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Gene: Txnrd1 (thioredoxin reductase 1) Rattus norvegicus
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Symbol: Txnrd1
Name: thioredoxin reductase 1
Description: Exhibits several functions, including mercury ion binding activity; oxidoreductase activity, acting on NAD(P)H; and selenate reductase activity. Involved in several processes, including NADPH oxidation; cellular response to hyperoxia; and hydrogen peroxide catabolic process. Localizes to the cytosol and neuronal cell body. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human TXNRD1 (thioredoxin reductase 1); PARTICIPATES IN pyrimidine metabolic pathway; selenoamino acid metabolic pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC93353; NADPH-dependent thioredoxin reductase; selenoprotein oxidoreductase; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase TR1; Tr
Orthologs:
Homo sapiens (human) : TXNRD1 (thioredoxin reductase 1)  HGNC  Alliance
Mus musculus (house mouse) : Txnrd1 (thioredoxin reductase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Txnrd1 (thioredoxin reductase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TXNRD1 (thioredoxin reductase 1)
Canis lupus familiaris (dog) : TXNRD1 (thioredoxin reductase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Txnrd1 (thioredoxin reductase 1)
Sus scrofa (pig) : TXNRD1 (thioredoxin reductase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0726,946,124 - 26,984,400 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,946,125 - 26,984,400 (-)Ensembl
Rnor_5.0727,065,819 - 27,104,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,055,544 - 23,093,815 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1723,075,818 - 23,112,858 (-)NCBI
Celera718,009,974 - 18,048,177 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Txnrd1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61959
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.