Dmbt1 (deleted in malignant brain tumors 1) - Rat Genome Database

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Gene: Dmbt1 (deleted in malignant brain tumors 1) Rattus norvegicus
Analyze
Symbol: Dmbt1
Name: deleted in malignant brain tumors 1
RGD ID: 61984
Description: Predicted to enable several functions, including heparan sulfate binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including response to biphenyl; response to estrogen; and tissue regeneration. Located in collagen-containing extracellular matrix. Biomarker of pheochromocytoma. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human DMBT1 (deleted in malignant brain tumors 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: crp-ductin; Crpd; Dbmt1; deleted in malignant brain tumors 1 protein; deleted in malignant brain tumors 1 protein-like; ebnerin; hensin; LOC100361701; LOC100911344; LOC691969; pancrin; similar to deleted in malignant brain tumors 1 isoform a precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,047,702 - 195,126,704 (+)NCBIGRCr8
mRatBN7.21185,617,469 - 185,696,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,617,294 - 185,696,478 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,967,662 - 194,046,681 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01201,145,205 - 201,224,201 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01193,816,971 - 193,895,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01203,149,414 - 203,228,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01201,620,642 - 201,689,905 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01210,207,368 - 210,243,040 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01208,653,663 - 208,723,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41190,378,428 - 190,470,536 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11190,528,292 - 190,620,410 (+)NCBI
Celera1183,224,487 - 183,303,321 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
anthracen-2-amine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
dibutyl phthalate  (EXP)
estrone  (EXP)
ethanol  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
genistein  (ISO)
glafenine  (EXP)
indole-3-methanol  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paraquat  (EXP)
phenformin  (EXP)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
raloxifene  (EXP,ISO)
resveratrol  (EXP,ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
XL147  (ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1. Bisgaard HC, etal., Am J Pathol 2002 Oct;161(4):1187-98.
2. Gene expression profiling of rat pheochromocytoma. Elkahloun AG, etal., Ann N Y Acad Sci. 2006 Aug;1073:290-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Genter MB, etal., Physiol Genomics. 2002 Dec 26;12(1):35-45.
5. Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3. Hikita C, etal., J Cell Biol. 2000 Dec 11;151(6):1235-46.
6. Molecular cloning of Ebnerin, a von Ebner's gland protein associated with taste buds. Li XJ and Snyder SH, J Biol Chem 1995 Jul 28;270(30):17674-9.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Mollenhauer J, etal., Nat Genet. 1997 Sep;17(1):32-9.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium. Tynan S, etal., Endocrinology. 2005 Mar;146(3):1066-73. Epub 2004 Nov 24.
Additional References at PubMed
PMID:7876332   PMID:9247472   PMID:10485905   PMID:11007786   PMID:12884308   PMID:15292166   PMID:15452149   PMID:19189310   PMID:19199708   PMID:22664934   PMID:23012479   PMID:36916375  


Genomics

Comparative Map Data
Dmbt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,047,702 - 195,126,704 (+)NCBIGRCr8
mRatBN7.21185,617,469 - 185,696,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,617,294 - 185,696,478 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,967,662 - 194,046,681 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01201,145,205 - 201,224,201 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01193,816,971 - 193,895,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01203,149,414 - 203,228,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01201,620,642 - 201,689,905 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01210,207,368 - 210,243,040 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01208,653,663 - 208,723,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41190,378,428 - 190,470,536 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11190,528,292 - 190,620,410 (+)NCBI
Celera1183,224,487 - 183,303,321 (+)NCBICelera
Cytogenetic Map1q41NCBI
DMBT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810122,560,754 - 122,643,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10122,560,665 - 122,643,736 (+)EnsemblGRCh38hg38GRCh38
GRCh3710124,320,270 - 124,403,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610124,310,171 - 124,393,242 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410124,310,170 - 124,393,242NCBI
Celera10118,052,442 - 118,110,650 (+)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10117,951,140 - 118,021,117 (+)NCBIHuRef
CHM1_110124,604,802 - 124,685,026 (+)NCBICHM1_1
T2T-CHM13v2.010123,456,615 - 123,518,779 (+)NCBIT2T-CHM13v2.0
Dmbt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397130,633,787 - 130,723,357 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7130,633,776 - 130,723,357 (+)EnsemblGRCm39 Ensembl
GRCm387131,032,057 - 131,121,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7131,032,046 - 131,121,628 (+)EnsemblGRCm38mm10GRCm38
MGSCv377138,175,590 - 138,265,142 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367130,823,224 - 130,912,776 (+)NCBIMGSCv36mm8
Celera7130,843,517 - 130,932,972 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map773.2NCBI
Dmbt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955477863,388 - 899,703 (+)NCBIChiLan1.0ChiLan1.0
DMBT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28134,416,181 - 134,487,065 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110134,421,533 - 134,492,318 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010119,129,440 - 119,200,232 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110122,540,855 - 123,474,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10122,540,855 - 123,474,497 (+)Ensemblpanpan1.1panPan2
DMBT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12832,198,250 - 32,286,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2832,219,448 - 32,286,532 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2832,273,452 - 32,352,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02832,734,599 - 32,843,241 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12832,266,372 - 32,367,335 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,288,134 - 32,391,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02832,492,566 - 32,643,099 (+)NCBIUU_Cfam_GSD_1.0
LOC101959402
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721314,015,522 - 14,082,223 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648611,377,485 - 11,545,624 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMBT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114132,154,346 - 132,231,274 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,728,925 - 43,753,137 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DMBT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19115,344,861 - 115,346,308 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604876,594,741 - 76,679,974 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dmbt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473724,135,083 - 24,164,935 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dmbt1
508 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
D1Rat110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21185,635,395 - 185,635,534 (+)MAPPERmRatBN7.2
Rnor_6.01201,638,095 - 201,638,231NCBIRnor6.0
Rnor_5.01208,671,125 - 208,671,261UniSTSRnor5.0
RGSC_v3.41190,396,289 - 190,396,654RGDRGSC3.4
RGSC_v3.41190,396,336 - 190,396,472UniSTSRGSC3.4
RGSC_v3.11190,546,170 - 190,546,535RGD
Celera1183,242,431 - 183,242,567UniSTS
RH 3.4 Map11426.9UniSTS
RH 3.4 Map11426.9RGD
FHH x ACI Map188.84UniSTS
FHH x ACI Map188.84RGD
Cytogenetic Map1q37UniSTS
D1Rat470  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41190,403,127 - 190,403,344UniSTSRGSC3.4
RGSC_v3.41190,403,126 - 190,403,344RGDRGSC3.4
RGSC_v3.11190,553,007 - 190,553,225RGD
Celera1183,249,222 - 183,249,421UniSTS
FHH x ACI Map189.99UniSTS
FHH x ACI Map189.99RGD
Cytogenetic Map1q37UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000054910   ⟹   ENSRNOP00000051793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1185,617,294 - 185,696,478 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093308   ⟹   ENSRNOP00000076279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1185,617,294 - 185,696,478 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093490   ⟹   ENSRNOP00000076163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1185,617,294 - 185,696,478 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093674   ⟹   ENSRNOP00000076237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1185,617,294 - 185,696,478 (+)Ensembl
RefSeq Acc Id: NM_022849   ⟹   NP_074040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,047,702 - 195,126,704 (+)NCBI
mRatBN7.21185,617,469 - 185,696,476 (+)NCBI
Rnor_6.01201,620,642 - 201,689,905 (+)NCBI
Rnor_5.01210,207,368 - 210,243,040 (+)NCBI
Celera1183,224,487 - 183,303,321 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001416823 (Get FASTA)   NCBI Sequence Viewer  
  NP_074040 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52248 (Get FASTA)   NCBI Sequence Viewer  
  AAS46613 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051793.4
  ENSRNOP00000076163.2
  ENSRNOP00000076237.2
  ENSRNOP00000076279.2
GenBank Protein Q8CIZ5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_074040   ⟸   NM_022849
- Peptide Label: precursor
- Sequence:
Ensembl Acc Id: ENSRNOP00000076237   ⟸   ENSRNOT00000093674
Ensembl Acc Id: ENSRNOP00000051793   ⟸   ENSRNOT00000054910
Ensembl Acc Id: ENSRNOP00000076279   ⟸   ENSRNOT00000093308
Ensembl Acc Id: ENSRNOP00000076163   ⟸   ENSRNOT00000093490
Protein Domains
CUB   SRCR   ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZV0-F1-model_v2 AlphaFold D3ZZV0 1-1034 view protein structure
AF-Q8CIZ5-F1-model_v2 AlphaFold Q8CIZ5 1-1418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61984 AgrOrtholog
BioCyc Gene G2FUF-57244 BioCyc
Ensembl Genes ENSRNOG00000020560 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000054910.4 UniProtKB/TrEMBL
  ENSRNOT00000093308.2 UniProtKB/TrEMBL
  ENSRNOT00000093490.2 UniProtKB/TrEMBL
  ENSRNOT00000093674.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.4100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_domain-containing UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170568 UniProtKB/Swiss-Prot
NCBI Gene Dmbt1 ENTREZGENE
PANTHER DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCAVENGER RECEPTOR DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zona_pellucida UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dmbt1 PhenoGen
PRINTS SPERACTRCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020560 RatGTEx
SMART CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207016
UniProt A0A1W2Q668_RAT UniProtKB/TrEMBL
  A0A1W2Q6D7_RAT UniProtKB/TrEMBL
  A0A1W2Q6H6_RAT UniProtKB/TrEMBL
  D3ZZV0 ENTREZGENE, UniProtKB/TrEMBL
  DMBT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q62827 UniProtKB/Swiss-Prot
  Q6QD54 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Dmbt1  deleted in malignant brain tumors 1  LOC100911344  deleted in malignant brain tumors 1 protein-like  Data merged from RGD:6493486 737654 PROVISIONAL
2013-04-17 Dmbt1  deleted in malignant brain tumors 1  LOC691969  similar to deleted in malignant brain tumors 1 isoform a precursor  Data merged from RGD:1593323 737654 PROVISIONAL
2013-04-17 Dmbt1  deleted in malignant brain tumors 1  LOC100361701  deleted in malignant brain tumors 1  Data merged from RGD:2319573 737654 PROVISIONAL
2012-07-05 LOC100911344  deleted in malignant brain tumors 1 protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 LOC100361701  deleted in malignant brain tumors 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC691969  similar to deleted in malignant brain tumors 1 isoform a precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Dmbt1  deleted in malignant brain tumors 1      Name updated 70584 APPROVED
2001-12-06 Dmbt1  deleted in malignant brain tumors 1      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains extracellular region contains a number of repeated domains with homology to the scavenger receptor cysteine-rich domain and to a repeated domain of bone morphogenetic protein-I 61559
gene_expression expressed in secretory duct epithelial cells of von Ebner's glands (VEG) 61559
gene_protein 1290 amino acids 61559