RGD Reference Report - Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. - Rat Genome Database

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Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium.

Authors: Tran, KL  Lu, X  Lei, M  Feng, Q  Wu, Q 
Citation: Tran KL, etal., Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1625-31. Epub 2004 Jun 10.
RGD ID: 1581217
Pubmed: PMID:15191894   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpheart.00298.2004   (Journal Full-text)

High levels of plasma atrial natriuretic peptides (ANP) are associated with pathological conditions such as congestive heart failure (CHF). Recently, we have identified a cardiac serine protease, corin, that is the pro-ANP convertase. In this study, we examined the regulation of corin gene expression in cultured hypertrophic cardiomyocytes and in the left ventricular (LV) myocardium of a rat model of heart failure. Quantitative RT-PCR analysis showed that both corin and ANP mRNA levels were significantly increased in phenylephrine (PE)-stimulated rat neonatal cardiomyocytes in culture. The increase in corin mRNA correlated closely with the increase in cell size and ANP mRNA expression in the PE-treated cells (r = 0.95, P < 0.01; r = 0.92, P < 0.01, respectively). The PE-treated cardiomyocytes had an increased activity in converting recombinant human pro-ANP to biologically active ANP, as determined by a pro-ANP processing assay and a cell-based cGMP assay. In a rat model of heart failure induced by ligation of the left coronary artery, corin mRNA expression in the noninfarcted LV myocardium was significantly higher than that of control heart tissues from sham-operated animals, when examined by Northern blot analysis and RT-PCR at 8 wk. These results indicate that the corin gene is upregulated in hypertrophic cardiomyocytes and failing myocardium. Increased corin expression may contribute to elevation of ANP in the setting of cardiac hypertrophy and heart failure.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CORINHumanCardiomegaly  ISOCorin (Rattus norvegicus)mRNA:increased expression:heart (rat)RGD 
CorinRatCardiomegaly  IEP mRNA:increased expression:heart (rat)RGD 
CorinMouseCardiomegaly  ISOCorin (Rattus norvegicus)mRNA:increased expression:heart (rat)RGD 
CORINHumancongestive heart failure  ISOCorin (Rattus norvegicus)mRNA:increased expression:heart (rat)RGD 
CorinRatcongestive heart failure  IEP mRNA:increased expression:heart (rat)RGD 
CorinMousecongestive heart failure  ISOCorin (Rattus norvegicus)mRNA:increased expression:heart (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Corin  (corin, serine peptidase)

Genes (Mus musculus)
Corin  (corin, serine peptidase)

Genes (Homo sapiens)
CORIN  (corin, serine peptidase)


Additional Information