RGD Reference Report - The serine protease corin in cardiovascular biology and disease. - Rat Genome Database

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The serine protease corin in cardiovascular biology and disease.

Authors: Wu, Q 
Citation: Wu Q Front Biosci. 2007 May 1;12:4179-90.
RGD ID: 1626338
Pubmed: PMID:17485366   (View Abstract at PubMed)

Corin is a type II transmembrane serine protease expressed primarily in the heart. Functional studies have shown that corin converts pro-atrial natriuretic peptide (pro-ANP) to mature ANP, a cardiac hormone important in regulating salt-water balance and maintaining normal blood pressure. In corin-deficient mice, pro-ANP processing is abolished, demonstrating that corin is the physiological pro-ANP convertase. Corin-deficient mice develop hypertension that is exacerbated by a high-salt diet and during pregnancy, indicating the importance of this enzyme in controlling blood pressure. More recently, single nucleotide polymorphisms (SNPs) are found in the human corin gene, which are associated with an increased risk for hypertension and cardiac hypertrophy. This review describes the biology of corin and its potential role in cardiovascular disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CORINHumanCardiomegaly  IAGP DNA:SNPs:associated with increased riskRGD 
CorinRatCardiomegaly  ISOCORIN (Homo sapiens) RGD 
CorinMouseCardiomegaly  ISOCORIN (Homo sapiens) RGD 
CORINHumanhypertension  IAGP DNA:SNPs:associated with increased riskRGD 
CorinRathypertension  ISOCORIN (Homo sapiens) RGD 
CorinMousehypertension  ISOCORIN (Homo sapiens) RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Corin  (corin, serine peptidase)

Genes (Mus musculus)
Corin  (corin, serine peptidase)

Genes (Homo sapiens)
CORIN  (corin, serine peptidase)


Additional Information