Corin (corin, serine peptidase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Corin (corin, serine peptidase) Mus musculus
Analyze
Symbol: Corin
Name: corin, serine peptidase
RGD ID: 1551691
MGI Page MGI
Description: Enables serine-type endopeptidase activity. Involved in several processes, including peptide hormone processing; regulation of renal sodium excretion; and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Located in cell surface. Is expressed in several structures, including floor plate; heart; jaw; phalanx; and skin. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertension; and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: atrial natriuretic peptide-converting enzyme; AV273130; L; low density lipoprotein receptor-related protein 4; low density lipoprotein-related protein 4; Lrp4; MGC118735; pro-ANP-converting enzyme; Prsc-pending
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39572,457,291 - 72,661,884 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl572,457,368 - 72,661,816 (-)EnsemblGRCm39 Ensembl
GRCm38572,299,948 - 72,504,540 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,300,025 - 72,504,473 (-)EnsemblGRCm38mm10GRCm38
MGSCv37572,691,264 - 72,895,779 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36572,579,161 - 72,783,343 (-)NCBIMGSCv36mm8
Celera569,553,363 - 69,759,090 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
cantharidin  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
cypermethrin  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
fulvestrant  (ISO)
furan  (ISO)
isoprenaline  (EXP)
mercaptopurine  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
mitoxantrone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
purine-6-thiol  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
testosterone undecanoate  (ISO)
Tetrachlorobisphenol A  (ISO)
triadimefon  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. Dries DL, etal., Circulation. 2005 Oct 18;112(16):2403-10. Epub 2005 Oct 10.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Rat corin gene: molecular cloning and reduced expression in experimental heart failure. Langenickel TH, etal., Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1516-21. Epub 2004 May 20.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart. Tomita Y, etal., J Biochem (Tokyo) 1998 Oct;124(4):784-9.
12. Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. Tran KL, etal., Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1625-31. Epub 2004 Jun 10.
13. The serine protease corin in cardiovascular biology and disease. Wu Q Front Biosci. 2007 May 1;12:4179-90.
Additional References at PubMed
PMID:10329693   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11884416   PMID:12154094   PMID:12477932   PMID:15637153   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17660514  
PMID:17670789   PMID:17996891   PMID:18057101   PMID:18549807   PMID:18669922   PMID:18988802   PMID:19605494   PMID:19951692   PMID:20035737   PMID:20412777   PMID:20460368   PMID:20574444  
PMID:20613715   PMID:20802129   PMID:21098273   PMID:21267068   PMID:21288900   PMID:21606375   PMID:21677750   PMID:21689430   PMID:21752929   PMID:21873635   PMID:21880902   PMID:21903139  
PMID:22278924   PMID:22418978   PMID:22437503   PMID:22627282   PMID:22696295   PMID:22987923   PMID:23232642   PMID:23431057   PMID:23487317   PMID:23676498   PMID:23948231   PMID:25127144  
PMID:25451932   PMID:25775569   PMID:25804738   PMID:26241673   PMID:26259032   PMID:26288357   PMID:26542012   PMID:27166947   PMID:27592798   PMID:27789623   PMID:30044987   PMID:30192780  
PMID:30195494   PMID:30352487   PMID:30595185   PMID:31892216   PMID:32040930   PMID:32325033   PMID:32422879   PMID:32719113   PMID:32828311   PMID:33037205   PMID:33591965   PMID:33898467  
PMID:34166673   PMID:36076959   PMID:36232551   PMID:37563109   PMID:37827215   PMID:38246101   PMID:38246520  


Genomics

Comparative Map Data
Corin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39572,457,291 - 72,661,884 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl572,457,368 - 72,661,816 (-)EnsemblGRCm39 Ensembl
GRCm38572,299,948 - 72,504,540 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,300,025 - 72,504,473 (-)EnsemblGRCm38mm10GRCm38
MGSCv37572,691,264 - 72,895,779 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36572,579,161 - 72,783,343 (-)NCBIMGSCv36mm8
Celera569,553,363 - 69,759,090 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
CORIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38447,594,001 - 47,838,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl447,593,999 - 47,838,106 (-)EnsemblGRCh38hg38GRCh38
GRCh37447,596,018 - 47,840,084 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36447,290,775 - 47,534,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 34447,436,945 - 47,680,987NCBI
Celera448,045,262 - 48,288,937 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef446,915,569 - 47,159,628 (-)NCBIHuRef
CHM1_1447,594,966 - 47,839,077 (-)NCBICHM1_1
T2T-CHM13v2.0447,561,341 - 47,805,399 (-)NCBIT2T-CHM13v2.0
Corin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81436,034,613 - 36,264,671 (+)NCBIGRCr8
mRatBN7.21435,680,601 - 35,910,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,681,304 - 35,909,503 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1436,046,467 - 36,253,208 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,351,221 - 37,557,958 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,839,588 - 36,046,301 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,247,379 - 38,474,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,247,791 - 38,473,648 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01438,163,662 - 38,284,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01438,103,553 - 38,135,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01438,058,862 - 38,064,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41438,109,932 - 38,339,631 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11438,113,281 - 38,342,022 (+)NCBI
Celera1434,932,916 - 35,141,793 (+)NCBICelera
Cytogenetic Map14p11NCBI
Corin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955443722,201 - 969,014 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955443721,655 - 970,600 (+)NCBIChiLan1.0ChiLan1.0
CORIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2380,022,875 - 80,265,634 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1480,284,385 - 80,529,361 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0474,311,036 - 74,555,742 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1485,043,182 - 85,286,573 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl485,043,182 - 85,286,573 (+)Ensemblpanpan1.1panPan2
CORIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11343,501,287 - 43,737,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1343,502,665 - 43,737,813 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1343,450,870 - 43,689,393 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01344,105,939 - 44,336,477 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1344,106,274 - 44,336,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11343,785,410 - 44,014,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01343,450,913 - 43,546,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01344,200,216 - 44,429,325 (-)NCBIUU_Cfam_GSD_1.0
Corin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528532,298,699 - 32,556,998 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648213,743,433 - 13,999,348 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648213,782,571 - 13,999,561 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CORIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl837,530,815 - 37,809,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1837,530,812 - 37,811,226 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2839,515,890 - 39,787,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CORIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1272,407,451 - 2,662,855 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl272,408,219 - 2,662,279 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604748,427,060 - 48,704,165 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Corin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476119,089,424 - 19,404,952 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476119,089,111 - 19,404,148 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Corin
7470 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1355
Count of miRNA genes:468
Interacting mature miRNAs:562
Transcripts:ENSMUST00000005352, ENSMUST00000167460, ENSMUST00000175766, ENSMUST00000176320, ENSMUST00000176439, ENSMUST00000176974, ENSMUST00000177290
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse

Markers in Region
AU023070  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,496,246 - 72,496,395UniSTSGRCm38
MGSCv37572,887,485 - 72,887,634UniSTSGRCm37
Celera569,750,816 - 69,750,965UniSTS
Cytogenetic Map5C3.2UniSTS
Whitehead/MRC_RH5914.95UniSTS
BB498413  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,300,105 - 72,300,186UniSTSGRCm38
MGSCv37572,691,344 - 72,691,425UniSTSGRCm37
Celera569,553,443 - 69,553,524UniSTS
Cytogenetic Map5C3.2UniSTS
Whitehead/MRC_RH5917.57UniSTS
AV273130  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,300,110 - 72,300,189UniSTSGRCm38
MGSCv37572,691,349 - 72,691,428UniSTSGRCm37
Celera569,553,448 - 69,553,527UniSTS
Cytogenetic Map5C3.2UniSTS
Whitehead/MRC_RH5917.37UniSTS
40.MMHAP25FRF10.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,381,597 - 72,381,782UniSTSGRCm38
MGSCv37572,772,836 - 72,773,021UniSTSGRCm37
Celera569,633,454 - 69,633,639UniSTS
Cytogenetic Map5C3.2UniSTS
Whitehead_YAC5 UniSTS
D5Mit305  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,409,148 - 72,409,253UniSTSGRCm38
MGSCv37572,800,387 - 72,800,492UniSTSGRCm37
Celera569,660,925 - 69,661,030UniSTS
Cytogenetic Map5C3.2UniSTS
cM Map540.0UniSTS
cM Map540.0UniSTS
Whitehead Genetic527.3UniSTS
Whitehead/MRC_RH5915.15UniSTS
Whitehead_YAC5 UniSTS
D5Mit336  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,488,531 - 72,488,652UniSTSGRCm38
MGSCv37572,879,770 - 72,879,891UniSTSGRCm37
Celera569,743,227 - 69,743,351UniSTS
Cytogenetic Map5C3.2UniSTS
cM Map541.0UniSTS
Whitehead Genetic527.3UniSTS
Whitehead_YAC5 UniSTS
AB013874  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,301,116 - 72,301,231UniSTSGRCm38
MGSCv37572,692,355 - 72,692,470UniSTSGRCm37
Celera569,554,454 - 69,554,569UniSTS
Cytogenetic Map5C3.2UniSTS
Whitehead/MRC_RH5917.17UniSTS
D5Buc20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,425,281 - 72,425,562UniSTSGRCm38
MGSCv37572,816,520 - 72,816,801UniSTSGRCm37
Celera569,677,796 - 69,678,077UniSTS
Cytogenetic Map5C3.2UniSTS
cM Map540.0UniSTS
D5Buc22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,331,403 - 72,331,574UniSTSGRCm38
MGSCv37572,722,642 - 72,722,813UniSTSGRCm37
Celera569,584,735 - 69,584,906UniSTS
Cytogenetic Map5C3.2UniSTS
cM Map540.0UniSTS
D5Mit305  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38572,409,248 - 72,409,344UniSTSGRCm38
MGSCv37572,800,487 - 72,800,583UniSTSGRCm37
Celera569,661,025 - 69,661,121UniSTS
Cytogenetic Map5C3.2UniSTS
cM Map540.0UniSTS
Whitehead Genetic527.3UniSTS
Whitehead/MRC_RH5915.15UniSTS
Whitehead_YAC5 UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000005352   ⟹   ENSMUSP00000005352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl572,457,369 - 72,661,551 (-)Ensembl
GRCm38.p6 Ensembl572,300,026 - 72,504,208 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167460   ⟹   ENSMUSP00000127389
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl572,457,368 - 72,661,816 (-)Ensembl
GRCm38.p6 Ensembl572,300,025 - 72,504,473 (-)Ensembl
Ensembl Acc Id: ENSMUST00000175766   ⟹   ENSMUSP00000135889
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl572,458,829 - 72,661,776 (-)Ensembl
GRCm38.p6 Ensembl572,301,486 - 72,504,433 (-)Ensembl
Ensembl Acc Id: ENSMUST00000176320
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl572,510,923 - 72,518,042 (-)Ensembl
GRCm38.p6 Ensembl572,353,580 - 72,360,699 (-)Ensembl
Ensembl Acc Id: ENSMUST00000176439
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl572,515,727 - 72,537,631 (-)Ensembl
GRCm38.p6 Ensembl572,358,384 - 72,380,288 (-)Ensembl
Ensembl Acc Id: ENSMUST00000176974   ⟹   ENSMUSP00000135722
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl572,458,841 - 72,661,782 (-)Ensembl
GRCm38.p6 Ensembl572,301,498 - 72,504,439 (-)Ensembl
Ensembl Acc Id: ENSMUST00000177290   ⟹   ENSMUSP00000135511
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl572,458,829 - 72,661,782 (-)Ensembl
GRCm38.p6 Ensembl572,301,486 - 72,504,439 (-)Ensembl
RefSeq Acc Id: NM_001122756   ⟹   NP_001116228
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39572,457,366 - 72,661,884 (-)NCBI
GRCm38572,300,025 - 72,504,540 (-)NCBI
MGSCv37572,691,264 - 72,895,779 (-)RGD
Celera569,553,363 - 69,759,090 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001421227   ⟹   NP_001408156
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39572,457,366 - 72,659,229 (-)NCBI
RefSeq Acc Id: NM_016869   ⟹   NP_058565
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39572,457,366 - 72,661,562 (-)NCBI
GRCm38572,300,025 - 72,504,208 (-)NCBI
MGSCv37572,691,264 - 72,895,779 (-)RGD
Celera569,553,363 - 69,759,090 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011240755   ⟹   XP_011239057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39572,457,291 - 72,661,700 (-)NCBI
GRCm38572,299,948 - 72,504,357 (-)NCBI
Sequence:
RefSeq Acc Id: NP_058565   ⟸   NM_016869
- Peptide Label: isoform 1
- UniProtKB: Q9Z319 (UniProtKB/Swiss-Prot),   Q566K6 (UniProtKB/Swiss-Prot),   B2RRC6 (UniProtKB/Swiss-Prot),   B7ZNH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001116228   ⟸   NM_001122756
- Peptide Label: isoform 2
- UniProtKB: H3BLB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011239057   ⟸   XM_011240755
- Peptide Label: isoform X1
- UniProtKB: H3BKS9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000135511   ⟸   ENSMUST00000177290
Ensembl Acc Id: ENSMUSP00000127389   ⟸   ENSMUST00000167460
Ensembl Acc Id: ENSMUSP00000005352   ⟸   ENSMUST00000005352
Ensembl Acc Id: ENSMUSP00000135722   ⟸   ENSMUST00000176974
Ensembl Acc Id: ENSMUSP00000135889   ⟸   ENSMUST00000175766
RefSeq Acc Id: NP_001408156   ⟸   NM_001421227
- Peptide Label: isoform 3
- UniProtKB: H3BKS9 (UniProtKB/TrEMBL)
Protein Domains
FZ   LDL-receptor class A   Peptidase S1   SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z319-F1-model_v2 AlphaFold Q9Z319 1-1113 view protein structure

Promoters
RGD ID:6886848
Promoter ID:EPDNEW_M6875
Type:initiation region
Name:Corin_1
Description:Mus musculus corin , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6876  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38572,504,219 - 72,504,279EPDNEW
RGD ID:6886850
Promoter ID:EPDNEW_M6876
Type:initiation region
Name:Corin_2
Description:Mus musculus corin , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6875  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38572,504,541 - 72,504,601EPDNEW
RGD ID:6837292
Promoter ID:MM_KWN:42515
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NM_001122756,   NM_016869
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36572,895,331 - 72,895,831 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1349451 AgrOrtholog
Ensembl Genes ENSMUSG00000005220 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000005352 ENTREZGENE
  ENSMUST00000005352.10 UniProtKB/Swiss-Prot
  ENSMUST00000167460 ENTREZGENE
  ENSMUST00000167460.9 UniProtKB/Swiss-Prot
  ENSMUST00000175766.8 UniProtKB/TrEMBL
  ENSMUST00000176974.2 UniProtKB/TrEMBL
  ENSMUST00000177290.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Corin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Corin_CRD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Corin_CRD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:53419 UniProtKB/Swiss-Prot
MGD MGI:1349451 ENTREZGENE
NCBI Gene Corin ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME ISOFORM X1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HYALIN UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Corin PhenoGen
PIRSF Corin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_1 UniProtKB/Swiss-Prot
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FRI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RRC6 ENTREZGENE
  B7ZNH6 ENTREZGENE, UniProtKB/TrEMBL
  CORIN_MOUSE UniProtKB/Swiss-Prot
  H3BKS9 ENTREZGENE, UniProtKB/TrEMBL
  H3BLB2 ENTREZGENE, UniProtKB/TrEMBL
  H3BLR7_MOUSE UniProtKB/TrEMBL
  Q566K6 ENTREZGENE
  Q9Z319 ENTREZGENE
UniProt Secondary B2RRC6 UniProtKB/Swiss-Prot
  Q566K6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Corin  corin, serine peptidase  Prsc-pending  corin  Symbol and/or name change 5135510 APPROVED
2024-08-21 Prsc-pending  corin  Corin  corin, serine peptidase  Symbol and/or name change 5135510 APPROVED
2019-03-12 Corin  corin, serine peptidase    corin  Symbol and/or name change 5135510 APPROVED