Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Atp7a (ATPase copper transporting alpha) Rattus norvegicus
Symbol: Atp7a
Name: ATPase copper transporting alpha
Description: Exhibits Rac GTPase binding activity and chaperone binding activity. Involved in several processes, including cellular response to metal ion; gland development; and regulation of cation transmembrane transport. Localizes to several cellular components, including brush border membrane; cytoplasmic vesicle; and perikaryon. Biomarker of Alzheimer's disease; Wilson disease; congenital diaphragmatic hernia; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Menkes disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to human ATP7A (ATPase copper transporting alpha); PARTICIPATES IN cisplatin drug pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: ATPase Cu++ transporting alpha polypeptide (Menkes syndrome); ATPase, Cu++ transporting, alpha polypeptide; ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome); copper pump 1; copper-transporting ATPase 1; menkes disease-associated protein homolog; Mnk
Homo sapiens (human) : ATP7A (ATPase copper transporting alpha)  HGNC  Alliance
Mus musculus (house mouse) : Atp7a (ATPase, Cu++ transporting, alpha polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp7a (ATPase copper transporting alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP7A (ATPase copper transporting alpha)
Canis lupus familiaris (dog) : ATP7A (ATPase copper transporting alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp7a (ATPase copper transporting alpha)
Sus scrofa (pig) : ATP7A (ATPase copper transporting alpha)
Chlorocebus sabaeus (African green monkey) : ATP7A (ATPase copper transporting alpha)
Heterocephalus glaber (naked mole-rat) : Atp7a (ATPase copper transporting alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,192,540 - 94,249,776 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X94,265,972 - 94,323,206 (+)NCBI
CeleraX72,450,404 - 72,510,070 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Atp7a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2179
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.