Trpv2 (transient receptor potential cation channel, subfamily V, member 2) - Rat Genome Database

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Gene: Trpv2 (transient receptor potential cation channel, subfamily V, member 2) Rattus norvegicus
Analyze
Symbol: Trpv2
Name: transient receptor potential cation channel, subfamily V, member 2
RGD ID: 3965
Description: Enables identical protein binding activity. Involved in negative regulation of cell population proliferation and response to heat. Located in several cellular components, including endomembrane system; lamellipodium; and plasma membrane. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2); INTERACTS WITH 11-hydroxy-Delta(9)-tetrahydrocannabinol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105451; osm-9-like TRP channel 2; OTRPC2; stretch-activated channel 2B; transient receptor potential cation channel subfamily V member 2; vanilloid receptor-like protein 1; VRL-1; Vrl1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Trpv2em1Mcwi  
Genetic Models: WKY-Trpv2em1Mcwi
Candidate Gene For: Pia26
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21047,265,524 - 47,294,263 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1047,272,931 - 47,294,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1051,975,970 - 51,997,253 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01051,466,516 - 51,487,799 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01046,969,925 - 46,991,212 (+)NCBIRnor_WKY
Rnor_6.01048,903,540 - 48,925,036 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,903,540 - 48,925,030 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01048,686,500 - 48,707,996 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41048,764,894 - 48,786,150 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11048,778,506 - 48,799,767 (+)NCBI
Celera1046,520,118 - 46,541,280 (+)NCBICelera
Cytogenetic Map10q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
11-hydroxy-Delta(9)-tetrahydrocannabinol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Cannabichromene  (ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (ISO)
Cannabidivarin  (ISO)
Cannabinol  (EXP)
choline  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glycidol  (ISO)
indometacin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nabilone  (EXP)
nickel atom  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
tranilast  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
vincristine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
axonal growth cone  (IEA,ISO)
cell body  (IEA,ISO)
cell surface  (IEA,ISO)
cytoplasm  (IDA)
endomembrane system  (IDA)
growth cone membrane  (IEA,ISO)
lamellipodium  (IDA)
melanosome  (IEA)
plasma membrane  (IBA,IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. Barnhill JC, etal., J Cell Biochem. 2004 Mar 1;91(4):808-20.
2. A capsaicin-receptor homologue with a high threshold for noxious heat. Caterina MJ, etal., Nature 1999 Apr 1;398(6726):436-41.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Structural insight into the assembly of TRPV channels. Huynh KW, etal., Structure. 2014 Feb 4;22(2):260-8. doi: 10.1016/j.str.2013.11.008. Epub 2013 Dec 26.
5. Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. Jung J, etal., J Biol Chem 2002 Nov 15;277(46):44448-54.
6. The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. Laragione T, etal., Clin Immunol. 2015 Apr 11. pii: S1521-6616(15)00131-X. doi: 10.1016/j.clim.2015.04.001.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue. Sun W, etal., EMBO Rep. 2016 Mar;17(3):383-99. doi: 10.15252/embr.201540819. Epub 2016 Feb 11.
Additional References at PubMed
PMID:10559903   PMID:12062441   PMID:12477932   PMID:12829722   PMID:12867271   PMID:14622291   PMID:14625457   PMID:14725976   PMID:14961565   PMID:15174083   PMID:15249591   PMID:15254097  
PMID:15489334   PMID:15547947   PMID:15620571   PMID:15653710   PMID:16533525   PMID:17287441   PMID:17517374   PMID:17712480   PMID:19579031   PMID:19619635   PMID:20357111   PMID:21998141  
PMID:22188460   PMID:22190268   PMID:22750329   PMID:23584686   PMID:24392006   PMID:25136832   PMID:25956061   PMID:27021073   PMID:27074678   PMID:27468746   PMID:27784066   PMID:28007781  
PMID:29505690   PMID:30764505   PMID:31062423   PMID:31566564   PMID:31719194   PMID:31724952   PMID:33763489   PMID:34605028   PMID:35406761   PMID:35686730   PMID:36134661  


Genomics

Comparative Map Data
Trpv2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21047,265,524 - 47,294,263 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1047,272,931 - 47,294,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1051,975,970 - 51,997,253 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01051,466,516 - 51,487,799 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01046,969,925 - 46,991,212 (+)NCBIRnor_WKY
Rnor_6.01048,903,540 - 48,925,036 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,903,540 - 48,925,030 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01048,686,500 - 48,707,996 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41048,764,894 - 48,786,150 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11048,778,506 - 48,799,767 (+)NCBI
Celera1046,520,118 - 46,541,280 (+)NCBICelera
Cytogenetic Map10q23NCBI
TRPV2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381716,415,571 - 16,437,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1716,415,571 - 16,437,003 (+)EnsemblGRCh38hg38GRCh38
GRCh371716,318,885 - 16,340,317 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361716,259,613 - 16,281,042 (+)NCBINCBI36Build 36hg18NCBI36
Build 341716,259,612 - 16,281,040NCBI
Celera1716,221,759 - 16,243,216 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1716,185,329 - 16,206,779 (+)NCBIHuRef
CHM1_11716,328,475 - 16,349,923 (+)NCBICHM1_1
T2T-CHM13v2.01716,317,872 - 16,339,304 (+)NCBIT2T-CHM13v2.0
Trpv2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,465,312 - 62,491,131 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,465,312 - 62,491,341 (+)EnsemblGRCm39 Ensembl
GRCm381162,574,486 - 62,600,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,574,486 - 62,600,515 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,387,988 - 62,413,807 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,390,733 - 62,416,491 (+)NCBIMGSCv36mm8
Celera1169,494,115 - 69,519,933 (+)NCBICelera
Cytogenetic Map11B2NCBI
TRPV2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A110,620,793 - 110,642,926 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A110,620,793 - 110,642,926 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01735,329,283 - 35,350,729 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TRPV2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1539,488,155 - 39,512,454 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl539,491,484 - 39,509,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha539,632,760 - 39,656,359 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0539,596,549 - 39,620,384 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl539,600,757 - 39,620,349 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1539,568,532 - 39,592,119 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0539,513,796 - 39,537,381 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0539,705,961 - 39,729,555 (-)NCBIUU_Cfam_GSD_1.0
Trpv2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560259,586,614 - 59,613,898 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936821198,098 - 226,025 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936821198,622 - 225,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPV2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,135,329 - 59,152,228 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11259,132,529 - 59,152,633 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,259,257 - 62,278,900 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPV2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11615,226,276 - 15,246,488 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1615,225,554 - 15,244,364 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660595,726,313 - 5,748,264 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpv2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248774,016,973 - 4,034,495 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248774,016,964 - 4,034,522 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpv2
120 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:113
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000004248
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat

Markers in Region
Trpv2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21047,289,885 - 47,291,406 (+)MAPPERmRatBN7.2
Rnor_6.01048,920,659 - 48,922,179NCBIRnor6.0
Rnor_5.01048,703,619 - 48,705,139UniSTSRnor5.0
Celera1046,536,903 - 46,538,423UniSTS
Cytogenetic Map10q23UniSTS


Genetic Models
This gene Trpv2 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 13 45 4 11
Low 3 43 44 39 6 39 8 9 29 35 35 8
Below cutoff 2 2 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004248   ⟹   ENSRNOP00000004248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1047,272,931 - 47,294,260 (+)Ensembl
Rnor_6.0 Ensembl1048,903,540 - 48,925,030 (+)Ensembl
RefSeq Acc Id: NM_001270797   ⟹   NP_001257726
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21047,272,942 - 47,294,263 (+)NCBI
Rnor_6.01048,903,540 - 48,925,036 (+)NCBI
Rnor_5.01048,686,500 - 48,707,996 (+)NCBI
Celera1046,520,118 - 46,541,280 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270798   ⟹   NP_001257727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21047,272,942 - 47,294,263 (+)NCBI
Rnor_6.01048,903,540 - 48,925,036 (+)NCBI
Rnor_5.01048,686,500 - 48,707,996 (+)NCBI
Celera1046,520,118 - 46,541,280 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017207   ⟹   NP_058903
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21047,272,942 - 47,294,263 (+)NCBI
Rnor_6.01048,903,540 - 48,925,036 (+)NCBI
Rnor_5.01048,686,500 - 48,707,996 (+)NCBI
RGSC_v3.41048,764,894 - 48,786,150 (+)RGD
Celera1046,520,118 - 46,541,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085741   ⟹   XP_038941669
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21047,265,524 - 47,294,259 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058903   ⟸   NM_017207
- UniProtKB: Q9WUD2 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257726   ⟸   NM_001270797
- UniProtKB: Q9WUD2 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257727   ⟸   NM_001270798
- UniProtKB: Q9WUD2 (UniProtKB/Swiss-Prot),   A0A0G2JSH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004248   ⟸   ENSRNOT00000004248
RefSeq Acc Id: XP_038941669   ⟸   XM_039085741
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSH6 (UniProtKB/TrEMBL)
Protein Domains
Ion_trans

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUD2-F1-model_v2 AlphaFold Q9WUD2 1-761 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697275
Promoter ID:EPDNEW_R7800
Type:initiation region
Name:Trpv2_1
Description:transient receptor potential cation channel, subfamily V, member2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01048,903,548 - 48,903,608EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3965 AgrOrtholog
BioCyc Gene G2FUF-24770 BioCyc
Ensembl Genes ENSRNOG00000003104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004248 ENTREZGENE
  ENSRNOP00000004248.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004248 ENTREZGENE
  ENSRNOT00000004248.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302251 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPV1-4_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPV2_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105451 IMAGE-MGC_LOAD
NCBI Gene 29465 ENTREZGENE
PANTHER PTHR10582 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10582:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpv2 PhenoGen
PRINTS TRPVRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSH6 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUD2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5FWT3 UniProtKB/Swiss-Prot
  Q9JMI8 UniProtKB/Swiss-Prot
  Q9QYH8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Trpv2  transient receptor potential cation channel, subfamily V, member 2  Vrl1  vanilloid receptor-like protein 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Vrl1  vanilloid receptor-like protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation insensitive to capsaicin 70055