Muc5ac (mucin 5AC, oligomeric mucus/gel-forming) - Rat Genome Database

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Gene: Muc5ac (mucin 5AC, oligomeric mucus/gel-forming) Rattus norvegicus
Symbol: Muc5ac
Name: mucin 5AC, oligomeric mucus/gel-forming
RGD ID: 62001
Description: Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to lipid; and response to vitamin A. Located in extracellular space. Used to study chronic obstructive pulmonary disease; dry eye syndrome; gastric ulcer; and stomach disease. Biomarker of asthma; gastric ulcer; otitis media; pulmonary fibrosis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming); INTERACTS WITH (E)-roxithromycin; (R,R,R)-alpha-tocopherol; 1,8-cineole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07006032.1; LOC682837; mucin 5, subtypes A and C; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin-5AC; similar to mucin 5, subtype B, tracheobronchial
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21196,864,336 - 196,896,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,864,336 - 196,896,475 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01214,725,482 - 214,756,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,727,416 - 214,741,252 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01221,642,507 - 221,671,770 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1194,493,496 - 194,524,940 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-roxithromycin  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-naphthoquinone  (ISO)
1,8-cineole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6alpha-methylprednisolone  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (EXP,ISO)
afatinib  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
alizarin  (ISO)
all-trans-4-hydroxyretinoic acid  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allyl isothiocyanate  (ISO)
aluminium hydroxide  (ISO)
amitrole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astragaloside IV  (EXP)
Atractylodin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
bisphenol A  (ISO)
bleomycin A2  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
ceric oxide  (ISO)
CHIR 99021  (ISO)
chlorphenamine  (ISO)
chromium(6+)  (ISO)
citric acid  (ISO)
coniferyl aldehyde  (ISO)
curcumin  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
erlotinib hydrochloride  (ISO)
ethyl methanesulfonate  (ISO)
euxanthone  (ISO)
Fidarestat  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (ISO)
glycerol  (EXP)
glycyrrhizinic acid  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
icariin  (EXP)
kaempferol  (ISO)
lead diacetate  (ISO)
leukotriene B4  (EXP)
leukotriene C4  (EXP)
leukotriene D4  (EXP)
leukotriene E4  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mevalonic acid  (ISO)
MK 571  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
naringin  (ISO)
nickel atom  (ISO)
Niflumic acid  (ISO)
Nivalenol  (ISO)
nobiletin  (EXP)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
Paeonol  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
platycodin D  (ISO)
platycodin D3  (ISO)
potassium dichromate  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
scopolamine  (EXP,ISO)
selenium atom  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
tebuconazole  (ISO)
tobramycin  (ISO)
triamcinolone acetonide  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tyrphostin AG 1478  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zearalenone  (ISO)
zileuton  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: gastric foveolar type is associated with aggressive tumour behaviour. Aishima S, etal., Histopathology. 2006 Jul;49(1):35-44.
2. Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. Balague C, etal., Gastroenterology. 1994 Apr;106(4):1054-61.
3. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Balague C, etal., Gastroenterology. 1995 Sep;109(3):953-64.
4. Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma. Boonla C, etal., Cancer. 2003 Oct 1;98(7):1438-43.
5. MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma. Boonla C, etal., World J Gastroenterol. 2005 Aug 28;11(32):4939-46.
6. Effect of Myrtol standardized on mucus hypersecretion and clearance of Pseudomonas aeruginosa in a rat model of chronic obstructive pulmonary disease. Cao L, etal., Arzneimittelforschung. 2011;61(12):685-92. doi: 10.1055/s-0031-1300588.
7. Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm. Cao W, etal., Hum Pathol. 2010 Apr;41(4):513-21. Epub 2009 Dec 1.
8. MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. Caramori G, etal., Histopathology. 2009 Sep;55(3):321-31.
9. Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis. Chang HJ, etal., Pathol Int. 2004 Aug;54(8):576-84.
10. Toll-like receptor 4 relates to lipopolysaccharide-induced mucus hypersecretion in rat airway. Chen L, etal., Arch Med Res. 2009 Jan;40(1):10-7.
11. Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats. Cho HY, etal., Toxicol Sci. 1999 Sep;51(1):135-45.
12. In vivo characterization of the molecular-genetic changes in gastric mucosa during the development of acute gastritis and stress ulceration. Choo D, etal., J Trauma. 2002 Apr;52(4):720-5; discussion 725-6.
13. Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. Cortijo J, etal., Br J Pharmacol. 2009 Feb;156(3):534-44.
14. Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. Dogru M, etal., Allergy. 2008 Oct;63(10):1324-34. doi: 10.1111/j.1398-9995.2008.01781.x.
15. Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers. Dogru M, etal., Curr Eye Res. 2005 Oct;30(10):897-908.
16. Mucin deficiency causes functional and structural changes of the ocular surface. Floyd AM, etal., PLoS One. 2012;7(12):e50704. doi: 10.1371/journal.pone.0050704. Epub 2012 Dec 18.
17. Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis. Fortin M, etal., Cytokine. 2010 Aug 7.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Effect of Bifidobacterium bifidum BF-1 on gastric protection and mucin production in an acute gastric injury rat model. Gomi A, etal., J Dairy Sci. 2013 Feb;96(2):832-7. doi: 10.3168/jds.2012-5950. Epub 2012 Nov 29.
20. Regulation of MUC5 and MUC1 gene expression: correlation with airway mucous differentiation. Guzman K, etal., Am J Physiol 1996 May;270(5 Pt 1):L846-53.
21. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Hashimoto K, etal., Am J Respir Crit Care Med. 2004 Aug 1;170(3):306-12. Epub 2004 May 6.
22. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Hasnain SZ, etal., Gastroenterology. 2010 May;138(5):1763-71. doi: 10.1053/j.gastro.2010.01.045. Epub 2010 Feb 4.
23. MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation. Henke MO, etal., Am J Respir Crit Care Med. 2007 Apr 15;175(8):816-21. Epub 2007 Jan 25.
24. Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-kappaB and EGFR pathways. Hewson CA, etal., Eur Respir J. 2010 Dec;36(6):1425-35. Epub 2010 Jun 4.
25. Cloning of rat Muc5AC mucin gene: comparison of its structure and tissue distribution to that of human and mouse homologues. Inatomi T, etal., Biochem Biophys Res Commun 1997 Jul 30;236(3):789-97.
26. Differences in the expression of mucins in various forms of cystitis glandularis. Jankovic Velickovic L, etal., Pathol Res Pract. 2007;203(9):653-8. Epub 2007 Jul 30.
27. MUC5AC expression in human middle ear epithelium of patients with otitis media. Kerschner JE, etal., Arch Otolaryngol Head Neck Surg. 2010 Aug;136(8):819-24. doi: 10.1001/archoto.2010.123.
28. Effects of normal saline and selenium-enriched hot spring water on experimentally induced rhinosinusitis in rats. Kim DH and Yeo SW, Int J Pediatr Otorhinolaryngol. 2013 Jan;77(1):117-22. doi: 10.1016/j.ijporl.2012.10.008. Epub 2012 Nov 3.
29. Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model. Kim DY and Yang WM, J Ethnopharmacol. 2011 Jun 14;136(1):230-5. doi: 10.1016/j.jep.2011.04.048. Epub 2011 Apr 28.
30. Relation of epidermal growth factor receptor expression to mucus hypersecretion in diffuse panbronchiolitis. Kim JH, etal., Chest. 2004 Sep;126(3):888-95.
31. Up-regulation of MUC5AC mRNA expression in endotoxin-induced otitis media. Kim YT, etal., Acta Otolaryngol. 2001 Apr;121(3):364-70.
32. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Lee KT and Liu TS, Dig Dis Sci. 2001 Oct;46(10):2166-72.
33. Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats. Li R, etal., Regul Toxicol Pharmacol. 2007 Aug;48(3):284-91. Epub 2007 May 21.
34. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
35. A mouse dry eye model induced by topical administration of benzalkonium chloride. Lin Z, etal., Mol Vis. 2011 Jan 25;17:257-64.
36. The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. Liu W, etal., Mol Vis. 2010 Nov 9;16:2342-6.
37. Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells. Lu W, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L52-60. Epub 2004 Sep 10.
38. [Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium]. Lü H, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Nov;18(11):649-50.
39. Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats. Mata M, etal., Eur Respir J. 2003 Dec;22(6):900-5.
40. MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Matull WR, etal., Br J Cancer. 2008 May 20;98(10):1675-81. Epub 2008 May 13.
41. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
42. Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone. Nam SY, etal., Dig Dis Sci. 2005 Nov;50(11):2110-20.
43. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Comprehensive gene review and curation RGD comprehensive gene curation
46. Elastase- and LPS-exposed mice display altered responses to rhinovirus infection. Sajjan U, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L931-44. Epub 2009 Sep 11.
47. Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma. Shahzeidi S, etal., Exp Lung Res. 2003 Dec;29(8):549-65.
48. Mucin secretion in the rat tracheal epithelial cells by epidermal growth factor and Pseudomonas aeruginosa extracts. Song JS, etal., Korean J Intern Med. 2001 Sep;16(3):167-72.
49. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Song XJ, etal., Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4223-9.
50. Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery? Souchier M, etal., Br J Ophthalmol. 2006 Nov;90(11):1366-9. Epub 2006 Jun 29.
51. The effect of formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice. Tan YF, etal., Eur Rev Med Pharmacol Sci. 2011 Jul;15(7):743-50.
52. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Tei M, etal., Invest Ophthalmol Vis Sci. 2000 Jan;41(1):82-8.
53. Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene. Tian C, etal., PLoS One. 2012;7(4):e34944. doi: 10.1371/journal.pone.0034944. Epub 2012 Apr 23.
54. Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection. Tsubokawa D, etal., Exp Parasitol. 2012 Mar;130(3):209-17. doi: 10.1016/j.exppara.2012.01.002. Epub 2012 Jan 18.
55. Metaplasia of the duodenum shows a Helicobacter pylori-correlated differentiation into gastric-type protein expression. Van De Bovenkamp JH, etal., Hum Pathol. 2003 Feb;34(2):156-65.
56. Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. Viau S, etal., Graefes Arch Clin Exp Ophthalmol. 2009 Aug;247(8):1039-50. Epub 2009 May 5.
57. Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats. Wagner JG, etal., Toxicol Pathol. 2009 Jun;37(4):481-91. doi: 10.1177/0192623309335630. Epub 2009 Apr 23.
58. Increased expression of human calcium-activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway. Wang K, etal., Cell Biol Int. 2007 Nov;31(11):1388-95. Epub 2007 Jun 29.
59. Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease. Wang K, etal., Chin Med J (Engl). 2007 Jun 20;120(12):1051-7.
60. Mucin 5 subtype AC expression and upregulation in the nasal mucosa of allergic rhinitis rats. Wang W and Zheng M, Otolaryngol Head Neck Surg. 2012 Dec;147(6):1012-9. doi: 10.1177/0194599812460977. Epub 2012 Sep 12.
61. Ocular surface and tear functions after topical cyclosporine treatment in dry eye patients with chronic graft-versus-host disease. Wang Y, etal., Bone Marrow Transplant. 2008 Feb;41(3):293-302. Epub 2007 Nov 5.
62. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. Wang Y, etal., Int J Cancer. 2007 Dec 15;121(12):2716-22.
63. Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. Yamasaki H, etal., Int J Oncol. 2004 Jan;24(1):107-13.
64. Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor. Yonezawa S, etal., Pathol Int. 1999 Jan;49(1):45-54.
65. MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients. Yu DF, etal., Exp Eye Res. 2008 Feb;86(2):403-11. doi: 10.1016/j.exer.2007.11.013. Epub 2007 Nov 28.
66. The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays. Yue T, etal., Mol Cell Proteomics. 2009 Jul;8(7):1697-707. Epub 2009 Apr 17.
67. Analysis of the correlations of mucins, inflammatory markers, and clinical tests in dry eye. Zhang J, etal., Cornea. 2013 Jul;32(7):928-32. doi: 10.1097/ICO.0b013e3182801622.
Additional References at PubMed
PMID:11992401   PMID:14749330   PMID:15632090   PMID:16229173   PMID:17066439   PMID:17203232   PMID:17426222   PMID:19199708   PMID:19558866   PMID:21265101   PMID:22489685   PMID:22931723  
PMID:24975055   PMID:26850552   PMID:31170201   PMID:33300069   PMID:35908134  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21196,864,336 - 196,896,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,864,336 - 196,896,475 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01214,725,482 - 214,756,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,727,416 - 214,741,252 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01221,642,507 - 221,671,770 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1194,493,496 - 194,524,940 (+)NCBICelera
Cytogenetic Map1q41NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38111,157,953 - 1,201,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,157,953 - 1,201,138 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,151,580 - 1,222,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,169,363 - 1,178,940 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,141,594 - 1,152,361NCBI
Celera111,216,270 - 1,325,135 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11979,261 - 1,006,024 (+)NCBIHuRef
CHM1_1111,141,384 - 1,221,279 (+)NCBICHM1_1
T2T-CHM13v2.0111,229,366 - 1,272,380 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397141,342,695 - 141,372,964 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,342,709 - 141,372,968 (+)EnsemblGRCm39 Ensembl
GRCm387141,788,958 - 141,819,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,788,972 - 141,819,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,974,916 - 149,005,040 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367148,974,916 - 149,005,040 (+)NCBIMGSCv36mm8
Celera7141,544,129 - 141,573,772 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.23NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495547611,061,405 - 11,084,294 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1112,783,098 - 2,826,292 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,191,223 - 1,234,373 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,225,362 - 1,272,411 (+)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11845,471,232 - 45,498,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,080,267 - 44,110,233 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,149,914 - 46,180,208 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11845,598,266 - 45,628,540 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,178,618 - 45,208,933 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,916,410 - 45,946,691 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947875,887 - 905,133 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936816129,926 - 159,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.12757,897 - 790,321 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11981,515 - 1,018,242 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603898,106,473 - 98,148,026 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462476621,439,023 - 21,461,108 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Muc5ac
285 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:64
Interacting mature miRNAs:73
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,896,152 - 196,896,418 (+)MAPPERmRatBN7.2
Rnor_6.01214,756,331 - 214,756,596NCBIRnor6.0
Rnor_5.01221,671,448 - 221,671,713UniSTSRnor5.0
Celera1194,524,618 - 194,524,883UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,896,121 - 196,896,302 (+)MAPPERmRatBN7.2
Rnor_6.01214,756,300 - 214,756,480NCBIRnor6.0
Rnor_5.01221,671,417 - 221,671,597UniSTSRnor5.0
Celera1194,524,587 - 194,524,767UniSTS
RH 3.4 Map11437.21UniSTS



RefSeq Acc Id: ENSRNOT00000085159   ⟹   ENSRNOP00000072033
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,864,336 - 196,896,475 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091110   ⟹   ENSRNOP00000074773
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,864,336 - 196,896,475 (+)Ensembl
RefSeq Acc Id: NM_001419868   ⟹   NP_001406797
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21196,864,336 - 196,896,475 (+)NCBI
RefSeq Acc Id: XM_039101269   ⟹   XP_038957197
Rat AssemblyChrPosition (strand)Source
mRatBN7.21196,864,375 - 196,896,475 (+)NCBI
RefSeq Acc Id: XP_038957197   ⟸   XM_039101269
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000072033   ⟸   ENSRNOT00000085159
RefSeq Acc Id: ENSRNOP00000074773   ⟸   ENSRNOT00000091110
RefSeq Acc Id: NP_001406797   ⟸   NM_001419868
- Peptide Label: precursor
- UniProtKB: A0A0G2K1Y4 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8X5-F1-model_v2 AlphaFold A0A0G2K8X5 1-1032 view protein structure
AF-A0A0G2K1Y4-F1-model_v2 AlphaFold A0A0G2K1Y4 1-1103 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62001 AgrOrtholog
BioCyc Gene G2FUF-56933 BioCyc
Ensembl Genes ENSRNOG00000055996 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085159.2 UniProtKB/TrEMBL
  ENSRNOT00000091110.2 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TIL_dom UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
  WxxW_domain UniProtKB/TrEMBL
Pfam Mucin2_WxxW UniProtKB/TrEMBL
  PF08742 UniProtKB/TrEMBL
PhenoGen Muc5ac PhenoGen
RatGTEx ENSRNOG00000055996 RatGTEx
  SM00832 UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/TrEMBL
  SSF57567 UniProtKB/TrEMBL
  O35888_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Muc5ac  mucin 5AC, oligomeric mucus/gel-forming  AABR07006032.1    Data merged from RGD:15009889 737654 PROVISIONAL
2019-11-08 AABR07006032.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-09-19 Muc5ac  mucin 5AC, oligomeric mucus/gel-forming  LOC682837  similar to mucin 5, subtype B, tracheobronchial  Data merged from RGD:1594011 737654 APPROVED
2008-08-29 Muc5ac  mucin 5AC, oligomeric mucus/gel-forming  Muc5ac  mucin 5, subtypes A and C, tracheobronchial/gastric  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC682837  similar to mucin 5, subtype B, tracheobronchial      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Muc5ac  mucin 5, subtypes A and C, tracheobronchial/gastric    mucin 5, subtypes A and C  Name updated 1299863 APPROVED
2002-06-10 Muc5ac  mucin 5, subtypes A and C      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference