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Gene: Txnrd1 (thioredoxin reductase 1) Rattus norvegicus
Symbol: Txnrd1
Name: thioredoxin reductase 1
RGD ID: 61959
Description: Exhibits several functions, including mercury ion binding activity; oxidoreductase activity, acting on NAD(P)H; and selenate reductase activity. Involved in several processes, including NADPH oxidation; cellular response to copper ion; and cellular response to hyperoxia. Localizes to cytosol and neuronal cell body. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human TXNRD1 (thioredoxin reductase 1); PARTICIPATES IN pyrimidine metabolic pathway; selenoamino acid metabolic pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC93353; NADPH-dependent thioredoxin reductase; selenoprotein oxidoreductase; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase TR1; Tr
Homo sapiens (human) : TXNRD1 (thioredoxin reductase 1)  HGNC  Alliance
Mus musculus (house mouse) : Txnrd1 (thioredoxin reductase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Txnrd1 (thioredoxin reductase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100977237 (thioredoxin reductase 1, cytoplasmic)
Canis lupus familiaris (dog) : TXNRD1 (thioredoxin reductase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Txnrd1 (thioredoxin reductase 1)
Sus scrofa (pig) : TXNRD1 (thioredoxin reductase 1)
Chlorocebus sabaeus (African green monkey) : TXNRD1 (thioredoxin reductase 1)
Heterocephalus glaber (naked mole-rat) : Txnrd1 (thioredoxin reductase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0726,946,124 - 26,984,400 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,946,125 - 26,984,400 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,065,819 - 27,104,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,055,544 - 23,093,815 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1723,075,818 - 23,112,858 (-)NCBI
Celera718,009,974 - 18,048,177 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Txnrd1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61959
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.