Dph3 (diphthamide biosynthesis 3)

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Gene: Dph3 (diphthamide biosynthesis 3) Rattus norvegicus

Analyze

Symbol:

Dph3

Name:

diphthamide biosynthesis 3

RGD ID:

1590566

Description:

Predicted to be involved in negative regulation of protein secretion and protein histidyl modification to diphthamide. Predicted to be located in cytosol and nucleoplasm. Orthologous to several human genes including DPH3 (diphthamide biosynthesis 3); INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; amitrole.

Type:

protein-coding (Ensembl: lncRNA)

RefSeq Status:

VALIDATED

Previously known as:

diphthamide biosynthesis protein 3; DPH3 homolog; DPH3, KTI11 homolog; DPH3, KTI11 homolog (S. cerevisiae); LOC680594; MGC188477; similar to zinc finger, CSL domain containing 2; zinc finger, CSL domain containing 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DPH3 (diphthamide biosynthesis 3)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dph3 (diphthamine biosynthesis 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dph3 (diphthamide biosynthesis 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DPH3 (diphthamide biosynthesis 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DPH3 (diphthamide biosynthesis 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dph3 (diphthamide biosynthesis 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DPH3 (diphthamide biosynthesis 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DPH3 (diphthamide biosynthesis 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dph3 (diphthamide biosynthesis 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DPH3P1 (diphthamide biosynthesis 3 pseudogene 1)	HGNC	Panther
Homo sapiens (human):	UBE2K (ubiquitin conjugating enzyme E2 K)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DPH3P1 (diphthamide biosynthesis 3 pseudogene 1)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Homo sapiens (human):	DPH3 (diphthamide biosynthesis 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dph3 (diphthamine biosynthesis 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dph3 (diphthamide biosynthesis 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14701	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	KTI11	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dph-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dph3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	7,288,295 - 7,293,734 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	7,282,705 - 7,291,265 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	7,289,080 - 7,294,550 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	8,433,932 - 8,439,402 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	7,298,934 - 7,304,354 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	8,202,048 - 8,207,492 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	8,202,048 - 8,207,464 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	8,119,073 - 8,124,489 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	7,541,193 - 7,546,609 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	7,904,888 - 7,910,304 (+)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3p deletion syndrome (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP)

amitrole (EXP)

anthracen-2-amine (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

carbon nanotube (ISO)

clotrimazole (EXP)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

disodium selenite (ISO)

disulfiram (ISO)

endosulfan (EXP)

fenthion (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

glafenine (EXP)

leflunomide (EXP)

menadione (ISO)

methimazole (EXP)

nefazodone (EXP)

nimesulide (EXP)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

quercetin (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium fluoride (ISO)

succimer (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

toluene (EXP)

triadimefon (EXP)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of protein secretion (ISO)

protein histidyl modification to diphthamide (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14980502

Genomics

Comparative Map Data

Dph3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	7,288,295 - 7,293,734 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	7,282,705 - 7,291,265 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	7,289,080 - 7,294,550 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	8,433,932 - 8,439,402 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	7,298,934 - 7,304,354 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	8,202,048 - 8,207,492 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	8,202,048 - 8,207,464 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	8,119,073 - 8,124,489 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	7,541,193 - 7,546,609 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	7,904,888 - 7,910,304 (+)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

DPH3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	16,257,061 - 16,264,943 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	16,257,061 - 16,264,969 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	16,298,568 - 16,306,450 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	16,276,969 - 16,281,490 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	16,277,013 - 16,281,409	NCBI
Celera	3	16,237,487 - 16,245,416 (-)	NCBI		Celera
Cytogenetic Map	3	p25.1	NCBI
HuRef	3	16,231,591 - 16,239,520 (-)	NCBI		HuRef
CHM1_1	3	16,249,497 - 16,257,426 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	16,258,288 - 16,266,169 (-)	NCBI		T2T-CHM13v2.0

Dph3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	31,802,474 - 31,807,649 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	31,802,523 - 31,807,686 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	32,080,517 - 32,085,692 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	32,080,566 - 32,085,729 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	32,893,748 - 32,898,851 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	30,909,578 - 30,914,591 (-)	NCBI		MGSCv36	mm8
Celera	14	28,339,467 - 28,344,570 (-)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	19.4	NCBI

Dph3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	8,544,314 - 8,550,276 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	8,544,314 - 8,550,276 (-)	NCBI	ChiLan1.0	ChiLan1.0

DPH3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	16,247,905 - 16,254,959 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	16,183,158 - 16,190,184 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	16,520,076 - 16,527,196 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	16,520,076 - 16,527,196 (-)	Ensembl	panpan1.1		panPan2

DPH3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	26,522,367 - 26,529,808 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	26,522,374 - 26,527,827 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	26,497,520 - 26,505,024 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	27,023,638 - 27,031,142 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	27,023,665 - 27,031,141 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	26,724,242 - 26,731,957 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	26,786,230 - 26,793,945 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	27,035,260 - 27,042,764 (+)	NCBI		UU_Cfam_GSD_1.0

Dph3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	175,907,489 - 175,913,939 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936473	9,046,062 - 9,052,522 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DPH3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	3,391,823 - 3,395,856 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	3,391,833 - 3,395,856 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	3,582,105 - 3,586,124 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DPH3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	61,103,247 - 61,111,114 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	61,103,102 - 61,111,115 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	34,108,453 - 34,115,488 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dph3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624821	1,496,565 - 1,500,896 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624821	1,494,321 - 1,500,911 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dph3
12 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	64
Count of miRNA genes:	60
Interacting mature miRNAs:	64
Transcripts:	ENSRNOT00000026742
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	9639137	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	2851709	15884239	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
737825	Alc13	Alcohol consumption QTL 13	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	16039848	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4227730	17696785	Rat

Markers in Region

RH130662

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	7,288,315 - 7,288,496 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	8,202,069 - 8,202,249	NCBI	Rnor6.0
Rnor_5.0	16	8,119,094 - 8,119,274	UniSTS	Rnor5.0
RGSC_v3.4	16	7,541,214 - 7,541,394	UniSTS	RGSC3.4
Celera	16	7,910,103 - 7,910,283	UniSTS
RH 3.4 Map	16	60.3	UniSTS
Cytogenetic Map	16	p16	UniSTS

RH131117

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	7,290,476 - 7,290,669 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	8,204,230 - 8,204,422	NCBI	Rnor6.0
Rnor_5.0	16	8,121,255 - 8,121,447	UniSTS	Rnor5.0
RGSC_v3.4	16	7,543,375 - 7,543,567	UniSTS	RGSC3.4
Celera	16	7,907,930 - 7,908,122	UniSTS
RH 3.4 Map	16	62.2	UniSTS
Cytogenetic Map	16	p16	UniSTS

AA875318

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	7,291,025 - 7,291,229 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	8,204,779 - 8,204,982	NCBI	Rnor6.0
Rnor_5.0	16	8,121,804 - 8,122,007	UniSTS	Rnor5.0
RGSC_v3.4	16	7,543,924 - 7,544,127	UniSTS	RGSC3.4
Celera	16	7,907,370 - 7,907,573	UniSTS
RH 3.4 Map	16	62.8	UniSTS
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	23	18	10	18	7	10	66	27	39	10	7
Low		9	34	23	9	23	1	1	8	8	2	1	1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000026742 ⟹ ENSRNOP00000026742

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	7,282,728 - 7,291,265 (+)	Ensembl
Rnor_6.0 Ensembl	16	8,202,048 - 8,207,464 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108682

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	7,282,705 - 7,290,858 (+)	Ensembl

RefSeq Acc Id:

NM_001134850 ⟹ NP_001128322

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	7,288,295 - 7,293,711 (-)	NCBI
Rnor_6.0	16	8,202,048 - 8,207,464 (-)	NCBI
Rnor_5.0	16	8,119,073 - 8,124,489 (-)	NCBI
RGSC_v3.4	16	7,541,193 - 7,546,609 (-)	RGD
Celera	16	7,904,888 - 7,910,304 (+)	RGD

Sequence:

show sequence

GGAAGTGACTGTTCCTGCTCCAGGGAGGGCCGCCCGGGCCTACCCTGCCTGGGCGCAGCTAGGC
AAACTGATGCGGTCCGGACCGGGTGACCATGGCGGTGTTTCATGACGAGGTGGAGATCGAGGAC
TTTCAATATGACGAGGACACAGAGACGTATTTCTACCCCTGCCCCTGTGGGGATAACTTCTCCA
TCACCAAGGAAGATTTGGAAAATGGAGAAGATGTGGCAACGTGTCCTAGCTGCTCACTCATTAT
AAAAGTGATTTATGACAAAGATCAGTTCATGTGTGGAGAAACAGTCCCAGCTCCTTCAACCAAC
AAAGGGTTAGTTAAGTGCTGAGGACGCTCTCAGAACCCACATCCAGAACAGCGGGGGCTGAGCC
CAGGTGGCTGGATCCGGTGCAGAGTTACCAACCTCCTCAGTGGGCAACTATCCTGTGGATGGCC
TCATGGGTGTGATCTACATCAGCCACTGACCTCGGCGTGAAGAAGTGAGCCTGTGACACATCAG
CCCTGGATTCCATGCTTACCTGACTGGCAGGATTCCTCTCTGTCCATCTGAATTTAAGGAAGAG
CCCTGTGAACTGATGGTTTTTCCTTCAATTGGTTGCATCATTTGAATATCTGAAAATTCATTTT
CTGAAAATAACATCATCCGCTCAGTCCTGAGAGTGTTCTTTTATTTTTTAAGATTTATGATTTT
ATTCTTAATTGTGTGTATATGTACATTTGTGTGTGGGTATGTGCATGTGAGAATCATGTGAGAA
TCGTTGCCCAAGATGGCCAGAGGCACTGGATCTCCTGGAGCAGGAGTCACAGGCAGTTGGGAGC
CACCTGACATGGGTGGTGGGACCCAAACTTTGGTTCCCTGACAGCACTACACACTCCAACCTCT
GACCCCTCTCTCCAGCCCATGGTGGGTTCAGATGAGGCAGCCTGCCTTTCCAGTGCTGCACTTC
CAGTTCCTCCCACACCCAGTCAGCCTGGGCTCGCCGTGATCGCATTGTCCTGTGCTCGGTCACT
TCTGTTACTTTTCATGCACAGAGTACAGTCCTGCTGTTAGACTGTGAGGCCACGGTTTCCCCGT
AGCTTCCAGTTAGTGCAGAAGGAAGGACCGTCTGAAGTGAAATGGTAAAAGAAATGCTGCCTAA
CGCCCTGTGCATCCTTATGTCAGGACAAATGTAAAGGAAACAGCCGACGGAGGGTACCCCTGGC
GGCAGCGAGAGGCGCAAGGCCTGCTAACTCGGCAAGTGGAAGTACGTGAATAGTTGCCAGTGGG
AACAAGTCTTTCTGTATCACGGCCTTGATTTCTTGAAATGCCTGATGGGATCCATCTCAGACGG
GCGAGGCTGATCTTCATACGCAGTAGTTGTAACGTAGCACAGCTCTGTGTCGGCGTTAGGCCTA
AGGAGTGCAGACTACAACAGGGTGAGCTCTAACAGACACGCCCGTGATGCACACCTAGGAACAC
TGCACATAACAGAACCCAAGTCAACACGTACCCCTGCTGCGATTCTTCCCCTGAAGAAAGAGAC
GTATGTCAGATGGCTATTAGTCTTTCTCCACTGCAGTCTGAGAGCATCAAGAAGTTAGATTCAC
CCATTCAGAAATTTAAAAAGTTCCCTTGTAAACACAGCTTTGCTGTGAATGCATAAAGTTTTGA
AAATCCATTGCTTATCCAGCAGATTGTTTGGGGTATGGCTCCTGCAACTAAAAAAAGCCAGAAG
GGACTGGAGAGATGGCTGGTAGGCTAAGATCTCTTGCTGTTCTTCTAGAAGACCCGTGTTCAAT
TCTTAGCACCCACATAGCAGCTCACAACTCCGCCTGACTCCAGTTCCTGGGGCTCTGACTCCTT
CTTCTAACCTCTAAATACCAGGCATGCACATAGTTCAGAGACATACATGCAGACAAAAGACCCA
TACAACTAAAGAAAAATGTACTTAAAAAGAAAGAAATGGGGGCTGGGGATTTAGCTCAGTGGTA
GAGCGCTTACCTAGGAAGCGCAAGGCCCTGGGTTCGGTCCCCAGCTCCGAAAAAAAGAACCAAA
AAAAAAAAAAAAGAAATGGCCAATAAATGCATTGTATCCACTCATTGGAGGTTTAAATTAAAAT
GTGTAACCAGGTTTTTTAACCATAGAGAAGTGTGTGGTTCTAGGCAACCATTAGGCTGAGACTA
AGTTAAAAGTTGTCTGAAGTGTGTTGTCCAGTACATTCTTTGGGGGAGGTGGGAAGGTGTTGAA
CCCAAGGCCTGGCTCACGCTGGGCAAATGCTCCAGTGCAGGGCTGCATCTCCGGCGGACAGTTC
TCATAGGAAATCTCACTGCTGTTTGGTGTCTCCCAAATTACCGTACAAAACAGCCGCTACTCAA
ACAGGCGGAGCAAGGTGGTTCTGGTGAGAAGGAGCTACATGGAGACACAGATTGTCTGTGCTCC
TCAGATCGATGGTTTTGGAGAGTCCACTAACAGTCGTCGTCGTCCTCCTCTTCCTCCTCCTCCT
CCTCCTCCTCTTCCTTCTCCTCCTCCTCCTCCTTCTCCTCCTTCTTGCTGCTACTGTTGCATTC
CACAGCAGATGTCTTGTTGCAGGTGTTCTGTGAACACAAAGGAGCAGGAGTCCAAGTTCAAACA
CCTCAGGAGACAAAGCATGGACAGACTGGTGGTGAGTGCCTGGTGGGGTGGATGTGATTTTGTC
TTAAAGCAACCGAGCAACTTTATAGAAGCACCAGCTATTAGCCCCGTATTAAACAGAAAAACCC
AAGGTCTTTCAGATGTGACTGGAGTCCCAGACGCTTCCAGAACACCTTTGAGAACCAGTAAGAG
TATCTGCTCTGCTTGTGAGCTCTGTCGTCTTTGACAGGGCCTGTGGATGGATAACTCATCTGTA
CAGCAAAGTGATGGACGGGGTCAGGTGATCTCTCAGCTGTCAGTTCTCATTTTAGATGTGGTTC
CTTGTCAGAACACAAAACTATCATGAGTAGAAGCTTCATTTTTCTTTCACAACAACACACTTCA
GAGTGAAGTTTCTAGTCAGTTCTTCAAAGGGTTCTTTCCTCTCATGCTCATGCTTTTCTTTCCT
GAGGTGCTTGAACTTGGGACTCTGCTCCCTTTTGATCACAGAAGACCTACATCATTGTGTTCAC
ATATGTGTCTGAAGGCACAGCCAATGATTTTTGTAGTACTGTAATGAATCAATTCATTAGAATG
ACTTGCATCGCCAAGCTAATAAAATGAGACCATGCAAATTCA

hide sequence

RefSeq Acc Id:

XM_006252668 ⟹ XP_006252730

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	7,290,867 - 7,293,734 (-)	NCBI
Rnor_6.0	16	8,204,620 - 8,207,492 (-)	NCBI
Rnor_5.0	16	8,119,073 - 8,124,489 (-)	NCBI

Sequence:

show sequence

TGGAAGTTACGTCATCGCCTGTGCGTCCGGAAGTGACTGTTCCTGCTCCAGGGAGGGCCGCCCG
GGCCTACCCTGCCTGGGCGCAGCTAGGCAAACTGATGCGGTCCGGACCGGGTGACCATGGCGGT
GTTTCATGACGAGGTGGAGATCGAGGACTTTCAATATGACGAGGACACAGAGACGTATTTCTAC
CCCTGCCCCTGTGGGGATAACTTCTCCATCACCAAGGATCAGTTCATGTGTGGAGAAACAGTCC
CAGCTCCTTCAACCAACAAAGGGTTAGTTAAGTGCTGAGGACGCTCTCAGAACCCACATCCAGA
ACAGCGGGGGCTGAGCCCAGGTGGCTGGATCCGGTGCAGAGTTACCAACCTCCTCAGTGGGCAA
CTATCCTGTGGATGGCCTCATGGGTGTGATCTACATCAGCCACTGACCTCGGCGTGAAGAAGTG
AGCCTGTGACACATCAGCCCTGGATTCCATGCTTACCTGACTGGCAGGATTCCTCTCTGTCCAT
CTGAATTTAAGGAAGAGCCCTGTGAACTGATGGTTTTTCCTTCAATTGGTTGCATCATTTGAAT
ATCTGAAAATTCATTTTCTGAAAATAACATCATCCGCTCAGTCCTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001128322	(Get FASTA)	NCBI Sequence Viewer
	XP_006252730	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68674	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001128322 ⟸ NM_001134850
- UniProtKB:	D4A0Z4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVFHDEVEIEDFQYDEDTETYFYPCPCGDNFSITKEDLENGEDVATCPSCSLIIKVIYDKDQF MCGETVPAPSTNKGLVKC hide sequence

RefSeq Acc Id:	XP_006252730 ⟸ XM_006252668
- Peptide Label:	isoform X1
- Sequence:	show sequence MAVFHDEVEIEDFQYDEDTETYFYPCPCGDNFSITKDQFMCGETVPAPSTNKGLVKC hide sequence

RefSeq Acc Id:

ENSRNOP00000026742 ⟸ ENSRNOT00000026742

Protein Domains

DPH-type MB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A0Z4-F1-model_v2	AlphaFold	D4A0Z4	1-82	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1590566	AgrOrtholog
BioCyc Gene	G2FUF-12124	BioCyc
Ensembl Genes	ENSRNOG00000019727	Ensembl
Gene3D-CATH	3.10.660.10	UniProtKB/TrEMBL
InterPro	DPH3/4-like	UniProtKB/TrEMBL
	Znf_DHP	UniProtKB/TrEMBL
	Znf_DHP_sf	UniProtKB/TrEMBL
NCBI Gene	680594	ENTREZGENE
PANTHER	DPH3 HOMOLOG	UniProtKB/TrEMBL
	PTHR21454	UniProtKB/TrEMBL
Pfam	zf-CSL	UniProtKB/TrEMBL
PhenoGen	Dph3	PhenoGen
PROSITE	ZF_DPH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF144217	UniProtKB/TrEMBL
UniProt	B5DEH8_RAT	UniProtKB/TrEMBL
	D4A0Z4	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-07-09	Dph3	diphthamide biosynthesis 3	Dph3	DPH3, KTI11 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Dph3	DPH3, KTI11 homolog (S. cerevisiae)	LOC680594	similar to zinc finger, CSL domain containing 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC680594	similar to zinc finger, CSL domain containing 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar