Maob (monoamine oxidase B) - Rat Genome Database

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Gene: Maob (monoamine oxidase B) Rattus norvegicus
Analyze
Symbol: Maob
Name: monoamine oxidase B
RGD ID: 3041
Description: Exhibits flavin adenine dinucleotide binding activity; identical protein binding activity; and primary amine oxidase activity. Involved in several processes, including negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; and response to corticosterone. Localizes to mitochondrial outer membrane. Biomarker of Parkinson's disease and cholestasis. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (monoamine oxidase B); PARTICIPATES IN citalopram pharmacodynamics pathway; citalopram pharmacokinetics pathway; Parkinson's disease pathway; INTERACTS WITH (+)-schisandrin B; (-)-selegiline; (3,4-dihydroxyphenyl)acetic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: amine oxidase [flavin-containing] B; MAO-B; monoamine oxidase type B; monoamine oxidase-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X5,907,327 - 6,010,996 (+)NCBI
Rnor_6.0 EnsemblX6,430,594 - 6,533,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X6,430,694 - 6,533,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X7,249,779 - 7,352,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,553,529 - 17,657,852 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X17,606,846 - 17,711,170 (+)NCBI
CeleraX6,397,919 - 6,500,914 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-selegiline  (EXP,ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-phenylethylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amitraz  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
Anetholtrithion  (EXP)
aripiprazole  (EXP)
baclofen  (ISO)
barbituric acid  (EXP)
benzo[a]pyrene  (ISO)
benzyl benzoate  (ISO)
benzyl cinnamate  (ISO)
beta-carboline  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroform  (EXP)
chlorogenic acid  (ISO)
cis-caffeic acid  (ISO)
clorgyline  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichlorvos  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (EXP)
erythromycin estolate  (EXP)
ethanol  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fucoxanthin  (ISO)
geraniol  (ISO)
glafenine  (EXP)
glutathione  (ISO)
Heliotrine  (ISO)
heptachlor  (EXP)
homovanillic acid  (EXP)
indol-3-ylacetaldehyde  (ISO)
indometacin  (ISO)
kojic acid  (EXP)
kynuramine  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (ISO)
monocrotophos  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nitroglycerin  (EXP)
nitroprusside  (ISO)
olanzapine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
Pargyline  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phencyclidine  (ISO)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylpropanolamine  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
phosphamidon  (EXP)
pioglitazone  (ISO)
piperine  (EXP)
pirinixic acid  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rasagiline  (ISO)
resveratrol  (EXP,ISO)
risperidone  (EXP)
rosmarinic acid  (ISO)
SB 431542  (ISO)
Senkirkine  (ISO)
serotonin  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thiouracil  (EXP)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tryptamine  (ISO)
undecane  (EXP)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zonisamide  (ISO)

References

References - curated
1. Arai R, etal., Neuroscience 2002;114(4):825-35.
2. Birgner C, etal., Brain Res. 2008 Jul 11;1219:103-10. Epub 2008 May 17.
3. Castoldi AF, etal., Brain Res. 2006 Sep 27;1112(1):91-8. Epub 2006 Aug 10.
4. Costa P, etal., Am J Med Genet 1997 Apr 18;74(2):154-6.
5. Ekuni D, etal., Am J Pathol. 2009 Oct;175(4):1398-409. Epub 2009 Sep 24.
6. Falk EM, etal., Pharmacol Biochem Behav. 2002 Jun;72(3):617-22.
7. Finberg JP and Sader-Mazbar O, J Neural Transm. 2007;114(6):801-5. Epub 2007 Apr 10.
8. GOA data from the GO Consortium
9. Huang YH, etal., Eur J Histochem. 2008 Jan-Mar;52(1):11-8.
10. Ito A, etal., Biochem Biophys Res Commun 1988 Dec 30;157(3):970-6.
11. KEGG
12. Khudoerkov RM, etal., Bull Exp Biol Med. 2007 Jul;144(1):36-8.
13. Lindley SE, etal., Psychoneuroendocrinology. 2005 Sep;30(8):785-90.
14. MGD data from the GO Consortium
15. NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Ou XM, etal., Biol Psychiatry. 2009 Dec 18.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. Pipeline to import SMPDB annotations from SMPDB into RGD
19. RGD automated data pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Sherif F, etal., J Neural Transm Park Dis Dement Sect. 1992;4(3):227-40.
23. Tang YL, etal., Br J Nutr. 2008 Sep;100(3):660-5. Epub 2008 Feb 28.
24. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Upadhyay AK and Edmondson DE, Protein Expr Purif. 2008 Jun;59(2):349-56. Epub 2008 Mar 10.
26. Upadhyay AK, etal., Biochemistry. 2008 Feb 12;47(6):1554-66. Epub 2008 Jan 17.
27. Zhang J, etal., Saudi Med J. 2009 Jun;30(6):760-6.
28. Zimatkin SM, etal., Neurosci Behav Physiol. 2008 Oct;38(8):807-10. Epub 2008 Sep 18.
Additional References at PubMed
PMID:9162023   PMID:12477932   PMID:12865426   PMID:14697889   PMID:14986002   PMID:15489334   PMID:15526171   PMID:16098487   PMID:18092818   PMID:18614015   PMID:19909795   PMID:20204567  
PMID:20547771   PMID:20833797   PMID:21341713   PMID:21700703   PMID:22926577   PMID:23376485   PMID:27503749  


Genomics

Comparative Map Data
Maob
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X5,907,327 - 6,010,996 (+)NCBI
Rnor_6.0 EnsemblX6,430,594 - 6,533,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X6,430,694 - 6,533,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X7,249,779 - 7,352,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,553,529 - 17,657,852 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X17,606,846 - 17,711,170 (+)NCBI
CeleraX6,397,919 - 6,500,914 (+)NCBICelera
Cytogenetic MapXq11NCBI
MAOB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX43,766,610 - 43,882,450 (-)EnsemblGRCh38hg38GRCh38
GRCh38X43,766,610 - 43,882,450 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X43,625,857 - 43,741,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X43,510,801 - 43,626,665 (-)NCBINCBI36hg18NCBI36
Build 34X43,382,111 - 43,497,935NCBI
CeleraX47,765,631 - 47,881,481 (-)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX41,355,388 - 41,470,732 (-)NCBIHuRef
CHM1_1X43,659,020 - 43,774,882 (-)NCBICHM1_1
Maob
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X16,575,520 - 16,683,605 (-)NCBIGRCm39mm39
GRCm39 EnsemblX16,575,521 - 16,683,605 (-)Ensembl
GRCm38X16,709,281 - 16,817,366 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX16,709,282 - 16,817,366 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X16,286,407 - 16,394,492 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X15,866,241 - 15,974,323 (-)NCBImm8
CeleraX14,324,831 - 14,433,074 (-)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX11.88NCBI
Maob
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555164,328,476 - 4,472,593 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555164,328,286 - 4,473,419 (+)NCBIChiLan1.0ChiLan1.0
MAOB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X44,042,000 - 44,157,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX44,042,000 - 44,157,941 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X36,217,710 - 36,333,516 (-)NCBIMhudiblu_PPA_v0panPan3
MAOB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X37,765,810 - 37,883,955 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX37,765,813 - 37,883,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX24,993,868 - 25,112,008 (-)NCBI
ROS_Cfam_1.0X37,854,043 - 37,972,251 (-)NCBI
UMICH_Zoey_3.1X37,895,301 - 38,013,405 (-)NCBI
UNSW_CanFamBas_1.0X37,878,280 - 37,996,408 (-)NCBI
UU_Cfam_GSD_1.0X37,973,208 - 38,091,371 (-)NCBI
Maob
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X30,066,432 - 30,229,771 (-)NCBI
SpeTri2.0NW_0049365029,907,181 - 10,014,756 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAOB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX39,025,971 - 39,144,345 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X39,025,973 - 39,144,389 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X43,355,507 - 43,474,320 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAOB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X40,936,789 - 41,054,547 (-)NCBI
ChlSab1.1 EnsemblX40,936,711 - 41,054,641 (-)Ensembl
Maob
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476211,584,925 - 11,720,273 (+)NCBI

Position Markers
RH129056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X6,010,770 - 6,010,952 (+)MAPPER
Rnor_6.0X6,533,295 - 6,533,476NCBIRnor6.0
Rnor_5.0X7,352,045 - 7,352,226UniSTSRnor5.0
RGSC_v3.4X17,657,627 - 17,657,808UniSTSRGSC3.4
CeleraX6,500,689 - 6,500,870UniSTS
Cytogenetic MapXq12UniSTS
RH142419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X6,010,684 - 6,010,885 (+)MAPPER
Rnor_6.0X6,533,209 - 6,533,409NCBIRnor6.0
Rnor_5.0X7,351,959 - 7,352,159UniSTSRnor5.0
RGSC_v3.4X17,657,541 - 17,657,741UniSTSRGSC3.4
CeleraX6,500,603 - 6,500,803UniSTS
Cytogenetic MapXq12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X144092703Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X166245312370298Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X166245321592783Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X166260933443848Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X183816624331837Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X428214049282140Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X595407850954078Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:158
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000044009
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 39 39 39 33 17 11
Low 3 43 17 2 18 2 8 11 41 35 24 8
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044009   ⟹   ENSRNOP00000043466
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX6,430,594 - 6,533,534 (+)Ensembl
RefSeq Acc Id: NM_013198   ⟹   NP_037330
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X5,907,327 - 6,010,996 (+)NCBI
Rnor_6.0X6,430,694 - 6,533,520 (+)NCBI
Rnor_5.0X7,249,779 - 7,352,270 (+)NCBI
RGSC_v3.4X17,553,529 - 17,657,852 (+)RGD
CeleraX6,397,919 - 6,500,914 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037330 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41566 (Get FASTA)   NCBI Sequence Viewer  
  AAH89814 (Get FASTA)   NCBI Sequence Viewer  
  AAK14225 (Get FASTA)   NCBI Sequence Viewer  
  EDL97664 (Get FASTA)   NCBI Sequence Viewer  
  P19643 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037330   ⟸   NM_013198
- UniProtKB: P19643 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043466   ⟸   ENSRNOT00000044009
Protein Domains
Amino_oxidase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701704
Promoter ID:EPDNEW_R12227
Type:initiation region
Name:Maob_1
Description:monoamine oxidase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X6,430,684 - 6,430,744EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3041 AgrOrtholog
Ensembl Genes ENSRNOG00000029778 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000043466 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044009 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122068 IMAGE-MGC_LOAD
  IMAGE:7323595 IMAGE-MGC_LOAD
InterPro Amino_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_amine_oxidase UniProtKB/Swiss-Prot
KEGG Report rno:25750 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108745 IMAGE-MGC_LOAD
  MGC:93583 IMAGE-MGC_LOAD
NCBI Gene 25750 ENTREZGENE
Pfam Amino_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAOB RGD
PhenoGen Maob PhenoGen
PRINTS AMINEOXDASEF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228489
UniProt AOFB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99PC8_RAT UniProtKB/TrEMBL
UniProt Secondary Q5EBB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Maob  Monoamine oxidase B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression abundant in serotonergic neurons and astrocytes 633242