Corin (corin, serine peptidase) - Rat Genome Database

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Gene: Corin (corin, serine peptidase) Rattus norvegicus
Analyze
Symbol: Corin
Name: corin, serine peptidase
RGD ID: 727887
Description: Predicted to enable serine-type endopeptidase activity. Involved in regulation of blood pressure and regulation of renal sodium excretion. Located in cytoplasmic vesicle and plasma membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertension; and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase); PARTICIPATES IN atrial natriuretic peptide signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: atrial natriuretic peptide-converting enzyme; LOC289596; pro-ANP-converting enzyme
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81436,034,613 - 36,264,671 (+)NCBIGRCr8
mRatBN7.21435,680,601 - 35,910,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,681,304 - 35,909,503 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1436,046,467 - 36,253,208 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,351,221 - 37,557,958 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,839,588 - 36,046,301 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,247,379 - 38,474,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,247,791 - 38,473,648 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01438,103,553 - 38,135,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01438,058,862 - 38,064,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01438,163,662 - 38,284,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41438,109,932 - 38,339,631 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11438,113,281 - 38,342,022 (+)NCBI
Celera1434,932,916 - 35,141,793 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cypermethrin  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fulvestrant  (ISO)
furan  (EXP)
isoprenaline  (ISO)
mercaptopurine  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
mitoxantrone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
testosterone undecanoate  (ISO)
Tetrachlorobisphenol A  (ISO)
triadimefon  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IEA,ISO)
cell surface  (IEA,ISO)
cytoplasmic vesicle  (IDA)
extracellular region  (IEA)
nuclear body  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Scar myofibroblasts of the infarcted rat heart express natriuretic peptides. Calderone A, etal., J Cell Physiol. 2006 Apr;207(1):165-73.
2. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. Dries DL, etal., Circulation. 2005 Oct 18;112(16):2403-10. Epub 2005 Oct 10.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat corin gene: molecular cloning and reduced expression in experimental heart failure. Langenickel TH, etal., Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1516-21. Epub 2004 May 20.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases. Polzin D, etal., Kidney Int. 2010 Oct;78(7):650-9. doi: 10.1038/ki.2010.197. Epub 2010 Jul 7.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. Tran KL, etal., Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1625-31. Epub 2004 Jun 10.
14. The serine protease corin in cardiovascular biology and disease. Wu Q Front Biosci. 2007 May 1;12:4179-90.
Additional References at PubMed
PMID:10880574   PMID:11884416   PMID:15637153   PMID:17660514   PMID:17670789   PMID:20489134   PMID:21518754   PMID:21763278   PMID:22418978   PMID:22437503   PMID:26446774   PMID:28106289  
PMID:28985241  


Genomics

Comparative Map Data
Corin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81436,034,613 - 36,264,671 (+)NCBIGRCr8
mRatBN7.21435,680,601 - 35,910,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,681,304 - 35,909,503 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1436,046,467 - 36,253,208 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,351,221 - 37,557,958 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,839,588 - 36,046,301 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,247,379 - 38,474,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,247,791 - 38,473,648 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01438,103,553 - 38,135,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01438,058,862 - 38,064,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01438,163,662 - 38,284,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41438,109,932 - 38,339,631 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11438,113,281 - 38,342,022 (+)NCBI
Celera1434,932,916 - 35,141,793 (+)NCBICelera
Cytogenetic Map14p11NCBI
CORIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38447,594,001 - 47,838,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl447,593,999 - 47,838,106 (-)EnsemblGRCh38hg38GRCh38
GRCh37447,596,018 - 47,840,084 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36447,290,775 - 47,534,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 34447,436,945 - 47,680,987NCBI
Celera448,045,262 - 48,288,937 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef446,915,569 - 47,159,628 (-)NCBIHuRef
CHM1_1447,594,966 - 47,839,077 (-)NCBICHM1_1
T2T-CHM13v2.0447,561,341 - 47,805,399 (-)NCBIT2T-CHM13v2.0
Corin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39572,457,291 - 72,661,884 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl572,457,368 - 72,661,816 (-)EnsemblGRCm39 Ensembl
GRCm38572,299,948 - 72,504,540 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,300,025 - 72,504,473 (-)EnsemblGRCm38mm10GRCm38
MGSCv37572,691,264 - 72,895,779 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36572,579,161 - 72,783,343 (-)NCBIMGSCv36mm8
Celera569,553,363 - 69,759,090 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
Corin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955443722,201 - 969,014 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955443721,655 - 970,600 (+)NCBIChiLan1.0ChiLan1.0
CORIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2380,022,875 - 80,265,634 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1480,284,385 - 80,529,361 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0474,311,036 - 74,555,742 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1485,043,182 - 85,286,573 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl485,043,182 - 85,286,573 (+)Ensemblpanpan1.1panPan2
CORIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11343,501,287 - 43,737,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1343,502,665 - 43,737,813 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1343,450,870 - 43,689,393 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01344,105,939 - 44,336,477 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1344,106,274 - 44,336,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11343,785,410 - 44,014,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01343,450,913 - 43,546,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01344,200,216 - 44,429,325 (-)NCBIUU_Cfam_GSD_1.0
Corin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528532,298,699 - 32,556,998 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648213,743,433 - 13,999,348 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648213,782,571 - 13,999,561 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CORIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl837,530,815 - 37,809,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1837,530,812 - 37,811,226 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2839,515,890 - 39,787,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CORIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1272,407,451 - 2,662,855 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl272,408,219 - 2,662,279 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604748,427,060 - 48,704,165 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Corin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476119,089,424 - 19,404,952 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476119,089,111 - 19,404,148 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Corin
1506 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:14
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000064128
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat

Markers in Region
D14Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01438,267,904 - 38,268,032NCBIRnor5.0
Rnor_5.01438,267,903 - 38,268,032NCBIRnor5.0
RGSC_v3.41438,319,972 - 38,320,210RGDRGSC3.4
RGSC_v3.41438,319,973 - 38,320,209UniSTSRGSC3.4
RGSC_v3.11438,322,007 - 38,322,640RGD
Celera1435,125,753 - 35,125,941UniSTS
SHRSP x BN Map1424.7899RGD
SHRSP x BN Map1424.7899UniSTS
Cytogenetic Map14p11UniSTS
D14Wox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01438,289,187 - 38,289,371NCBIRnor6.0
Rnor_5.01438,099,442 - 38,099,626UniSTSRnor5.0
RGSC_v3.41438,152,541 - 38,152,726RGDRGSC3.4
RGSC_v3.41438,152,542 - 38,152,726UniSTSRGSC3.4
RGSC_v3.11438,158,382 - 38,158,567RGD
Celera1434,967,653 - 34,967,837UniSTS
Cytogenetic Map14p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42 4
Low 1 21 15 5 15 23 30 26 11
Below cutoff 1 36 26 11 26 8 8 42 5 11 8

Sequence


Ensembl Acc Id: ENSRNOT00000064128   ⟹   ENSRNOP00000061602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1435,681,586 - 35,909,503 (+)Ensembl
Rnor_6.0 Ensembl1438,247,791 - 38,473,648 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094681   ⟹   ENSRNOP00000093839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1435,681,304 - 35,909,503 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101248   ⟹   ENSRNOP00000090772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1435,681,304 - 35,909,503 (+)Ensembl
RefSeq Acc Id: NM_182473   ⟹   NP_872279
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,035,566 - 36,263,469 (+)NCBI
mRatBN7.21435,681,586 - 35,909,501 (+)NCBI
Rnor_6.01438,247,940 - 38,473,729 (+)NCBI
Rnor_5.01438,163,662 - 38,284,564 (+)NCBI
Rnor_5.01438,058,862 - 38,064,976 (+)NCBI
Rnor_5.01438,103,553 - 38,135,786 (+)NCBI
RGSC_v3.41438,109,932 - 38,339,631 (+)RGD
Celera1434,932,916 - 35,141,793 (+)RGD
Sequence:
RefSeq Acc Id: XM_008770139   ⟹   XP_008768361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,034,613 - 36,264,671 (+)NCBI
mRatBN7.21435,680,601 - 35,910,703 (+)NCBI
Rnor_6.01438,247,379 - 38,474,931 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091707   ⟹   XP_038947635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,156,594 - 36,264,671 (+)NCBI
mRatBN7.21435,818,337 - 35,910,703 (+)NCBI
RefSeq Acc Id: XM_039091709   ⟹   XP_038947637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,156,604 - 36,264,671 (+)NCBI
mRatBN7.21435,818,340 - 35,910,703 (+)NCBI
RefSeq Acc Id: XM_063272920   ⟹   XP_063128990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,142,307 - 36,264,671 (+)NCBI
RefSeq Acc Id: XM_063272921   ⟹   XP_063128991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,156,603 - 36,264,671 (+)NCBI
RefSeq Acc Id: NP_872279   ⟸   NM_182473
- UniProtKB: Q80YN4 (UniProtKB/Swiss-Prot),   F1LS60 (UniProtKB/Swiss-Prot),   D3ZN44 (UniProtKB/Swiss-Prot),   J3QTE2 (UniProtKB/TrEMBL),   A6JD74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768361   ⟸   XM_008770139
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIB1 (UniProtKB/TrEMBL),   A0A8I6AD87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061602   ⟸   ENSRNOT00000064128
RefSeq Acc Id: XP_038947635   ⟸   XM_039091707
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038947637   ⟸   XM_039091709
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000090772   ⟸   ENSRNOT00000101248
Ensembl Acc Id: ENSRNOP00000093839   ⟸   ENSRNOT00000094681
RefSeq Acc Id: XP_063128990   ⟸   XM_063272920
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063128991   ⟸   XM_063272921
- Peptide Label: isoform X5
Protein Domains
FZ   LDL-receptor class A   Peptidase S1   SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80YN4-F1-model_v2 AlphaFold Q80YN4 1-1111 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727887 AgrOrtholog
BioCyc Gene G2FUF-15849 BioCyc
Ensembl Genes ENSRNOG00000002302 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064128.4 UniProtKB/TrEMBL
  ENSRNOT00000094681.1 UniProtKB/TrEMBL
  ENSRNOT00000101248.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Corin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Corin_CRD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Corin_CRD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:289596 UniProtKB/Swiss-Prot
NCBI Gene 289596 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME ISOFORM X1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Corin PhenoGen
PIRSF Corin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_1 UniProtKB/Swiss-Prot
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002302 RatGTEx
SMART FRI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AD87 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIB1 ENTREZGENE, UniProtKB/TrEMBL
  A6JD74 ENTREZGENE, UniProtKB/TrEMBL
  A6JD75_RAT UniProtKB/TrEMBL
  CORIN_RAT UniProtKB/Swiss-Prot
  D3ZN44 ENTREZGENE
  F1LS60 ENTREZGENE
  J3QTE2 ENTREZGENE, UniProtKB/TrEMBL
  Q80YN4 ENTREZGENE
UniProt Secondary D3ZN44 UniProtKB/Swiss-Prot
  F1LS60 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Corin  corin, serine peptidase  Corin  corin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Corin  corin  LOC289596    Symbol updated 1299863 APPROVED