1,8-cineole multiple interactions ISO RGD:733752 6480464 Eucalyptol inhibits the reaction [Glucose results in increased expression of ROCK1 protein], Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of ROCK1 protein] CTD PMID:31483951 17beta-estradiol multiple interactions ISO RGD:733751 6480464 Estradiol inhibits the reaction [TNF protein results in increased expression of ROCK1 mRNA] CTD PMID:24771768 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ROCK1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733752 6480464 Tetrachlorodibenzodioxin affects the expression of ROCK1 mRNA CTD PMID:18691609 , PMID:21570461 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:733752 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of ROCK1 mRNA CTD PMID:26251327 4-vinylcyclohexene dioxide affects expression ISO RGD:733752 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of ROCK1 mRNA CTD PMID:20829426 5-(1,4-diazepane-1-sulfonyl)isoquinoline decreases expression ISO RGD:733751 6480464 fasudil results in decreased expression of ROCK1 mRNA, fasudil results in decreased expression of ROCK1 protein CTD PMID:26172442 5-(1,4-diazepane-1-sulfonyl)isoquinoline multiple interactions ISO RGD:733751 6480464 fasudil inhibits the reaction [lipopolysaccharide more ... CTD PMID:30088170 , PMID:30924981 5-(1,4-diazepane-1-sulfonyl)isoquinoline multiple interactions ISO RGD:733752 6480464 fasudil inhibits the reaction [lipopolysaccharide more ... CTD PMID:30924981 5-(1,4-diazepane-1-sulfonyl)isoquinoline multiple interactions EXP 6480464 fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA] more ... CTD PMID:20037814 more ... 5-aza-2'-deoxycytidine decreases expression ISO RGD:733752 6480464 Decitabine results in decreased expression of ROCK1 mRNA CTD PMID:27915011 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ROCK1 mRNA CTD PMID:24780913 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of ROCK1 mRNA CTD PMID:31881176 aflatoxin B1 increases expression ISO RGD:733752 6480464 Aflatoxin B1 results in increased expression of ROCK1 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:733751 6480464 Aflatoxin B1 results in decreased methylation of ROCK1 gene CTD PMID:27153756 aflatoxin M1 decreases expression ISO RGD:733751 6480464 Aflatoxin M1 results in decreased expression of ROCK1 mRNA CTD PMID:30928695 aldehydo-D-glucose multiple interactions EXP 6480464 [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein, notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 aldehydo-D-glucose increases expression ISO RGD:733752 6480464 Glucose results in increased expression of ROCK1 protein CTD PMID:31483951 aldehydo-D-glucose multiple interactions ISO RGD:733752 6480464 Eucalyptol inhibits the reaction [Glucose results in increased expression of ROCK1 protein] CTD PMID:31483951 Alkannin multiple interactions ISO RGD:733751 6480464 alkannin inhibits the reaction [lipopolysaccharide more ... CTD PMID:30924981 Alkannin multiple interactions ISO RGD:733752 6480464 alkannin inhibits the reaction [lipopolysaccharide more ... CTD PMID:30924981 arsane affects methylation ISO RGD:733751 6480464 Arsenic affects the methylation of ROCK1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:733751 6480464 Arsenic affects the methylation of ROCK1 gene CTD PMID:25304211 arsenous acid increases expression ISO RGD:733751 6480464 Arsenic Trioxide results in increased expression of ROCK1 protein CTD PMID:25419056 arsenous acid decreases expression ISO RGD:733751 6480464 Arsenic Trioxide results in decreased expression of ROCK1 mRNA CTD PMID:26238599 aspartame multiple interactions ISO RGD:733752 6480464 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA CTD PMID:23783067 benzo[a]pyrene decreases expression ISO RGD:733751 6480464 Benzoapyrene results in decreased expression of ROCK1 mRNA CTD PMID:20064835 benzo[a]pyrene decreases methylation ISO RGD:733752 6480464 Benzoapyrene results in decreased methylation of ROCK1 intron CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:733751 6480464 Benzoapyrene metabolite results in increased expression of ROCK1 mRNA CTD PMID:26314263 benzo[a]pyrene increases expression ISO RGD:733752 6480464 Benzoapyrene results in increased expression of ROCK1 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:733751 6480464 7 more ... CTD PMID:19150397 , PMID:26238291 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ROCK1 mRNA CTD PMID:25181051 Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of ROCK1 protein CTD PMID:28903499 bufalin decreases expression ISO RGD:733751 6480464 bufalin results in decreased expression of ROCK1 protein CTD PMID:23949904 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of ROCK1 promoter CTD PMID:22457795 cadmium dichloride decreases expression ISO RGD:733752 6480464 Cadmium Chloride results in decreased expression of ROCK1 mRNA CTD PMID:24982889 calciol increases expression ISO RGD:733752 6480464 Cholecalciferol results in increased expression of ROCK1 mRNA CTD PMID:17170073 carbamazepine affects expression ISO RGD:733751 6480464 Carbamazepine affects the expression of ROCK1 mRNA CTD PMID:24752500 carbon nanotube multiple interactions ISO RGD:733751 6480464 ROCK1 protein promotes the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein] CTD PMID:24760326 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of ROCK1 mRNA CTD PMID:23125180 chromium atom increases expression EXP 6480464 Chromium results in increased expression of ROCK1 mRNA CTD PMID:17692352 cisplatin multiple interactions ISO RGD:733751 6480464 [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of ROCK1 mRNA CTD PMID:30871063 clobetasol decreases expression ISO RGD:733752 6480464 Clobetasol results in decreased expression of ROCK1 mRNA CTD PMID:27462272 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNA CTD PMID:17602206 cobalt dichloride increases expression ISO RGD:733751 6480464 cobaltous chloride results in increased expression of ROCK1 mRNA CTD PMID:26314263 crocidolite asbestos multiple interactions ISO RGD:733751 6480464 ROCK1 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein] CTD PMID:24760326 cyclosporin A decreases expression ISO RGD:733752 6480464 Cyclosporine results in decreased expression of ROCK1 mRNA CTD PMID:19770486 D-glucose multiple interactions EXP 6480464 [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein, notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 D-glucose increases expression ISO RGD:733752 6480464 Glucose results in increased expression of ROCK1 protein CTD PMID:31483951 D-glucose multiple interactions ISO RGD:733752 6480464 Eucalyptol inhibits the reaction [Glucose results in increased expression of ROCK1 protein] CTD PMID:31483951 daunorubicin affects expression EXP 6480464 Daunorubicin affects the expression of ROCK1 mRNA CTD PMID:20037814 daunorubicin multiple interactions EXP 6480464 fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA] CTD PMID:20037814 Deguelin decreases expression ISO RGD:733751 6480464 deguelin results in decreased expression of ROCK1 protein CTD PMID:25322282 , PMID:26884827 dexamethasone multiple interactions ISO RGD:733751 6480464 Dexamethasone inhibits the reaction [lipopolysaccharide more ... CTD PMID:30924981 dexamethasone multiple interactions ISO RGD:733752 6480464 Dexamethasone inhibits the reaction [lipopolysaccharide more ... CTD PMID:30924981 diarsenic trioxide increases expression ISO RGD:733751 6480464 Arsenic Trioxide results in increased expression of ROCK1 protein CTD PMID:25419056 diarsenic trioxide decreases expression ISO RGD:733751 6480464 Arsenic Trioxide results in decreased expression of ROCK1 mRNA CTD PMID:26238599 diclofenac affects expression ISO RGD:733751 6480464 Diclofenac affects the expression of ROCK1 mRNA CTD PMID:24752500 dicrotophos decreases expression ISO RGD:733751 6480464 dicrotophos results in decreased expression of ROCK1 mRNA CTD PMID:28302478 dimethylarsinic acid decreases expression EXP 6480464 Cacodylic Acid results in decreased expression of ROCK1 mRNA CTD PMID:17720352 dioxygen multiple interactions EXP 6480464 [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein, notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 dioxygen multiple interactions ISO RGD:733751 6480464 ROCK1 protein affects the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:30831131 disodium selenite increases expression ISO RGD:733751 6480464 Sodium Selenite results in increased expression of ROCK1 mRNA CTD PMID:18175754 doxorubicin decreases expression ISO RGD:733751 6480464 Doxorubicin results in decreased expression of ROCK1 mRNA CTD PMID:29803840 emodin decreases expression ISO RGD:733751 6480464 Emodin results in decreased expression of ROCK1 mRNA CTD PMID:16045814 endosulfan multiple interactions ISO RGD:733751 6480464 Endosulfan results in increased expression of and affects the localization of ROCK1 protein CTD PMID:22677888 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of ROCK1 mRNA CTD PMID:31464424 ethanol decreases expression ISO RGD:733752 6480464 Ethanol results in decreased expression of ROCK1 mRNA CTD PMID:29018328 ethanol increases expression ISO RGD:733752 6480464 Ethanol results in increased expression of ROCK1 mRNA CTD PMID:30319688 fasudil hydrochloride decreases expression ISO RGD:733751 6480464 fasudil results in decreased expression of ROCK1 mRNA, fasudil results in decreased expression of ROCK1 protein CTD PMID:26172442 fasudil hydrochloride multiple interactions ISO RGD:733752 6480464 fasudil inhibits the reaction [lipopolysaccharide more ... CTD PMID:30924981 fasudil hydrochloride multiple interactions ISO RGD:733751 6480464 fasudil inhibits the reaction [lipopolysaccharide more ... CTD PMID:30088170 , PMID:30924981 fasudil hydrochloride multiple interactions EXP 6480464 fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA] more ... CTD PMID:20037814 more ... glucose multiple interactions EXP 6480464 [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein, notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 glucose increases expression ISO RGD:733752 6480464 Glucose results in increased expression of ROCK1 protein CTD PMID:31483951 glucose multiple interactions ISO RGD:733752 6480464 Eucalyptol inhibits the reaction [Glucose results in increased expression of ROCK1 protein] CTD PMID:31483951 glycyrrhetinate multiple interactions ISO RGD:733751 6480464 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA], 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein] CTD PMID:31325423 glycyrrhetinic acid multiple interactions ISO RGD:733751 6480464 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA], 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein] CTD PMID:31325423 hyaluronic acid increases phosphorylation ISO RGD:733751 6480464 Hyaluronic Acid results in increased phosphorylation of ROCK1 protein CTD PMID:16864594 hypochlorous acid increases expression ISO RGD:733752 6480464 Hypochlorous Acid results in increased expression of ROCK1 mRNA CTD PMID:19376150 lead diacetate decreases expression ISO RGD:733752 6480464 lead acetate results in decreased expression of ROCK1 mRNA CTD PMID:22609695 maneb multiple interactions ISO RGD:733752 6480464 [Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA CTD PMID:22563483 methoxychlor affects expression ISO RGD:733752 6480464 Methoxychlor affects the expression of ROCK1 mRNA CTD PMID:20829426 methylmercury(1+) increases expression ISO RGD:733751 6480464 methylmercury II results in increased expression of ROCK1 mRNA CTD PMID:26314263 miconazole decreases expression ISO RGD:733752 6480464 Miconazole results in decreased expression of ROCK1 mRNA CTD PMID:27462272 monosodium L-glutamate multiple interactions ISO RGD:733752 6480464 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA CTD PMID:23783067 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNA CTD PMID:17602206 Niclosamide decreases expression ISO RGD:733751 6480464 Niclosamide results in decreased expression of ROCK1 mRNA, Niclosamide results in decreased expression of ROCK1 protein CTD PMID:29251334 notoginsenoside R1 multiple interactions EXP 6480464 notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein] CTD PMID:25305180 ochratoxin A increases expression ISO RGD:733751 6480464 ochratoxin A metabolite results in increased expression of ROCK1 mRNA, ochratoxin A results in increased expression of ROCK1 mRNA CTD PMID:26314263 ouabain increases cleavage ISO RGD:733751 6480464 Ouabain results in increased cleavage of ROCK1 protein CTD PMID:20661774 ouabain multiple interactions ISO RGD:733751 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein] CTD PMID:20661774 paclitaxel increases expression ISO RGD:733751 6480464 Paclitaxel results in increased expression of ROCK1 mRNA CTD PMID:15000894 pamidronate decreases expression ISO RGD:733751 6480464 pamidronate results in decreased expression of ROCK1 protein CTD PMID:16298452 paraquat multiple interactions ISO RGD:733752 6480464 [Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA CTD PMID:22563483 paraquat multiple interactions EXP 6480464 fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein] CTD PMID:30088170 paraquat increases expression EXP 6480464 Paraquat results in increased expression of ROCK1 protein CTD PMID:30088170 paraquat multiple interactions ISO RGD:733751 6480464 fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein] CTD PMID:30088170 paraquat increases expression ISO RGD:733751 6480464 Paraquat results in increased expression of ROCK1 protein CTD PMID:30088170 paraquat increases expression ISO RGD:733752 6480464 Paraquat results in increased expression of ROCK1 mRNA CTD PMID:22563483 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:733751 6480464 perfluorooctane sulfonic acid results in decreased expression of ROCK1 mRNA CTD PMID:27153767 phenethyl isothiocyanate decreases expression EXP 6480464 phenethyl isothiocyanate results in decreased expression of ROCK1 mRNA CTD PMID:17616710 phenobarbital decreases expression ISO RGD:733752 6480464 Phenobarbital results in decreased expression of ROCK1 mRNA CTD PMID:19363144 , PMID:23091169 phorbol 13-acetate 12-myristate increases expression ISO RGD:733751 6480464 Tetradecanoylphorbol Acetate results in increased expression of ROCK1 protein CTD PMID:24760326 propiconazole decreases expression ISO RGD:733752 6480464 propiconazole results in decreased expression of ROCK1 mRNA CTD PMID:19363144 , PMID:21278054 pyridaben increases expression ISO RGD:733752 6480464 pyridaben results in increased expression of ROCK1 mRNA CTD PMID:22563483 quercetin increases expression ISO RGD:733751 6480464 Quercetin results in increased expression of ROCK1 protein CTD PMID:15221776 , PMID:23645742 quercitrin affects expression ISO RGD:733751 6480464 quercitrin affects the expression of ROCK1 mRNA CTD PMID:25193878 raloxifene decreases expression EXP 6480464 Raloxifene Hydrochloride results in decreased expression of ROCK1 mRNA CTD PMID:20970835 resveratrol decreases expression ISO RGD:733751 6480464 Resveratrol results in decreased expression of ROCK1 mRNA, Resveratrol results in decreased expression of ROCK1 protein CTD PMID:18089832 silicon dioxide increases expression ISO RGD:733751 6480464 Silicon Dioxide analog results in increased expression of ROCK1 mRNA CTD PMID:25895662 sodium arsenate increases expression ISO RGD:733752 6480464 sodium arsenate results in increased expression of ROCK1 mRNA CTD PMID:21795629 sorafenib decreases expression EXP 6480464 sorafenib results in decreased expression of ROCK1 mRNA, sorafenib results in decreased expression of ROCK1 protein CTD PMID:19338580 sorafenib increases expression EXP 6480464 sorafenib results in increased expression of ROCK1 protein CTD PMID:19338580 streptozocin multiple interactions EXP 6480464 fasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein], fasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA] CTD PMID:22429817 , PMID:23376009 streptozocin increases activity EXP 6480464 Streptozocin results in increased activity of ROCK1 protein CTD PMID:23376009 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of ROCK1 mRNA, Streptozocin results in increased expression of ROCK1 protein CTD PMID:22429817 , PMID:31062909 succimer multiple interactions ISO RGD:733752 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ROCK1 mRNA CTD PMID:26378955 testosterone affects expression EXP 6480464 Testosterone affects the expression of ROCK1 mRNA CTD PMID:22028410 tipifarnib increases expression EXP 6480464 tipifarnib results in increased expression of ROCK1 mRNA CTD PMID:16403772 tributylstannane increases expression ISO RGD:733751 6480464 tributyltin results in increased expression of ROCK1 mRNA CTD PMID:26314263 Tributyltin oxide increases expression ISO RGD:733751 6480464 bistri-n-butyltinoxide results in increased expression of ROCK1 mRNA CTD PMID:26314263 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of ROCK1 mRNA CTD PMID:27554044 Triptolide decreases expression ISO RGD:733752 6480464 triptolide results in decreased expression of ROCK1 mRNA CTD PMID:26420756 troglitazone increases expression ISO RGD:733751 6480464 troglitazone results in increased expression of ROCK1 mRNA CTD PMID:19140230 tungsten decreases expression ISO RGD:733752 6480464 Tungsten results in decreased expression of ROCK1 mRNA CTD PMID:30912803 valproic acid decreases methylation ISO RGD:733751 6480464 Valproic Acid results in decreased methylation of ROCK1 gene CTD PMID:29154799 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of ROCK1 mRNA CTD PMID:29427782 valproic acid decreases expression ISO RGD:733751 6480464 Valproic Acid results in decreased expression of ROCK1 mRNA CTD PMID:23179753 Y-27632 multiple interactions ISO RGD:733752 6480464 ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein] CTD PMID:14615541 Y-27632 decreases activity ISO RGD:733751 6480464 [Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein CTD PMID:16675616
