1,1'-azobis(N,N-dimethylformamide) multiple interactions ISO RGD:10216 6480464 Diamide promotes the reaction [CLU protein binds to ATP7A protein] CTD PMID:21242307 1,1-dichloroethene increases expression ISO RGD:10215 6480464 vinylidene chloride results in increased expression of ATP7A mRNA CTD PMID:26682919 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in increased expression of ATP7A mRNA CTD PMID:27840820 1,2-dimethylhydrazine multiple interactions ISO RGD:10215 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ATP7A mRNA CTD PMID:22206623 1,4-dithiothreitol multiple interactions ISO RGD:10216 6480464 Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 17alpha-ethynylestradiol multiple interactions ISO RGD:10215 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP7A mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:10215 6480464 Ethinyl Estradiol results in decreased expression of ATP7A mRNA, Ethinyl Estradiol results in decreased expression of ATP7A protein CTD PMID:27690074 17alpha-ethynylestradiol increases expression ISO RGD:10215 6480464 Ethinyl Estradiol results in increased expression of ATP7A mRNA CTD PMID:17942748 2,2,2-tetramine increases expression EXP 6480464 Trientine results in increased expression of ATP7A mRNA, Trientine results in increased expression of ATP7A protein CTD PMID:24927960 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10215 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP7A mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ATP7A mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10215 6480464 Tetrachlorodibenzodioxin affects the expression of ATP7A mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10215 6480464 Tetrachlorodibenzodioxin results in decreased expression of ATP7A mRNA CTD PMID:19770486 , PMID:33956508 2-hydroxypropanoic acid decreases expression ISO RGD:10216 6480464 Lactic Acid results in decreased expression of ATP7A mRNA CTD PMID:30851411 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:10215 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of ATP7A mRNA CTD PMID:20188158 , PMID:26251327 4,4'-sulfonyldiphenol decreases methylation ISO RGD:10215 6480464 bis(4-hydroxyphenyl)sulfone results in decreased methylation of ATP7A exon CTD PMID:33297965 4-hydroxy-TEMPO multiple interactions ISO RGD:10215 6480464 tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]], tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]] CTD PMID:18768397 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions ISO RGD:10216 6480464 Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein] CTD PMID:25337692 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions ISO RGD:10215 6480464 Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein], Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein] CTD PMID:25337692 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ATP7A mRNA CTD PMID:22504374 acetamide increases expression EXP 6480464 acetamide results in increased expression of ATP7A mRNA CTD PMID:31881176 acetylcholine multiple interactions ISO RGD:10215 6480464 ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine], tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]] CTD PMID:18768397 aflatoxin B1 decreases methylation ISO RGD:10216 6480464 Aflatoxin B1 results in decreased methylation of ATP7A gene CTD PMID:27153756 Aflatoxin B2 alpha increases methylation ISO RGD:10216 6480464 aflatoxin B2 results in increased methylation of ATP7A intron CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:10216 6480464 Tretinoin results in increased expression of ATP7A mRNA CTD PMID:16012519 , PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ATP7A mRNA CTD PMID:16483693 aristolochic acid A decreases expression ISO RGD:10216 6480464 aristolochic acid I results in decreased expression of ATP7A mRNA CTD PMID:33212167 ATP multiple interactions ISO RGD:10216 6480464 [Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7A protein CTD PMID:20964302 atrazine decreases expression ISO RGD:10216 6480464 Atrazine results in decreased expression of ATP7A mRNA CTD PMID:22378314 bathocuproine disulfonic acid multiple interactions ISO RGD:10216 6480464 [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein] more ... CTD PMID:11092760 , PMID:21242307 benzo[a]pyrene increases expression ISO RGD:10215 6480464 Benzo(a)pyrene results in increased expression of ATP7A mRNA CTD PMID:20504355 , PMID:22228805 benzo[a]pyrene increases methylation ISO RGD:10216 6480464 Benzo(a)pyrene results in increased methylation of ATP7A exon CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:10216 6480464 Benzo(a)pyrene affects the methylation of ATP7A promoter CTD PMID:27901495 benzo[e]pyrene affects methylation ISO RGD:10216 6480464 benzo(e)pyrene affects the methylation of ATP7A intron CTD PMID:30157460 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ATP7A mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:10216 6480464 bisphenol A results in increased expression of ATP7A mRNA CTD PMID:29275510 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ATP7A mRNA CTD PMID:30816183 , PMID:34947998 bisphenol A decreases expression ISO RGD:10215 6480464 bisphenol A results in decreased expression of ATP7A mRNA, bisphenol A results in decreased expression of ATP7A protein CTD PMID:27690074 brefeldin A multiple interactions ISO RGD:10216 6480464 Brefeldin A inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 butanal decreases expression ISO RGD:10216 6480464 butyraldehyde results in decreased expression of ATP7A mRNA CTD PMID:26079696 cadmium atom decreases expression ISO RGD:10216 6480464 Cadmium results in decreased expression of ATP7A mRNA CTD PMID:24376830 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of ATP7A mRNA, Cadmium results in increased expression of ATP7A protein CTD PMID:32879253 cadmium dichloride decreases expression ISO RGD:10215 6480464 Cadmium Chloride results in decreased expression of ATP7A mRNA CTD PMID:24982889 carboplatin affects localization ISO RGD:10216 6480464 Carboplatin affects the localization of ATP7A protein CTD PMID:24150977 carboplatin multiple interactions ISO RGD:10216 6480464 [MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to Carboplatin, ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin] CTD PMID:24038379 , PMID:24150977 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of ATP7A mRNA CTD PMID:23125180 chromium(6+) decreases expression ISO RGD:10216 6480464 chromium hexavalent ion results in decreased expression of ATP7A mRNA CTD PMID:30690063 cisplatin decreases response to substance ISO RGD:10215 6480464 ATP7A protein results in decreased susceptibility to Cisplatin CTD PMID:16170571 cisplatin affects localization ISO RGD:10216 6480464 Cisplatin affects the localization of ATP7A protein CTD PMID:24150977 cisplatin multiple interactions ISO RGD:10216 6480464 [ATOX1 protein binds to Cisplatin] promotes the reaction [ATP7A protein binds to and results in increased metabolism of Cisplatin] more ... CTD PMID:23751120 more ... cisplatin affects response to substance ISO RGD:10216 6480464 ATP7A protein affects the susceptibility to Cisplatin CTD PMID:17609664 cisplatin decreases response to substance ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to Cisplatin CTD PMID:17510416 , PMID:25801007 cisplatin increases response to substance ISO RGD:10216 6480464 ATP7A mutant form results in increased susceptibility to Cisplatin CTD PMID:22304828 cisplatin increases expression ISO RGD:10215 6480464 Cisplatin results in increased expression of ATP7A mRNA CTD PMID:21151649 cobalt dichloride increases expression ISO RGD:10216 6480464 cobaltous chloride results in increased expression of ATP7A mRNA CTD PMID:24614111 cobalt dichloride multiple interactions EXP 6480464 Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of ATP7A mRNA] CTD PMID:23814049 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of ATP7A mRNA CTD PMID:23814049 copper atom affects metabolic processing ISO RGD:10216 6480464 ATP7A protein affects the metabolism of Copper CTD PMID:16890543 copper atom affects localization ISO RGD:10216 6480464 Copper affects the localization of ATP7A protein CTD PMID:20964302 , PMID:23423674 copper atom decreases abundance ISO RGD:10215 6480464 ATP7A gene mutant form results in decreased abundance of Copper more ... CTD PMID:21336677 more ... copper atom increases transport EXP 6480464 ATP7A protein results in increased transport of Copper CTD PMID:24614235 copper atom affects localization EXP 6480464 Copper affects the localization of ATP7A protein CTD PMID:20671235 , PMID:24614235 copper atom decreases export EXP 6480464 ATP7A mutant form results in decreased export of Copper CTD PMID:24316150 copper atom affects export ISO RGD:10215 6480464 ATP7A protein affects the export of Copper CTD PMID:21409224 copper atom increases export ISO RGD:10216 6480464 ATP7A protein results in increased export of Copper CTD PMID:16397091 more ... copper atom increases abundance ISO RGD:10216 6480464 ATP7A gene mutant form results in increased abundance of Copper CTD PMID:15923132 copper atom decreases abundance ISO RGD:10216 6480464 ATP7A gene mutant form results in decreased abundance of Copper more ... CTD PMID:11350187 more ... copper atom multiple interactions ISO RGD:10215 6480464 [ATP7A gene mutant form co-treated with Iron deficiency] results in increased uptake of Copper more ... CTD PMID:15467011 more ... copper atom increases abundance ISO RGD:10215 6480464 ATP7A gene mutant form results in increased abundance of Copper CTD PMID:15467011 copper atom affects localization ISO RGD:10215 6480464 ATP7A gene mutant form affects the localization of Copper, Copper affects the localization of ATP7A protein CTD PMID:17483305 more ... copper atom increases transport ISO RGD:10216 6480464 ATP7A protein results in increased transport of Copper CTD PMID:21667063 copper atom increases expression EXP 6480464 Copper results in increased expression of ATP7A mRNA CTD PMID:15591161 copper atom multiple interactions EXP 6480464 [Iron deficiency results in increased expression of ATP7A] which results in increased abundance of Copper, PRL protein promotes the reaction [ATP7A protein results in increased secretion of Copper] CTD PMID:16741141 , PMID:24174620 copper atom increases secretion EXP 6480464 ATP7A protein results in increased secretion of Copper CTD PMID:16741141 copper atom affects transport ISO RGD:10216 6480464 ATP7A protein affects the transport of Copper CTD PMID:17109627 copper atom affects binding ISO RGD:10216 6480464 ATP7A protein binds to Copper, Copper binds to ATP7A protein CTD PMID:16873374 , PMID:22577880 copper atom multiple interactions ISO RGD:10216 6480464 [ATP7A protein affects the oxidation of SCO1 protein] which affects the abundance of Copper more ... CTD PMID:10841766 more ... copper(0) affects metabolic processing ISO RGD:10216 6480464 ATP7A protein affects the metabolism of Copper CTD PMID:16890543 copper(0) affects localization ISO RGD:10216 6480464 Copper affects the localization of ATP7A protein CTD PMID:20964302 , PMID:23423674 copper(0) decreases abundance ISO RGD:10215 6480464 ATP7A gene mutant form results in decreased abundance of Copper more ... CTD PMID:21336677 more ... copper(0) increases transport EXP 6480464 ATP7A protein results in increased transport of Copper CTD PMID:24614235 copper(0) affects localization EXP 6480464 Copper affects the localization of ATP7A protein CTD PMID:20671235 , PMID:24614235 copper(0) decreases export EXP 6480464 ATP7A mutant form results in decreased export of Copper CTD PMID:24316150 copper(0) affects export ISO RGD:10215 6480464 ATP7A protein affects the export of Copper CTD PMID:21409224 copper(0) increases export ISO RGD:10216 6480464 ATP7A protein results in increased export of Copper CTD PMID:16397091 more ... copper(0) increases abundance ISO RGD:10216 6480464 ATP7A gene mutant form results in increased abundance of Copper CTD PMID:15923132 copper(0) decreases abundance ISO RGD:10216 6480464 ATP7A gene mutant form results in decreased abundance of Copper more ... CTD PMID:11350187 more ... copper(0) multiple interactions ISO RGD:10215 6480464 [ATP7A gene mutant form co-treated with Iron deficiency] results in increased uptake of Copper more ... CTD PMID:15467011 more ... copper(0) increases abundance ISO RGD:10215 6480464 ATP7A gene mutant form results in increased abundance of Copper CTD PMID:15467011 copper(0) affects localization ISO RGD:10215 6480464 ATP7A gene mutant form affects the localization of Copper, Copper affects the localization of ATP7A protein CTD PMID:17483305 more ... copper(0) increases transport ISO RGD:10216 6480464 ATP7A protein results in increased transport of Copper CTD PMID:21667063 copper(0) increases expression EXP 6480464 Copper results in increased expression of ATP7A mRNA CTD PMID:15591161 copper(0) multiple interactions EXP 6480464 [Iron deficiency results in increased expression of ATP7A] which results in increased abundance of Copper, PRL protein promotes the reaction [ATP7A protein results in increased secretion of Copper] CTD PMID:16741141 , PMID:24174620 copper(0) increases secretion EXP 6480464 ATP7A protein results in increased secretion of Copper CTD PMID:16741141 copper(0) affects transport ISO RGD:10216 6480464 ATP7A protein affects the transport of Copper CTD PMID:17109627 copper(0) affects binding ISO RGD:10216 6480464 ATP7A protein binds to Copper, Copper binds to ATP7A protein CTD PMID:16873374 , PMID:22577880 copper(0) multiple interactions ISO RGD:10216 6480464 [ATP7A protein affects the oxidation of SCO1 protein] which affects the abundance of Copper more ... CTD PMID:10841766 more ... copper(II) chloride increases transport ISO RGD:10216 6480464 ATP7A protein results in increased transport of cupric chloride CTD PMID:17009961 copper(II) chloride multiple interactions ISO RGD:10215 6480464 Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein] CTD PMID:25337692 copper(II) chloride affects localization ISO RGD:10215 6480464 cupric chloride affects the localization of ATP7A protein CTD PMID:16317117 , PMID:25337692 copper(II) chloride decreases glutathionylation ISO RGD:10216 6480464 cupric chloride results in decreased glutathionylation of ATP7A protein CTD PMID:20566629 copper(II) chloride multiple interactions ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to [cupric chloride results in increased abundance of Copper] more ... CTD PMID:11092760 more ... copper(II) chloride increases expression EXP 6480464 cupric chloride results in increased expression of ATP7A protein CTD PMID:23174565 copper(II) chloride multiple interactions EXP 6480464 cupric chloride inhibits the reaction [Cycloheximide results in decreased expression of ATP7A protein] more ... CTD PMID:23174565 copper(II) sulfate increases expression ISO RGD:10216 6480464 Copper Sulfate results in increased expression of ATP7A protein CTD PMID:24815816 CU-O LINKAGE increases expression ISO RGD:10216 6480464 cupric oxide analog results in increased expression of ATP7A mRNA, cupric oxide analog results in increased expression of ATP7A protein CTD PMID:24815816 cycloheximide decreases expression EXP 6480464 Cycloheximide results in decreased expression of ATP7A protein CTD PMID:23174565 cycloheximide multiple interactions EXP 6480464 cupric chloride inhibits the reaction [Cycloheximide results in decreased expression of ATP7A protein] CTD PMID:23174565 cyclosporin A decreases expression ISO RGD:10215 6480464 Cyclosporine results in decreased expression of ATP7A mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO RGD:10216 6480464 Cyclosporine results in decreased expression of ATP7A mRNA CTD PMID:25562108 D-penicillamine multiple interactions ISO RGD:10216 6480464 [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein] CTD PMID:21242307 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of ATP7A mRNA CTD PMID:23914054 desferrioxamine B increases expression EXP 6480464 Deferoxamine results in increased expression of ATP7A mRNA CTD PMID:23174565 desferrioxamine B multiple interactions EXP 6480464 cupric chloride promotes the reaction [Deferoxamine results in increased expression of ATP7A mRNA], Deferoxamine promotes the reaction [cupric chloride results in increased expression of ATP7A protein] CTD PMID:23174565 dextran sulfate multiple interactions ISO RGD:10215 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ATP7A mRNA CTD PMID:29950665 dibutyl phthalate increases expression ISO RGD:10215 6480464 Dibutyl Phthalate results in increased expression of ATP7A mRNA CTD PMID:21266533 dioxygen increases expression ISO RGD:10215 6480464 Oxygen deficiency results in increased expression of ATP7A mRNA, Oxygen deficiency results in increased expression of ATP7A protein CTD PMID:19351718 , PMID:24614111 dioxygen increases expression ISO RGD:10216 6480464 Oxygen deficiency results in increased expression of ATP7A mRNA CTD PMID:24614111 dioxygen affects localization ISO RGD:10215 6480464 Oxygen deficiency affects the localization of ATP7A protein CTD PMID:19351718 dioxygen multiple interactions ISO RGD:10215 6480464 tetrathiomolybdate inhibits the reaction [Oxygen deficiency affects the localization of ATP7A protein] CTD PMID:19351718 dorsomorphin multiple interactions ISO RGD:10216 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP7A mRNA CTD PMID:27188386 doxorubicin affects localization ISO RGD:10216 6480464 ATP7A protein affects the localization of Doxorubicin CTD PMID:17510416 doxorubicin decreases response to substance ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to Doxorubicin CTD PMID:17510416 doxorubicin multiple interactions ISO RGD:10216 6480464 Brefeldin A inhibits the reaction [ATP7A protein affects the localization of Doxorubicin], Monensin inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 doxorubicin increases export ISO RGD:10216 6480464 ATP7A protein results in increased export of Doxorubicin CTD PMID:17510416 entinostat decreases expression ISO RGD:10216 6480464 entinostat results in decreased expression of ATP7A mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:10216 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP7A mRNA CTD PMID:27188386 ethyl methanesulfonate increases expression ISO RGD:10216 6480464 Ethyl Methanesulfonate results in increased expression of ATP7A mRNA CTD PMID:23649840 etoposide decreases response to substance ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to Etoposide CTD PMID:17510416 folic acid multiple interactions ISO RGD:10215 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ATP7A mRNA CTD PMID:22206623 hexadecanoic acid increases phosphorylation ISO RGD:10216 6480464 Palmitic Acid results in increased phosphorylation of ATP7A protein CTD PMID:28073184 hydrogen peroxide multiple interactions ISO RGD:10216 6480464 ATP7A protein promotes the reaction [Paraquat results in increased chemical synthesis of Hydrogen Peroxide], Hydrogen Peroxide promotes the reaction [CLU protein binds to ATP7A protein] CTD PMID:21242307 , PMID:29058724 irinotecan decreases response to substance ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to Irinotecan CTD PMID:17510416 irinotecan increases export ISO RGD:10216 6480464 ATP7A protein results in increased export of Irinotecan CTD PMID:17510416 iron atom increases expression EXP 6480464 Iron deficiency results in increased expression of ATP7A more ... CTD PMID:16629162 more ... iron atom affects metabolic processing ISO RGD:10215 6480464 ATP7A protein mutant form affects the metabolism of Iron CTD PMID:25247420 iron atom increases expression ISO RGD:10215 6480464 Iron deficiency results in increased expression of ATP7A mRNA CTD PMID:23776592 , PMID:24089420 iron atom increases response to substance ISO RGD:10215 6480464 ATP7A gene mutant form results in increased susceptibility to Iron deficiency CTD PMID:23776592 iron atom affects transport EXP 6480464 ATP7A mutant form affects the transport of Iron CTD PMID:24174620 iron atom multiple interactions EXP 6480464 [Iron deficiency results in increased expression of ATP7A] which results in increased abundance of Copper CTD PMID:24174620 iron atom decreases oxidation ISO RGD:10215 6480464 ATP7A gene mutant form results in decreased oxidation of Iron CTD PMID:23776592 iron atom multiple interactions ISO RGD:10215 6480464 [ATP7A gene mutant form co-treated with Iron deficiency] results in increased uptake of Copper more ... CTD PMID:23776592 iron(0) increases expression EXP 6480464 Iron deficiency results in increased expression of ATP7A more ... CTD PMID:16629162 more ... iron(0) affects metabolic processing ISO RGD:10215 6480464 ATP7A protein mutant form affects the metabolism of Iron CTD PMID:25247420 iron(0) multiple interactions ISO RGD:10215 6480464 [ATP7A gene mutant form co-treated with Iron deficiency] results in increased uptake of Copper more ... CTD PMID:23776592 iron(0) affects transport EXP 6480464 ATP7A mutant form affects the transport of Iron CTD PMID:24174620 iron(0) decreases oxidation ISO RGD:10215 6480464 ATP7A gene mutant form results in decreased oxidation of Iron CTD PMID:23776592 iron(0) multiple interactions EXP 6480464 [Iron deficiency results in increased expression of ATP7A] which results in increased abundance of Copper CTD PMID:24174620 iron(0) increases expression ISO RGD:10215 6480464 Iron deficiency results in increased expression of ATP7A mRNA CTD PMID:23776592 , PMID:24089420 iron(0) increases response to substance ISO RGD:10215 6480464 ATP7A gene mutant form results in increased susceptibility to Iron deficiency CTD PMID:23776592 ketamine decreases expression EXP 6480464 Ketamine results in decreased expression of ATP7A mRNA CTD PMID:20080153 L-1,4-dithiothreitol multiple interactions ISO RGD:10216 6480464 Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 lead diacetate multiple interactions EXP 6480464 ATP7A protein modified form inhibits the reaction [lead acetate binds to HSPA5 protein] CTD PMID:10702365 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of ATP7A mRNA, lead acetate results in decreased expression of ATP7A protein CTD PMID:24316150 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of ATP7A mRNA CTD PMID:25579025 lipopolysaccharide increases expression ISO RGD:10215 6480464 Lipopolysaccharides results in increased expression of ATP7A mRNA CTD PMID:22369063 manganese atom affects localization EXP 6480464 Manganese affects the localization of ATP7A protein CTD PMID:24614235 manganese atom decreases expression EXP 6480464 Manganese results in decreased expression of ATP7A mRNA, Manganese results in decreased expression of ATP7A protein CTD PMID:24614235 manganese(0) affects localization EXP 6480464 Manganese affects the localization of ATP7A protein CTD PMID:24614235 manganese(0) decreases expression EXP 6480464 Manganese results in decreased expression of ATP7A mRNA, Manganese results in decreased expression of ATP7A protein CTD PMID:24614235 manganese(II) chloride affects localization EXP 6480464 manganese chloride affects the localization of ATP7A protein CTD PMID:24614235 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of ATP7A mRNA, manganese chloride results in decreased expression of ATP7A protein CTD PMID:24614235 melanins multiple interactions ISO RGD:10216 6480464 [TYR protein co-treated with ATP7A protein] results in increased abundance of Melanins CTD PMID:11092760 methapyrilene affects methylation ISO RGD:10216 6480464 Methapyrilene affects the methylation of ATP7A intron CTD PMID:30157460 methimazole increases expression EXP 6480464 Methimazole results in increased expression of ATP7A mRNA CTD PMID:22504374 methyl methanesulfonate increases expression ISO RGD:10216 6480464 Methyl Methanesulfonate results in increased expression of ATP7A mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:10216 6480464 methylmercuric chloride results in decreased expression of ATP7A mRNA CTD PMID:28001369 mithramycin multiple interactions EXP 6480464 Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of ATP7A mRNA] CTD PMID:23814049 mithramycin decreases expression EXP 6480464 Plicamycin results in decreased expression of ATP7A mRNA CTD PMID:23814049 mitoxantrone decreases response to substance ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to Mitoxantrone CTD PMID:17510416 monensin A multiple interactions ISO RGD:10216 6480464 Monensin inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 N-ethylmaleimide increases glutathionylation ISO RGD:10216 6480464 Ethylmaleimide results in increased glutathionylation of ATP7A protein CTD PMID:20566629 N-ethylmaleimide multiple interactions ISO RGD:10216 6480464 Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 neocuproine multiple interactions ISO RGD:10215 6480464 neocuproine inhibits the reaction [ATP7A protein mutant form promotes the reaction [lipopolysaccharide more ... CTD PMID:23604539 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of ATP7A mRNA, nitrofen results in decreased expression of ATP7A protein CTD PMID:25319798 omeprazole multiple interactions ISO RGD:10216 6480464 Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein] CTD PMID:25337692 omeprazole multiple interactions ISO RGD:10215 6480464 Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein], Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein] CTD PMID:25337692 oxaliplatin multiple interactions ISO RGD:10216 6480464 [MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to oxaliplatin CTD PMID:24038379 oxaliplatin decreases response to substance ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to oxaliplatin CTD PMID:25801007 oxaliplatin affects response to substance ISO RGD:10216 6480464 ATP7A protein affects the susceptibility to oxaliplatin CTD PMID:16773204 , PMID:17609664 oxaliplatin increases expression ISO RGD:10216 6480464 oxaliplatin results in increased expression of ATP7A mRNA CTD PMID:16773204 paclitaxel decreases response to substance ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to Paclitaxel CTD PMID:17510416 paclitaxel increases expression ISO RGD:10216 6480464 Paclitaxel results in increased expression of ATP7A mRNA CTD PMID:20737486 paracetamol affects expression ISO RGD:10215 6480464 Acetaminophen affects the expression of ATP7A mRNA CTD PMID:17562736 paraquat multiple interactions ISO RGD:10216 6480464 ATP7A protein promotes the reaction [Paraquat results in increased chemical synthesis of Hydrogen Peroxide] CTD PMID:29058724 paraquat increases expression ISO RGD:10216 6480464 Paraquat results in increased expression of ATP7A mRNA CTD PMID:34097952 paraquat increases response to substance ISO RGD:10216 6480464 ATP7A protein results in increased susceptibility to Paraquat CTD PMID:29058724 phorbol 13-acetate 12-myristate increases expression ISO RGD:10216 6480464 Tetradecanoylphorbol Acetate results in increased expression of ATP7A protein CTD PMID:19205902 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10216 6480464 [Tetradecanoylphorbol Acetate results in increased expression of ATP7A protein] which results in increased export of Copper, ATP7A protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FLT1 mRNA] CTD PMID:19205902 pirinixic acid multiple interactions ISO RGD:10215 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ATP7A mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:10215 6480464 pirinixic acid results in decreased expression of ATP7A mRNA CTD PMID:20813756 platinum increases uptake ISO RGD:10215 6480464 ATP7A protein results in increased uptake of Platinum CTD PMID:16170571 platinum(0) increases uptake ISO RGD:10215 6480464 ATP7A protein results in increased uptake of Platinum CTD PMID:16170571 potassium chromate decreases expression ISO RGD:10216 6480464 potassium chromate(VI) results in decreased expression of ATP7A mRNA CTD PMID:22714537 pyrrolidine dithiocarbamate decreases expression ISO RGD:10216 6480464 pyrrolidine dithiocarbamic acid results in decreased expression of ATP7A CTD PMID:25070243 quercetin decreases expression ISO RGD:10216 6480464 Quercetin results in decreased expression of ATP7A mRNA CTD PMID:21632981 rac-lactic acid decreases expression ISO RGD:10216 6480464 Lactic Acid results in decreased expression of ATP7A mRNA CTD PMID:30851411 resveratrol multiple interactions ISO RGD:10216 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of ATP7A mRNA CTD PMID:23557933 satraplatin decreases response to substance ISO RGD:10215 6480464 ATP7A protein results in decreased susceptibility to satraplatin metabolite CTD PMID:16170571 SB 431542 multiple interactions ISO RGD:10216 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP7A mRNA CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:10216 6480464 Silicon Dioxide analog results in decreased expression of ATP7A mRNA CTD PMID:25895662 silver atom affects localization ISO RGD:10215 6480464 Silver affects the localization of ATP7A protein CTD PMID:16317117 silver atom decreases expression ISO RGD:10215 6480464 Silver results in decreased expression of ATP7A mRNA CTD PMID:27131904 silver atom affects binding ISO RGD:10216 6480464 Silver binds to ATP7A protein CTD PMID:10841766 , PMID:21646353 silver monochloride affects localization ISO RGD:10215 6480464 silver chloride affects the localization of ATP7A protein CTD PMID:16317117 silver(0) affects localization ISO RGD:10215 6480464 Silver affects the localization of ATP7A protein CTD PMID:16317117 silver(0) decreases expression ISO RGD:10215 6480464 Silver results in decreased expression of ATP7A mRNA CTD PMID:27131904 silver(0) affects binding ISO RGD:10216 6480464 Silver binds to ATP7A protein CTD PMID:10841766 , PMID:21646353 sodium arsenate increases expression ISO RGD:10215 6480464 sodium arsenate results in increased expression of ATP7A mRNA CTD PMID:21795629 streptozocin multiple interactions ISO RGD:10215 6480464 ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides] more ... CTD PMID:23884884 streptozocin decreases expression ISO RGD:10215 6480464 Streptozocin results in decreased expression of ATP7A protein CTD PMID:23884884 succimer multiple interactions ISO RGD:10215 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ATP7A mRNA CTD PMID:26378955 superoxide increases abundance ISO RGD:10215 6480464 ATP7A mutant form results in increased abundance of Superoxides CTD PMID:18768397 superoxide multiple interactions ISO RGD:10215 6480464 [ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides more ... CTD PMID:18768397 , PMID:23884884 tetrachloromethane increases expression ISO RGD:10215 6480464 Carbon Tetrachloride results in increased expression of ATP7A mRNA CTD PMID:27339419 tetrathiomolybdate(2-) multiple interactions ISO RGD:10215 6480464 tetrathiomolybdate inhibits the reaction [Oxygen deficiency affects the localization of ATP7A protein] CTD PMID:19351718 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of ATP7A mRNA CTD PMID:23411599 titanium dioxide decreases expression ISO RGD:10215 6480464 titanium dioxide results in decreased expression of ATP7A mRNA CTD PMID:29264374 titanium dioxide multiple interactions ISO RGD:10215 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ATP7A mRNA CTD PMID:29950665 trichostatin A increases expression ISO RGD:10216 6480464 trichostatin A results in increased expression of ATP7A mRNA CTD PMID:28542535 troglitazone decreases expression ISO RGD:10215 6480464 troglitazone results in decreased expression of ATP7A mRNA CTD PMID:28973697 tungsten increases expression ISO RGD:10215 6480464 Tungsten results in increased expression of ATP7A mRNA CTD PMID:30912803 valproic acid increases expression ISO RGD:10216 6480464 Valproic Acid results in increased expression of ATP7A mRNA CTD PMID:19101580 , PMID:29154799 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of ATP7A mRNA CTD PMID:29427782 valproic acid decreases expression ISO RGD:10215 6480464 Valproic Acid results in decreased expression of ATP7A mRNA CTD PMID:20546886 valproic acid increases methylation ISO RGD:10216 6480464 Valproic Acid results in increased methylation of ATP7A gene CTD PMID:29154799 vincristine decreases response to substance ISO RGD:10216 6480464 ATP7A protein results in decreased susceptibility to Vincristine CTD PMID:17510416
