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Gene: Srd5a1 (steroid 5 alpha-reductase 1) Rattus norvegicus
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Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
Description: Exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including animal organ development; cellular hormone metabolic process; and cellular response to organic cyclic compound. Localizes to several cellular components, including the cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in prostate cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1); PARTICIPATES IN testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; MGC156498; S5AR 1; SR type 1; steroid 5-alpha-reductase 1; steroid-5-alpha-reductase 1; Steroid-5-alpha-reductase alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Orthologs:
Homo sapiens (human) : SRD5A1 (steroid 5 alpha-reductase 1)  HGNC  Alliance
Mus musculus (house mouse) : Srd5a1 (steroid 5 alpha-reductase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srd5a1 (steroid 5 alpha-reductase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SRD5A1 (steroid 5 alpha-reductase 1)
Canis lupus familiaris (dog) : SRD5A1 (steroid 5 alpha-reductase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srd5a1 (steroid 5 alpha-reductase 1)
Sus scrofa (pig) : SRD5A1 (steroid 5 alpha-reductase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Celera132,290,558 - 32,325,770 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Srd5a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3757
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.