Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to lipid; and response to vitamin A. Located in extracellular space. Used to study chronic obstructive pulmonary disease; dry eye syndrome; gastric ulcer; and stomach disease. Biomarker of asthma; gastric ulcer; otitis media; pulmonary fibrosis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming); INTERACTS WITH (E)-roxithromycin; (R,R,R)-alpha-tocopherol; 1,8-cineole.
AABR07006032.1; LOC682837; mucin 5, subtypes A and C; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin-5AC; similar to mucin 5, subtype B, tracheobronchial
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA], Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]
Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA], Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA] more ...
Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA], MMP9 gene mutant form inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]
alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA], alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]
[Chir 99021 co-treated with BMP4 protein co-treated with FGF10 protein co-treated with FGF7 protein co-treated with Tretinoin] results in increased expression of MUC5AC mRNA, Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of MUC5AC mRNA]
[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA, dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA, [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA], Phytochemicals inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA]
[Chir 99021 co-treated with BMP4 protein co-treated with FGF10 protein co-treated with FGF7 protein co-treated with Tretinoin] results in increased expression of MUC5AC mRNA
Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA], Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein]
Capsaicin promotes the reaction [Citric Acid results in increased secretion of MUC5AC protein], capsazepine inhibits the reaction [Citric Acid results in increased secretion of MUC5AC protein]
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA] more ...
fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein], fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]
gefitinib inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA], gefitinib inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA], Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA, [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein
kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA], kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]
verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA], verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA], naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased secretion of MUC5AC protein]
[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5AC mRNA, CCL2 protein affects the reaction [[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5AC mRNA]
Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA], Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA, [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein
[Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC5AC mRNA, [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in increased secretion of MUC5AC protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA, [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein
resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC mRNA], resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC protein]
Tetradecanoylphorbol Acetate results in increased expression of MUC5AC mRNA, Tetradecanoylphorbol Acetate results in increased expression of MUC5AC protein
atractylodin promotes the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]] more ...
Reactive Oxygen Species affects the reaction [ELANE protein results in increased expression of MUC5AC mRNA], Reactive Oxygen Species promotes the reaction [ELANE protein results in increased expression of MUC5AC mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]], Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]
sodium arsenite results in decreased expression of and results in decreased secretion of MUC5AC protein, Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of MUC5AC mRNA]
Tobramycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA], Tobramycin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]
RTKI cpd inhibits the reaction [[Smoke results in increased abundance of Particulate Matter] which results in increased expression of MUC5AC mRNA] more ...
zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA], zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA], zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]
Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: gastric foveolar type is associated with aggressive tumour behaviour.
Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis.
Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery?
Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection.
Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease.
Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas.
