DMBT1 (deleted in malignant brain tumors 1) - Rat Genome Database

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Gene: DMBT1 (deleted in malignant brain tumors 1) Canis lupus familiaris
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Symbol: DMBT1
Name: deleted in malignant brain tumors 1
RGD ID: 12222524
Description: ENCODES a protein that exhibits DNA binding (ortholog); heparan sulfate binding (ortholog); lipopolysaccharide binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); blastocyst development (ortholog); cell differentiation (ortholog); ASSOCIATED WITH Colonic Neoplasms (ortholog); craniosynostosis (ortholog); genetic disease (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); cytoplasm (ortholog); extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: deleted in malignant brain tumors 1 protein; deleted in malignant brain tumors 1 protein-like; LOC610335
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12832,198,250 - 32,286,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2832,219,448 - 32,286,532 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2832,273,452 - 32,352,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02832,734,599 - 32,843,241 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12832,266,372 - 32,367,335 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,288,134 - 32,391,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02832,492,566 - 32,643,099 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DMBT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12832,198,250 - 32,286,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2832,219,448 - 32,286,532 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2832,273,452 - 32,352,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02832,734,599 - 32,843,241 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12832,266,372 - 32,367,335 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,288,134 - 32,391,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02832,492,566 - 32,643,099 (+)NCBIUU_Cfam_GSD_1.0
DMBT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810122,560,754 - 122,643,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10122,560,665 - 122,643,736 (+)EnsemblGRCh38hg38GRCh38
GRCh3710124,320,270 - 124,403,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610124,310,171 - 124,393,242 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410124,310,170 - 124,393,242NCBI
Celera10118,052,442 - 118,110,650 (+)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10117,951,140 - 118,021,117 (+)NCBIHuRef
CHM1_110124,604,802 - 124,685,026 (+)NCBICHM1_1
T2T-CHM13v2.010123,456,615 - 123,518,779 (+)NCBIT2T-CHM13v2.0
Dmbt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397130,633,787 - 130,723,357 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7130,633,776 - 130,723,357 (+)EnsemblGRCm39 Ensembl
GRCm387131,032,057 - 131,121,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7131,032,046 - 131,121,628 (+)EnsemblGRCm38mm10GRCm38
MGSCv377138,175,590 - 138,265,142 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367130,823,224 - 130,912,776 (+)NCBIMGSCv36mm8
Celera7130,843,517 - 130,932,972 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map773.2NCBI
Dmbt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,047,702 - 195,126,704 (+)NCBIGRCr8
mRatBN7.21185,617,469 - 185,696,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,617,294 - 185,696,478 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,967,662 - 194,046,681 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01201,145,205 - 201,224,201 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01193,816,971 - 193,895,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01203,149,414 - 203,228,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01201,620,642 - 201,689,905 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01210,207,368 - 210,243,040 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01208,653,663 - 208,723,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41190,378,428 - 190,470,536 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11190,528,292 - 190,620,410 (+)NCBI
Celera1183,224,487 - 183,303,321 (+)NCBICelera
Cytogenetic Map1q41NCBI
Dmbt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955477863,388 - 899,703 (+)NCBIChiLan1.0ChiLan1.0
DMBT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28134,416,181 - 134,487,065 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110134,421,533 - 134,492,318 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010119,129,440 - 119,200,232 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110122,540,855 - 123,474,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10122,540,855 - 123,474,497 (+)Ensemblpanpan1.1panPan2
LOC101959402
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721314,015,522 - 14,082,223 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648611,377,485 - 11,545,624 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMBT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114132,154,346 - 132,231,274 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,728,925 - 43,753,137 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DMBT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19115,344,861 - 115,346,308 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604876,594,741 - 76,679,974 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dmbt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473724,135,083 - 24,164,935 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DMBT1
1697 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 4 1 1 1 1
Low 6 5 5 1 2 4
Below cutoff 1 7 2 4 1 5 6 2 2

Sequence


RefSeq Acc Id: ENSCAFT00000019948   ⟹   ENSCAFP00000018502
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2832,219,448 - 32,286,532 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000019961   ⟹   ENSCAFP00000018515
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2832,219,448 - 32,286,532 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000019984   ⟹   ENSCAFP00000018537
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2832,219,448 - 32,286,532 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090693   ⟹   ENSCAFP00000060375
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2832,219,448 - 32,286,532 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000091564   ⟹   ENSCAFP00000047398
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2832,219,448 - 32,286,532 (+)Ensembl
RefSeq Acc Id: XM_038439657   ⟹   XP_038295585
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02832,734,599 - 32,843,241 (+)NCBI
RefSeq Acc Id: XM_038460329   ⟹   XP_038316257
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2832,273,452 - 32,352,858 (+)NCBI
RefSeq Acc Id: XM_038515407   ⟹   XP_038371335
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12832,266,372 - 32,367,335 (+)NCBI
RefSeq Acc Id: XM_038579001   ⟹   XP_038434929
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02832,492,566 - 32,643,099 (+)NCBI
RefSeq Acc Id: XM_038643226   ⟹   XP_038499154
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02832,288,134 - 32,391,575 (+)NCBI
RefSeq Acc Id: ENSCAFP00000018537   ⟸   ENSCAFT00000019984
RefSeq Acc Id: ENSCAFP00000018515   ⟸   ENSCAFT00000019961
RefSeq Acc Id: ENSCAFP00000018502   ⟸   ENSCAFT00000019948
RefSeq Acc Id: ENSCAFP00000047398   ⟸   ENSCAFT00000091564
RefSeq Acc Id: ENSCAFP00000060375   ⟸   ENSCAFT00000090693
RefSeq Acc Id: XP_038371335   ⟸   XM_038515407
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038499154   ⟸   XM_038643226
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038295585   ⟸   XM_038439657
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038316257   ⟸   XM_038460329
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038434929   ⟸   XM_038579001
- Peptide Label: isoform X4
Protein Domains
CUB   SRCR   ZP

Promoters
RGD ID:13688363
Promoter ID:EPDNEW_C6431
Type:single initiation site
Name:DMBT1_1
Description:deleted in malignant brain tumors 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12832,198,239 - 32,198,299EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012561 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019948.6 UniProtKB/TrEMBL
  ENSCAFT00000090693.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
  2.60.40.4100 UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  ZP-C UniProtKB/TrEMBL
  ZP_dom UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/TrEMBL
NCBI Gene DMBT1 ENTREZGENE
PANTHER DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN UniProtKB/TrEMBL
  SRCR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
  Zona_pellucida UniProtKB/TrEMBL
PRINTS SPERACTRCPTR UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
  ZP_1 UniProtKB/TrEMBL
  ZP_2 UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  SM00202 UniProtKB/TrEMBL
  SM00241 UniProtKB/TrEMBL
Superfamily-SCOP Spermadhesin, CUB domain UniProtKB/TrEMBL
  SRCR-like UniProtKB/TrEMBL
UniProt A0A8P0SH86_CANLF UniProtKB/TrEMBL
  A0A8P0TC63_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:39996 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 DMBT1  deleted in malignant brain tumors 1  LOC610335  deleted in malignant brain tumors 1 protein-like  Data merged from RGD:12184906 737654 PROVISIONAL