Srd5a1 (steroid 5 alpha-reductase 1) - Rat Genome Database

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Gene: Srd5a1 (steroid 5 alpha-reductase 1) Rattus norvegicus
Analyze
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
RGD ID: 3757
Description: Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including cellular response to organic cyclic compound; forebrain development; and reproductive structure development. Located in several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in prostate cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1); PARTICIPATES IN testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; MGC156498; S5AR 1; SR type 1; steroid 5-alpha-reductase 1; steroid-5-alpha-reductase 1; Steroid-5-alpha-reductase alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2133,686,069 - 33,720,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,515,801 - 33,550,297 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0139,514,407 - 39,548,898 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0133,714,648 - 33,748,614 (+)NCBIRnor_WKY
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Celera132,290,558 - 32,325,770 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5alpha-Pregnan-20alpha-ol-3-one  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
Bisphenol B  (EXP)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyproconazole  (ISO)
D-aspartic acid  (EXP)
dehydroepiandrosterone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
fenthion  (ISO)
finasteride  (EXP,ISO)
fluconazole  (EXP)
fluoroethene  (ISO)
flurbiprofen  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
ganoderol B  (EXP)
genistein  (ISO)
hydroxyflutamide  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
isoflavones  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
lycopene  (EXP)
methidathion  (ISO)
metoclopramide  (EXP)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
piperidine  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP,ISO)
rotenone  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulpiride  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
urethane  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP,ISO)
vitamin E  (EXP)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Acute exercise activates local bioactive androgen metabolism in skeletal muscle. Aizawa K, etal., Steroids. 2010 Mar;75(3):219-23. Epub 2010 Jan 4.
2. Mechanism underlying transient gestational-onset hypothyroidism-induced impairment of posttesticular sperm maturation in adult rats. Anbalagan J, etal., Fertil Steril. 2010 May 15;93(8):2491-7. Epub 2010 Mar 19.
3. Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Andersson S and Russell DW, Proc Natl Acad Sci U S A 1990 May;87(10):3640-4.
4. Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation. Andersson S, etal., J Biol Chem 1989 Sep 25;264(27):16249-55.
5. Expression and regulation of steroid 5 alpha-reductase in the urogenital tract of the fetal rat. Berman DM, etal., Mol Endocrinol. 1995 Nov;9(11):1561-70.
6. Site-directed mutagenesis studies of rat steroid 5alpha-reductase (isozyme-1): mutation of residues in the cofactor binding and C-terminal regions. Bhattacharyya AK and Collins DC, J Steroid Biochem Mol Biol. 2001 May;77(2-3):177-82.
7. Dimorphic expression of testosterone metabolizing enzymes in the hypothalamic area of developing rats. Colciago A, etal., Brain Res Dev Brain Res. 2005 Mar 31;155(2):107-16.
8. Distribution of rat hepatic steroid 5 alpha-reductase 1 as shown by immunohistochemistry. Eicheler W, etal., Exp Clin Endocrinol Diabetes. 1995;103(2):105-12.
9. Steroid 5alpha reductase mRNA type 1 is differentially regulated by androgens and glucocorticoids in the rat liver. El-Awady MK, etal., Endocr J. 2004 Feb;51(1):37-46.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Nerve growth factor induces elevation of steroid 5alpha-reductase mRNA levels in rat C6 glioma cells through expression of transcription factor Egr-1. Her S, etal., Brain Res Mol Brain Res. 2004 Jul 26;126(2):157-64.
13. Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. Her S, etal., J Mol Neurosci. 2010 Jun;41(2):252-62. Epub 2009 Sep 2.
14. Stimulatory effect of insulin on 5alpha-reductase type 1 (SRD5A1) expression through an Akt-dependent pathway in ovarian granulosa cells. Kayampilly PP, etal., Endocrinology. 2010 Oct;151(10):5030-7. Epub 2010 Sep 1.
15. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
16. 5alpha-reductase isoenzymes 1 and 2 in the rat testis during postnatal development. Killian J, etal., Biol Reprod. 2003 May;68(5):1711-8. Epub 2002 Dec 11.
17. Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. Kim TS, etal., J Toxicol Environ Health A. 2010 Jan;73(21-22):1544-59.
18. A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH. Klotsman M, etal., Pharmacogenomics J. 2004;4(4):251-9.
19. Ontogeny of 5 alpha-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones. Lauber ME and Lichtensteiger W, Endocrinology. 1996 Jul;137(7):2718-30.
20. Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma. Lewis MJ, etal., BMC Cancer. 2004 Jun 22;4:27.
21. Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone. Lopez-Solache I, etal., Biochim Biophys Acta 1996 Mar 1;1305(3):139-44.
22. Influence of 17beta-estradiol on the synthesis of reduced neurosteroids in the brain (in vivo) and in glioma cells (in vitro): possible relevance to mental disorders in women. Maayan R, etal., Brain Res. 2004 Sep 10;1020(1-2):167-72.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
25. Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1. Morita K, etal., Brain Res Mol Brain Res. 2005 Oct 3;139(2):193-200.
26. Adrenergic activation of steroid 5alpha-reductase gene expression in rat C6 glioma cells: involvement of cyclic amp/protein kinase A-mediated signaling pathway. Morita K, etal., J Mol Neurosci. 2004;22(3):205-12.
27. Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation. Morita K, etal., Life Sci. 2003 Mar 14;72(17):1973-82.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Adrenocortical insufficiency in Otsuka Long-Evans Tokushima Fatty rats, a type 2 diabetes mellitus model. Noguchi S, etal., Metabolism. 2007 Oct;56(10):1326-33.
30. Gender differences in the responsiveness of the sex-dependent isoforms of hepatic P450 to the feminine plasma growth hormone profile. Pampori NA and Shapiro BH, Endocrinology. 1999 Mar;140(3):1245-54.
31. Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord. Patte-Mensah C, etal., J Comp Neurol. 2004 Sep 20;477(3):286-99.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brain. Poletti A, etal., Mol Cell Endocrinol. 1997 May 16;129(2):181-90.
34. Differential regulation of rat testicular 5alpha-reductase type 1 and 2 isoforms by testosterone and FSH. Pratis K, etal., J Endocrinol. 2003 Mar;176(3):393-403.
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Oleoyl-estrone increases adrenal corticosteroid synthesis gene expression in overweight male rats. Romero Mdel M, etal., Steroids. 2010 Jan;75(1):20-6. Epub 2009 Sep 28.
39. Effects of sulpiride on mRNA levels of steroid 5alpha-reductase isozymes in prostate of adult rats. Sanchez P, etal., IUBMB Life. 2008 Jan;60(1):68-72.
40. Effects of sulpiride on prolactin and mRNA levels of steroid 5alpha-reductase isozymes in adult rat brain. Sanchez P, etal., Neurochem Res. 2008 May;33(5):820-5. Epub 2007 Oct 17.
41. Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer. Shao TC, etal., J Urol. 2007 Oct;178(4 Pt 1):1521-7. Epub 2007 Aug 16.
42. Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats. Stimson RH, etal., PLoS One. 2010 Jan 19;5(1):e8779.
43. Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat. Stuart JD, etal., Biochem Pharmacol 2001 Oct 1;62(7):933-42.
44. Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines. Szecsi M, etal., Acta Biol Hung. 2010 Sep;61(3):274-81.
45. Inhibition of rat steroid 5 alpha-reductase (isozyme 1) by suramin. Taylor MF, etal., Steroids. 1995 Jul;60(7):452-6.
46. Expression of rat steroid 5 alpha-reductase (isozyme-1) in Spodoptera frugiperda, SF21, insect cells: expression of rat steroid 5 alpha-reductase. Taylor MF, etal., Steroids. 1997 Apr;62(4):373-8.
47. Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. Thigpen AE and Russell DW, J Biol Chem. 1992 Apr 25;267(12):8577-83.
48. Testosterone, cytochrome P450, and cardiac hypertrophy. Thum T and Borlak J, FASEB J. 2002 Oct;16(12):1537-49.
49. Expression and regulation of steroid 5 alpha-reductase in the genital tubercle of the fetal rat. Tian H and Russell DW, Dev Dyn. 1997 May;209(1):117-26.
50. Steroid 5alpha-reductase isozymes in the adult female rat brain: central role of dihydrotestosterone. Torres JM and Ortega E, J Mol Endocrinol. 2006 Apr;36(2):239-45.
51. Influence of serum-free culture conditions on subcellular localization of steroid 5alpha-reductase in rat C6 glioma cells. Tsuruo Y, etal., Brain Res. 1998 Aug 10;801(1-2):130-6.
52. Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. van der Eerden BC, etal., J Endocrinol. 2004 Mar;180(3):457-67.
53. Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer. Wako K, etal., J Clin Pathol. 2008 Apr;61(4):448-54. Epub 2007 Aug 24.
54. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Xu Y, etal., Clin Cancer Res. 2006 Jul 1;12(13):4072-9.
55. Steroid 5 alpha-reductase type 1 immunolocalized in the adrenal gland of normal, gonadectomized, and sex hormone-supplemented rats. Yokoi H, etal., Histochem Cell Biol. 1998 Feb;109(2):127-34.
Additional References at PubMed
PMID:12477932   PMID:15249131   PMID:17826869   PMID:17986282   PMID:18354385   PMID:20447326   PMID:22131296   PMID:23122426   PMID:23405234   PMID:25239636   PMID:26021641   PMID:28707553  


Genomics

Comparative Map Data
Srd5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2133,686,069 - 33,720,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,515,801 - 33,550,297 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0139,514,407 - 39,548,898 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0133,714,648 - 33,748,614 (+)NCBIRnor_WKY
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Celera132,290,558 - 32,325,770 (+)NCBICelera
Cytogenetic Map1p11NCBI
SRD5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3856,633,440 - 6,674,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl56,633,427 - 6,674,386 (+)EnsemblGRCh38hg38GRCh38
GRCh3756,633,553 - 6,674,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,686,500 - 6,722,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 3456,686,562 - 6,722,673NCBI
Celera56,660,560 - 6,696,748 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef56,608,126 - 6,644,172 (+)NCBIHuRef
CHM1_156,633,460 - 6,669,635 (+)NCBICHM1_1
T2T-CHM13v2.056,564,115 - 6,605,062 (+)NCBIT2T-CHM13v2.0
Srd5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,721,568 - 69,759,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1369,721,568 - 69,759,561 (-)EnsemblGRCm39 Ensembl
GRCm381369,573,449 - 69,611,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,573,449 - 69,611,442 (-)EnsemblGRCm38mm10GRCm38
MGSCv371369,712,327 - 69,750,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361370,040,821 - 70,078,835 (-)NCBIMGSCv36mm8
Celera1371,919,533 - 71,956,201 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Srd5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555044,360,453 - 4,391,133 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,360,909 - 4,388,964 (+)NCBIChiLan1.0ChiLan1.0
SRD5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.156,629,093 - 6,664,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl56,629,093 - 6,664,264 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v056,953,795 - 6,996,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SRD5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,118,814 - 7,144,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,118,814 - 7,144,828 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3411,627,110 - 11,653,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,026,936 - 7,052,848 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,026,936 - 7,052,848 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,074,036 - 7,099,998 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,054,526 - 7,080,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,269,539 - 7,295,565 (-)NCBIUU_Cfam_GSD_1.0
Srd5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213240,167,012 - 240,207,515 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936634758,231 - 798,809 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRD5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1675,310,211 - 75,335,391 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11675,309,830 - 75,335,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,671,335 - 81,695,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,312,770 - 6,348,449 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,312,757 - 6,350,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606422,370,694 - 22,406,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srd5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247514,309,447 - 4,336,083 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247514,309,518 - 4,335,332 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srd5a1
326 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:175
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000023659
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat

Markers in Region
RH140207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,720,058 - 33,720,268 (+)MAPPERmRatBN7.2
Rnor_6.0136,354,290 - 36,354,499NCBIRnor6.0
Rnor_5.0137,751,312 - 37,751,521UniSTSRnor5.0
RGSC_v3.4173,878,761 - 3,878,970UniSTSRGSC3.4
Celera132,325,366 - 32,325,575UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 29 29 64 10 8 3
Low 40 20 12 19 12 7 9 10 25 33 8 7
Below cutoff 3 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023659   ⟹   ENSRNOP00000023659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)Ensembl
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)Ensembl
RefSeq Acc Id: NM_017070   ⟹   NP_058766
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2133,686,470 - 33,720,463 (+)NCBI
Rnor_6.0136,320,504 - 36,354,694 (+)NCBI
Rnor_5.0137,717,526 - 37,751,716 (+)NCBI
RGSC_v3.4173,845,190 - 3,879,165 (+)RGD
Celera132,290,558 - 32,325,770 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101160   ⟹   XP_038957088
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2133,686,069 - 33,720,468 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058766   ⟸   NM_017070
- UniProtKB: P24008 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023659   ⟸   ENSRNOT00000023659
RefSeq Acc Id: XP_038957088   ⟸   XM_039101160
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24008-F1-model_v2 AlphaFold P24008 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689576
Promoter ID:EPDNEW_R100
Type:multiple initiation site
Name:Srd5a1_1
Description:steroid 5 alpha-reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0136,320,634 - 36,320,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3757 AgrOrtholog
BioCyc Gene G2FUF-61869 BioCyc
BioCyc Pathway PWY-7455 [allopregnanolone biosynthesis] BioCyc
  PWY-8200 [backdoor pathway of androgen biosynthesis] BioCyc
  PWY-8202 [11-oxyandrogens biosynthesis] BioCyc
  PWY66-378 [androgen biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000017601 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000023659 ENTREZGENE
  ENSRNOP00000023659.6 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023659 ENTREZGENE
  ENSRNOT00000023659.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.1630 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313862 IMAGE-MGC_LOAD
InterPro 3-oxo-5-alpha-steroid_4-DH UniProtKB/Swiss-Prot
  3-oxo-5_a-steroid_4-DH_C UniProtKB/Swiss-Prot
  SRD5A/TECR UniProtKB/Swiss-Prot
KEGG Report rno:24950 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156498 IMAGE-MGC_LOAD
NCBI Gene 24950 ENTREZGENE
PANTHER 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 UniProtKB/Swiss-Prot
  PTHR10556 UniProtKB/Swiss-Prot
Pfam Steroid_dh UniProtKB/Swiss-Prot
PhenoGen Srd5a1 PhenoGen
PIRSF 5_alpha-SR2 UniProtKB/Swiss-Prot
PROSITE S5A_REDUCTASE UniProtKB/Swiss-Prot
UniProt P24008 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JPJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Srd5a1  steroid 5 alpha-reductase 1  Srd5a1  steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Srd5a1  steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)  Srd5a1  steroid 5 alpha-reductase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Srd5a1  steroid 5 alpha-reductase 1      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Srd5a1  steroid 5 alpha-reductase 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression steroid 5- alpha-reductase is present in liver and pancreas 70276
gene_expression steroid 5- alpha-reductase is present in liver and pancreas 70289
gene_function converts testosterone into dihydrotestosterone 70289
gene_regulation expression is increased by pituitary hormones and castration and is decreased by dihydrotestosterone and hypophysectomy 730122
gene_regulation expression is differentially regulated by testosterone in androgen-responsive and androgen non-responsive tissues 730219
gene_transcript alternative mRNA transcripts encode proteins with different affinities for testosterone 730122