Srd5a1 (steroid 5 alpha-reductase 1) - Rat Genome Database

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Gene: Srd5a1 (steroid 5 alpha-reductase 1) Rattus norvegicus
Analyze
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
RGD ID: 3757
Description: Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including cellular hormone metabolic process; cellular response to organic cyclic compound; and forebrain development. Located in several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in prostate cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1); PARTICIPATES IN testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; MGC156498; S5AR 1; SR type 1; steroid 5-alpha-reductase 1; steroid-5-alpha-reductase 1; Steroid-5-alpha-reductase alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2133,686,069 - 33,720,468 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)Ensembl
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Celera132,290,558 - 32,325,770 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5alpha-Pregnan-20alpha-ol-3-one  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
Bisphenol B  (EXP)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyproconazole  (ISO)
D-aspartic acid  (EXP)
dehydroepiandrosterone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
finasteride  (EXP,ISO)
fluconazole  (EXP)
fluoroethene  (ISO)
flurbiprofen  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
ganoderol B  (EXP)
genistein  (ISO)
hydroxyflutamide  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
isoflavones  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
lycopene  (EXP)
metoclopramide  (EXP)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
orphenadrine  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
piperidine  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP,ISO)
rotenone  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulpiride  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
urethane  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP,ISO)
vitamin E  (EXP)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Aizawa K, etal., Steroids. 2010 Mar;75(3):219-23. Epub 2010 Jan 4.
2. Anbalagan J, etal., Fertil Steril. 2010 May 15;93(8):2491-7. Epub 2010 Mar 19.
3. Andersson S and Russell DW, Proc Natl Acad Sci U S A 1990 May;87(10):3640-4.
4. Andersson S, etal., J Biol Chem 1989 Sep 25;264(27):16249-55.
5. Berman DM, etal., Mol Endocrinol. 1995 Nov;9(11):1561-70.
6. Bhattacharyya AK and Collins DC, J Steroid Biochem Mol Biol. 2001 May;77(2-3):177-82.
7. Colciago A, etal., Brain Res Dev Brain Res. 2005 Mar 31;155(2):107-16.
8. Eicheler W, etal., Exp Clin Endocrinol Diabetes. 1995;103(2):105-12.
9. El-Awady MK, etal., Endocr J. 2004 Feb;51(1):37-46.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GOA data from the GO Consortium
12. Her S, etal., Brain Res Mol Brain Res. 2004 Jul 26;126(2):157-64.
13. Her S, etal., J Mol Neurosci. 2010 Jun;41(2):252-62. Epub 2009 Sep 2.
14. Kayampilly PP, etal., Endocrinology. 2010 Oct;151(10):5030-7. Epub 2010 Sep 1.
15. KEGG
16. Killian J, etal., Biol Reprod. 2003 May;68(5):1711-8. Epub 2002 Dec 11.
17. Kim TS, etal., J Toxicol Environ Health A. 2010 Jan;73(21-22):1544-59.
18. Klotsman M, etal., Pharmacogenomics J. 2004;4(4):251-9.
19. Lauber ME and Lichtensteiger W, Endocrinology. 1996 Jul;137(7):2718-30.
20. Lewis MJ, etal., BMC Cancer. 2004 Jun 22;4:27.
21. Lopez-Solache I, etal., Biochim Biophys Acta 1996 Mar 1;1305(3):139-44.
22. Maayan R, etal., Brain Res. 2004 Sep 10;1020(1-2):167-72.
23. MGD data from the GO Consortium
24. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
25. Morita K, etal., Brain Res Mol Brain Res. 2005 Oct 3;139(2):193-200.
26. Morita K, etal., J Mol Neurosci. 2004;22(3):205-12.
27. Morita K, etal., Life Sci. 2003 Mar 14;72(17):1973-82.
28. NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Noguchi S, etal., Metabolism. 2007 Oct;56(10):1326-33.
30. Pampori NA and Shapiro BH, Endocrinology. 1999 Mar;140(3):1245-54.
31. Patte-Mensah C, etal., J Comp Neurol. 2004 Sep 20;477(3):286-99.
32. Pipeline to import KEGG annotations from KEGG into RGD
33. Poletti A, etal., Mol Cell Endocrinol. 1997 May 16;129(2):181-90.
34. Pratis K, etal., J Endocrinol. 2003 Mar;176(3):393-403.
35. RGD automated data pipeline
36. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. RGD automated import pipeline for gene-chemical interactions
38. Romero Mdel M, etal., Steroids. 2010 Jan;75(1):20-6. Epub 2009 Sep 28.
39. Sanchez P, etal., IUBMB Life. 2008 Jan;60(1):68-72.
40. Sanchez P, etal., Neurochem Res. 2008 May;33(5):820-5. Epub 2007 Oct 17.
41. Shao TC, etal., J Urol. 2007 Oct;178(4 Pt 1):1521-7. Epub 2007 Aug 16.
42. Stimson RH, etal., PLoS One. 2010 Jan 19;5(1):e8779.
43. Stuart JD, etal., Biochem Pharmacol 2001 Oct 1;62(7):933-42.
44. Szecsi M, etal., Acta Biol Hung. 2010 Sep;61(3):274-81.
45. Taylor MF, etal., Steroids. 1995 Jul;60(7):452-6.
46. Taylor MF, etal., Steroids. 1997 Apr;62(4):373-8.
47. Thigpen AE and Russell DW, J Biol Chem. 1992 Apr 25;267(12):8577-83.
48. Thum T and Borlak J, FASEB J. 2002 Oct;16(12):1537-49.
49. Tian H and Russell DW, Dev Dyn. 1997 May;209(1):117-26.
50. Torres JM and Ortega E, J Mol Endocrinol. 2006 Apr;36(2):239-45.
51. Tsuruo Y, etal., Brain Res. 1998 Aug 10;801(1-2):130-6.
52. van der Eerden BC, etal., J Endocrinol. 2004 Mar;180(3):457-67.
53. Wako K, etal., J Clin Pathol. 2008 Apr;61(4):448-54. Epub 2007 Aug 24.
54. Xu Y, etal., Clin Cancer Res. 2006 Jul 1;12(13):4072-9.
55. Yokoi H, etal., Histochem Cell Biol. 1998 Feb;109(2):127-34.
Additional References at PubMed
PMID:12477932   PMID:15249131   PMID:17826869   PMID:17986282   PMID:18354385   PMID:20447326   PMID:22131296   PMID:23122426   PMID:23405234   PMID:25239636   PMID:26021641   PMID:28707553  


Genomics

Comparative Map Data
Srd5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2133,686,069 - 33,720,468 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)Ensembl
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Celera132,290,558 - 32,325,770 (+)NCBICelera
Cytogenetic Map1p11NCBI
SRD5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3856,633,440 - 6,674,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl56,633,427 - 6,674,386 (+)EnsemblGRCh38hg38GRCh38
GRCh3756,633,553 - 6,674,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,686,500 - 6,722,675 (+)NCBINCBI36hg18NCBI36
Build 3456,686,562 - 6,722,673NCBI
Celera56,660,560 - 6,696,748 (+)NCBI
Cytogenetic Map5p15.31NCBI
HuRef56,608,126 - 6,644,172 (+)NCBIHuRef
CHM1_156,633,460 - 6,669,635 (+)NCBICHM1_1
Srd5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,721,568 - 69,759,611 (-)NCBIGRCm39mm39
GRCm39 Ensembl1369,721,568 - 69,759,561 (-)Ensembl
GRCm381369,573,449 - 69,611,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,573,449 - 69,611,442 (-)EnsemblGRCm38mm10GRCm38
MGSCv371369,712,327 - 69,750,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv361370,040,821 - 70,078,835 (-)NCBImm8
Celera1371,919,533 - 71,956,201 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Srd5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555044,360,453 - 4,391,133 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,360,909 - 4,388,964 (+)NCBIChiLan1.0ChiLan1.0
SRD5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.156,629,093 - 6,664,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl56,629,093 - 6,664,264 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v056,953,795 - 6,996,010 (+)NCBIMhudiblu_PPA_v0panPan3
SRD5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,118,814 - 7,144,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,118,814 - 7,144,828 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3411,627,110 - 11,653,073 (-)NCBI
ROS_Cfam_1.0347,026,936 - 7,052,848 (-)NCBI
ROS_Cfam_1.0 Ensembl347,026,936 - 7,052,848 (-)Ensembl
UMICH_Zoey_3.1347,074,036 - 7,099,998 (-)NCBI
UNSW_CanFamBas_1.0347,054,526 - 7,080,522 (-)NCBI
UU_Cfam_GSD_1.0347,269,539 - 7,295,565 (-)NCBI
Srd5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213240,167,012 - 240,207,515 (-)NCBI
SpeTri2.0NW_004936634758,231 - 798,809 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRD5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11675,309,830 - 75,335,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,671,335 - 81,695,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,312,770 - 6,348,449 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl46,312,757 - 6,350,550 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606422,370,694 - 22,406,674 (-)NCBIVero_WHO_p1.0
Srd5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247514,309,518 - 4,335,332 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH140207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,720,058 - 33,720,268 (+)MAPPERmRatBN7.2
Rnor_6.0136,354,290 - 36,354,499NCBIRnor6.0
Rnor_5.0137,751,312 - 37,751,521UniSTSRnor5.0
RGSC_v3.4173,878,761 - 3,878,970UniSTSRGSC3.4
Celera132,325,366 - 32,325,575UniSTS
Cytogenetic Map17p14UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)150910843284926Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:175
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000023659
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 29 29 64 10 8 3
Low 40 20 12 19 12 7 9 10 25 33 8 7
Below cutoff 3 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023659   ⟹   ENSRNOP00000023659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)Ensembl
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)Ensembl
RefSeq Acc Id: NM_017070   ⟹   NP_058766
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2133,686,470 - 33,720,463 (+)NCBI
Rnor_6.0136,320,504 - 36,354,694 (+)NCBI
Rnor_5.0137,717,526 - 37,751,716 (+)NCBI
RGSC_v3.4173,845,190 - 3,879,165 (+)RGD
Celera132,290,558 - 32,325,770 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101160   ⟹   XP_038957088
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2133,686,069 - 33,720,468 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058766   ⟸   NM_017070
- UniProtKB: P24008 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023659   ⟸   ENSRNOT00000023659
RefSeq Acc Id: XP_038957088   ⟸   XM_039101160
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24008-F1-model_v2 AlphaFold P24008 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689576
Promoter ID:EPDNEW_R100
Type:multiple initiation site
Name:Srd5a1_1
Description:steroid 5 alpha-reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0136,320,634 - 36,320,694EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 3854509 3854510 G T snv HCR/1Mco (UMich)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3757 AgrOrtholog
BioCyc Gene G2FUF-61869 BioCyc
BioCyc Pathway PWY-7455 [allopregnanolone biosynthesis] BioCyc
  PWY-8200 [backdoor pathway of androgen biosynthesis] BioCyc
  PWY-8202 [11-oxyandrogens biosynthesis] BioCyc
  PWY66-378 [androgen biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000017601 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000023659 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023659 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313862 IMAGE-MGC_LOAD
InterPro 3-oxo-5-alpha-steroid_4-DH UniProtKB/Swiss-Prot
  3-oxo-5_a-steroid_4-DH_C UniProtKB/Swiss-Prot
  SRD5A/TECR UniProtKB/Swiss-Prot
KEGG Report rno:24950 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156498 IMAGE-MGC_LOAD
NCBI Gene 24950 ENTREZGENE
PANTHER PTHR10556 UniProtKB/Swiss-Prot
Pfam Steroid_dh UniProtKB/Swiss-Prot
PhenoGen Srd5a1 PhenoGen
PIRSF 5_alpha-SR2 UniProtKB/Swiss-Prot
PROSITE S5A_REDUCTASE UniProtKB/Swiss-Prot
UniProt P24008 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JPJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Srd5a1  steroid 5 alpha-reductase 1  Srd5a1  steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Srd5a1  steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)  Srd5a1  steroid 5 alpha-reductase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Srd5a1  steroid 5 alpha-reductase 1      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Srd5a1  steroid 5 alpha-reductase 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression steroid 5- alpha-reductase is present in liver and pancreas 70276
gene_expression steroid 5- alpha-reductase is present in liver and pancreas 70289
gene_function converts testosterone into dihydrotestosterone 70289
gene_regulation expression is increased by pituitary hormones and castration and is decreased by dihydrotestosterone and hypophysectomy 730122
gene_regulation expression is differentially regulated by testosterone in androgen-responsive and androgen non-responsive tissues 730219
gene_transcript alternative mRNA transcripts encode proteins with different affinities for testosterone 730122