Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to lipid; and response to ozone. Localizes to extracellular space. Used to study chronic obstructive pulmonary disease; dry eye syndrome; gastric ulcer; and stomach disease. Biomarker of asthma; gastric ulcer; otitis media; pulmonary fibrosis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming); INTERACTS WITH (+)-alpha-tocopherol; (E)-roxithromycin; 6alpha-methylprednisolone.
LOC682837; LOW QUALITY PROTEIN: mucin-5AC; mucin 5, subtypes A and C; mucin 5, subtypes A and C, tracheobronchial/gastric; similar to mucin 5, subtype B, tracheobronchial
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA], Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA] more ...
Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA], MMP9 gene mutant form inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA], Phytochemicals inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA]
Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA], Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein]
Capsaicin promotes the reaction [Citric Acid results in increased secretion of MUC5AC protein], capsazepine inhibits the reaction [Citric Acid results in increased secretion of MUC5AC protein]
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA] more ...
fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein], fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]
gefitinib inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA], gefitinib inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA], Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein]
kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA], kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]
verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA], verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA], naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased secretion of MUC5AC protein]
[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5AC mRNA, CCL2 protein affects the reaction [[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5AC mRNA]
Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA], Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC protein]
[Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC5AC mRNA, [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in increased secretion of MUC5AC protein
resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC mRNA], resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC protein]
Tetradecanoylphorbol Acetate results in increased expression of MUC5AC mRNA, Tetradecanoylphorbol Acetate results in increased expression of MUC5AC protein
Reactive Oxygen Species affects the reaction [ELANE protein results in increased expression of MUC5AC mRNA], Reactive Oxygen Species promotes the reaction [ELANE protein results in increased expression of MUC5AC mRNA]
resveratrol inhibits the reaction [OVAL protein results in increased expression of MUC5AC mRNA], resveratrol inhibits the reaction [OVAL protein results in increased expression of MUC5AC protein]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]], Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]
Tobramycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA], Tobramycin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]
RTKI cpd inhibits the reaction [[Smoke results in increased abundance of Particulate Matter] which results in increased expression of MUC5AC mRNA] more ...
zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA], zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA], zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
