Atp7a (ATPase copper transporting alpha) - Rat Genome Database

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Gene: Atp7a (ATPase copper transporting alpha) Heterocephalus glaber
Analyze
Symbol: Atp7a
Name: ATPase copper transporting alpha
RGD ID: 18924052
Description: ENCODES a protein that exhibits copper ion transmembrane transporter activity (ortholog); P-type divalent copper transporter activity (ortholog); protein-folding chaperone binding (ortholog); INVOLVED IN ATP metabolic process (ortholog); blood vessel development (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN cisplatin drug pathway; ASSOCIATED WITH alpha thalassemia-X-linked intellectual disability syndrome (ortholog); Alzheimer's disease (ortholog); anemia (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Copper-transporting ATPase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248362,808,681 - 2,993,452 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cartilage development  (ISO)
catecholamine metabolic process  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to copper ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron ion  (ISO)
cellular response to lead ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
central nervous system neuron development  (ISO)
cerebellar Purkinje cell differentiation  (ISO)
collagen fibril organization  (ISO)
copper ion export  (IEA,ISO)
copper ion import  (ISO)
copper ion transmembrane transport  (IEA)
copper ion transport  (IEA,ISO)
dendrite morphogenesis  (ISO)
detoxification of copper ion  (ISO)
dopamine metabolic process  (ISO)
elastic fiber assembly  (ISO)
elastin biosynthetic process  (ISO)
epinephrine metabolic process  (ISO)
establishment of localization in cell  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (ISO)
hair follicle morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
in utero embryonic development  (ISO)
inorganic ion transmembrane transport  (IEA)
intracellular copper ion homeostasis  (IEA,ISO)
lactation  (ISO)
liver development  (ISO)
locomotory behavior  (ISO)
lung alveolus development  (ISO)
mitochondrion organization  (ISO)
monoatomic cation transport  (IEA)
negative regulation of catecholamine metabolic process  (ISO)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuron apoptotic process  (ISO)
neuron cellular homeostasis  (ISO)
neuron projection morphogenesis  (ISO)
norepinephrine biosynthetic process  (ISO)
norepinephrine metabolic process  (ISO)
peptidyl-lysine modification  (ISO)
pigmentation  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell size  (ISO)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of melanin biosynthetic process  (IEA)
positive regulation of response to wounding  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of tyrosinase activity  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
pyramidal neuron development  (ISO)
regulation of cytochrome-c oxidase activity  (ISO)
regulation of gene expression  (ISO)
regulation of oxidative phosphorylation  (ISO)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (ISO)
response to copper ion  (ISO)
response to iron(III) ion  (ISO)
response to lead ion  (ISO)
response to manganese ion  (ISO)
response to zinc ion  (ISO)
serotonin metabolic process  (ISO)
skin development  (ISO)
T-helper cell differentiation  (ISO)
tryptophan metabolic process  (ISO)
tyrosine metabolic process  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
Atp7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248362,808,681 - 2,993,452 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ATP7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X77,910,693 - 78,050,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX77,910,690 - 78,050,395 (+)EnsemblGRCh38hg38GRCh38
GRCh37X77,166,190 - 77,305,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,052,876 - 77,192,208 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X76,972,343 - 77,111,584NCBI
CeleraX77,407,059 - 77,546,975 (+)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX70,752,187 - 70,892,316 (+)NCBIHuRef
CHM1_1X77,058,882 - 77,198,586 (+)NCBICHM1_1
T2T-CHM13v2.0X76,345,749 - 76,485,475 (+)NCBIT2T-CHM13v2.0
Atp7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,070,830 - 105,171,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,070,882 - 105,168,532 (+)EnsemblGRCm39 Ensembl
GRCm38X106,027,224 - 106,128,161 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,027,276 - 106,124,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X103,222,615 - 103,323,499 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X102,230,036 - 102,327,636 (+)NCBIMGSCv36mm8
CeleraX92,880,992 - 92,982,185 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
Atp7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,159,635 - 75,267,094 (+)NCBIGRCr8
mRatBN7.2X71,094,144 - 71,201,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,094,202 - 71,198,354 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX72,646,905 - 72,707,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,147,215 - 76,207,599 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X73,710,399 - 73,770,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,192,540 - 94,249,776 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X94,265,972 - 94,323,206 (+)NCBI
CeleraX72,450,404 - 72,510,070 (+)NCBICelera
Cytogenetic MapXq22NCBI
Atp7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555571,355,397 - 1,515,393 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555571,355,471 - 1,515,725 (+)NCBIChiLan1.0ChiLan1.0
ATP7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X77,492,788 - 77,630,493 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X77,496,415 - 77,634,104 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X67,093,675 - 67,231,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X77,205,579 - 77,342,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,255,312 - 77,342,756 (+)Ensemblpanpan1.1panPan2
ATP7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,203,336 - 60,356,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,203,270 - 60,352,869 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,216,457 - 51,369,626 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X61,442,067 - 61,595,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX61,442,069 - 61,592,549 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X59,148,063 - 59,301,397 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X60,758,474 - 60,911,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X60,346,304 - 60,499,464 (+)NCBIUU_Cfam_GSD_1.0
Atp7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X42,009,558 - 42,154,264 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366832,874,042 - 2,935,040 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366832,874,022 - 2,936,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX61,972,991 - 62,110,048 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X70,891,299 - 71,026,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X66,843,519 - 66,985,655 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX66,843,558 - 66,985,709 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606714,518,402 - 14,662,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004867484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021246498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01085501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01085522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01006497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JH173801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000002431   ⟹   ENSHGLP00000002382
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248362,808,681 - 2,993,452 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000002432   ⟹   ENSHGLP00000002383
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248362,808,681 - 2,993,452 (-)Ensembl
RefSeq Acc Id: XM_004867484   ⟹   XP_004867541
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBI
RefSeq Acc Id: XM_021246498   ⟹   XP_021102157
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004867541 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102157 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG47437 (Get FASTA)   NCBI Sequence Viewer  
  EHB17739 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000002382
  ENSHGLP00000029982
  ENSHGLP00100057998
GenBank Protein JAN97135 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021102157   ⟸   XM_021246498
- Peptide Label: isoform X2
- UniProtKB: A0A0P6IYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867541   ⟸   XM_004867484
- Peptide Label: isoform X1
- UniProtKB: A0A0P6IYJ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000002383   ⟸   ENSHGLT00000002432
Ensembl Acc Id: ENSHGLP00000002382   ⟸   ENSHGLT00000002431


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001804 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100001461 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000002431 ENTREZGENE
  ENSHGLT00000064089 UniProtKB/TrEMBL
  ENSHGLT00100087476 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.100 UniProtKB/TrEMBL
  3.40.1110.10 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/TrEMBL
  Calcium-transporting ATPase, transmembrane domain UniProtKB/TrEMBL
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  Heavy-metal-associated_CS UniProtKB/TrEMBL
  HMA_Cu_ion-bd UniProtKB/TrEMBL
  HMA_dom UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/TrEMBL
  P-typ_ATPase_IB UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/TrEMBL
NCBI Gene Atp7a ENTREZGENE
PANTHER P-TYPE CATION-TRANSPORTING ATPASE UniProtKB/TrEMBL
  P-TYPE CATION-TRANSPORTING ATPASE UniProtKB/TrEMBL
Pfam E1-E2_ATPase UniProtKB/TrEMBL
  HMA UniProtKB/TrEMBL
  Hydrolase UniProtKB/TrEMBL
PRINTS CATATPASE UniProtKB/TrEMBL
  CUATPASEI UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/TrEMBL
  HMA_1 UniProtKB/TrEMBL
  HMA_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55008 UniProtKB/TrEMBL
  SSF56784 UniProtKB/TrEMBL
  SSF81653 UniProtKB/TrEMBL
  SSF81665 UniProtKB/TrEMBL
UniProt A0A0P6IYJ0 ENTREZGENE, UniProtKB/TrEMBL
  Q99NW7_HETGA UniProtKB/TrEMBL