Atp7a (ATPase copper transporting alpha) - Rat Genome Database

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Gene: Atp7a (ATPase copper transporting alpha) Chinchilla lanigera
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Symbol: Atp7a
Name: ATPase copper transporting alpha
RGD ID: 8837623
Description: ENCODES a protein that exhibits ATP binding (ortholog); chaperone binding (ortholog); copper ion binding (ortholog); INVOLVED IN ATP metabolic process (ortholog); blood vessel development (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN cisplatin drug pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ATPase, Cu++ transporting, alpha polypeptide; copper-transporting ATPase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555571,355,397 - 1,515,393 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555571,355,471 - 1,515,725 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cartilage development  (ISO)
catecholamine metabolic process  (ISO)
cellular copper ion homeostasis  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to copper ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron ion  (ISO)
cellular response to lead ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
central nervous system neuron development  (ISO)
cerebellar Purkinje cell differentiation  (ISO)
collagen fibril organization  (ISO)
copper ion export  (ISO)
copper ion import  (ISO)
copper ion transport  (ISO)
dendrite morphogenesis  (ISO)
detoxification of copper ion  (ISO)
dopamine metabolic process  (ISO)
elastic fiber assembly  (ISO)
elastin biosynthetic process  (ISO)
epinephrine metabolic process  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (ISO)
hair follicle morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
in utero embryonic development  (ISO)
lactation  (ISO)
liver development  (ISO)
locomotory behavior  (ISO)
lung alveolus development  (ISO)
mitochondrion organization  (ISO)
negative regulation of catecholamine metabolic process  (ISO)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuron projection morphogenesis  (ISO)
norepinephrine biosynthetic process  (ISO)
norepinephrine metabolic process  (ISO)
peptidyl-lysine modification  (ISO)
pigmentation  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell size  (ISO)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of melanin biosynthetic process  (ISO)
positive regulation of oxidoreductase activity  (ISO)
positive regulation of response to wounding  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of tyrosinase activity  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
pyramidal neuron development  (ISO)
regulation of cytochrome-c oxidase activity  (ISO)
regulation of gene expression  (ISO)
regulation of oxidative phosphorylation  (ISO)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (ISO)
response to copper ion  (ISO)
response to iron(III) ion  (ISO)
response to lead ion  (ISO)
response to manganese ion  (ISO)
response to zinc ion  (ISO)
serotonin metabolic process  (ISO)
skin development  (ISO)
T-helper cell differentiation  (ISO)
tryptophan metabolic process  (ISO)
tyrosine metabolic process  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Atp7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555571,355,397 - 1,515,393 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555571,355,471 - 1,515,725 (+)NCBIChiLan1.0ChiLan1.0
ATP7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX77,910,656 - 78,050,395 (+)EnsemblGRCh38hg38GRCh38
GRCh38X77,910,693 - 78,050,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X77,166,190 - 77,305,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,052,876 - 77,192,208 (+)NCBINCBI36hg18NCBI36
Build 34X76,972,343 - 77,111,584NCBI
CeleraX77,407,059 - 77,546,975 (+)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX70,752,187 - 70,892,316 (+)NCBIHuRef
CHM1_1X77,058,882 - 77,198,586 (+)NCBICHM1_1
Atp7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,070,830 - 105,171,766 (+)NCBIGRCm39mm39
GRCm39 EnsemblX105,070,882 - 105,168,532 (+)Ensembl
GRCm38X106,027,224 - 106,128,161 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,027,276 - 106,124,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X103,222,615 - 103,323,499 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X102,230,036 - 102,327,636 (+)NCBImm8
CeleraX92,880,992 - 92,982,185 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
Atp7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X71,094,144 - 71,201,550 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX71,094,202 - 71,198,354 (+)Ensembl
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,192,540 - 94,249,776 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X94,265,972 - 94,323,206 (+)NCBI
CeleraX72,450,404 - 72,510,070 (+)NCBICelera
Cytogenetic MapXq22NCBI
ATP7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X77,205,579 - 77,342,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,255,312 - 77,342,756 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X67,093,675 - 67,231,318 (+)NCBIMhudiblu_PPA_v0panPan3
ATP7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,203,336 - 60,356,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,203,270 - 60,352,869 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,216,457 - 51,369,626 (+)NCBI
ROS_Cfam_1.0X61,442,067 - 61,595,242 (+)NCBI
UMICH_Zoey_3.1X59,148,063 - 59,301,397 (+)NCBI
UNSW_CanFamBas_1.0X60,758,474 - 60,911,162 (+)NCBI
UU_Cfam_GSD_1.0X60,346,304 - 60,499,464 (+)NCBI
Atp7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X42,009,558 - 42,154,264 (-)NCBI
SpeTri2.0NW_0049366832,874,022 - 2,936,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX61,972,874 - 62,110,058 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X70,891,299 - 71,026,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X66,843,519 - 66,985,655 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX66,843,558 - 66,985,709 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606714,518,402 - 14,662,927 (-)NCBIVero_WHO_p1.0
Atp7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000000578   ⟹   ENSCLAP00000000547
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555571,355,397 - 1,515,393 (+)Ensembl
RefSeq Acc Id: XM_005412628   ⟹   XP_005412685
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555571,392,527 - 1,515,725 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005412629   ⟹   XP_005412686
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555571,355,471 - 1,515,725 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013508826   ⟹   XP_013364280
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555571,392,541 - 1,515,725 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005412685 (Get FASTA)   NCBI Sequence Viewer  
  XP_005412686 (Get FASTA)   NCBI Sequence Viewer  
  XP_013364280 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEO95414 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005412686   ⟸   XM_005412629
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005412685   ⟸   XM_005412628
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013364280   ⟸   XM_013508826
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000000547   ⟸   ENSCLAT00000000578
Protein Domains
HMA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000444 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000000547 ENTREZGENE
Ensembl Transcript ENSCLAT00000000578 ENTREZGENE
InterPro Heavy-metal-associated_CS UniProtKB/TrEMBL
  HMA_Cu_ion-bd UniProtKB/TrEMBL
  HMA_dom UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/TrEMBL
NCBI Gene Atp7a ENTREZGENE
Pfam HMA UniProtKB/TrEMBL
PROSITE HMA_1 UniProtKB/TrEMBL
  HMA_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55008 UniProtKB/TrEMBL
TIGRFAMs TIGR00003 UniProtKB/TrEMBL
UniProt G3M807_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Atp7a  ATPase copper transporting alpha    ATPase, Cu++ transporting, alpha polypeptide  Symbol and/or name change 5135510 APPROVED