Atp7a (ATPase copper transporting alpha) - Rat Genome Database

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Gene: Atp7a (ATPase copper transporting alpha) Rattus norvegicus
Analyze
Symbol: Atp7a
Name: ATPase copper transporting alpha
RGD ID: 2179
Description: Enables protein-folding chaperone binding activity and small GTPase binding activity. Involved in several processes, including cellular response to cobalt ion; cellular response to lead ion; and regulation of monoatomic cation transmembrane transport. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and cytoplasmic vesicle. Biomarker of Alzheimer's disease; Wilson disease; congenital diaphragmatic hernia; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Menkes disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to human ATP7A (ATPase copper transporting alpha); PARTICIPATES IN cisplatin drug pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase Cu++ transporting alpha polypeptide (Menkes syndrome); ATPase, Cu++ transporting, alpha polypeptide; ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome); copper pump 1; copper-transporting ATPase 1; menkes disease-associated protein homolog; Mnk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,159,635 - 75,267,094 (+)NCBIGRCr8
mRatBN7.2X71,094,144 - 71,201,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,094,202 - 71,198,354 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX72,646,905 - 72,707,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,147,215 - 76,207,599 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X73,710,399 - 73,770,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,192,540 - 94,249,776 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X94,265,972 - 94,323,206 (+)NCBI
CeleraX72,450,404 - 72,510,070 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dithiothreitol  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylcholine  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
brefeldin A  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
carboplatin  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (EXP)
desferrioxamine B  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
FR900359  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
ketamine  (EXP)
L-1,4-dithiothreitol  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melanins  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mithramycin  (EXP)
mitoxantrone  (ISO)
monensin A  (ISO)
N-ethylmaleimide  (ISO)
neocuproine  (ISO)
nitrofen  (EXP)
omeprazole  (ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
potassium chromate  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
satraplatin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver monochloride  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
succimer  (ISO)
superoxide  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cartilage development  (ISO)
catecholamine metabolic process  (ISO)
cellular response to amino acid stimulus  (IMP)
cellular response to antibiotic  (IEP)
cellular response to cadmium ion  (IEP)
cellular response to cobalt ion  (IEP)
cellular response to copper ion  (IDA,IEP)
cellular response to hypoxia  (IEP)
cellular response to iron ion  (IEP)
cellular response to lead ion  (IEP)
cellular response to platelet-derived growth factor stimulus  (IMP)
central nervous system neuron development  (ISO)
cerebellar Purkinje cell differentiation  (ISO)
collagen fibril organization  (ISO)
copper ion export  (IBA,IMP,ISO,ISS)
copper ion import  (IBA,ISO)
copper ion transmembrane transport  (IEA)
copper ion transport  (IEA,ISO)
dendrite morphogenesis  (ISO)
detoxification of copper ion  (ISO)
dopamine metabolic process  (ISO)
elastic fiber assembly  (ISO)
epinephrine metabolic process  (ISO)
establishment of localization in cell  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (IEP)
glycoprotein biosynthetic process  (ISO)
hair follicle morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
in utero embryonic development  (IEP)
intracellular copper ion homeostasis  (IBA,ISO,ISS)
L-tryptophan metabolic process  (ISO)
lactation  (IEP)
liver development  (IEP)
locomotory behavior  (ISO)
lung alveolus development  (ISO)
mitochondrion organization  (ISO)
monoatomic cation transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of catecholamine metabolic process  (ISO)
negative regulation of iron ion transmembrane transport  (IMP)
negative regulation of neuron apoptotic process  (ISO)
neuron apoptotic process  (ISO)
neuron cellular homeostasis  (ISO)
neuron projection morphogenesis  (ISO)
norepinephrine biosynthetic process  (ISO)
norepinephrine metabolic process  (ISO)
peptidyl-lysine modification  (ISO)
pigmentation  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell size  (IMP)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of lamellipodium assembly  (IMP)
positive regulation of melanin biosynthetic process  (ISO,ISS)
positive regulation of response to wounding  (IMP)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
pyramidal neuron development  (ISO)
regulation of cytochrome-c oxidase activity  (IMP)
regulation of gene expression  (ISO)
regulation of oxidative phosphorylation  (ISO)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (ISO)
response to copper ion  (IDA,IEP)
response to iron(III) ion  (IEP)
response to lead ion  (IEP)
response to manganese ion  (IDA,IEP)
response to zinc ion  (IEP)
serotonin metabolic process  (ISO)
skin development  (ISO)
T-helper cell differentiation  (ISO)
tyrosine metabolic process  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration. Ashino T, etal., Circ Res. 2010 Sep 17;107(6):787-99. doi: 10.1161/CIRCRESAHA.110.225334. Epub 2010 Jul 29.
2. Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis. Babich PS, etal., Bull Exp Biol Med. 2009 Aug;148(2):217-22.
3. Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model. Bauerly KA, etal., Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G1007-14. Epub 2004 Dec 9.
4. Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine alpha-Amidating Monooxygenase, a Luminal Cuproenzyme. Bonnemaison ML, etal., J Biol Chem. 2015 Aug 28;290(35):21264-79. doi: 10.1074/jbc.M115.641027. Epub 2015 Jul 13.
5. Homocysteine induces cardiac hypertrophy by up-regulating ATP7a expression. Cao Z, etal., Int J Clin Exp Pathol. 2015 Oct 1;8(10):12829-36. eCollection 2015.
6. Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts. Chou DK, etal., Toxicol Sci. 2007 Sep;99(1):267-76. Epub 2007 Jun 20.
7. Gene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunum. Collins JF Biol Res. 2006;39(1):25-37.
8. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Collins JF, etal., Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G964-71. Epub 2005 Jan 6.
9. Alternative splicing of the Menkes copper Atpase (Atp7a) transcript in the rat intestinal epithelium. Collins JF, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G695-707. doi: 10.1152/ajpgi.00203.2009. Epub 2009 Aug 13.
10. Menkes protein localization in rat parotid acinar cells. D'Amico F, etal., Acta Histochem. 2005;107(5):373-8. Epub 2005 Sep 23.
11. Similar splicing mutations of the Menkes/mottled copper-transporting ATPase gene in occipital horn syndrome and the blotchy mouse. Das S, etal., Am J Hum Genet. 1995 Mar;56(3):570-6.
12. Favorably skewed X-inactivation accounts for neurological sparing in female carriers of Menkes disease. Desai V, etal., Clin Genet. 2011 Feb;79(2):176-82. doi: 10.1111/j.1399-0004.2010.01451.x.
13. Regulation of copper transport crossing brain barrier systems by Cu-ATPases: effect of manganese exposure. Fu X, etal., Toxicol Sci. 2014 Jun;139(2):432-51. doi: 10.1093/toxsci/kfu048. Epub 2014 Mar 10.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease. Grimes A, etal., Hum Mol Genet. 1997 Jul;6(7):1037-42.
17. Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1). Gulec S and Collins JF, J Nutr. 2014 Jan;144(1):12-9. doi: 10.3945/jn.113.183160. Epub 2013 Oct 30.
18. Silencing of the Menkes copper-transporting ATPase (Atp7a) gene increases cyclin D1 protein expression and impairs proliferation of rat intestinal epithelial (IEC-6) cells. Gulec S and Collins JF, J Trace Elem Med Biol. 2014 Oct;28(4):459-64. doi: 10.1016/j.jtemb.2014.07.010. Epub 2014 Aug 4.
19. Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ). Gulec S and Collins JF, PLoS One. 2013 Jun 11;8(6):e66010. doi: 10.1371/journal.pone.0066010. Print 2013.
20. Loss of divalent metal transporter 1 (DMT1) function promotes brain copper accumulation and increases impulsivity. Han M, etal., J Neurochem. 2016 Jun 22. doi: 10.1111/jnc.13717.
21. Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue. Ip V, etal., Mol Pain. 2010 Sep 13;6:53. doi: 10.1186/1744-8069-6-53.
22. Occipital horn syndrome and a mild Menkes phenotype associated with splice site mutations at the MNK locus. Kaler SG, etal., Nat Genet. 1994 Oct;8(2):195-202.
23. Mammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localization. Kelleher SL and Lonnerdal B, Am J Physiol Regul Integr Comp Physiol. 2006 Oct;291(4):R1181-91. Epub 2006 Jun 1.
24. Marginal maternal Zn intake in rats alters mammary gland Cu transporter levels and milk Cu concentration and affects neonatal Cu metabolism. Kelleher SL and Lonnerdal B, J Nutr. 2003 Jul;133(7):2141-8.
25. Missense mutations in the copper transporter gene ATP7A cause X-linked distal hereditary motor neuropathy. Kennerson ML, etal., Am J Hum Genet. 2010 Mar 12;86(3):343-52. doi: 10.1016/j.ajhg.2010.01.027. Epub 2010 Feb 18.
26. Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury. Kohno T, etal., Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):805-13. doi: 10.1161/ATVBAHA.112.300862. Epub 2013 Jan 24.
27. Transcriptional regulation of copper metabolism genes in the liver of fetal and neonatal control and iron-deficient rats. Lenartowicz M, etal., Biometals. 2015 Feb;28(1):51-9. doi: 10.1007/s10534-014-9802-z. Epub 2014 Oct 28.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Exon duplications in the ATP7A gene: frequency and transcriptional behaviour. Mogensen M, etal., Orphanet J Rare Dis. 2011 Nov 10;6:73. doi: 10.1186/1750-1172-6-73.
30. Twenty-five novel mutations including duplications in the ATP7A gene. Moizard MP, etal., Clin Genet. 2011 Mar;79(3):243-53. doi: 10.1111/j.1399-0004.2010.01461.x.
31. Similar splice-site mutations of the ATP7A gene lead to different phenotypes: classical Menkes disease or occipital horn syndrome. Moller LB, etal., Am J Hum Genet 2000 Apr;66(4):1211-20. Epub 2000 Mar 17.
32. Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model. Monnot AD, etal., Exp Biol Med (Maywood). 2012 Mar;237(3):327-33. doi: 10.1258/ebm.2011.011170.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. DYNAMICS OF ENDOGENOUS ATP7A (MENKES PROTEIN) IN INTESTINAL EPITHELIAL CELLS: COPPER-DEPENDENT REDISTRIBUTION BETWEEN TWO INTRACELLULAR SITES. Nyasae L, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Dec 7;.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Characterizing the molecular phenotype of an Atp7aT985I conditional knock in mouse model for X-linked distal hereditary motor neuropathy (dHMNX). Perez-Siles G, etal., Metallomics. 2016 Jun 13.
37. Ceruloplasmin gene expression profile changes in the rat mammary gland during pregnancy, lactation and involution. Platonova NA, etal., J Trace Elem Med Biol. 2017 Sep;43:126-134. doi: 10.1016/j.jtemb.2016.12.013. Epub 2017 Jan 3.
38. Constitutive skipping of alternatively spliced exon 10 in the ATP7A gene abolishes Golgi localization of the menkes protein and produces the occipital horn syndrome. Qi M and Byers PH, Hum Mol Genet. 1998 Mar;7(3):465-9.
39. Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases. Qian Y, etal., Mol Cell Biochem 1998 Apr;181(1-2):49-61.
40. Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains. Ravia JJ, etal., J Biol Chem. 2005 Oct 28;280(43):36221-7. Epub 2005 Aug 4.
41. GOA pipeline RGD automated data pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Comprehensive gene review and curation RGD comprehensive gene curation
45. Subcellular targets of cisplatin cytotoxicity: an integrated view. Sancho-Martinez SM, etal., Pharmacol Ther. 2012 Oct;136(1):35-55. doi: 10.1016/j.pharmthera.2012.07.003. Epub 2012 Jul 14.
46. NMDA receptor activation mediates copper homeostasis in hippocampal neurons. Schlief ML, etal., J Neurosci. 2005 Jan 5;25(1):239-46.
47. Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. Steveson TC, etal., Endocrinology. 2003 Jan;144(1):188-200.
48. Disruption of copper-dependent signaling pathway in the nitrofen-induced congenital diaphragmatic hernia. Takahashi T, etal., Pediatr Surg Int. 2015 Jan;31(1):31-5. doi: 10.1007/s00383-014-3620-9. Epub 2014 Oct 16.
49. Lysyl oxidase and P-ATPase-7A expression during embryonic development in the rat. Tchaparian EH, etal., Arch Biochem Biophys. 2000 Jul 1;379(1):71-7.
50. Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Xie L and Collins JF, Am J Physiol Cell Physiol. 2011 Jun;300(6):C1298-305. doi: 10.1152/ajpcell.00023.2011. Epub 2011 Feb 23.
51. Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells. Xie L and Collins JF, Am J Physiol Cell Physiol. 2013 Feb 1;304(3):C257-62. doi: 10.1152/ajpcell.00336.2012. Epub 2012 Nov 21.
52. Transcription factors Sp1 and Hif2alpha mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia. Xie L and Collins JF, J Biol Chem. 2013 Aug 16;288(33):23943-52. doi: 10.1074/jbc.M113.489500. Epub 2013 Jun 28.
53. Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat. Yamaguchi Y, etal., Biochem J 1994 Jul 1;301 ( Pt 1):1-4.
54. Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. Zhang S, etal., Cardiovasc Diabetol. 2014 Jun 14;13:100. doi: 10.1186/1475-2840-13-100.
55. [Effects of lead exposure on copper and copper transporters in choroid plexus of rats]. Zhao H, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Nov;32(11):819-22.
56. Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells. Zheng G, etal., Toxicol Lett. 2014 Feb 10;225(1):110-8. doi: 10.1016/j.toxlet.2013.11.034. Epub 2013 Dec 6.
Additional References at PubMed
PMID:14140   PMID:17511   PMID:20889   PMID:27591   PMID:187892   PMID:564942   PMID:571898   PMID:573617   PMID:573619   PMID:937819   PMID:1115218   PMID:1752214  
PMID:1779648   PMID:2288383   PMID:2473662   PMID:3385878   PMID:3674914   PMID:4147174   PMID:4405722   PMID:4561716   PMID:4670054   PMID:4808708   PMID:4858102   PMID:6542992  
PMID:6685755   PMID:7197928   PMID:7509170   PMID:7688531   PMID:7769737   PMID:7873696   PMID:8009964   PMID:8025644   PMID:8096378   PMID:8174230   PMID:8434133   PMID:8550574  
PMID:8640230   PMID:8895222   PMID:8943055   PMID:9321757   PMID:9686356   PMID:9817923   PMID:10098864   PMID:10332039   PMID:10497213   PMID:10567439   PMID:10632785   PMID:11092760  
PMID:11214319   PMID:11311799   PMID:11391006   PMID:12812980   PMID:14572476   PMID:15035611   PMID:15634671   PMID:15670166   PMID:16338116   PMID:16371425   PMID:16397091   PMID:16641100  
PMID:17003121   PMID:19946888   PMID:22130675   PMID:22579041   PMID:30257103  


Genomics

Comparative Map Data
Atp7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,159,635 - 75,267,094 (+)NCBIGRCr8
mRatBN7.2X71,094,144 - 71,201,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,094,202 - 71,198,354 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX72,646,905 - 72,707,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,147,215 - 76,207,599 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X73,710,399 - 73,770,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,192,540 - 94,249,776 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X94,265,972 - 94,323,206 (+)NCBI
CeleraX72,450,404 - 72,510,070 (+)NCBICelera
Cytogenetic MapXq22NCBI
ATP7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X77,910,693 - 78,050,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX77,910,690 - 78,050,395 (+)EnsemblGRCh38hg38GRCh38
GRCh37X77,166,190 - 77,305,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,052,876 - 77,192,208 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X76,972,343 - 77,111,584NCBI
CeleraX77,407,059 - 77,546,975 (+)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX70,752,187 - 70,892,316 (+)NCBIHuRef
CHM1_1X77,058,882 - 77,198,586 (+)NCBICHM1_1
T2T-CHM13v2.0X76,345,749 - 76,485,475 (+)NCBIT2T-CHM13v2.0
Atp7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,070,830 - 105,171,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,070,882 - 105,168,532 (+)EnsemblGRCm39 Ensembl
GRCm38X106,027,224 - 106,128,161 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,027,276 - 106,124,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X103,222,615 - 103,323,499 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X102,230,036 - 102,327,636 (+)NCBIMGSCv36mm8
CeleraX92,880,992 - 92,982,185 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
Atp7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555571,355,397 - 1,515,393 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555571,355,471 - 1,515,725 (+)NCBIChiLan1.0ChiLan1.0
ATP7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X77,492,788 - 77,630,493 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X77,496,415 - 77,634,104 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X67,093,675 - 67,231,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X77,205,579 - 77,342,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,255,312 - 77,342,756 (+)Ensemblpanpan1.1panPan2
ATP7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,203,336 - 60,356,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,203,270 - 60,352,869 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,216,457 - 51,369,626 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X61,442,067 - 61,595,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX61,442,069 - 61,592,549 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X59,148,063 - 59,301,397 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X60,758,474 - 60,911,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X60,346,304 - 60,499,464 (+)NCBIUU_Cfam_GSD_1.0
Atp7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X42,009,558 - 42,154,264 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366832,874,042 - 2,935,040 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366832,874,022 - 2,936,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX61,972,991 - 62,110,048 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X70,891,299 - 71,026,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X66,843,519 - 66,985,655 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX66,843,558 - 66,985,709 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606714,518,402 - 14,662,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248362,808,681 - 2,993,452 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp7a
153 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:50
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000065388
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
DXWox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X71,160,291 - 71,160,568 (+)MAPPERmRatBN7.2
Rnor_6.0X77,142,228 - 77,142,504NCBIRnor6.0
Rnor_5.0X56,265,346 - 56,265,622UniSTSRnor5.0
RGSC_v3.4X94,214,857 - 94,215,133UniSTSRGSC3.4
CeleraX72,472,721 - 72,472,997UniSTS
Cytogenetic MapXq31UniSTS
Atp7a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X71,163,343 - 71,163,869 (+)MAPPERmRatBN7.2
Rnor_6.0X77,145,280 - 77,145,805NCBIRnor6.0
Rnor_5.0X56,268,398 - 56,268,923UniSTSRnor5.0
RGSC_v3.4X94,217,909 - 94,218,434UniSTSRGSC3.4
CeleraX72,475,773 - 72,476,298UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_052803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ817345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ817347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ817348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU131267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU131268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU131269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U59245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000080141   ⟹   ENSRNOP00000071625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX71,137,973 - 71,198,354 (+)Ensembl
Rnor_6.0 EnsemblX77,119,911 - 77,190,449 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085227   ⟹   ENSRNOP00000073682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX77,143,892 - 77,146,290 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089381   ⟹   ENSRNOP00000071914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX77,076,151 - 77,136,010 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091527   ⟹   ENSRNOP00000073176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX71,094,202 - 71,164,219 (+)Ensembl
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)Ensembl
RefSeq Acc Id: NM_052803   ⟹   NP_434690
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,203,520 - 75,263,898 (+)NCBI
mRatBN7.2X71,137,973 - 71,198,354 (+)NCBI
Rnor_6.0X77,119,911 - 77,190,449 (+)NCBI
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBI
RGSC_v3.4X94,192,540 - 94,249,776 (+)RGD
CeleraX72,450,404 - 72,510,070 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256995   ⟹   XP_006257057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,159,665 - 75,267,094 (+)NCBI
mRatBN7.2X71,094,145 - 71,201,550 (+)NCBI
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBI
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256997   ⟹   XP_006257059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,159,675 - 75,267,094 (+)NCBI
mRatBN7.2X71,094,145 - 71,201,550 (+)NCBI
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBI
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099486   ⟹   XP_038955414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,159,635 - 75,267,094 (+)NCBI
mRatBN7.2X71,094,145 - 71,201,550 (+)NCBI
RefSeq Acc Id: XM_039099487   ⟹   XP_038955415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,159,703 - 75,267,094 (+)NCBI
mRatBN7.2X71,094,144 - 71,201,550 (+)NCBI
RefSeq Acc Id: XM_063279806   ⟹   XP_063135876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,159,635 - 75,267,094 (+)NCBI
RefSeq Acc Id: NP_434690   ⟸   NM_052803
- UniProtKB: P70705 (UniProtKB/Swiss-Prot),   A6IV40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257057   ⟸   XM_006256995
- Peptide Label: isoform X1
- UniProtKB: P70705 (UniProtKB/Swiss-Prot),   A6IV40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257059   ⟸   XM_006256997
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000071625   ⟸   ENSRNOT00000080141
Ensembl Acc Id: ENSRNOP00000073682   ⟸   ENSRNOT00000085227
Ensembl Acc Id: ENSRNOP00000071914   ⟸   ENSRNOT00000089381
Ensembl Acc Id: ENSRNOP00000073176   ⟸   ENSRNOT00000091527
RefSeq Acc Id: XP_038955415   ⟸   XM_039099487
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038955414   ⟸   XM_039099486
- Peptide Label: isoform X1
- UniProtKB: P70705 (UniProtKB/Swiss-Prot),   A6IV40 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135876   ⟸   XM_063279806
- Peptide Label: isoform X2
Protein Domains
HMA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70705-F1-model_v2 AlphaFold P70705 1-1492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701903
Promoter ID:EPDNEW_R12424
Type:multiple initiation site
Name:Atp7a_1
Description:ATPase copper transporting alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X77,076,161 - 77,076,221EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2179 AgrOrtholog
BioCyc Gene G2FUF-1925 BioCyc
Ensembl Genes ENSRNOG00000061367 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080141 ENTREZGENE
  ENSRNOT00000080141.2 UniProtKB/Swiss-Prot
  ENSRNOT00000086595 ENTREZGENE
Gene3D-CATH 3.30.70.100 UniProtKB/Swiss-Prot
  3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  Heavy-metal-associated_CS UniProtKB/Swiss-Prot
  HMA_Cu_ion-bd UniProtKB/Swiss-Prot
  HMA_dom UniProtKB/Swiss-Prot
  HMA_dom_sf UniProtKB/Swiss-Prot
  P-typ_ATPase_IB UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
KEGG Report rno:24941 UniProtKB/Swiss-Prot
NCBI Gene 24941 ENTREZGENE
PANTHER P-TYPE CATION-TRANSPORTING ATPASE UniProtKB/Swiss-Prot
  P-TYPE CATION-TRANSPORTING ATPASE UniProtKB/Swiss-Prot
Pfam E1-E2_ATPase UniProtKB/Swiss-Prot
  HMA UniProtKB/Swiss-Prot
  Hydrolase UniProtKB/Swiss-Prot
PharmGKB ATP7A RGD
PhenoGen Atp7a PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
  CUATPASEI UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
  HMA_1 UniProtKB/Swiss-Prot
  HMA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061367 RatGTEx
Superfamily-SCOP SSF55008 UniProtKB/Swiss-Prot
  SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
UniProt A0A8L2UQX4_RAT UniProtKB/TrEMBL
  A6IV40 ENTREZGENE, UniProtKB/TrEMBL
  A6IV41_RAT UniProtKB/TrEMBL
  ATP7A_RAT UniProtKB/Swiss-Prot
  D1GCS2_RAT UniProtKB/TrEMBL
  D1GCS3_RAT UniProtKB/TrEMBL
  D1MCF1_RAT UniProtKB/TrEMBL
  D1MCF3_RAT UniProtKB/TrEMBL
  P70705 ENTREZGENE
  Q99NX2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp7a  ATPase copper transporting alpha  Atp7a  ATPase, Cu++ transporting, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Atp7a  ATPase, Cu++ transporting, alpha polypeptide    ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)  Name updated 625702 APPROVED
2002-06-10 Atp7a  ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains has six metal binding sites 631784
gene_homology has 98% identity to mouse protein 631784
gene_protein 1492 amino acids 631784