ATP7A (ATPase copper transporting alpha) - Rat Genome Database

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Gene: ATP7A (ATPase copper transporting alpha) Pan paniscus
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Symbol: ATP7A
Name: ATPase copper transporting alpha
RGD ID: 11759491
Description: ENCODES a protein that exhibits copper ion transmembrane transporter activity (ortholog); P-type divalent copper transporter activity (ortholog); protein-folding chaperone binding (ortholog); INVOLVED IN ATP metabolic process (ortholog); blood vessel development (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN cisplatin drug pathway; ASSOCIATED WITH alpha thalassemia-X-linked intellectual disability syndrome (ortholog); Alzheimer's disease (ortholog); anemia (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: copper-transporting ATPase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X77,492,788 - 77,630,493 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X77,496,415 - 77,634,104 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X67,093,675 - 67,231,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X77,205,579 - 77,342,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,255,312 - 77,342,756 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cartilage development  (ISO)
catecholamine metabolic process  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to copper ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron ion  (ISO)
cellular response to lead ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
central nervous system neuron development  (ISO)
cerebellar Purkinje cell differentiation  (ISO)
collagen fibril organization  (ISO)
copper ion export  (IEA,ISO)
copper ion import  (ISO)
copper ion transmembrane transport  (IEA)
copper ion transport  (IEA,ISO)
dendrite morphogenesis  (ISO)
detoxification of copper ion  (ISO)
dopamine metabolic process  (ISO)
elastic fiber assembly  (ISO)
elastin biosynthetic process  (ISO)
epinephrine metabolic process  (ISO)
establishment of localization in cell  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (ISO)
hair follicle morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
in utero embryonic development  (ISO)
intracellular copper ion homeostasis  (IEA,ISO)
L-tryptophan metabolic process  (ISO)
lactation  (ISO)
liver development  (ISO)
locomotory behavior  (ISO)
lung alveolus development  (ISO)
mitochondrion organization  (ISO)
monoatomic cation transport  (IEA)
negative regulation of catecholamine metabolic process  (ISO)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuron apoptotic process  (ISO)
neuron cellular homeostasis  (ISO)
neuron projection morphogenesis  (ISO)
norepinephrine biosynthetic process  (ISO)
norepinephrine metabolic process  (ISO)
peptidyl-lysine modification  (ISO)
pigmentation  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell size  (ISO)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of melanin biosynthetic process  (IEA)
positive regulation of response to wounding  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of tyrosinase activity  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
pyramidal neuron development  (ISO)
regulation of cytochrome-c oxidase activity  (ISO)
regulation of gene expression  (ISO)
regulation of oxidative phosphorylation  (ISO)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (ISO)
response to copper ion  (ISO)
response to iron(III) ion  (ISO)
response to lead ion  (ISO)
response to manganese ion  (ISO)
response to zinc ion  (ISO)
serotonin metabolic process  (ISO)
skin development  (ISO)
T-helper cell differentiation  (ISO)
tyrosine metabolic process  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ATP7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X77,492,788 - 77,630,493 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X77,496,415 - 77,634,104 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X67,093,675 - 67,231,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X77,205,579 - 77,342,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,255,312 - 77,342,756 (+)Ensemblpanpan1.1panPan2
ATP7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X77,910,693 - 78,050,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX77,910,690 - 78,050,395 (+)EnsemblGRCh38hg38GRCh38
GRCh37X77,166,190 - 77,305,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,052,876 - 77,192,208 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X76,972,343 - 77,111,584NCBI
CeleraX77,407,059 - 77,546,975 (+)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX70,752,187 - 70,892,316 (+)NCBIHuRef
CHM1_1X77,058,882 - 77,198,586 (+)NCBICHM1_1
T2T-CHM13v2.0X76,345,749 - 76,485,475 (+)NCBIT2T-CHM13v2.0
Atp7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,070,830 - 105,171,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,070,882 - 105,168,532 (+)EnsemblGRCm39 Ensembl
GRCm38X106,027,224 - 106,128,161 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,027,276 - 106,124,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X103,222,615 - 103,323,499 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X102,230,036 - 102,327,636 (+)NCBIMGSCv36mm8
CeleraX92,880,992 - 92,982,185 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
Atp7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,159,635 - 75,267,094 (+)NCBIGRCr8
mRatBN7.2X71,094,144 - 71,201,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,094,202 - 71,198,354 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX72,646,905 - 72,707,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,147,215 - 76,207,599 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X73,710,399 - 73,770,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,192,540 - 94,249,776 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X94,265,972 - 94,323,206 (+)NCBI
CeleraX72,450,404 - 72,510,070 (+)NCBICelera
Cytogenetic MapXq22NCBI
Atp7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555571,355,397 - 1,515,393 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555571,355,471 - 1,515,725 (+)NCBIChiLan1.0ChiLan1.0
ATP7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,203,336 - 60,356,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,203,270 - 60,352,869 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,216,457 - 51,369,626 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X61,442,067 - 61,595,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX61,442,069 - 61,592,549 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X59,148,063 - 59,301,397 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X60,758,474 - 60,911,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X60,346,304 - 60,499,464 (+)NCBIUU_Cfam_GSD_1.0
Atp7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X42,009,558 - 42,154,264 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366832,874,042 - 2,935,040 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366832,874,022 - 2,936,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX61,972,991 - 62,110,048 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X70,891,299 - 71,026,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X66,843,519 - 66,985,655 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX66,843,558 - 66,985,709 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606714,518,402 - 14,662,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248362,808,681 - 2,993,452 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000061375   ⟹   ENSPPAP00000038472
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX77,255,312 - 77,339,282 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000061384   ⟹   ENSPPAP00000038481
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX77,255,312 - 77,338,946 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000061393   ⟹   ENSPPAP00000038490
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX77,264,300 - 77,342,756 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000061395   ⟹   ENSPPAP00000038492
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX77,264,331 - 77,338,946 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000061396   ⟹   ENSPPAP00000038493
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX77,264,331 - 77,338,946 (+)Ensembl
RefSeq Acc Id: XM_003824407   ⟹   XP_003824455
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X77,492,791 - 77,630,493 (+)NCBI
NHGRI_mPanPan1X77,496,466 - 77,634,104 (+)NCBI
Mhudiblu_PPA_v0X67,093,699 - 67,231,318 (+)NCBI
PanPan1.1X77,205,579 - 77,342,762 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008978125   ⟹   XP_008976373
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X77,492,788 - 77,630,493 (+)NCBI
NHGRI_mPanPan1X77,496,415 - 77,634,104 (+)NCBI
Mhudiblu_PPA_v0X67,093,699 - 67,227,833 (+)NCBI
PanPan1.1X77,205,579 - 77,339,282 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055106355   ⟹   XP_054962330
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X77,492,863 - 77,630,493 (+)NCBI
NHGRI_mPanPan1X77,496,474 - 77,634,104 (+)NCBI
RefSeq Acc Id: XM_063601824   ⟹   XP_063457894
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X77,492,863 - 77,630,493 (+)NCBI
RefSeq Acc Id: XP_003824455   ⟸   XM_003824407
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CJU6 (UniProtKB/TrEMBL),   A0A2R9CJX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008976373   ⟸   XM_008978125
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CJU6 (UniProtKB/TrEMBL),   A0A2R9CJX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000038481   ⟸   ENSPPAT00000061384
Ensembl Acc Id: ENSPPAP00000038472   ⟸   ENSPPAT00000061375
Ensembl Acc Id: ENSPPAP00000038490   ⟸   ENSPPAT00000061393
Ensembl Acc Id: ENSPPAP00000038492   ⟸   ENSPPAT00000061395
Ensembl Acc Id: ENSPPAP00000038493   ⟸   ENSPPAT00000061396
RefSeq Acc Id: XP_054962330   ⟸   XM_055106355
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CJX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063457894   ⟸   XM_063601824
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CJU6 (UniProtKB/TrEMBL),   A0A2R9CJX0 (UniProtKB/TrEMBL)
Protein Domains
HMA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041943 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061375.1 UniProtKB/TrEMBL
  ENSPPAT00000061384.1 UniProtKB/TrEMBL
  ENSPPAT00000061393.1 UniProtKB/TrEMBL
  ENSPPAT00000061395.1 UniProtKB/TrEMBL
  ENSPPAT00000061396.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.100 UniProtKB/TrEMBL
  3.40.1110.10 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/TrEMBL
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  Heavy-metal-associated_CS UniProtKB/TrEMBL
  HMA_Cu_ion-bd UniProtKB/TrEMBL
  HMA_dom UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/TrEMBL
  P-typ_ATPase_IB UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/TrEMBL
KEGG Report pps:100987145 UniProtKB/TrEMBL
NCBI Gene ATP7A ENTREZGENE
PANTHER ATP7, ISOFORM B UniProtKB/TrEMBL
  COPPER-TRANSPORTING ATPASE 1 UniProtKB/TrEMBL
  COPPER-TRANSPORTING ATPASE 2 UniProtKB/TrEMBL
Pfam E1-E2_ATPase UniProtKB/TrEMBL
  HMA UniProtKB/TrEMBL
  Hydrolase UniProtKB/TrEMBL
PRINTS CATATPASE UniProtKB/TrEMBL
  CUATPASEI UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/TrEMBL
  HMA_1 UniProtKB/TrEMBL
  HMA_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55008 UniProtKB/TrEMBL
  SSF56784 UniProtKB/TrEMBL
  SSF81653 UniProtKB/TrEMBL
  SSF81660 UniProtKB/TrEMBL
  SSF81665 UniProtKB/TrEMBL
UniProt A0A2R9C960_PANPA UniProtKB/TrEMBL
  A0A2R9CBY4_PANPA UniProtKB/TrEMBL
  A0A2R9CJU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CJX0 ENTREZGENE, UniProtKB/TrEMBL