Il13ra2 (interleukin 13 receptor subunit alpha 2)

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Gene: Il13ra2 (interleukin 13 receptor subunit alpha 2) Rattus norvegicus

Analyze

Symbol:

Il13ra2

Name:

interleukin 13 receptor subunit alpha 2

RGD ID:

620838

Description:

Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in cellular response to mechanical stimulus. Predicted to be located in extracellular space. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human IL13RA2 (interleukin 13 receptor subunit alpha 2); PARTICIPATES IN interleukin-4 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

IL-13 receptor alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA-2; IL-13RA2; interleukin 13 receptor, alpha 2; interleukin-13 receptor alpha-2; interleukin-13 receptor subunit alpha-2; LOC100361488; rCG23169-like

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	111,002,590 - 111,074,053 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	111,002,592 - 111,072,381 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	113,111,924 - 113,176,074 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	116,610,790 - 116,674,931 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	114,150,841 - 114,214,825 (-)	NCBI	Rnor_WKY
Rnor_6.0	X	118,443,955 - 118,514,716 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	118,443,823 - 118,513,061 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	118,588,748 - 118,658,727 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	30,505,850 - 30,533,002 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	30,559,318 - 30,586,471 (-)	NCBI
Celera	X	110,307,396 - 110,375,950 (-)	NCBI		Celera
Cytogenetic Map	X	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic rhinitis (ISO)

asthma (ISO)

atopic dermatitis (ISO)

autistic disorder (ISO)

Brain Injuries (ISO)

breast cancer (ISO)

bronchiolitis obliterans (ISO)

dilated cardiomyopathy (ISO)

fatty liver disease (IMP)

genetic disease (ISO)

oral squamous cell carcinoma (ISO)

osteoporosis (ISO)

pancreatic cancer (ISO)

pneumonia (ISO)

pulmonary hypertension (ISO)

rhinitis (ISO)

schizophrenia (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

T-cell non-Hodgkin lymphoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

cobalt dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibenzo[a,l]pyrene (ISO)

dibutyl phthalate (EXP)

dimethylarsinic acid (ISO)

dioxygen (ISO)

endosulfan (ISO)

epoxiconazole (ISO)

fluoranthene (ISO)

folic acid (EXP,ISO)

furan (EXP)

genistein (ISO)

glyphosate (ISO)

imiquimod (ISO)

indometacin (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lead(II) chloride (ISO)

lipopolysaccharide (ISO)

malathion (ISO)

methotrexate (ISO)

methylarsonic acid (ISO)

mifepristone (ISO)

mitoxantrone (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (ISO)

paraquat (EXP)

pemetrexed (ISO)

perfluorooctane-1-sulfonic acid (ISO)

progesterone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 203580 (ISO)

Senkirkine (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

succimer (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

vincaleukoblastine (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to mechanical stimulus (IEP)

cytokine-mediated signaling pathway (IBA,IEA)

immunoglobulin mediated immune response (IEA,ISO)

negative regulation of immunoglobulin production (IEA,ISO)

negative regulation of mast cell degranulation (IEA,ISO)

Cellular Component

external side of plasma membrane (IBA,ISO)

extracellular space (ISO)

membrane (IEA)

receptor complex (IBA)

Molecular Function

cytokine binding (IBA)

cytokine receptor activity (IBA,IEA,TAS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-4 signaling pathway (ISO)

Jak-Stat signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development.	Aspord C, etal., J Exp Med. 2007 May 14;204(5):1037-47. Epub 2007 Apr 16.
2.	Upregulation of interleukin-13 receptor chains in bronchial smooth muscle tissues of mouse experimental asthma.	Chiba Y, etal., J Smooth Muscle Res. 2010;46(1):49-55.
3.	IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma.	Deepak P, etal., Int Immunol. 2010 Jan;22(1):53-63. doi: 10.1093/intimm/dxp114. Epub 2009 Nov 30.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension.	Hecker M, etal., Am J Respir Crit Care Med. 2010 Sep 15;182(6):805-18. Epub 2010 Jun 3.
7.	Interleukin 13 receptors as biochemical markers in atopic patients.	Hussein YM, etal., J Investig Allergol Clin Immunol. 2011;21(2):101-7.
8.	Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia.	Jakubzick C, etal., Am J Pathol. 2004 Jun;164(6):1989-2001.
9.	In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice.	Kawakami K, etal., J Exp Med. 2001 Dec 17;194(12):1743-54.
10.	IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome.	Keane MP, etal., J Immunol. 2007 Jan 1;178(1):511-9.
11.	IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma.	Kioi M, etal., Int J Cancer. 2009 Mar 15;124(6):1440-8. doi: 10.1002/ijc.24067.
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	IL-13 is essential to the late-phase response in allergic rhinitis.	Miyahara S, etal., J Allergy Clin Immunol. 2006 Nov;118(5):1110-6. Epub 2006 Aug 7.
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	Mechanical stretch and angiotensin II increase interleukin-13 production and interleukin-13 receptor alpha2 expression in rat neonatal cardiomyocytes.	Nishimura Y, etal., Circ J. 2008 Apr;72(4):647-53.
16.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
17.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18.	GOA pipeline	RGD automated data pipeline
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model.	Shimamura T, etal., J Immunol. 2008 Oct 1;181(7):4656-65.
22.	IL-13Ralpha2 has a protective role in a mouse model of cutaneous inflammation.	Sivaprasad U, etal., J Immunol. 2010 Dec 1;185(11):6802-8. doi: 10.4049/jimmunol.1002118. Epub 2010 Oct 22.
23.	IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.	Wilson MS, etal., J Clin Invest. 2007 Oct;117(10):2941-51.
24.	Molecular cloning of the rat IL-13 alpha 2 receptor cDNA and its expression in rat tissues.	Wu AH and Low WC, J Neurooncol 2002 Sep;59(2):99-105.

Additional References at PubMed

PMID:15632090	PMID:15944273	PMID:17429054	PMID:34168643

Genomics

Comparative Map Data

Il13ra2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	111,002,590 - 111,074,053 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	111,002,592 - 111,072,381 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	113,111,924 - 113,176,074 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	116,610,790 - 116,674,931 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	114,150,841 - 114,214,825 (-)	NCBI	Rnor_WKY
Rnor_6.0	X	118,443,955 - 118,514,716 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	118,443,823 - 118,513,061 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	118,588,748 - 118,658,727 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	30,505,850 - 30,533,002 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	30,559,318 - 30,586,471 (-)	NCBI
Celera	X	110,307,396 - 110,375,950 (-)	NCBI		Celera
Cytogenetic Map	X	q34	NCBI

IL13RA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	115,003,982 - 115,017,616 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	X	115,003,975 - 115,019,977 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	114,238,545 - 114,252,179 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	114,144,794 - 114,158,463 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	114,061,519 - 114,075,187	NCBI
Celera	X	114,673,713 - 114,687,382 (-)	NCBI		Celera
Cytogenetic Map	X	q23	NCBI
HuRef	X	103,824,475 - 103,837,544 (-)	NCBI		HuRef
CHM1_1	X	114,149,412 - 114,163,077 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	113,412,686 - 113,451,239 (-)	NCBI		T2T-CHM13v2.0

Il13ra2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	146,166,474 - 146,214,982 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	146,166,472 - 146,212,188 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	147,383,478 - 147,429,192 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	147,383,476 - 147,429,192 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	143,818,021 - 143,838,375 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	142,629,846 - 142,650,204 (-)	NCBI		MGSCv36	mm8
Celera	X	131,321,061 - 131,341,527 (-)	NCBI		Celera
Cytogenetic Map	X	F2	NCBI
cM Map	X	68.46	NCBI

Il13ra2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955490	709,446 - 758,272 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955490	708,144 - 758,195 (+)	NCBI	ChiLan1.0	ChiLan1.0

IL13RA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	X	114,449,615 - 114,464,266 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	104,092,993 - 104,146,062 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	114,597,088 - 114,635,253 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	114,597,077 - 114,635,253 (-)	Ensembl	panpan1.1		panPan2

IL13RA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	87,747,373 - 87,776,797 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	87,747,373 - 87,776,798 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	73,868,563 - 73,897,928 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	89,462,267 - 89,540,412 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	89,462,346 - 89,522,049 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	86,906,747 - 86,936,111 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	88,581,088 - 88,610,454 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	88,414,159 - 88,443,524 (-)	NCBI		UU_Cfam_GSD_1.0

Il13ra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	86,774,105 - 86,816,943 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936499	863,599 - 883,855 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936499	860,179 - 883,884 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL13RA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	94,402,676 - 94,439,060 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	94,402,665 - 94,455,609 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	108,965,152 - 109,018,148 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IL13RA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	102,589,947 - 102,628,853 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	102,590,045 - 102,603,260 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	27,932,342 - 27,946,445 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Il13ra2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624940	819,854 - 842,284 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624940	825,368 - 842,268 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Il13ra2
193 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	133
Count of miRNA genes:	107
Interacting mature miRNAs:	110
Transcripts:	ENSRNOT00000043338
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat
724551	Glom1	Glomerulus QTL 1	2.8	0.0004	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	X	75294106	120294106	Rat
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	93956491	138956491	Rat
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	100567703	150256146	Rat
1598809	Memor15	Memory QTL 15	4.4		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	103312877	148312877	Rat
1598856	Memor1	Memory QTL 1	1.9		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	X	103312877	148312877	Rat

Markers in Region

D11Bhm88

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	111,074,368 - 111,074,463 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	118,515,032 - 118,515,126	NCBI	Rnor6.0
Rnor_5.0	X	118,659,043 - 118,659,137	UniSTS	Rnor5.0
RGSC_v3.4	X	30,478,134 - 30,478,228	UniSTS	RGSC3.4
RGSC_v3.4	X	30,830,187 - 30,830,281	UniSTS	RGSC3.4
Celera	X	110,376,266 - 110,376,360	UniSTS
Cytogenetic Map	X	q14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium										18	17
Low	2	20	38	28	19	28	1	1	10	4	14	9	1
Below cutoff	1	20	19	13		13	7	8	52	11	7	2	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006257427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006257428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006257430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006257431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008773388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008773389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008773390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF448818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000043338 ⟹ ENSRNOP00000041564

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	111,002,592 - 111,072,381 (-)	Ensembl
Rnor_6.0 Ensembl	X	118,444,474 - 118,513,061 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000084465 ⟹ ENSRNOP00000069280

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	118,443,823 - 118,459,355 (-)	Ensembl

RefSeq Acc Id:

NM_133538 ⟹ NP_598222

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	111,002,594 - 111,074,053 (-)	NCBI
Rnor_6.0	X	118,444,476 - 118,514,716 (-)	NCBI
Rnor_5.0	X	118,588,748 - 118,658,727 (-)	NCBI
RGSC_v3.4	X	30,505,850 - 30,533,002 (-)	RGD
Celera	X	110,307,396 - 110,375,950 (-)	RGD

Sequence:

show sequence

TAAGATGGAGACCATTTCTAAGACGGAGTAGGTTTGGCCTCTCAGTTTCAGGAAATGCACTCTA
GCAGTTGTATAAAGGCCAGGGCATGTGAAACCTTGGAAGATAAGTCGTGTTAGCGGATGGGGAT
CTGAGGAATAGGAATCCAAGGACTGAGCAGTTACTTGATTGAGGCTCAGCTGCCCTACCAGGTC
AACCTTAAAGTACACTAGAGATCCAGGCTTCCAGGCTAAAGCAGAATAAGCACAATCCTGTCTA
GAGGAAAGCACATACTAGAACTCTTTGGGACTGTGTTCTGCTACATTGTTTTATCCCTGACAGT
TTTCAAGATAACAAAAGAAAAGGAAAAGGAAAAGGATATATAAACAGTCTCATAGAACAAAGAG
AAATCATACACAGAAGGCAACAAATGAAACTTCAGAGTGCTTCCAGAAACTAGAGATGTTCAAT
TTTCTGGAGATGTGATTTCACACACGGGAGAAAGCTTGCCTTTCTGACTTATATGATCATTTTG
ATGTAAAGGATCTTCTTTGTTTGAAGATTTAATTTCTTGCAACACAACTCGTACTTGGGCTTGC
CTAAGAGAGTGGAACTTTTAGCACACTAAATTTCGGAGAAATGGCTTTGATGGCTGTGAATACC
AGATGCTTGTGTCTCTTTCTTCTTTGTACAATAACTGGTCATTCTTTGGAGATAAAAGTTAATC
CTCCTCAGGATTTTGAAATACTGGATCCTGGATTACTGGGTTATCTCTATTTGCAATGGAAACC
TCCCGTGGTCATGGACAATTTTAAGGAATGCAAGCTAGAATATGAGTTAAAATACCGAAATGTT
GACAGTGACAGTTGGAAAACCATAATTACTAGGAATCTAATTTACAAGGATGGGTTTGATCTTA
ATAAAGGCATTGAAGGAAAGATACGTACGCACTTGTCAGAGCATTGTACAAATGGATCAGAAGT
TCAAAGTCCATGGACAGAAGCTTCTTATGGGATAGCAGATGAAGGAAGCCTGGGAACTAAAATT
CAGGACATGAAGTGTATATATTATAACTGGCAGTATTTGGTCTGCTCTTGGAAGCCTGGCAAGA
CAGTACATTCCGATACGAACTATACTATGTTTTTCTGGTATGAGGGCTTGGATCATGCCTTACA
GTGTGCTGATTACCTCCAGGATAATGAGAAAAACGTTGGATGCAAACTTTCCAACTTGGACTCA
TCAGATTATAAAGATTTTTTTATTCGTGTTAATGGATCCTCAAAGCTGGAGCCTATCAGATCCA
GCTACATGGTTTTTCAACTTCAAAATATAGTTAAACCATTGCCACCAGAATTCCTTCATATTAG
TGTGGAGAACTCTATTGACATTAGAATGAAATGGAGCACACCTGGAGGCCCCATTCCACCAAGC
TGTTACACTTATGAAATTGTGGTCCGAGAAGATGATATTTCTTGGGAGTCTGCCACAGATAAAA
ATGATATGAAGCTGAAGAGGAGAGCAAATGAAAGTGAAGACCTGTGCTTTTTTGTAAGATGTAA
AATCAATATATATTGTGCAGATGATGGGATTTGGAGTGAATGGAGTGAAGAGGAATGCTGGGAA
GGTTACACAGGGCCAGACTCAAAGATTATTTTTATAGTACCAGTTTGTCTTTTCTTTATATTCC
TTTTATTACTTCTTTGTCTTATTGTGGAAAAGGAAGACCCTGAACCCACACTGAGCCTCCATGT
GGATTTGAACAAAGAAATGTATGCTTATGAAGAGACGCTCTGCTAAACTACTCTTTTCCTCACA
TAGAGTCAGCCAGCAGGAGTCATATTAAACTCAATGTCTCTTCAACTTTCAAATACATCTTCTT
GCAAATCAGTGTTTGTCCTAATATTGTTGGTTTTTTGAGTAAAGTGTTGGATATGTATC

hide sequence

RefSeq Acc Id:

XM_006257427 ⟹ XP_006257489

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	111,002,590 - 111,049,099 (-)	NCBI
Rnor_6.0	X	118,443,955 - 118,490,738 (-)	NCBI
Rnor_5.0	X	118,588,748 - 118,658,727 (-)	NCBI

Sequence:

show sequence

AAGCTTAGAAGCTCTTCCTTGAGGCAGGCTTCAGTGCTATTTCAGAAGAATTTGATTACATCTG
GACACATTATTCACATTGAGCTTCCAGGCTAAAGCAGAATAAGCACAATCCTGTCTAGAGGAAA
GCACATACTAGAACTCTTTGGGACTGTGTTCTGCTACATTGTTTTATCCCTGACAGTTTTCAAG
ATAACAAAAGAAAAGGAAAAGGAAAAGGATATATAAACAGTCTCATAGAACAAAGAGAAATCAT
ACACAGAAGGCAACAAATGAAACTTCAGAGTGCTTCCAGAAACTAGAGATGTTCAATTTTCTGG
AGATGTGATTTCACACACGGGAGAAAGCTTGCCTTTCTGACTTATATGATCATTTTGATGTAAA
GGATCTTCTTTGTTTGAAGATTTAATTTCTTGCAACACAACTCGTACTTGGGCTTGCCTAAGAG
AGTGGAACTTTTAGCACACTAAATTTCGGAGAAATGGCTTTGATGGCTGTGAATACCAGATGCT
TGTGTCTCTTTCTTCTTTGTACAATAACTGGTCATTCTTTGGAGATAAAAGTTAATCCTCCTCA
GGATTTTGAAATACTGGATCCTGGATTACTGGGTTATCTCTATTTGCAATGGAAACCTCCCGTG
GTCATGGACAATTTTAAGGAATGCAAGCTAGAATATGAGTTAAAATACCGAAATGTTGACAGTG
ACAGTTGGAAAACCATAATTACTAGGAATCTAATTTACAAGGATGGGTTTGATCTTAATAAAGG
CATTGAAGGAAAGATACGTACGCACTTGTCAGAGCATTGTACAAATGGATCAGAAGTTCAAAGT
CCATGGACAGAAGCTTCTTATGGGATAGCAGATGAAGGAAGCCTGGGAACTAAAATTCAGGACA
TGAAGTGTATATATTATAACTGGCAGTATTTGGTCTGCTCTTGGAAGCCTGGCAAGACAGTACA
TTCCGATACGAACTATACTATGTTTTTCTGGTATGAGGGCTTGGATCATGCCTTACAGTGTGCT
GATTACCTCCAGGATAATGAGAAAAACGTTGGATGCAAACTTTCCAACTTGGACTCATCAGATT
ATAAAGATTTTTTTATTCGTGTTAATGGATCCTCAAAGCTGGAGCCTATCAGATCCAGCTACAT
GGTTTTTCAACTTCAAAATATAGTTAAACCATTGCCACCAGAATTCCTTCATATTAGTGTGGAG
AACTCTATTGACATTAGAATGAAATGGAGCACACCTGGAGGCCCCATTCCACCAAGCTGTTACA
CTTATGAAATTGTGGTCCGAGAAGATGATATTTCTTGGGAGTCTGCCACAGATAAAAATGATAT
GAAGCTGAAGAGGAGAGCAAATGAAAGTGAAGACCTGTGCTTTTTTGTAAGATGTAAAATCAAT
ATATATTGTGCAGATGATGGGATTTGGAGTGAATGGAGTGAAGAGGAATGCTGGGAAGGTTACA
CAGGGCCAGACTCAAAGATTATTTTTATAGTACCAGTTTGTCTTTTCTTTATATTCCTTTTATT
ACTTCTTTGTCTTATTGTGGAAAAGGAAGACCCTGAACCCACACTGAGCCTCCATGTGGATTTG
AACAAAGAAATGTATGCTTATGAAGAGACGCTCTGCTAAACTACTCTTTTCCTCACATAGAGTC
AGCCAGCAGGAGTCATATTAAACTCAATGTCTCTTCAACTTTCAAATACATCTTCTTGCAAATC
AGTGTTTGTCCTAATATTGTTGGTTTTTTGAGTAAAGTGTTGGATATGTATCTCAAGTTGGCTT
AGTGTGTGATAGTTCTGAATCAGTCTTTCAAGTACTGGCATAACACATGTGTGATATCATGGTC
ACCTTCATTATTGCATTTAGGTATACTTTATGGGGCACAAACCCTTAGCAATAGTAAATTTACT
ATATCCTAGTAATTGCTTTGTTTCCTAATAACTTTGTGGTGAGAGATCTATATGTAGATCCATC
AAGAGATGGGTCAGATTTTATTCAATGTTGTATTAATAAGATACTATGTTCTTCCAACTTGAAC
TAACCTATGGAGATACTGCCAAACCATGAAAAAAGAGATTTAATGGTTTTATGGATGGTTCTTT
TAAACTAAATTCTGGGTTAAAGAACTCACCATGAATAAGTATAAAGGAAGCTTTGAATATATTC
CCAGTTGTGTGGGTATCACATTTTATAAAAGAAAAAGTTTCTATAAGGGTGAAAACTATGACAT
GAGTAGGAACTATACTTGAAAATTTCAGAACTCATACTGACAGGAGGCTGATATAGCTGTC

hide sequence

RefSeq Acc Id:

XM_039099436 ⟹ XP_038955364

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	111,002,590 - 111,069,653 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_598222	(Get FASTA)	NCBI Sequence Viewer
	XP_006257489	(Get FASTA)	NCBI Sequence Viewer
	XP_038955364	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL57513	(Get FASTA)	NCBI Sequence Viewer
	EDL85168	(Get FASTA)	NCBI Sequence Viewer
	EDL85169	(Get FASTA)	NCBI Sequence Viewer
	Q8VHK6	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_598222 ⟸ NM_133538
- Peptide Label:	precursor
- UniProtKB:	G3V9B6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALMAVNTRCLCLFLLCTITGHSLEIKVNPPQDFEILDPGLLGYLYLQWKPPVVMDNFKECKLE YELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTHLSEHCTNGSEVQSPWTEASYGIAD EGSLGTKIQDMKCIYYNWQYLVCSWKPGKTVHSDTNYTMFFWYEGLDHALQCADYLQDNEKNVG CKLSNLDSSDYKDFFIRVNGSSKLEPIRSSYMVFQLQNIVKPLPPEFLHISVENSIDIRMKWST PGGPIPPSCYTYEIVVREDDISWESATDKNDMKLKRRANESEDLCFFVRCKINIYCADDGIWSE WSEEECWEGYTGPDSKIIFIVPVCLFFIFLLLLLCLIVEKEDPEPTLSLHVDLNKEMYAYEETL C hide sequence

RefSeq Acc Id:	XP_006257489 ⟸ XM_006257427
- Peptide Label:	isoform X1
- UniProtKB:	G3V9B6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALMAVNTRCLCLFLLCTITGHSLEIKVNPPQDFEILDPGLLGYLYLQWKPPVVMDNFKECKLE YELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTHLSEHCTNGSEVQSPWTEASYGIAD EGSLGTKIQDMKCIYYNWQYLVCSWKPGKTVHSDTNYTMFFWYEGLDHALQCADYLQDNEKNVG CKLSNLDSSDYKDFFIRVNGSSKLEPIRSSYMVFQLQNIVKPLPPEFLHISVENSIDIRMKWST PGGPIPPSCYTYEIVVREDDISWESATDKNDMKLKRRANESEDLCFFVRCKINIYCADDGIWSE WSEEECWEGYTGPDSKIIFIVPVCLFFIFLLLLLCLIVEKEDPEPTLSLHVDLNKEMYAYEETL C hide sequence

RefSeq Acc Id:

ENSRNOP00000041564 ⟸ ENSRNOT00000043338

RefSeq Acc Id:

ENSRNOP00000069280 ⟸ ENSRNOT00000084465

RefSeq Acc Id:	XP_038955364 ⟸ XM_039099436
- Peptide Label:	isoform X1
- UniProtKB:	G3V9B6 (UniProtKB/TrEMBL)

Protein Domains

Fibronectin type-III

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8VHK6-F1-model_v2	AlphaFold	Q8VHK6	1-385	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620838	AgrOrtholog
BioCyc Gene	G2FUF-1442	BioCyc
Ensembl Genes	ENSRNOG00000032973	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000041564	ENTREZGENE
	ENSRNOP00000041564.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000043338	ENTREZGENE
	ENSRNOT00000043338.6	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	FN3_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN3_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Short_hematopoietin_rcpt_2_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TypeI_recpt_CBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171060	UniProtKB/TrEMBL
NCBI Gene	171060	ENTREZGENE
PANTHER	CYTOKINE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR23037:SF35	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	IL6Ra-bind	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Il13ra2	PhenoGen
PROSITE	FN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HEMATOPO_REC_S_F2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF49265	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	G3V9B6	ENTREZGENE, UniProtKB/TrEMBL
	I13R2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-16	Il13ra2	interleukin 13 receptor subunit alpha 2	Il13ra2	interleukin 13 receptor, alpha 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-04-17	Il13ra2	interleukin 13 receptor, alpha 2	LOC100361488	rCG23169-like	Data Merged	737654	PROVISIONAL
2010-05-05	LOC100361488	rCG23169-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Il13ra2	interleukin 13 receptor, alpha 2			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Il13ra2	interleukin 13 receptor, alpha 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	has a short cytoplasmic domain and an extracellular domain	633080
gene_expression	expressed in the brain, spleen, liver, thymus, stomach, and testis	633080
gene_homology	91.2% and 54.2% homologous to mouse and human gene	633080

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)