Gene: Melk (maternal embryonic leucine zipper kinase) Rattus norvegicus
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Symbol: Melk
Name: maternal embryonic leucine zipper kinase
Description: Predicted to have calcium ion binding activity, non-membrane spanning protein tyrosine kinase activity, and protein serine/threonine kinase activity; predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress, neural precursor cell proliferation, and positive regulation of apoptotic process; predicted to localize to the cell cortex, nucleus, and plasma membrane; orthologous to human MELK (maternal embryonic leucine zipper kinase); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC362510
Orthologs:
Homo sapiens (human) : MELK (maternal embryonic leucine zipper kinase)  HGNC  Alliance
Mus musculus (house mouse) : Melk (maternal embryonic leucine zipper kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Melk (maternal embryonic leucine zipper kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MELK (maternal embryonic leucine zipper kinase)
Canis lupus familiaris (dog) : MELK (maternal embryonic leucine zipper kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Melk (maternal embryonic leucine zipper kinase)
Sus scrofa (pig) : MELK (maternal embryonic leucine zipper kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0559,783,835 - 59,844,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0564,307,418 - 64,367,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,787,123 - 60,848,620 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1560,787,312 - 60,848,021 (+)NCBI
Celera557,118,072 - 57,178,790 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Melk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308974
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.