GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | multiple interactions | EXP | | 6480464 | CTD | Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein] | PMID:15288473 | Akt1 | decreases expression | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Emodin results in decreased expression of AKT1 mRNA | PMID:16045814 | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Emodin results in decreased phosphorylation of AKT1 protein | PMID:27032576 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein] | PMID:17077332 PMID:23848338 PMID:27032576 | |
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