Dusp4 (dual specificity phosphatase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dusp4 (dual specificity phosphatase 4) Rattus norvegicus
Analyze
Symbol: Dusp4
Name: dual specificity phosphatase 4
RGD ID: 620625
Description: Enables MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human DUSP4 (dual specificity phosphatase 4); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity protein phosphatase 4; MAP kinase phosphatase; MAP kinase phosphatase 2; mitogen-activated protein kinase phosphatase 2; Mkp-2; Mkp2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81664,079,893 - 64,101,396 (-)NCBIGRCr8
mRatBN7.21657,376,659 - 57,398,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1657,377,229 - 57,398,138 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1662,711,691 - 62,721,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01666,125,603 - 66,135,836 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01661,345,654 - 61,355,885 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01661,080,767 - 61,090,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1661,078,175 - 61,091,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01660,749,903 - 60,769,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41661,109,626 - 61,119,981 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11661,109,700 - 61,120,056 (-)NCBI
Celera1655,427,894 - 55,438,053 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
daidzein  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
equol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
febuxostat  (ISO)
fenpyroximate  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GSK-J4  (ISO)
indole-3-methanol  (EXP)
ionomycin  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
metacetamol  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
Rebamipide  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation. Misra-Press A, etal., J Biol Chem 1995 Jun 16;270(24):14587-96.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease. Zhen X, etal., Mol Pharmacol 2002 Dec;62(6):1356-63.
Additional References at PubMed
PMID:7535768   PMID:12865160   PMID:16849326   PMID:24531476   PMID:24973647   PMID:32959171  


Genomics

Comparative Map Data
Dusp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81664,079,893 - 64,101,396 (-)NCBIGRCr8
mRatBN7.21657,376,659 - 57,398,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1657,377,229 - 57,398,138 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1662,711,691 - 62,721,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01666,125,603 - 66,135,836 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01661,345,654 - 61,355,885 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01661,080,767 - 61,090,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1661,078,175 - 61,091,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01660,749,903 - 60,769,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41661,109,626 - 61,119,981 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11661,109,700 - 61,120,056 (-)NCBI
Celera1655,427,894 - 55,438,053 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
DUSP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38829,333,064 - 29,350,684 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl829,333,064 - 29,350,684 (-)EnsemblGRCh38hg38GRCh38
GRCh37829,190,581 - 29,208,201 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36829,249,530 - 29,264,104 (-)NCBINCBI36Build 36hg18NCBI36
Build 34829,249,538 - 29,262,241NCBI
Celera828,153,208 - 28,167,802 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef827,734,943 - 27,752,631 (-)NCBIHuRef
CHM1_1829,392,567 - 29,410,254 (-)NCBICHM1_1
T2T-CHM13v2.0829,611,341 - 29,628,961 (-)NCBIT2T-CHM13v2.0
Dusp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39835,274,448 - 35,289,106 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl835,274,451 - 35,287,048 (+)EnsemblGRCm39 Ensembl
GRCm38834,807,610 - 34,819,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl834,807,297 - 34,819,894 (+)EnsemblGRCm38mm10GRCm38
MGSCv37835,870,664 - 35,882,948 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36836,276,127 - 36,288,411 (+)NCBIMGSCv36mm8
Celera837,423,596 - 37,435,832 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map821.16NCBI
Dusp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554635,778,700 - 5,794,282 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554635,778,945 - 5,794,282 (-)NCBIChiLan1.0ChiLan1.0
DUSP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2747,882,880 - 47,900,548 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1823,598,583 - 23,616,218 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0828,623,777 - 28,641,432 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1825,816,714 - 25,834,307 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl825,819,989 - 25,834,332 (-)Ensemblpanpan1.1panPan2
DUSP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.01636,828,592 - 36,844,313 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1636,828,997 - 36,841,190 (+)EnsemblROS_Cfam_1.0 Ensembl
Dusp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494344,363,746 - 44,376,514 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936573765,927 - 781,567 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936573765,954 - 778,524 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1555,491,087 - 55,508,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11555,491,084 - 55,508,460 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21562,906,062 - 62,923,413 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1827,459,455 - 27,473,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl827,456,430 - 27,473,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605214,654,175 - 14,671,595 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248395,870,274 - 5,887,741 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dusp4
87 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:82
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000016328
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016328   ⟹   ENSRNOP00000016328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1657,377,229 - 57,398,138 (-)Ensembl
Rnor_6.0 Ensembl1661,078,175 - 61,091,169 (-)Ensembl
RefSeq Acc Id: NM_022199   ⟹   NP_071535
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81664,079,893 - 64,093,700 (-)NCBI
mRatBN7.21657,376,659 - 57,390,467 (-)NCBI
Rnor_6.01661,080,767 - 61,090,973 (-)NCBI
Rnor_5.01660,749,903 - 60,769,025 (-)NCBI
RGSC_v3.41661,109,626 - 61,119,981 (-)RGD
Celera1655,427,894 - 55,438,053 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094803   ⟹   XP_038950731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81664,079,895 - 64,101,396 (-)NCBI
mRatBN7.21657,376,659 - 57,398,161 (-)NCBI
RefSeq Acc Id: XM_063275682   ⟹   XP_063131752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81664,079,895 - 64,092,779 (-)NCBI
Protein Sequences
Protein RefSeqs NP_071535 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950731 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131752 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52493 (Get FASTA)   NCBI Sequence Viewer  
  AAK31620 (Get FASTA)   NCBI Sequence Viewer  
  EDM09188 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016328
GenBank Protein Q62767 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071535   ⟸   NM_022199
- UniProtKB: Q62767 (UniProtKB/Swiss-Prot),   G3V7L2 (UniProtKB/TrEMBL),   A6IVN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016328   ⟸   ENSRNOT00000016328
RefSeq Acc Id: XP_038950731   ⟸   XM_039094803
- Peptide Label: isoform X1
- UniProtKB: Q62767 (UniProtKB/Swiss-Prot),   G3V7L2 (UniProtKB/TrEMBL),   A6IVN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131752   ⟸   XM_063275682
- Peptide Label: isoform X2
Protein Domains
Rhodanese   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62767-F1-model_v2 AlphaFold Q62767 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620625 AgrOrtholog
BioCyc Gene G2FUF-11150 BioCyc
Ensembl Genes ENSRNOG00000011921 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016328 ENTREZGENE
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  MKP UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report rno:60587 UniProtKB/Swiss-Prot
NCBI Gene 60587 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 4 UniProtKB/Swiss-Prot
Pfam DSPc UniProtKB/Swiss-Prot
  Rhodanese UniProtKB/Swiss-Prot
PhenoGen Dusp4 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot
PRINTS MAPKPHPHTASE UniProtKB/Swiss-Prot
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011921 RatGTEx
SMART DSPc UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
  RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
  SSF52821 UniProtKB/Swiss-Prot
UniProt A6IVN4 ENTREZGENE, UniProtKB/TrEMBL
  DUS4_RAT UniProtKB/Swiss-Prot
  G3V7L2 ENTREZGENE, UniProtKB/TrEMBL
  Q62767 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-10 Dusp4  dual specificity phosphatase 4  Mkp-2  MAP kinase phosphatase  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Mkp-2  MAP kinase phosphatase      Symbol and Name status set to provisional 70820 PROVISIONAL