Tagln (transgelin) - Rat Genome Database

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Gene: Tagln (transgelin) Rattus norvegicus
Analyze
Symbol: Tagln
Name: transgelin
RGD ID: 3723
Description: Predicted to enable actin filament binding activity and protein-macromolecule adaptor activity. Predicted to be involved in epithelial cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in cytoskeleton. Orthologous to human TAGLN (transgelin); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: see also D8Mcw1; Sm22; SM22-alpha; smooth muscle 22 protein; smooth muscle protein 22-alpha; Transgelin (Smooth muscle 22 protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHRSP-Tg(Tagln-ACE2)6918Bdr  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,224,939 - 46,230,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,222,472 - 46,230,668 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx851,725,392 - 51,730,788 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0850,004,159 - 50,009,555 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0847,868,429 - 47,873,827 (-)NCBIRnor_WKY
Rnor_6.0850,222,895 - 50,228,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,222,896 - 50,231,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0848,847,354 - 48,853,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,902,208 - 48,907,682 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1848,910,973 - 48,916,459 (-)NCBI
Celera845,807,491 - 45,812,962 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2-butoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
cytochalasin D  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
Didecyldimethylammonium  (ISO)
diethyl maleate  (EXP)
dihydroartemisinin  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxepin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flecainide  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
isobutanol  (ISO)
isoflavones  (EXP)
isotretinoin  (ISO)
jaspamide  (EXP,ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
latrunculin B  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
loratadine  (ISO)
medroxyprogesterone acetate  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perhexiline  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phylloquinone  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quinidine  (ISO)
resorcinol  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vitamin K  (EXP)
vorinostat  (ISO)
warfarin  (EXP,ISO)
XL147  (ISO)
Y-27632  (EXP)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin. Dong K, etal., Circulation. 2021 Dec 7;144(23):1856-1875. doi: 10.1161/CIRCULATIONAHA.121.055949. Epub 2021 Oct 25.
2. SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis. Feil S, etal., Circ Res. 2004 Apr 16;94(7):863-5. Epub 2004 Mar 25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regulation of SM22 alpha expression by arginine vasopressin and PDGF-BB in vascular smooth muscle cells. Kaplan-Albuquerque N, etal., Am J Physiol Heart Circ Physiol 2003 Oct;285(4):H1444-52. Epub 2003 Jun 26.
6. Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy. Koike G, etal., Mamm Genome 1998 Jan;9(1):76-7.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. Nishida W, etal., Biochem Int 1991 Mar;23(4):663-8.
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Cloning and sequencing of cDNAs encoding the actin cross-linking protein transgelin defines a new family of actin-associated proteins. Prinjha RK, etal., Cell Motil Cytoskeleton 1994;28(3):243-55.
11. LncRNA H19 regulates smooth muscle cell functions and participates in the development of aortic dissection through sponging miR-193b-3p. Ren M, etal., Biosci Rep. 2021 Jan 29;41(1):BSR20202298. doi: 10.1042/BSR20202298.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Shanahan CM, etal., Circ Res 1993 Jul;73(1):193-204.
16. Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. Shields JM, etal., J Biol Chem 2002 Mar 22;277(12):9790-9.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Ablation of SM22alpha decreases contractility and actin contents of mouse vascular smooth muscle. Zeidan A, etal., FEBS Lett. 2004 Mar 26;562(1-3):141-6.
19. Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Zhang JC, etal., Mol Cell Biol. 2001 Feb;21(4):1336-44.
Additional References at PubMed
PMID:8359698   PMID:15486317   PMID:15489334   PMID:17519556   PMID:19011151   PMID:19390219   PMID:20139360   PMID:20224039   PMID:20924204   PMID:21158134   PMID:21162287   PMID:21492153  
PMID:22469697   PMID:22798525   PMID:22904629   PMID:23840546   PMID:25108144   PMID:25617350   PMID:25937534   PMID:26291555   PMID:27665774   PMID:28419207   PMID:28525410  


Genomics

Comparative Map Data
Tagln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,224,939 - 46,230,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,222,472 - 46,230,668 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx851,725,392 - 51,730,788 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0850,004,159 - 50,009,555 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0847,868,429 - 47,873,827 (-)NCBIRnor_WKY
Rnor_6.0850,222,895 - 50,228,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,222,896 - 50,231,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0848,847,354 - 48,853,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,902,208 - 48,907,682 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1848,910,973 - 48,916,459 (-)NCBI
Celera845,807,491 - 45,812,962 (-)NCBICelera
Cytogenetic Map8q22NCBI
TAGLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811117,199,294 - 117,207,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11117,199,370 - 117,207,464 (+)EnsemblGRCh38hg38GRCh38
GRCh3711117,070,010 - 117,078,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,575,250 - 116,580,718 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411116,575,249 - 116,580,717NCBI
Celera11114,227,663 - 114,233,128 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11113,002,838 - 113,008,303 (+)NCBIHuRef
CHM1_111116,954,875 - 116,960,340 (+)NCBICHM1_1
T2T-CHM13v2.011117,214,594 - 117,222,762 (+)NCBIT2T-CHM13v2.0
Tagln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,840,926 - 45,847,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,840,917 - 45,847,356 (-)EnsemblGRCm39 Ensembl
GRCm38945,929,628 - 45,936,058 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,929,619 - 45,936,058 (-)EnsemblGRCm38mm10GRCm38
MGSCv37945,737,711 - 45,744,141 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,680,623 - 45,686,893 (-)NCBIMGSCv36mm8
Celera943,212,780 - 43,219,212 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Tagln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,523,469 - 18,529,285 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,523,469 - 18,529,285 (+)NCBIChiLan1.0ChiLan1.0
TAGLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111115,966,516 - 115,972,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,966,516 - 115,972,129 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011112,033,257 - 112,038,749 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TAGLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,390,259 - 16,395,471 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,390,573 - 16,397,207 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,442,731 - 16,447,933 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,334,629 - 16,339,831 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1516,472,895 - 16,478,074 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,375,367 - 16,380,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,417,555 - 16,422,762 (-)NCBIUU_Cfam_GSD_1.0
Tagln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,524,359 - 99,529,792 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,445,659 - 2,451,216 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365422,445,825 - 2,451,216 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAGLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,560,785 - 44,567,385 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,561,756 - 44,567,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,631,082 - 49,636,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAGLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,570,342 - 108,575,789 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,574,007 - 108,575,348 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,478,701 - 17,484,300 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tagln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,647,071 - 12,663,863 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,653,591 - 12,659,373 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tagln
16 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir98rno-miR-98-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir139rno-miR-139-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mirlet7erno-let-7e-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir204rno-miR-204-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir485rno-miR-485-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir34arno-miR-34a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:78
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000024030
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat

Markers in Region
D8Hmgc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,229,322 - 46,229,437 (+)MAPPERmRatBN7.2
Rnor_6.0850,227,279 - 50,227,393NCBIRnor6.0
Rnor_5.0848,851,748 - 48,851,862UniSTSRnor5.0
RGSC_v3.4848,906,592 - 48,906,706UniSTSRGSC3.4
Celera845,811,875 - 45,811,986UniSTS
RH 3.4 Map8468.5UniSTS
RH 3.4 Map8468.5RGD
Cytogenetic Map8q24UniSTS
PMC193673P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,230,517 - 46,230,729 (+)MAPPERmRatBN7.2
Rnor_6.0850,228,474 - 50,228,685NCBIRnor6.0
Rnor_5.0848,852,943 - 48,853,154UniSTSRnor5.0
RGSC_v3.4848,907,787 - 48,907,998UniSTSRGSC3.4
Celera845,813,067 - 45,813,278UniSTS
Cytogenetic Map8q24UniSTS
RH141059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,225,034 - 46,225,249 (+)MAPPERmRatBN7.2
Rnor_6.0850,222,991 - 50,223,205NCBIRnor6.0
Rnor_5.0848,847,460 - 48,847,674UniSTSRnor5.0
RGSC_v3.4848,902,304 - 48,902,518UniSTSRGSC3.4
Celera845,807,587 - 45,807,801UniSTS
RH 3.4 Map8467.7UniSTS
Cytogenetic Map8q24UniSTS
MARC_7597-7598:992008547:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,225,443 - 46,226,299 (+)MAPPERmRatBN7.2
Rnor_6.0850,223,400 - 50,224,255NCBIRnor6.0
Rnor_5.0848,847,869 - 48,848,724UniSTSRnor5.0
RGSC_v3.4848,902,713 - 48,903,568UniSTSRGSC3.4
Celera845,807,996 - 45,808,851UniSTS
Cytogenetic Map8q24UniSTS
PMC150745P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,225,855 - 46,226,403 (+)MAPPERmRatBN7.2
Rnor_6.0850,223,812 - 50,224,359NCBIRnor6.0
Rnor_5.0848,848,281 - 48,848,828UniSTSRnor5.0
RGSC_v3.4848,903,125 - 48,903,672UniSTSRGSC3.4
Celera845,808,408 - 45,808,955UniSTS
Cytogenetic Map8q24UniSTS
Tagln  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,226,351 - 46,226,728 (+)MAPPERmRatBN7.2
Rnor_6.0850,224,308 - 50,224,684NCBIRnor6.0
Rnor_5.0848,848,777 - 48,849,153UniSTSRnor5.0
RGSC_v3.4848,903,621 - 48,903,997UniSTSRGSC3.4
Celera845,808,904 - 45,809,280UniSTS
Cytogenetic Map8q24UniSTS


Related Rat Strains
The following Strains have been annotated to Tagln


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 5
Medium 2 43 43 27 19 27 8 11 61 35 36 11 8
Low 14 14 14 13
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC096909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000024030   ⟹   ENSRNOP00000024030
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl846,222,472 - 46,230,668 (-)Ensembl
Rnor_6.0 Ensembl850,222,896 - 50,228,369 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081737   ⟹   ENSRNOP00000069919
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl846,224,951 - 46,230,549 (-)Ensembl
Rnor_6.0 Ensembl850,223,089 - 50,231,357 (-)Ensembl
RefSeq Acc Id: NM_031549   ⟹   NP_113737
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2846,224,939 - 46,230,413 (-)NCBI
Rnor_6.0850,222,895 - 50,228,369 (-)NCBI
Rnor_5.0848,847,354 - 48,853,081 (-)NCBI
RGSC_v3.4848,902,208 - 48,907,682 (-)RGD
Celera845,807,491 - 45,812,962 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113737   ⟸   NM_031549
- UniProtKB: P31232 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024030   ⟸   ENSRNOT00000024030
RefSeq Acc Id: ENSRNOP00000069919   ⟸   ENSRNOT00000081737
Protein Domains
Calponin-homology (CH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31232-F1-model_v2 AlphaFold P31232 1-201 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695922
Promoter ID:EPDNEW_R6447
Type:multiple initiation site
Name:Tagln_1
Description:transgelin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0850,228,392 - 50,228,452EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3723 AgrOrtholog
BioCyc Gene G2FUF-30662 BioCyc
Ensembl Genes ENSRNOG00000017628 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024030.4 UniProtKB/TrEMBL
  ENSRNOP00000069919 ENTREZGENE
  ENSRNOP00000069919.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024030.7 UniProtKB/TrEMBL
  ENSRNOT00000081737 ENTREZGENE
  ENSRNOT00000081737.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621257 IMAGE-MGC_LOAD
InterPro Calponin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM22_calponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25123 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72401 IMAGE-MGC_LOAD
NCBI Gene 25123 ENTREZGENE
PANTHER CALPONIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSGELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tagln PhenoGen
PRINTS SM22CALPONIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSGELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CALPONIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALPONIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWK7_RAT UniProtKB/TrEMBL
  A0A8L2QCF4_RAT UniProtKB/TrEMBL
  P31232 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tagln  Transgelin (Smooth muscle 22 protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression marker for vascular smooth muscle cells 1299039
gene_expression may contribute to cardiac development as this is identified in cardiac and skeletal muscle cells during embryogenesis 1342445
gene_mapping maps to Bp35 QTL region which has an impact on blood pressure and cardiac mass 1342445
gene_process plays a role in cell transformation and shape change 625588
gene_process may participate in phenotypic modulation of vascular smooth muscle cells in vitro and in vivo 1299039
gene_regulation mRNA expression is suppressed by activated Ras through both the Raf-dependent and the Raf-independent pathways in RIE-1 cells 625588
gene_regulation expression of mRNA and protein is increased by arginine vasopressin and decreased by PDGF 1299039