RGD Reference Report - A capsaicin-receptor homologue with a high threshold for noxious heat. - Rat Genome Database

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A capsaicin-receptor homologue with a high threshold for noxious heat.

Authors: Caterina, MJ  Rosen, TA  Tominaga, M  Brake, AJ  Julius, D 
Citation: Caterina MJ, etal., Nature 1999 Apr 1;398(6726):436-41.
RGD ID: 70055
Pubmed: PMID:10201375   (View Abstract at PubMed)
DOI: DOI:10.1038/18906   (Journal Full-text)

Pain-producing heat is detected by several classes of nociceptive sensory neuron that differ in their thermal response thresholds. The cloned capsaicin receptor, also known as the vanilloid receptor subtype 1 (VR1), is a heat-gated ion channel that has been proposed to mediate responses of small-diameter sensory neurons to moderate (43 degrees C) thermal stimuli. VR1 is also activated by protons, indicating that it may participate in the detection of noxious thermal and chemical stimuli in vivo. Here we identify a structurally related receptor, VRL-1, that does not respond to capsaicin, acid or moderate heat. Instead, VRL-1 is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. We propose that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to heat acts_upstream_of_or_withinIDA 70055PMID:10201375MGI 
response to pH acts_upstream_of_or_withinIDA 70055PMID:10201375MGI 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
membrane located_inIDA 70055PMID:10201375MGI 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
monoatomic cation transmembrane transporter activity enablesIDA 70055PMID:10201375MGI 

Objects Annotated

Genes (Rattus norvegicus)
Trpv1  (transient receptor potential cation channel, subfamily V, member 1)

Objects referenced in this article
Gene TRPV2 transient receptor potential cation channel subfamily V member 2 Homo sapiens
Gene Trpv1 transient receptor potential cation channel, subfamily V, member 1 Mus musculus
Gene Trpv2 transient receptor potential cation channel, subfamily V, member 2 Mus musculus
Gene Trpv2 transient receptor potential cation channel, subfamily V, member 2 Rattus norvegicus

Additional Information