GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Mitoxantrone results in decreased expression of BCL2 mRNA | PMID:8219202 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein] | PMID:15582267 PMID:8840993 | |
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