Map1lc3b (microtubule-associated protein 1 light chain 3 beta) - Rat Genome Database

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Gene: Map1lc3b (microtubule-associated protein 1 light chain 3 beta) Rattus norvegicus
Analyze
Symbol: Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
RGD ID: 621315
Description: Enables microtubule binding activity and protein domain specific binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Predicted to act upstream of or within positive regulation of mucus secretion. Located in several cellular components, including autophagosome membrane; dendrite; and neuronal cell body. Part of microtubule associated complex. Orthologous to several human genes including MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2); PARTICIPATES IN autophagy pathway; INTERACTS WITH 1,3-dichloropropan-2-ol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; LC3B; MAP1 light chain 3-like protein 2; MAP1A/1B light chain 3 B; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; Map1lc3; MGC93422; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3B; MPL3; zbs559
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Map1lc3b2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81966,571,631 - 66,582,270 (+)NCBIGRCr8
mRatBN7.21949,665,795 - 49,673,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1949,665,791 - 49,677,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1956,456,727 - 56,464,411 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,140,942 - 57,148,612 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01959,355,262 - 59,362,946 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01953,635,449 - 53,643,970 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,629,779 - 53,646,058 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01964,373,068 - 64,381,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41951,847,187 - 51,854,858 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11951,852,067 - 51,859,738 (+)NCBI
Celera1948,912,797 - 48,920,467 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1-monopalmitoylglycerol  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP,ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxyethyl methacrylate  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP,ISO)
3-Nitrofluoranthene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-TEMPO  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
abamectin  (EXP)
ABT-737  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
aloxistatin  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-amanitin  (EXP,ISO)
Alpinetin  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP,ISO)
amphotericin B  (ISO)
amsacrine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
auramine O  (ISO)
AZD4547  (ISO)
bafilomycin A1  (EXP,ISO)
Bafilomycin B1  (ISO)
BAPTA  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
beta-ionone  (ISO)
beta-lapachone  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
buprofezin  (ISO)
buspirone  (EXP)
butachlor  (ISO)
butanal  (ISO)
butein  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
calix[6]arene  (ISO)
Calpeptin  (ISO)
capivasertib  (ISO)
carbamazepine  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carglumic acid  (ISO)
carteolol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colistin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (ISO)
Curcumol  (EXP)
cyanamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
deguelin  (ISO)
Dehydroeburicoic acid  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (EXP,ISO)
diisononyl phthalate  (ISO)
diosgenin  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
enzalutamide  (ISO)
erastin  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
everolimus  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
ferrostatin-1  (EXP)
finasteride  (EXP)
flavokawain B  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
formaldehyde  (EXP,ISO)
fructose  (EXP)
gamma-hexachlorocyclohexane  (EXP)
Garcinol  (ISO)
gingerol  (ISO)
ginsenoside Rg2  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (EXP)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indoxyl sulfate  (ISO)
inositol  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
JTE-013  (EXP)
juglone  (ISO)
kainic acid  (EXP)
L-ascorbic acid 2-phosphate  (ISO)
L-leucine  (ISO)
L-serine  (EXP)
lactulose  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
melibiose  (ISO)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP,ISO)
metyrapone  (ISO)
miconazole  (ISO)
mitoxantrone  (ISO)
MJN110  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
myriocin  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
Naftopidil  (ISO)
nefazodone  (EXP,ISO)
nelfinavir  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nimesulide  (EXP)
Nivalenol  (ISO)
Nonylphenol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
octreotide  (ISO)
olaparib  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
Ophiopogonin D  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraformaldehyde macromolecule  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
PD 0325901  (ISO)
pectolinarigenin  (ISO)
Pentoxifylline  (EXP)
pepstatin A  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylethanolamine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin B2  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
roxadustat  (EXP)
ruthenium red  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SCH772984  (ISO)
sepantronium  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sphingosine 1-phosphate  (EXP)
spironolactone  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
swainsonine  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thiamine(1+) chloride  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toosendanin  (ISO)
trametinib  (ISO)
tricalcium bis(phosphate)  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trimethyltin  (EXP)
Triptolide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vismodegib  (ISO)
vorinostat  (EXP,ISO)
wortmannin  (ISO)
zearalenone  (EXP,ISO)
zinc atom  (ISO)
zinc oxide  (EXP,ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Network organization of the human autophagy system. Behrends C, etal., Nature. 2010 Jul 1;466(7302):68-76. Epub 2010 Jun 20.
2. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. Kabeya Y, etal., J Cell Sci. 2004 Jun 1;117(Pt 13):2805-12.
5. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. Mann SS and Hammarback JA, J Biol Chem 1994 Apr 15;269(15):11492-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
12. Molecular cloning and characterization of rat LC3A and LC3B--two novel markers of autophagosome. Wu J, etal., Biochem Biophys Res Commun. 2006 Jan 6;339(1):437-42. Epub 2005 Nov 14.
13. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
Additional References at PubMed
PMID:11060023   PMID:14760703   PMID:15095872   PMID:15489334   PMID:16854843   PMID:19279012   PMID:22783020   PMID:22948227   PMID:23629966   PMID:24089209   PMID:24185898   PMID:24351649  
PMID:24747438   PMID:25127057   PMID:25215947   PMID:25244949   PMID:25494214   PMID:26284655   PMID:27187184   PMID:27442348   PMID:28223137   PMID:29554128   PMID:29901175   PMID:31140414  
PMID:33391467  


Genomics

Comparative Map Data
Map1lc3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81966,571,631 - 66,582,270 (+)NCBIGRCr8
mRatBN7.21949,665,795 - 49,673,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1949,665,791 - 49,677,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1956,456,727 - 56,464,411 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,140,942 - 57,148,612 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01959,355,262 - 59,362,946 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01953,635,449 - 53,643,970 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,629,779 - 53,646,058 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01964,373,068 - 64,381,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41951,847,187 - 51,854,858 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11951,852,067 - 51,859,738 (+)NCBI
Celera1948,912,797 - 48,920,467 (+)NCBICelera
Cytogenetic Map19q12NCBI
MAP1LC3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381687,392,336 - 87,404,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1687,383,953 - 87,404,779 (+)EnsemblGRCh38hg38GRCh38
GRCh371687,425,942 - 87,438,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,983,320 - 85,995,881 (+)NCBINCBI36Build 36hg18NCBI36
Build 341685,983,450 - 85,995,880NCBI
Celera1671,722,569 - 71,735,146 (+)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1673,168,889 - 73,180,793 (+)NCBIHuRef
CHM1_11688,837,611 - 88,850,167 (+)NCBICHM1_1
T2T-CHM13v2.01693,463,228 - 93,475,656 (+)NCBIT2T-CHM13v2.0
Map1lc3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,317,177 - 122,325,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8122,317,100 - 122,325,499 (+)EnsemblGRCm39 Ensembl
GRCm388121,590,438 - 121,598,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,590,361 - 121,598,760 (+)EnsemblGRCm38mm10GRCm38
MGSCv378124,114,368 - 124,121,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368124,476,528 - 124,484,107 (+)NCBIMGSCv36mm8
Celera8125,811,811 - 125,819,390 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.67NCBI
Map1lc3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555411,852,388 - 1,868,194 (+)NCBIChiLan1.0ChiLan1.0
MAP1LC3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21897,140,144 - 97,163,688 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116103,065,985 - 103,080,043 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01668,063,869 - 68,076,772 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11687,393,976 - 87,399,736 (+)NCBIpanpan1.1PanPan1.1panPan2
MAP1LC3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1565,669,553 - 65,683,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha565,681,248 - 65,695,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0565,891,103 - 65,905,466 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1565,915,961 - 65,929,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0565,747,849 - 65,761,805 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0566,161,995 - 66,175,961 (-)NCBIUU_Cfam_GSD_1.0
MAP1LC3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,915,387 - 1,941,069 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,919,879 - 1,941,069 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.262,007,809 - 2,029,003 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP1LC3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1572,762,428 - 72,774,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl572,763,050 - 72,772,770 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660472,921,927 - 2,933,888 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map1lc3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,084,392 - 3,094,250 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,084,418 - 3,094,250 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map1lc3b
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:193
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000051352, ENSRNOT00000067141
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

Markers in Region
RH128740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21949,673,499 - 49,673,652 (+)MAPPERmRatBN7.2
Rnor_6.01953,643,815 - 53,643,967NCBIRnor6.0
Rnor_5.01964,381,250 - 64,381,402UniSTSRnor5.0
RGSC_v3.41951,854,708 - 51,854,860UniSTSRGSC3.4
Celera1948,920,317 - 48,920,469UniSTS
RH 3.4 Map19680.7UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000051352   ⟹   ENSRNOP00000049421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1953,629,779 - 53,646,055 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000067141   ⟹   ENSRNOP00000062130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1949,665,984 - 49,677,690 (+)Ensembl
Rnor_6.0 Ensembl1953,635,688 - 53,643,964 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079382   ⟹   ENSRNOP00000072338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1949,665,791 - 49,675,743 (+)Ensembl
Rnor_6.0 Ensembl1953,635,445 - 53,646,058 (+)Ensembl
RefSeq Acc Id: NM_022867   ⟹   NP_074058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,574,595 - 66,582,265 (+)NCBI
mRatBN7.21949,665,979 - 49,673,650 (+)NCBI
Rnor_6.01953,635,633 - 53,643,965 (+)NCBI
Rnor_5.01964,373,068 - 64,381,400 (+)NCBI
RGSC_v3.41951,847,187 - 51,854,858 (+)RGD
Celera1948,912,797 - 48,920,467 (+)RGD
Sequence:
RefSeq Acc Id: XM_017601351   ⟹   XP_017456840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,571,631 - 66,582,270 (+)NCBI
mRatBN7.21949,665,795 - 49,673,655 (+)NCBI
Rnor_6.01953,635,449 - 53,643,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063278272   ⟹   XP_063134342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81966,574,599 - 66,582,270 (+)NCBI
RefSeq Acc Id: NP_074058   ⟸   NM_022867
- UniProtKB: A6IZP8 (UniProtKB/TrEMBL),   A0A0G2K9Q7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456840   ⟸   XM_017601351
- Peptide Label: isoform X2
- UniProtKB: Q6XVN7 (UniProtKB/Swiss-Prot),   Q62625 (UniProtKB/Swiss-Prot),   A6IZP7 (UniProtKB/TrEMBL),   A0A0G2K9Q7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072338   ⟸   ENSRNOT00000079382
RefSeq Acc Id: ENSRNOP00000062130   ⟸   ENSRNOT00000067141
RefSeq Acc Id: ENSRNOP00000049421   ⟸   ENSRNOT00000051352
RefSeq Acc Id: XP_063134342   ⟸   XM_063278272
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62625-F1-model_v2 AlphaFold Q62625 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701192
Promoter ID:EPDNEW_R11715
Type:initiation region
Name:Map1lc3b_1
Description:microtubule-associated protein 1 light chain 3 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01953,635,650 - 53,635,710EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621315 AgrOrtholog
BioCyc Gene G2FUF-5427 BioCyc
Ensembl Genes ENSRNOG00000017905 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000038106 UniProtKB/TrEMBL
  ENSRNOG00055020808 UniProtKB/Swiss-Prot
  ENSRNOG00065001119 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019033.6 UniProtKB/TrEMBL
  ENSRNOT00000067141.3 UniProtKB/TrEMBL
  ENSRNOT00000079382.2 UniProtKB/TrEMBL
  ENSRNOT00055035566 UniProtKB/Swiss-Prot
  ENSRNOT00065001486 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889616 IMAGE-MGC_LOAD
  IMAGE:7189855 IMAGE-MGC_LOAD
InterPro Atg8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64862 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72811 IMAGE-MGC_LOAD
  MGC:93422 IMAGE-MGC_LOAD
NCBI Gene 64862 ENTREZGENE
PANTHER MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3 BETA 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10969 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Atg8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map1lc3b PhenoGen
RatGTEx ENSRNOG00000017905 RatGTEx
  ENSRNOG00000038106 RatGTEx
  ENSRNOG00055020808 RatGTEx
  ENSRNOG00065001119 RatGTEx
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9Q7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UNA3_RAT UniProtKB/TrEMBL
  A6IZP7 ENTREZGENE, UniProtKB/TrEMBL
  A6IZP8 ENTREZGENE, UniProtKB/TrEMBL
  MLP3B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6XVN7 ENTREZGENE
  Q7TQ75_RAT UniProtKB/TrEMBL
UniProt Secondary Q6XVN7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Map1lc3b  microtubule-associated protein 1 light chain 3 beta    microtubule-associated proteins 1A/1B light chain 3  Name updated 1299863 APPROVED
2004-09-10 Map1lc3b  microtubule-associated proteins 1A/1B light chain 3  MPL3    Symbol and Name updated 1299863 APPROVED
2002-08-07 MPL3  microtubule-associated proteins 1A/1B light chain 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in neurons 633201
gene_protein 16.4 kDa 633201