Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nqo1 (NAD(P)H quinone dehydrogenase 1) Rattus norvegicus
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Description: Exhibits NAD(P)H dehydrogenase (quinone) activity and superoxide dismutase activity. Involved in several processes, including cellular response to hydrogen peroxide; regulation of apoptotic process; and response to estradiol. Localizes to cytosol; dendrite; and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including acute kidney failure; brain disease (multiple); fatty liver disease (multiple); prostatitis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including asthma; hematologic cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; oxidative stress response pathway; doxorubicin pharmacokinetics pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (-)-selegiline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: azoreductase; Dia4; Diaphorase (NADH/NADPH); DT-diaphorase; DTD; menadione reductase; MGC93075; NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NAD(P)H:menadione oxidoreductase; NAD(P)H:quinone oxidoreductase 1; phylloquinone reductase; QR1; quinone reductase 1
Homo sapiens (human) : NQO1 (NAD(P)H quinone dehydrogenase 1)  HGNC  Alliance
Mus musculus (house mouse) : Nqo1 (NAD(P)H dehydrogenase, quinone 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nqo1 (NAD(P)H quinone dehydrogenase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NQO1 (NAD(P)H quinone dehydrogenase 1)
Canis lupus familiaris (dog) : NQO1 (NAD(P)H quinone dehydrogenase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nqo1 (NAD(P)H quinone dehydrogenase 1)
Sus scrofa (pig) : NQO1 (NAD(P)H quinone dehydrogenase 1)
Chlorocebus sabaeus (African green monkey) : NQO1 (NAD(P)H quinone dehydrogenase 1)
Heterocephalus glaber (naked mole-rat) : Nqo1 (NAD(P)H quinone dehydrogenase 1)
more info ...
Is Marker For: Strains:   WF.DA-(D19Mit1-D19Mit6)/Kop  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01938,422,210 - 38,437,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,291,903 - 49,306,856 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41937,251,147 - 37,266,040 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11937,255,967 - 37,270,906 (-)NCBI
Celera1934,717,059 - 34,731,947 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations