(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:735365 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XPO1 mRNA CTD PMID:22079256 1,2-dimethylhydrazine multiple interactions ISO RGD:732925 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of XPO1 mRNA CTD PMID:22206623 17beta-estradiol increases expression ISO RGD:735365 6480464 Estradiol results in increased expression of XPO1 mRNA CTD PMID:16514628 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:732925 6480464 2 more ... CTD PMID:30294300 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732925 6480464 Tetrachlorodibenzodioxin results in increased expression of XPO1 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732925 6480464 Tetrachlorodibenzodioxin affects the expression of XPO1 mRNA CTD PMID:24680724 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of XPO1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of XPO1 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:735365 6480464 beta-methylcholine affects the expression of XPO1 mRNA CTD PMID:21179406 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression ISO RGD:735365 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of XPO1 protein CTD PMID:20421341 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of XPO1 mRNA CTD PMID:21346803 afimoxifene decreases expression ISO RGD:735365 6480464 afimoxifene results in decreased expression of XPO1 mRNA CTD PMID:16514628 aflatoxin B1 increases expression ISO RGD:732925 6480464 Aflatoxin B1 results in increased expression of XPO1 mRNA CTD PMID:19770486 aflatoxin M1 decreases expression ISO RGD:735365 6480464 Aflatoxin M1 results in decreased expression of XPO1 mRNA CTD PMID:30928695 all-trans-retinoic acid decreases expression ISO RGD:735365 6480464 Tretinoin results in decreased expression of XPO1 mRNA CTD PMID:18614847 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of XPO1 mRNA CTD PMID:16483693 benzo[a]pyrene affects methylation ISO RGD:735365 6480464 Benzo(a)pyrene affects the methylation of XPO1 intron CTD PMID:30157460 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:735365 6480464 7 more ... CTD PMID:19150397 more ... bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of XPO1 mRNA CTD PMID:25181051 , PMID:30816183 buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of XPO1 mRNA CTD PMID:24136188 cadmium dichloride multiple interactions ISO RGD:732925 6480464 XPO1 protein affects the reaction [Cadmium Chloride affects the localization of BACH1 protein] CTD PMID:14504288 calcitriol decreases expression ISO RGD:735365 6480464 Calcitriol results in decreased expression of XPO1 mRNA CTD PMID:16847355 , PMID:18614847 chloropicrin increases expression ISO RGD:735365 6480464 chloropicrin results in increased expression of XPO1 mRNA CTD PMID:26352163 ciguatoxin CTX1B affects expression ISO RGD:732925 6480464 Ciguatoxins affects the expression of XPO1 mRNA CTD PMID:18353800 clofibrate increases expression ISO RGD:732925 6480464 Clofibrate results in increased expression of XPO1 mRNA CTD PMID:17585979 copper atom increases expression EXP 6480464 Copper results in increased expression of XPO1 mRNA CTD PMID:22465980 , PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of XPO1 mRNA CTD PMID:22465980 , PMID:30556269 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of XPO1 mRNA CTD PMID:15755911 crocidolite asbestos decreases expression ISO RGD:732925 6480464 Asbestos, Crocidolite results in decreased expression of XPO1 mRNA CTD PMID:29279043 curcumin multiple interactions ISO RGD:732925 6480464 Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein] CTD PMID:21519798 dibutyl phthalate decreases expression ISO RGD:732925 6480464 Dibutyl Phthalate results in decreased expression of XPO1 mRNA CTD PMID:21266533 dicrotophos decreases expression ISO RGD:735365 6480464 dicrotophos results in decreased expression of XPO1 mRNA CTD PMID:28302478 doxorubicin multiple interactions EXP 6480464 Doxorubicin promotes the reaction [MIRLET7F-2 mRNA results in decreased expression of XPO1 mRNA] more ... CTD PMID:31570982 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of XPO1 mRNA, Doxorubicin results in decreased expression of XPO1 protein CTD PMID:31570982 enzyme inhibitor multiple interactions ISO RGD:735365 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of XPO1 protein CTD PMID:23301498 ethanol affects expression ISO RGD:732925 6480464 Ethanol affects the expression of XPO1 mRNA CTD PMID:30319688 finasteride increases expression EXP 6480464 Finasteride results in increased expression of XPO1 mRNA CTD PMID:24136188 fluoxetine decreases expression EXP 6480464 Fluoxetine results in decreased expression of XPO1 mRNA CTD PMID:21852994 fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of XPO1 mRNA CTD PMID:21852994 flutamide increases expression EXP 6480464 Flutamide results in increased expression of XPO1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:732925 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of XPO1 mRNA CTD PMID:22206623 fulvestrant decreases expression ISO RGD:735365 6480464 fulvestrant results in decreased expression of XPO1 mRNA CTD PMID:16514628 furan increases expression EXP 6480464 furan results in increased expression of XPO1 mRNA CTD PMID:25539665 , PMID:26194646 hydrogen peroxide affects expression ISO RGD:735365 6480464 Hydrogen Peroxide affects the expression of XPO1 mRNA CTD PMID:20044591 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of XPO1 mRNA CTD PMID:24136188 leptomycin B multiple interactions ISO RGD:732925 6480464 [leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein CTD PMID:26354774 leptomycin B decreases activity ISO RGD:732925 6480464 leptomycin B results in decreased activity of XPO1 protein CTD PMID:26354774 levofloxacin decreases expression EXP 6480464 Levofloxacin results in decreased expression of XPO1 mRNA CTD PMID:24136188 menadione affects expression ISO RGD:735365 6480464 Vitamin K 3 affects the expression of XPO1 mRNA CTD PMID:20044591 methylparaben increases expression ISO RGD:735365 6480464 methylparaben results in increased expression of XPO1 mRNA CTD PMID:31745603 miconazole decreases expression ISO RGD:732925 6480464 Miconazole results in decreased expression of XPO1 mRNA CTD PMID:27462272 N-methyl-4-phenylpyridinium increases expression ISO RGD:735365 6480464 1-Methyl-4-phenylpyridinium results in increased expression of XPO1 mRNA CTD PMID:24810058 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of XPO1 mRNA CTD PMID:24136188 nickel atom decreases expression ISO RGD:735365 6480464 Nickel results in decreased expression of XPO1 mRNA CTD PMID:23195993 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of XPO1 mRNA CTD PMID:24136188 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of XPO1 mRNA CTD PMID:25729387 paclitaxel decreases expression ISO RGD:735365 6480464 Paclitaxel results in decreased expression of XPO1 mRNA CTD PMID:15000894 paracetamol affects expression ISO RGD:732925 6480464 Acetaminophen affects the expression of XPO1 mRNA CTD PMID:17562736 phenobarbital affects expression ISO RGD:735365 6480464 Phenobarbital affects the expression of XPO1 mRNA CTD PMID:19159669 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of XPO1 mRNA CTD PMID:15215175 potassium chromate decreases expression ISO RGD:735365 6480464 potassium chromate(VI) results in decreased expression of XPO1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:735365 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XPO1 mRNA CTD PMID:22079256 potassium dichromate affects expression ISO RGD:732925 6480464 Potassium Dichromate affects the expression of XPO1 mRNA CTD PMID:23608068 propiconazole increases expression ISO RGD:732925 6480464 propiconazole results in increased expression of XPO1 mRNA CTD PMID:21278054 quercetin decreases expression ISO RGD:735365 6480464 Quercetin results in decreased expression of XPO1 mRNA CTD PMID:21632981 raloxifene decreases expression ISO RGD:735365 6480464 Raloxifene Hydrochloride results in decreased expression of XPO1 mRNA CTD PMID:16514628 resveratrol decreases expression ISO RGD:732925 6480464 resveratrol results in decreased expression of XPO1 protein CTD PMID:25505154 sodium arsenite multiple interactions ISO RGD:732925 6480464 [sodium arsenite binds to ID3 protein] promotes the reaction [XPO1 protein affects the localization of ID3 protein] CTD PMID:23523789 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of XPO1 mRNA CTD PMID:25993096 sulindac multiple interactions EXP 6480464 [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of XPO1 mRNA CTD PMID:20371263 tetrachloromethane increases expression ISO RGD:732925 6480464 Carbon Tetrachloride results in increased expression of XPO1 mRNA CTD PMID:27339419 tetrachloromethane affects expression ISO RGD:732925 6480464 Carbon Tetrachloride affects the expression of XPO1 mRNA CTD PMID:31919559 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of XPO1 mRNA CTD PMID:23411599 titanium dioxide decreases expression ISO RGD:732925 6480464 titanium dioxide results in decreased expression of XPO1 mRNA CTD PMID:29264374 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of XPO1 mRNA CTD PMID:25729387 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of XPO1 gene CTD PMID:27618143 trichostatin A affects expression ISO RGD:735365 6480464 trichostatin A affects the expression of XPO1 mRNA CTD PMID:28542535 trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of XPO1 mRNA CTD PMID:24136188 valproic acid decreases expression ISO RGD:735365 6480464 Valproic Acid results in decreased expression of XPO1 mRNA CTD PMID:23179753 more ... vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of XPO1 mRNA CTD PMID:23034163
Biological Process mRNA transport IEA UniProtKB-KW:KW-0509 1600115 GO_REF:0000043 UniProt GO_REF:0000043 negative regulation of transcription by RNA polymerase II IMP 634529 RGD nucleocytoplasmic transport ISO RGD:735365 1624291 (PMID:11000203) RGD PMID:11000203 protein export from nucleus IDA 634529 RGD protein export from nucleus ISO RGD:732925 1624291 (MGI:2177366 more ... RGD MGI:2177366 more ... protein export from nucleus ISO RGD:735365 1624291 UniProtKB:Q6ICB0 (PMID:12773398), (PMID:22250199), (PMID:22427340), (PMID:29666234) RGD PMID:12773398 more ... protein localization to nucleus ISO RGD:732925 1624291 (MGI:3610707, PMID:16297385) RGD MGI:3610707 , PMID:16297385 regulation of centrosome duplication ISO RGD:732925 1624291 (MGI:3610707, PMID:16297385) RGD MGI:3610707 , PMID:16297385 regulation of proteasomal ubiquitin-dependent protein catabolic process ISO RGD:735365 1624291 (PMID:29666234) RGD PMID:29666234 regulation of protein catabolic process ISO RGD:732925 1624291 (MGI:3575842, PMID:15767664) RGD MGI:3575842 , PMID:15767664 regulation of protein export from nucleus IBA MGI:MGI:2144013 , PANTHER:PTN000131749 13792537 PMID:21873635 GO_Central regulation of protein export from nucleus ISO RGD:732925 1624291 (MGI:3036437, PMID:14981260) RGD MGI:3036437 , PMID:14981260 response to drug IEP 634529 leptomycin B RGD ribosomal large subunit export from nucleus ISO RGD:735365 1624291 (PMID:12773398) RGD PMID:12773398 ribosomal large subunit export from nucleus IBA PANTHER:PTN000131787 more ... 13792537 PMID:21873635 GO_Central ribosomal small subunit export from nucleus ISO RGD:735365 1624291 (PMID:12773398) RGD PMID:12773398 ribosomal small subunit export from nucleus IBA FB:FBgn0020497 more ... 13792537 PMID:21873635 GO_Central ribosomal subunit export from nucleus ISO RGD:735365 1624291 (PMID:12724356) RGD PMID:12724356 ribosome biogenesis ISO RGD:735365 1624291 (PMID:12724356) RGD PMID:12724356 Cellular Component annulate lamellae ISO RGD:735365 1624291 (PMID:12210765) RGD PMID:12210765 Cajal body IEA UniProtKB-SubCell:SL-0031 1600115 GO_REF:0000044 UniProt GO_REF:0000044 cytoplasm ISO RGD:735365 1624291 (PMID:23782956) RGD PMID:23782956 cytoplasm IBA PANTHER:PTN000131749 more ... 13792537 PMID:21873635 GO_Central cytosol IEA UniProtKB:O14980 , ensembl:ENSP000003848631600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:735365 1624291 RGD GO_REF:0000052 intracellular membrane-bounded organelle ISO RGD:735365 1624291 RGD GO_REF:0000052 kinetochore ISO RGD:735365 1624291 (PMID:17363900) RGD PMID:17363900 kinetochore ISS UniProtKB:O14980 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nuclear membrane ISO RGD:735365 1624291 RGD GO_REF:0000052 nuclear membrane IEA UniProtKB:O14980 , ensembl:ENSP000003848631600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleolus ISO RGD:735365 1624291 (PMID:23782956) RGD PMID:23782956 nucleoplasm ISO RGD:735365 1624291 RGD GO_REF:0000052 nucleus IBA FB:FBgn0020497 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:732925 1624291 (MGI:3610707, PMID:16297385) RGD MGI:3610707 , PMID:16297385 protein-containing complex ISO RGD:735365 1624291 (PMID:10557333), (PMID:29666234) RGD PMID:10557333 , PMID:29666234 ribonucleoprotein complex ISO RGD:735365 1624291 (PMID:18809582) RGD PMID:18809582 Molecular Function nuclear export signal receptor activity ISO RGD:735365 1624291 (PMID:12724356), (PMID:12773398), (PMID:29666234) RGD PMID:12724356 more ... nuclear export signal receptor activity ISO RGD:732925 1624291 (MGI:2446408, PMID:12446771) RGD MGI:2446408 , PMID:12446771 nuclear export signal receptor activity IBA PANTHER:PTN000131749 more ... 13792537 PMID:21873635 GO_Central protein binding IPI UniProtKB:Q8VIP2 8554541 PMID:20025850 BHF-UCL protein binding ISO RGD:732925 1624291 PR:E9Q9D5 more ... RGD MGI:3575842 more ... protein binding ISO RGD:735365 1624291 UniProtKB:O00571 more ... RGD PMID:10358091 more ... protein binding IPI UniProtKB:P0DJZ2 634528 PMID:10438867 IntAct protein binding IPI UniProtKB:Q5M834 8553476 PMID:20921223 UniProt protein domain specific binding IPI UniProtKB:P0C205 634529 nuclear export signal RGD RNA binding IEA UniProtKB-KW:KW-0694 1600115 GO_REF:0000043 UniProt GO_REF:0000043 small GTPase binding IEA InterPro:IPR001494 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
