Il13ra2 (interleukin 13 receptor subunit alpha 2) - Rat Genome Database

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Gene: Il13ra2 (interleukin 13 receptor subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Il13ra2
Name: interleukin 13 receptor subunit alpha 2
RGD ID: 620838
Description: Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in cellular response to mechanical stimulus. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Used to study steatotic liver disease. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human IL13RA2 (interleukin 13 receptor subunit alpha 2); PARTICIPATES IN interleukin-4 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-13 receptor alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA-2; IL-13RA2; interleukin 13 receptor, alpha 2; interleukin-13 receptor alpha-2; interleukin-13 receptor subunit alpha-2; LOC100361488; rCG23169-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X115,814,620 - 115,886,080 (-)NCBIGRCr8
mRatBN7.2X111,002,590 - 111,074,053 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX111,002,592 - 111,072,381 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX113,111,924 - 113,176,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X116,610,790 - 116,674,931 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X114,150,841 - 114,214,825 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X118,443,955 - 118,514,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX118,443,823 - 118,513,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X118,588,748 - 118,658,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X30,505,850 - 30,533,002 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X30,559,318 - 30,586,471 (-)NCBI
CeleraX110,307,396 - 110,375,950 (-)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
glyphosate  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paraquat  (EXP)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
progesterone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
succimer  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. Aspord C, etal., J Exp Med. 2007 May 14;204(5):1037-47. Epub 2007 Apr 16.
2. Upregulation of interleukin-13 receptor chains in bronchial smooth muscle tissues of mouse experimental asthma. Chiba Y, etal., J Smooth Muscle Res. 2010;46(1):49-55.
3. IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma. Deepak P, etal., Int Immunol. 2010 Jan;22(1):53-63. doi: 10.1093/intimm/dxp114. Epub 2009 Nov 30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension. Hecker M, etal., Am J Respir Crit Care Med. 2010 Sep 15;182(6):805-18. Epub 2010 Jun 3.
7. Interleukin 13 receptors as biochemical markers in atopic patients. Hussein YM, etal., J Investig Allergol Clin Immunol. 2011;21(2):101-7.
8. Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Jakubzick C, etal., Am J Pathol. 2004 Jun;164(6):1989-2001.
9. In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice. Kawakami K, etal., J Exp Med. 2001 Dec 17;194(12):1743-54.
10. IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. Keane MP, etal., J Immunol. 2007 Jan 1;178(1):511-9.
11. IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma. Kioi M, etal., Int J Cancer. 2009 Mar 15;124(6):1440-8. doi: 10.1002/ijc.24067.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. IL-13 is essential to the late-phase response in allergic rhinitis. Miyahara S, etal., J Allergy Clin Immunol. 2006 Nov;118(5):1110-6. Epub 2006 Aug 7.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Mechanical stretch and angiotensin II increase interleukin-13 production and interleukin-13 receptor alpha2 expression in rat neonatal cardiomyocytes. Nishimura Y, etal., Circ J. 2008 Apr;72(4):647-53.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. Shimamura T, etal., J Immunol. 2008 Oct 1;181(7):4656-65.
22. IL-13Ralpha2 has a protective role in a mouse model of cutaneous inflammation. Sivaprasad U, etal., J Immunol. 2010 Dec 1;185(11):6802-8. doi: 10.4049/jimmunol.1002118. Epub 2010 Oct 22.
23. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. Wilson MS, etal., J Clin Invest. 2007 Oct;117(10):2941-51.
24. Molecular cloning of the rat IL-13 alpha 2 receptor cDNA and its expression in rat tissues. Wu AH and Low WC, J Neurooncol 2002 Sep;59(2):99-105.
Additional References at PubMed
PMID:15632090   PMID:15944273   PMID:17429054   PMID:34168643  


Genomics

Comparative Map Data
Il13ra2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X115,814,620 - 115,886,080 (-)NCBIGRCr8
mRatBN7.2X111,002,590 - 111,074,053 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX111,002,592 - 111,072,381 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX113,111,924 - 113,176,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X116,610,790 - 116,674,931 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X114,150,841 - 114,214,825 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X118,443,955 - 118,514,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX118,443,823 - 118,513,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X118,588,748 - 118,658,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X30,505,850 - 30,533,002 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X30,559,318 - 30,586,471 (-)NCBI
CeleraX110,307,396 - 110,375,950 (-)NCBICelera
Cytogenetic MapXq34NCBI
IL13RA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X115,003,982 - 115,017,616 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX115,003,975 - 115,019,977 (-)EnsemblGRCh38hg38GRCh38
GRCh37X114,238,545 - 114,252,179 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X114,144,794 - 114,158,463 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X114,061,519 - 114,075,187NCBI
CeleraX114,673,713 - 114,687,382 (-)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX103,824,475 - 103,837,544 (-)NCBIHuRef
CHM1_1X114,149,412 - 114,163,077 (-)NCBICHM1_1
T2T-CHM13v2.0X113,412,686 - 113,451,239 (-)NCBIT2T-CHM13v2.0
Il13ra2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X146,166,474 - 146,214,982 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX146,166,472 - 146,212,188 (-)EnsemblGRCm39 Ensembl
GRCm38X147,383,478 - 147,429,192 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX147,383,476 - 147,429,192 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X143,818,021 - 143,838,375 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X142,629,846 - 142,650,204 (-)NCBIMGSCv36mm8
CeleraX131,321,061 - 131,341,527 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX68.46NCBI
Il13ra2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955490709,446 - 758,272 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955490708,144 - 758,195 (+)NCBIChiLan1.0ChiLan1.0
IL13RA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X114,446,011 - 114,499,710 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X114,449,620 - 114,464,266 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X104,092,993 - 104,146,062 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X114,597,088 - 114,635,253 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX114,597,077 - 114,635,253 (-)Ensemblpanpan1.1panPan2
IL13RA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X87,747,373 - 87,776,797 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX87,747,373 - 87,776,798 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX73,868,563 - 73,897,928 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X89,462,267 - 89,540,412 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX89,462,346 - 89,522,049 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X86,906,747 - 86,936,111 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X88,581,088 - 88,610,454 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X88,414,159 - 88,443,524 (-)NCBIUU_Cfam_GSD_1.0
Il13ra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X86,774,105 - 86,816,943 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936499863,599 - 883,855 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936499860,179 - 883,884 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL13RA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX94,402,676 - 94,439,060 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X94,402,665 - 94,455,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X108,965,152 - 109,018,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL13RA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X102,589,947 - 102,628,853 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX102,590,045 - 102,603,260 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606527,932,342 - 27,946,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il13ra2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624940819,854 - 842,284 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624940825,368 - 842,268 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il13ra2
248 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:107
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000043338
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat

Markers in Region
D11Bhm88  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X111,074,368 - 111,074,463 (+)MAPPERmRatBN7.2
Rnor_6.0X118,515,032 - 118,515,126NCBIRnor6.0
Rnor_5.0X118,659,043 - 118,659,137UniSTSRnor5.0
RGSC_v3.4X30,478,134 - 30,478,228UniSTSRGSC3.4
RGSC_v3.4X30,830,187 - 30,830,281UniSTSRGSC3.4
CeleraX110,376,266 - 110,376,360UniSTS
Cytogenetic MapXq14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 17
Low 2 20 38 28 19 28 1 1 10 4 14 9 1
Below cutoff 1 20 19 13 13 7 8 52 11 7 2 7

Sequence


RefSeq Acc Id: ENSRNOT00000043338   ⟹   ENSRNOP00000041564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX111,002,592 - 111,072,381 (-)Ensembl
Rnor_6.0 EnsemblX118,444,474 - 118,513,061 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084465   ⟹   ENSRNOP00000069280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX118,443,823 - 118,459,355 (-)Ensembl
RefSeq Acc Id: NM_133538   ⟹   NP_598222
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X115,814,624 - 115,886,080 (-)NCBI
mRatBN7.2X111,002,594 - 111,074,053 (-)NCBI
Rnor_6.0X118,444,476 - 118,514,716 (-)NCBI
Rnor_5.0X118,588,748 - 118,658,727 (-)NCBI
RGSC_v3.4X30,505,850 - 30,533,002 (-)RGD
CeleraX110,307,396 - 110,375,950 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257427   ⟹   XP_006257489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X115,814,620 - 115,861,126 (-)NCBI
mRatBN7.2X111,002,590 - 111,049,099 (-)NCBI
Rnor_6.0X118,443,955 - 118,490,738 (-)NCBI
Rnor_5.0X118,588,748 - 118,658,727 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099436   ⟹   XP_038955364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X115,814,620 - 115,881,519 (-)NCBI
mRatBN7.2X111,002,590 - 111,069,653 (-)NCBI
RefSeq Acc Id: XM_063279768   ⟹   XP_063135838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X115,814,620 - 115,837,161 (-)NCBI
RefSeq Acc Id: NP_598222   ⟸   NM_133538
- Peptide Label: precursor
- UniProtKB: Q8VHK6 (UniProtKB/Swiss-Prot),   G3V9B6 (UniProtKB/TrEMBL),   A6KGB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257489   ⟸   XM_006257427
- Peptide Label: isoform X1
- UniProtKB: Q8VHK6 (UniProtKB/Swiss-Prot),   G3V9B6 (UniProtKB/TrEMBL),   A6KGB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041564   ⟸   ENSRNOT00000043338
RefSeq Acc Id: ENSRNOP00000069280   ⟸   ENSRNOT00000084465
RefSeq Acc Id: XP_038955364   ⟸   XM_039099436
- Peptide Label: isoform X1
- UniProtKB: Q8VHK6 (UniProtKB/Swiss-Prot),   G3V9B6 (UniProtKB/TrEMBL),   A6KGB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135838   ⟸   XM_063279768
- Peptide Label: isoform X1
- UniProtKB: Q8VHK6 (UniProtKB/Swiss-Prot),   A6KGB0 (UniProtKB/TrEMBL),   G3V9B6 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHK6-F1-model_v2 AlphaFold Q8VHK6 1-385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620838 AgrOrtholog
BioCyc Gene G2FUF-1442 BioCyc
Ensembl Genes ENSRNOG00000032973 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065009803 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000043338 ENTREZGENE
  ENSRNOT00000043338.6 UniProtKB/TrEMBL
  ENSRNOT00065015767 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Short_hematopoietin_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TypeI_recpt_CBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171060 UniProtKB/TrEMBL
NCBI Gene 171060 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERYTHROPOIETIN RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL6Ra-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il13ra2 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_S_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032973 RatGTEx
  ENSRNOG00065009803 RatGTEx
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KGB0 ENTREZGENE, UniProtKB/TrEMBL
  G3V9B6 ENTREZGENE, UniProtKB/TrEMBL
  I13R2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il13ra2  interleukin 13 receptor subunit alpha 2  Il13ra2  interleukin 13 receptor, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Il13ra2  interleukin 13 receptor, alpha 2  LOC100361488  rCG23169-like  Data merged from RGD:2320077 737654 PROVISIONAL
2010-05-05 LOC100361488  rCG23169-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Il13ra2  interleukin 13 receptor, alpha 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il13ra2  interleukin 13 receptor, alpha 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains has a short cytoplasmic domain and an extracellular domain 633080
gene_expression expressed in the brain, spleen, liver, thymus, stomach, and testis 633080
gene_homology 91.2% and 54.2% homologous to mouse and human gene 633080