480464 notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 ochratoxin A increases expression ISO RGD:733751 6480464 ochratoxin A metabolite results in increased expression of ROCK1 mRNA, ochratoxin A results in increased expression of ROCK1 mRNA CTD PMID:26314263 ouabain increases cleavage ISO RGD:733751 6480464 Ouabain results in increased cleavage of ROCK1 protein CTD PMID:20661774 ouabain multiple interactions ISO RGD:733751 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein] CTD PMID:20661774 paclitaxel increases expression ISO RGD:733751 6480464 Paclitaxel results in increased expression of ROCK1 mRNA CTD PMID:15000894 pamidronate decreases expression ISO RGD:733751 6480464 pamidronate results in decreased expression of ROCK1 protein CTD PMID:16298452 paraquat multiple interactions ISO RGD:733752 6480464 [Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA CTD PMID:22563483 paraquat increases expression ISO RGD:733752 6480464 Paraquat results in increased expression of ROCK1 mRNA CTD PMID:22563483 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:733751 6480464 perfluorooctane sulfonic acid results in decreased expression of ROCK1 mRNA CTD PMID:27153767 phenethyl isothiocyanate decreases expression EXP 6480464 phenethyl isothiocyanate results in decreased expression of ROCK1 mRNA CTD PMID:17616710 phenobarbital decreases expression ISO RGD:733752 6480464 Phenobarbital results in decreased expression of ROCK1 mRNA CTD PMID:19363144 , PMID:23091169 phorbol 13-acetate 12-myristate increases expression ISO RGD:733751 6480464 Tetradecanoylphorbol Acetate results in increased expression of ROCK1 protein CTD PMID:24760326 propiconazole decreases expression ISO RGD:733752 6480464 propiconazole results in decreased expression of ROCK1 mRNA CTD PMID:19363144 , PMID:21278054 pyridaben increases expression ISO RGD:733752 6480464 pyridaben results in increased expression of ROCK1 mRNA CTD PMID:22563483 quercetin increases expression ISO RGD:733751 6480464 Quercetin results in increased expression of ROCK1 protein CTD PMID:15221776 , PMID:23645742 quercitrin affects expression ISO RGD:733751 6480464 quercitrin affects the expression of ROCK1 mRNA CTD PMID:25193878 raloxifene decreases expression EXP 6480464 Raloxifene Hydrochloride results in decreased expression of ROCK1 mRNA CTD PMID:20970835 resveratrol decreases expression ISO RGD:733751 6480464 Resveratrol results in decreased expression of ROCK1 mRNA, Resveratrol results in decreased expression of ROCK1 protein CTD PMID:18089832 silicon dioxide increases expression ISO RGD:733751 6480464 Silicon Dioxide analog results in increased expression of ROCK1 mRNA CTD PMID:25895662 sodium arsenate increases expression ISO RGD:733752 6480464 sodium arsenate results in increased expression of ROCK1 mRNA CTD PMID:21795629 sorafenib decreases expression EXP 6480464 sorafenib results in decreased expression of ROCK1 mRNA, sorafenib results in decreased expression of ROCK1 protein CTD PMID:19338580 sorafenib increases expression EXP 6480464 sorafenib results in increased expression of ROCK1 protein CTD PMID:19338580 streptozocin multiple interactions EXP 6480464 fasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein], fasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA] CTD PMID:22429817 , PMID:23376009 streptozocin increases activity EXP 6480464 Streptozocin results in increased activity of ROCK1 protein CTD PMID:23376009 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of ROCK1 mRNA CTD PMID:22429817 succimer multiple interactions ISO RGD:733752 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ROCK1 mRNA CTD PMID:26378955 testosterone affects expression EXP 6480464 Testosterone affects the expression of ROCK1 mRNA CTD PMID:22028410 tipifarnib increases expression EXP 6480464 tipifarnib results in increased expression of ROCK1 mRNA CTD PMID:16403772 tributylstannane increases expression ISO RGD:733751 6480464 tributyltin results in increased expression of ROCK1 mRNA CTD PMID:26314263 Tributyltin oxide increases expression ISO RGD:733751 6480464 bis(tri-n-butyltin)oxide results in increased expression of ROCK1 mRNA CTD PMID:26314263 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of ROCK1 mRNA CTD PMID:27554044 Triptolide decreases expression ISO RGD:733752 6480464 triptolide results in decreased expression of ROCK1 mRNA CTD PMID:26420756 troglitazone increases expression ISO RGD:733751 6480464 troglitazone results in increased expression of ROCK1 mRNA CTD PMID:19140230 tungsten decreases expression ISO RGD:733752 6480464 Tungsten results in decreased expression of ROCK1 mRNA CTD PMID:30912803 tungsten(4+) decreases expression ISO RGD:733752 6480464 Tungsten results in decreased expression of ROCK1 mRNA CTD PMID:30912803 valproic acid decreases methylation ISO RGD:733751 6480464 Valproic Acid results in decreased methylation of ROCK1 gene CTD PMID:29154799 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of ROCK1 mRNA CTD PMID:29427782 valproic acid decreases expression ISO RGD:733751 6480464 Valproic Acid results in decreased expression of ROCK1 mRNA CTD PMID:23179753 Y-27632 multiple interactions ISO RGD:733752 6480464 ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein] CTD PMID:14615541 Y-27632 decreases activity ISO RGD:733751 6480464 [Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein CTD PMID:16675616
Biological Process actin cytoskeleton organization ISO RGD:733752 1624291 MGI:MGI:107926 more ... RGD MGI:MGI:3610718 , PMID:16249236 actin cytoskeleton organization IEA InterPro:IPR020684 1600115 GO_REF:0000002 InterPro GO_REF:0000002 actomyosin structure organization IBA FB:FBgn0002466 more ... 13792537 PMID:21873635 GO_Central aortic valve morphogenesis ISO RGD:14219027 1624291 UniProtKB:M3TYT0 (PMID:26634652) RGD PMID:26634652 apical constriction ISO RGD:733752 1624291 MGI:MGI:2135608 more ... RGD MGI:MGI:5086051 , PMID:21685893 apical constriction IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 apoptotic process IEA UniProtKB-KW:KW-0053 1600115 GO_REF:0000037 UniProt GO_REF:0000037 bleb assembly ISO RGD:733752 1624291 (MGI:MGI:3706220, PMID:17135244) RGD MGI:MGI:3706220 , PMID:17135244 bleb assembly IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to transforming growth factor beta stimulus ISO RGD:14219027 1624291 UniProtKB:M3TYT0 (PMID:26634652) RGD PMID:26634652 cortical actin cytoskeleton organization ISO RGD:733751 1624291 UniProtKB:O75116 (PMID:25816133) RGD PMID:25816133 cortical actin cytoskeleton organization IBA FB:FBgn0026181 more ... 13792537 PMID:21873635 GO_Central cortical actin cytoskeleton organization IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoskeleton organization IMP 633784 RGD embryonic morphogenesis IBA FB:FBgn0026181 more ... 13792537 PMID:21873635 GO_Central I-kappaB kinase/NF-kappaB signaling ISO RGD:733751 1624291 (PMID:25816133) RGD PMID:25816133 I-kappaB kinase/NF-kappaB signaling IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 leukocyte cell-cell adhesion ISO RGD:733751 1624291 (PMID:12082081) RGD PMID:12082081 leukocyte migration ISO RGD:733751 1624291 (PMID:12082081) RGD PMID:12082081 leukocyte tethering or rolling ISO RGD:733751 1624291 (PMID:12082081) RGD PMID:12082081 leukocyte tethering or rolling IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane to membrane docking ISO RGD:733751 1624291 (PMID:12082081) RGD PMID:12082081 membrane to membrane docking IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitotic cytokinesis IBA FB:FBgn0026181 , PANTHER:PTN000542090 13792537 PMID:21873635 GO_Central mRNA destabilization IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 mRNA destabilization ISO RGD:733752 1624291 (MGI:MGI:6271078, PMID:29353861) RGD MGI:MGI:6271078 , PMID:29353861 myoblast migration IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 myoblast migration ISS UniProtKB:P70335 1600115 GO_REF:0000024 UniProt GO_REF:0000024 myoblast migration ISO RGD:733752 1624291 (MGI:MGI:5486551, PMID:17654484) RGD MGI:MGI:5486551 , PMID:17654484 negative regulation of amyloid precursor protein catabolic process ISO RGD:733751 1624291 (PMID:24305806), (PMID:27853422) RGD PMID:24305806 , PMID:27853422 negative regulation of amyloid-beta formation IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of amyloid-beta formation ISO RGD:733751 1624291 (PMID:24305806), (PMID:27853422) RGD PMID:24305806 , PMID:27853422 negative regulation of angiogenesis ISO RGD:733751 1624291 (PMID:19181962) RGD PMID:19181962 negative regulation of angiogenesis IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of bicellular tight junction assembly ISO RGD:733751 1624291 UniProtKB:O75116 (PMID:25816133) RGD PMID:25816133 negative regulation of bicellular tight junction assembly IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of biomineral tissue development ISO RGD:14219027 1624291 UniProtKB:M3TYT0 (PMID:26634652) RGD PMID:26634652 negative regulation of endopeptidase activity IEA GO:0019828 1600115 GO_REF:0000108 GOC GO_REF:0000108 negative regulation of myosin-light-chain-phosphatase activity ISO RGD:733751 1624291 UniProtKB:O75116 (PMID:25816133) RGD PMID:25816133 negative regulation of myosin-light-chain-phosphatase activity IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neuron apoptotic process ISO RGD:733752 1624291 (MGI:MGI:3588743, PMID:15071095) RGD MGI:MGI:3588743 , PMID:15071095 negative regulation of neuron apoptotic process IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of protein binding ISO RGD:733751 1624291 (PMID:18573880) RGD PMID:18573880 negative regulation of protein binding IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection arborization IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection arborization ISO RGD:733751 1624291 UniProtKB:O60890 (PMID:27160703) RGD PMID:27160703 neuron projection development ISO RGD:733751 1624291 UniProtKB:O60890 (PMID:27160703) RGD PMID:27160703 peptidyl-serine phosphorylation ISO RGD:733751 1624291 (PMID:18573880) RGD PMID:18573880 peptidyl-serine phosphorylation IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-threonine phosphorylation IBA PANTHER:PTN002743840 , UniProtKB:O75116 13792537 PMID:21873635 GO_Central positive regulation of amyloid-beta clearance IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of amyloid-beta clearance ISO RGD:733751 1624291 UniProtKB:Q14457 (PMID:27853422) RGD PMID:27853422 positive regulation of autophagy IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of autophagy ISO RGD:733751 1624291 UniProtKB:Q14457 (PMID:27853422) RGD PMID:27853422 positive regulation of cardiac muscle hypertrophy IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cardiac muscle hypertrophy ISO RGD:733751 1624291 (PMID:28679962) RGD PMID:28679962 positive regulation of connective tissue replacement IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of connective tissue replacement ISO RGD:733751 1624291 (PMID:28679962) RGD PMID:28679962 positive regulation of focal adhesion assembly IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of focal adhesion assembly ISS UniProtKB:P70335 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of focal adhesion assembly ISO RGD:733752 1624291 (MGI:MGI:5486551, PMID:17654484) RGD MGI:MGI:5486551 , PMID:17654484 positive regulation of gene expression IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:733751 1624291 (PMID:27853422), (PMID:28679962) RGD PMID:27853422 , PMID:28679962 positive regulation of gene expression IMP 13601991 PMID:28679962 ARUK-UCL positive regulation of MAPK cascade IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of MAPK cascade ISO RGD:733751 1624291 (PMID:28679962) RGD PMID:28679962 positive regulation of protein localization to nucleus ISO RGD:14219027 1624291 UniProtKB:M3TYT0 (PMID:26634652) RGD PMID:26634652 protein localization to plasma membrane ISO RGD:733751 1624291 UniProtKB:O75116 (PMID:25816133) RGD PMID:25816133 protein localization to plasma membrane IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein phosphorylation IEA InterPro:IPR000719 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of actin cytoskeleton organization ISO RGD:733751 1624291 (PMID:25911094) RGD PMID:25911094 regulation of actin cytoskeleton organization IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of actin filament-based process ISO RGD:733752 1624291 MGI:MGI:2135608 more ... RGD MGI:MGI:5086051 , PMID:21685893 regulation of angiotensin-activated signaling pathway IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of angiotensin-activated signaling pathway ISO RGD:733751 1624291 (PMID:28679962) RGD PMID:28679962 regulation of blood vessel diameter ISO RGD:733752 1624291 (MGI:MGI:6271078, PMID:29353861) RGD MGI:MGI:6271078 , PMID:29353861 regulation of blood vessel diameter IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of cell junction assembly IBA FB:FBgn0026181 more ... 13792537 PMID:21873635 GO_Central regulation of establishment of endothelial barrier ISO RGD:733751 1624291 UniProtKB:O75116 (PMID:25816133) RGD PMID:25816133 regulation of establishment of endothelial barrier IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of keratinocyte differentiation ISO RGD:733751 1624291 (PMID:19997641) RGD PMID:19997641 regulation of keratinocyte differentiation IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of neuron differentiation IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of neuron differentiation ISO RGD:733751 1624291 UniProtKB:O60890 (PMID:27160703) RGD PMID:27160703 regulation of synaptic vesicle endocytosis IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of synaptic vesicle endocytosis ISO RGD:733751 1624291 UniProtKB:O60890 (PMID:27160703) RGD PMID:27160703 response to angiotensin IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to angiotensin ISO RGD:733752 1624291 UniProtKB:P70336 (MGI:MGI:6158813 , PMID:28679962) RGD MGI:MGI:6158813 , PMID:28679962 response to transforming growth factor beta IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to transforming growth factor beta ISO RGD:733752 1624291 UniProtKB:P70336 (MGI:MGI:6158813 , PMID:28679962) RGD MGI:MGI:6158813 , PMID:28679962 response to transforming growth factor beta IGI UniProtKB:Q62868 13601991 PMID:28679962 ARUK-UCL Rho protein signal transduction IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 Rho protein signal transduction IEA InterPro:IPR037310 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Rho protein signal transduction IBA FB:FBgn0026181 more ... 13792537 PMID:21873635 GO_Central Rho protein signal transduction ISO RGD:733751 1624291 UniProtKB:O60890 (PMID:27160703) RGD PMID:27160703 Rho protein signal transduction IMP 8554725 PMID:18332105 MGI Cellular Component amyloid-beta complex IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 amyloid-beta complex colocalizes_with ISO RGD:733751 1624291 (PMID:27853422) RGD PMID:27853422 bleb IEA UniProtKB-SubCell:SL-0472 1600115 GO_REF:0000039 UniProt GO_REF:0000039 centriole IEA UniProtKB-SubCell:SL-0046 1600115 GO_REF:0000039 UniProt GO_REF:0000039 cytoplasm IBA FB:FBgn0002466 more ... 13792537 PMID:21873635 GO_Central cytoplasmic stress granule IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasmic stress granule IBA MGI:MGI:107927 , PANTHER:PTN002743865 13792537 PMID:21873635 GO_Central cytoplasmic stress granule ISO RGD:733752 1624291 (MGI:MGI:6148443, PMID:27430620) RGD MGI:MGI:6148443 , PMID:27430620 cytoskeleton IEA UniProtKB-KW:KW-0206 1600115 GO_REF:0000038 UniProt GO_REF:0000038 cytoskeleton IBA FB:FBgn0002466 more ... 13792537 PMID:21873635 GO_Central cytoskeleton ISS UniProtKB:P70335 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytoskeleton ISO RGD:733752 1624291 (MGI:MGI:5486556, PMID:16741948) RGD MGI:MGI:5486556 , PMID:16741948 cytoskeleton IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 Golgi membrane IEA UniProtKB-SubCell:SL-0134 1600115 GO_REF:0000039 UniProt GO_REF:0000039 lamellipodium IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 lamellipodium ISS UniProtKB:P70335 1600115 GO_REF:0000024 UniProt GO_REF:0000024 lamellipodium ISO RGD:733752 1624291 (MGI:MGI:5486556, PMID:16741948) RGD MGI:MGI:5486556 , PMID:16741948 plasma membrane IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane ISS UniProtKB:P70335 1600115 GO_REF:0000024 UniProt GO_REF:0000024 plasma membrane ISO RGD:733752 1624291 (MGI:MGI:5486556, PMID:16741948) RGD MGI:MGI:5486556 , PMID:16741948 ruffle IEA UniProtKB:P70335 , ensembl:ENSMUSP000000695491600115 GO_REF:0000107 Ensembl GO_REF:0000107 ruffle ISS UniProtKB:P70335 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ruffle ISO RGD:733752 1624291 (MGI:MGI:5486556, PMID:16741948) RGD MGI:MGI:5486556 , PMID:16741948 Molecular Function aspartic-type endopeptidase inhibitor activity IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107 aspartic-type endopeptidase inhibitor activity ISO RGD:733751 1624291 (PMID:24305806) RGD PMID:24305806 ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000038 UniProt GO_REF:0000038 ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000037 UniProt GO_REF:0000037 GTP-Rho binding IMP 633784 RGD GTP-Rho binding IEA InterPro:IPR037310 1600115 GO_REF:0000002 InterPro GO_REF:0000002 GTP-Rho binding IBA PANTHER:PTN000542090 , RGD:620424 13792537 PMID:21873635 GO_Central metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000038 UniProt GO_REF:0000038 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000037 UniProt GO_REF:0000037 protein binding ISO RGD:733752 1624291 UniProtKB:O35671 more ... RGD MGI:MGI:5486551 more ... protein binding ISO RGD:733751 1624291 UniProtKB:O15481 more ... RGD PMID:10652353 more ... protein binding ISO RGD:12423133 1624291 UniProtKB:Q13203 (PMID:22085929) RGD PMID:22085929 protein serine/threonine kinase activity NAS 633784 RGD protein serine/threonine kinase activity IBA FB:FBgn0026181 more ... 13792537 PMID:21873635 GO_Central protein serine/threonine kinase activity IEA UniProtKB-KW:KW-0723 1600115 GO_REF:0000038 UniProt GO_REF:0000038 protein serine/threonine kinase activity ISO RGD:733751 1624291 (PMID:10652353), (PMID:11018042), (PMID:18694941), (PMID:19036714) RGD PMID:10652353 more ... Rho-dependent protein serine/threonine kinase activity ISO RGD:733751 1624291 (PMID:18573880) RGD PMID:18573880 Rho-dependent protein serine/threonine kinase activity IBA PANTHER:PTN000542090 more ... 13792537 PMID:21873635 GO_Central Rho-dependent protein serine/threonine kinase activity IEA UniProtKB:Q13464 , ensembl:ENSP000003826971600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
