Asns (asparagine synthetase (glutamine-hydrolyzing)) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Asns (asparagine synthetase (glutamine-hydrolyzing)) Rattus norvegicus
Symbol: Asns
Name: asparagine synthetase (glutamine-hydrolyzing)
RGD ID: 2162
Description: Enables asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and response to follicle-stimulating hormone. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)); PARTICIPATES IN Canavan disease pathway; alanine, aspartate and glutamate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: asparagine synthetase; asparagine synthetase [glutamine-hydrolyzing]; glutamine-dependent asparagine synthetase; MGC93148
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2435,784,995 - 35,803,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl435,785,237 - 35,803,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx440,744,478 - 40,761,832 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0436,670,681 - 36,688,035 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0435,091,137 - 35,108,468 (-)NCBIRnor_WKY
Rnor_6.0433,742,876 - 33,761,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl433,743,364 - 33,761,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0433,608,301 - 33,626,631 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4432,758,866 - 32,776,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1432,877,146 - 32,895,094 (-)NCBI
Celera431,290,059 - 31,307,413 (-)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
antimycin A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxepin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
erythromycin A  (ISO)
ethanol  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
flecainide  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
haloperidol  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
imipramine  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
loratadine  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
mitoxantrone  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nitrofen  (EXP)
nobiletin  (EXP,ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
oxaliplatin  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentamidine  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorone  (EXP)
phosgene  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
prothioconazole  (ISO)
pyrazinecarboxamide  (EXP)
pyrimidifen  (ISO)
pyrogallol  (ISO)
quinidine  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ritodrine  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sotalol  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zidovudine  (ISO)
zimeldine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability. Barbosa-Tessmann IP, etal., Biochem J. 1999 Apr 1;339 ( Pt 1):151-8.
2. TSH is able to induce cell cycle-related gene expression in rat thyroid cell. Colletta G and Cirafici AM, Biochem Biophys Res Commun. 1992 Feb 28;183(1):265-72.
3. L-Asparagine synthetase in serum as a marker for neoplasia. Cooney DA, etal., Cancer Res. 1976 Sep;36(9 pt.1):3238-45.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Transcriptional responses in thyroid tissues from rats treated with a tumorigenic and a non-tumorigenic triazole conazole fungicide. Hester SD and Nesnow S, Toxicol Appl Pharmacol. 2008 Mar 15;227(3):357-69. Epub 2007 Nov 28.
7. Kinetic studies of asparagine synthetase from rat liver: role of Mg2+ in enzyme catalysis. Hongo S and Sato T, Arch Biochem Biophys. 1985 May 1;238(2):410-7.
8. Some molecular properties of asparagine synthetase from rat liver. Hongo S and Sato T, Biochim Biophys Acta. 1983 Feb 15;742(3):484-9.
9. Induction of asparagine synthetase by follicle-stimulating hormone in primary cultures of rat Sertoli cells. Hongo S, etal., Arch Biochem Biophys. 1994 Sep;313(2):222-8.
10. Glutamine-dependent asparagine synthetase in fetal, adult and neoplastic rat tissues. Huang YZ and Knox EW, Enzyme. 1975;19(5-6):314-28.
11. Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content. Hutson RG and Kilberg MS, Biochem J 1994 Dec 15;304 ( Pt 3):745-50.
12. Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. Hutson RG, etal., Am J Physiol. 1997 May;272(5 Pt 1):C1691-9.
13. Transpupillary thermotherapy-induced modification of angiogenesis- and coagulation-related gene expression in the rat posterior fundus. Ito YN, etal., Mol Vis. 2006 Jul 20;12:802-10.
14. Methotrexate stimulation of asparagine synthetase activity in rat liver. Maul DM and Schuster SM, Life Sci. 1982 Mar 22;30(12):1051-7.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Asparagine metabolism in chicks and rats. Penner M and Coon CN, Poult Sci. 1980 May;59(5):1109-13.
17. Topographical separation of the catalytic sites of asparagine synthetase explored with monoclonal antibodies. Pfeiffer NE, etal., J Biol Chem. 1987 Aug 25;262(24):11565-70.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
26. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
27. DNA microarray reveals novel genes induced by mechanical forces in fetal lung type II epithelial cells. Wang Y, etal., Pediatr Res. 2006 Aug;60(2):118-24.
Additional References at PubMed
PMID:2564390   PMID:2569668   PMID:2573597   PMID:2886907   PMID:15489334   PMID:16023613   PMID:17409444   PMID:30053369  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2435,784,995 - 35,803,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl435,785,237 - 35,803,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx440,744,478 - 40,761,832 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0436,670,681 - 36,688,035 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0435,091,137 - 35,108,468 (-)NCBIRnor_WKY
Rnor_6.0433,742,876 - 33,761,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl433,743,364 - 33,761,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0433,608,301 - 33,626,631 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4432,758,866 - 32,776,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1432,877,146 - 32,895,094 (-)NCBI
Celera431,290,059 - 31,307,413 (-)NCBICelera
Cytogenetic Map4q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38797,851,677 - 97,928,441 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl797,851,677 - 97,872,542 (-)EnsemblGRCh38hg38GRCh38
GRCh37797,480,989 - 97,557,753 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36797,319,376 - 97,339,732 (-)NCBINCBI36Build 36hg18NCBI36
Build 34797,126,093 - 97,146,434NCBI
Celera792,176,132 - 92,196,562 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef792,082,173 - 92,102,489 (-)NCBIHuRef
CHM1_1797,411,399 - 97,431,825 (-)NCBICHM1_1
T2T-CHM13v2.0799,081,731 - 99,158,507 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2796,803,932 - 96,824,039 (-)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3967,675,165 - 7,693,209 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl67,675,169 - 7,693,254 (-)EnsemblGRCm39 Ensembl
GRCm3867,675,165 - 7,693,209 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl67,675,169 - 7,693,254 (-)EnsemblGRCm38mm10GRCm38
MGSCv3767,625,171 - 7,643,182 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3667,625,171 - 7,643,182 (-)NCBIMGSCv36mm8
Celera67,815,329 - 7,836,615 (-)NCBICelera
Cytogenetic Map6A1NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.17103,392,540 - 103,413,035 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7103,392,540 - 103,413,046 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0789,811,363 - 89,831,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11422,718,020 - 22,734,109 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1422,718,042 - 22,734,054 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1422,293,460 - 22,309,559 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01422,536,829 - 22,552,941 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1422,535,259 - 22,552,931 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11422,683,018 - 22,699,299 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01422,417,885 - 22,434,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01422,679,813 - 22,695,891 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511836,008,688 - 36,029,092 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365852,834,008 - 2,855,387 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365852,834,202 - 2,854,740 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl977,318,213 - 77,343,035 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1977,318,341 - 77,336,290 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2984,880,365 - 85,078,501 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12151,244,514 - 51,264,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2151,247,742 - 51,265,241 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604253,107,858 - 53,128,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248134,641,372 - 4,661,778 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248134,642,420 - 4,661,362 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Asns
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:41
Interacting mature miRNAs:46
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8655949Rf62Renal function QTL 6222blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)43443011944463908Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2435,785,745 - 35,785,910 (+)MAPPERmRatBN7.2
Rnor_6.0433,743,385 - 33,743,549NCBIRnor6.0
Rnor_5.0433,608,914 - 33,609,078UniSTSRnor5.0
RGSC_v3.4432,758,889 - 32,759,053UniSTSRGSC3.4
Celera431,290,082 - 31,290,246UniSTS
RH 3.4 Map4213.7UniSTS
Cytogenetic Map4q13-q21UniSTS

Related Rat Strains
The following Strains have been annotated to Asns


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 18 38 26 17 26 74 21 35 11
Low 25 19 15 2 15 8 11 14 6 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010079   ⟹   ENSRNOP00000010079
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl435,785,237 - 35,803,423 (-)Ensembl
Rnor_6.0 Ensembl433,743,364 - 33,761,163 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083481   ⟹   ENSRNOP00000071140
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl433,743,366 - 33,760,716 (-)Ensembl
RefSeq Acc Id: NM_013079   ⟹   NP_037211
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,785,723 - 35,803,080 (-)NCBI
Rnor_6.0433,743,362 - 33,760,716 (-)NCBI
Rnor_5.0433,608,301 - 33,626,631 (-)NCBI
RGSC_v3.4432,758,866 - 32,776,220 (-)RGD
Celera431,290,059 - 31,307,413 (-)RGD
RefSeq Acc Id: XM_006236089   ⟹   XP_006236151
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,784,995 - 35,803,474 (-)NCBI
Rnor_6.0433,742,876 - 33,761,106 (-)NCBI
Rnor_5.0433,608,301 - 33,626,631 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037211   ⟸   NM_013079
- UniProtKB: Q66HR8 (UniProtKB/Swiss-Prot),   P49088 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236151   ⟸   XM_006236089
- Peptide Label: isoform X1
- UniProtKB: Q66HR8 (UniProtKB/Swiss-Prot),   P49088 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010079   ⟸   ENSRNOT00000010079
RefSeq Acc Id: ENSRNOP00000071140   ⟸   ENSRNOT00000083481
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49088-F1-model_v2 AlphaFold P49088 1-561 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692869
Promoter ID:EPDNEW_R3394
Type:initiation region
Description:asparagine synthetase (glutamine-hydrolyzing)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R3395  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0433,760,741 - 33,760,801EPDNEW
RGD ID:13692870
Promoter ID:EPDNEW_R3395
Type:initiation region
Description:asparagine synthetase (glutamine-hydrolyzing)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R3394  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0433,761,052 - 33,761,112EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2162 AgrOrtholog
BioCyc Gene G2FUF-45670 BioCyc
BioCyc Pathway ASPARAGINE-BIOSYNTHESIS [L-asparagine biosynthesis I] BioCyc
  CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  GLUTAMINDEG-PWY [L-glutamine degradation I] BioCyc
  PWY-5921 [glutaminyl-tRNAgln biosynthesis via transamidation] BioCyc
Ensembl Genes ENSRNOG00000007546 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010079 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010079 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot
InterPro Asn_synth_AEB UniProtKB/Swiss-Prot
  Asn_synthase UniProtKB/Swiss-Prot
  AsnB_N UniProtKB/Swiss-Prot
  GATase_2_dom UniProtKB/Swiss-Prot
  Ntn_hydrolases_N UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
KEGG Report rno:25612 UniProtKB/Swiss-Prot
Pfam Asn_synthase UniProtKB/Swiss-Prot
  GATase_7 UniProtKB/Swiss-Prot
PhenoGen Asns PhenoGen
PIRSF Asn_synthetase_glu-h UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot
TIGR TC205831
TIGRFAMs asn_synth_AEB UniProtKB/Swiss-Prot
UniProt Secondary Q66HR8 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-30 Asns  asparagine synthetase (glutamine-hydrolyzing)  Asns  asparagine synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Asns  Asparagine synthetase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70348