ATP7A (ATPase copper transporting alpha) - Rat Genome Database

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Gene: ATP7A (ATPase copper transporting alpha) Sus scrofa
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Symbol: ATP7A
Name: ATPase copper transporting alpha
RGD ID: 13924334
Description: ENCODES a protein that exhibits chaperone binding (ortholog); copper ion transmembrane transporter activity (ortholog); small GTPase binding (ortholog); INVOLVED IN ATP metabolic process (ortholog); blood vessel development (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN cisplatin drug pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome); copper transporting ATPase; copper-transporting ATPase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX61,972,874 - 62,110,058 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X70,891,299 - 71,026,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cartilage development  (ISO)
catecholamine metabolic process  (ISO)
cellular copper ion homeostasis  (IBA,ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to copper ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron ion  (ISO)
cellular response to lead ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
central nervous system neuron development  (ISO)
cerebellar Purkinje cell differentiation  (ISO)
collagen fibril organization  (ISO)
copper ion export  (IBA,ISO)
copper ion import  (ISO)
copper ion transmembrane transport  (IEA)
copper ion transport  (ISO)
dendrite morphogenesis  (ISO)
detoxification of copper ion  (ISO)
dopamine metabolic process  (ISO)
elastic fiber assembly  (ISO)
elastin biosynthetic process  (ISO)
epinephrine metabolic process  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (ISO)
hair follicle morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
in utero embryonic development  (ISO)
lactation  (ISO)
liver development  (ISO)
locomotory behavior  (ISO)
lung alveolus development  (ISO)
mitochondrion organization  (ISO)
negative regulation of catecholamine metabolic process  (ISO)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuron projection morphogenesis  (ISO)
norepinephrine biosynthetic process  (ISO)
norepinephrine metabolic process  (ISO)
peptidyl-lysine modification  (ISO)
pigmentation  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell size  (ISO)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of melanin biosynthetic process  (IEA)
positive regulation of monophenol monooxygenase activity  (IEA)
positive regulation of oxidoreductase activity  (ISO)
positive regulation of response to wounding  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
pyramidal neuron development  (ISO)
regulation of cytochrome-c oxidase activity  (ISO)
regulation of gene expression  (ISO)
regulation of oxidative phosphorylation  (ISO)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (ISO)
response to copper ion  (ISO)
response to iron(III) ion  (ISO)
response to lead ion  (ISO)
response to manganese ion  (ISO)
response to zinc ion  (ISO)
serotonin metabolic process  (ISO)
skin development  (ISO)
T-helper cell differentiation  (ISO)
tryptophan metabolic process  (ISO)
tyrosine metabolic process  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
ATP7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX61,972,874 - 62,110,058 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X70,891,299 - 71,026,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX77,910,656 - 78,050,395 (+)EnsemblGRCh38hg38GRCh38
GRCh38X77,910,693 - 78,050,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X77,166,190 - 77,305,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,052,876 - 77,192,208 (+)NCBINCBI36hg18NCBI36
Build 34X76,972,343 - 77,111,584NCBI
CeleraX77,407,059 - 77,546,975 (+)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX70,752,187 - 70,892,316 (+)NCBIHuRef
CHM1_1X77,058,882 - 77,198,586 (+)NCBICHM1_1
Atp7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,070,830 - 105,171,766 (+)NCBIGRCm39mm39
GRCm39 EnsemblX105,070,882 - 105,168,532 (+)Ensembl
GRCm38X106,027,224 - 106,128,161 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,027,276 - 106,124,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X103,222,615 - 103,323,499 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X102,230,036 - 102,327,636 (+)NCBImm8
CeleraX92,880,992 - 92,982,185 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
Atp7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X71,094,144 - 71,201,550 (+)NCBImRatBN7.2
Rnor_6.0 EnsemblX77,076,106 - 77,193,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X77,076,085 - 77,193,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X56,198,947 - 56,313,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,192,540 - 94,249,776 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X94,265,972 - 94,323,206 (+)NCBI
CeleraX72,450,404 - 72,510,070 (+)NCBICelera
Cytogenetic MapXq22NCBI
Atp7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555571,355,397 - 1,515,393 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555571,355,471 - 1,515,725 (+)NCBIChiLan1.0ChiLan1.0
ATP7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X77,205,579 - 77,342,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,255,312 - 77,342,756 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X67,093,675 - 67,231,318 (+)NCBIMhudiblu_PPA_v0panPan3
ATP7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,203,336 - 60,356,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,203,270 - 60,352,869 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,216,457 - 51,369,626 (+)NCBI
ROS_Cfam_1.0X61,442,067 - 61,595,242 (+)NCBI
UMICH_Zoey_3.1X59,148,063 - 59,301,397 (+)NCBI
UNSW_CanFamBas_1.0X60,758,474 - 60,911,162 (+)NCBI
UU_Cfam_GSD_1.0X60,346,304 - 60,499,464 (+)NCBI
Atp7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X42,009,558 - 42,154,264 (-)NCBI
SpeTri2.0NW_0049366832,874,022 - 2,936,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X66,843,519 - 66,985,655 (+)NCBI
ChlSab1.1 EnsemblX66,843,558 - 66,985,709 (+)Ensembl
Vero_WHO_p1.0NW_02366606714,518,402 - 14,662,927 (-)NCBI
Atp7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248362,804,349 - 3,058,125 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 5 2 3
Low 10 2 3 2 23 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000013601   ⟹   ENSSSCP00000013235
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX61,973,015 - 62,110,048 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000066838   ⟹   ENSSSCP00000070876
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX61,972,874 - 62,109,614 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081432   ⟹   ENSSSCP00000062090
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX61,972,997 - 62,110,058 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082081   ⟹   ENSSSCP00000065602
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX61,972,991 - 62,110,048 (+)Ensembl
RefSeq Acc Id: XM_003135200   ⟹   XP_003135248
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013990937   ⟹   XP_013846391
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X61,972,544 - 62,110,058 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013990938   ⟹   XP_013846392
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X61,972,544 - 62,105,071 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_003135248   ⟸   XM_003135200
- Peptide Label: isoform X1
- UniProtKB: F1RPH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013846391   ⟸   XM_013990937
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013846392   ⟸   XM_013990938
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000070876   ⟸   ENSSSCT00000066838
RefSeq Acc Id: ENSSSCP00000013235   ⟸   ENSSSCT00000013601
RefSeq Acc Id: ENSSSCP00000062090   ⟸   ENSSSCT00000081432
RefSeq Acc Id: ENSSSCP00000065602   ⟸   ENSSSCT00000082081
Protein Domains
HMA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012437 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070000795 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013235 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000062090 UniProtKB/TrEMBL
  ENSSSCP00000065602 UniProtKB/TrEMBL
  ENSSSCP00000070876 UniProtKB/TrEMBL
  ENSSSCP00070001362 UniProtKB/TrEMBL
  ENSSSCP00070001371 UniProtKB/TrEMBL
  ENSSSCP00070001383 UniProtKB/TrEMBL
  ENSSSCP00070001397 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013601 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000066838 UniProtKB/TrEMBL
  ENSSSCT00000081432 UniProtKB/TrEMBL
  ENSSSCT00000082081 UniProtKB/TrEMBL
  ENSSSCT00070001609 UniProtKB/TrEMBL
  ENSSSCT00070001617 UniProtKB/TrEMBL
  ENSSSCT00070001634 UniProtKB/TrEMBL
  ENSSSCT00070001650 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  Heavy-metal-associated_CS UniProtKB/TrEMBL
  HMA_Cu_ion-bd UniProtKB/TrEMBL
  HMA_dom UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/TrEMBL
  P-typ_ATPase_IB UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/TrEMBL
KEGG Report ssc:397159 UniProtKB/TrEMBL
NCBI Gene ATP7A ENTREZGENE
Pfam HMA UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/TrEMBL
  HMA_1 UniProtKB/TrEMBL
  HMA_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55008 UniProtKB/TrEMBL
  SSF56784 UniProtKB/TrEMBL
  SSF81653 UniProtKB/TrEMBL
  SSF81660 UniProtKB/TrEMBL
  SSF81665 UniProtKB/TrEMBL
TIGRFAMs ATPase-IB_hvy UniProtKB/TrEMBL
  ATPase_P-type UniProtKB/TrEMBL
  TIGR00003 UniProtKB/TrEMBL
UniProt A0A4X1SGI5_PIG UniProtKB/TrEMBL
  A0A4X1SGJ7_PIG UniProtKB/TrEMBL
  A0A4X1SGS3_PIG UniProtKB/TrEMBL
  A0A4X1SGT5_PIG UniProtKB/TrEMBL
  A0A5G2QJ89_PIG UniProtKB/TrEMBL
  A0A5G2QUF5_PIG UniProtKB/TrEMBL
  A0A5G2RHL9_PIG UniProtKB/TrEMBL
  A0A5K1U0J0_PIG UniProtKB/TrEMBL
  A5A788_PIG UniProtKB/TrEMBL
  F1RPH3 ENTREZGENE, UniProtKB/TrEMBL
  Q8MIA7_PIG UniProtKB/TrEMBL
  Q8WMV8_PIG UniProtKB/TrEMBL
  Q8WMV9_PIG UniProtKB/TrEMBL
  Q9BFM6_PIG UniProtKB/TrEMBL
UniProt Secondary K7GT44 UniProtKB/TrEMBL
VGNC ID VGNC:85678 ENTREZGENE