Maob (monoamine oxidase B) - Rat Genome Database

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Gene: Maob (monoamine oxidase B) Rattus norvegicus
Analyze
Symbol: Maob
Name: monoamine oxidase B
RGD ID: 3041
Description: Enables flavin adenine dinucleotide binding activity; identical protein binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Involved in several processes, including negative regulation of serotonin secretion; phenylethylamine catabolic process; and response to corticosterone. Located in dendrite; mitochondrial outer membrane; and neuronal cell body. Biomarker of Parkinson's disease and cholestasis. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (monoamine oxidase B); PARTICIPATES IN citalopram pharmacodynamics pathway; citalopram pharmacokinetics pathway; Parkinson's disease pathway; INTERACTS WITH (+)-schisandrin B; (-)-selegiline; (3,4-dihydroxyphenyl)acetic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amine oxidase [flavin-containing] B; MAO-B; monoamine oxidase type B; monoamine oxidase-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X8,490,405 - 8,594,065 (+)NCBIGRCr8
mRatBN7.2X5,907,327 - 6,010,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX5,907,266 - 6,011,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX5,962,563 - 6,066,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X9,438,380 - 9,542,028 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X5,758,453 - 5,862,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X6,430,694 - 6,533,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,430,594 - 6,533,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X7,249,779 - 7,352,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,553,529 - 17,657,852 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X17,606,846 - 17,711,170 (+)NCBI
CeleraX6,397,919 - 6,500,914 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-selegiline  (EXP,ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2,3,4-tetrahydroisoquinoline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-phenylethylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitraz  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
Anetholtrithion  (EXP)
aripiprazole  (EXP)
baclofen  (ISO)
barbituric acid  (EXP)
benzo[a]pyrene  (ISO)
benzyl benzoate  (ISO)
benzyl cinnamate  (ISO)
beta-carboline  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chlorogenic acid  (ISO)
cis-caffeic acid  (ISO)
clorgyline  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichlorvos  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (EXP)
erythromycin estolate  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
geraniol  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (ISO)
Heliotrine  (ISO)
heptachlor  (EXP)
homovanillic acid  (EXP)
hydrogen sulfide  (ISO)
indol-3-ylacetaldehyde  (ISO)
indometacin  (EXP,ISO)
kojic acid  (EXP)
kynuramine  (ISO)
linezolid  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nitroglycerin  (EXP)
nitroprusside  (ISO)
olanzapine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
Pargyline  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phencyclidine  (ISO)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylpropanolamine  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
phosphamidon  (EXP)
pioglitazone  (ISO)
piperine  (EXP)
pirinixic acid  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rasagiline  (ISO)
resveratrol  (EXP,ISO)
risperidone  (EXP)
rosmarinic acid  (ISO)
SB 431542  (ISO)
Senkirkine  (ISO)
serotonin  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thioacetamide  (EXP)
thiouracil  (EXP)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tryptamine  (ISO)
undecane  (EXP)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential subcellular location of mitochondria in rat serotonergic neurons depends on the presence and the absence of monoamine oxidase type B. Arai R, etal., Neuroscience 2002;114(4):825-35.
2. Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration. Birgner C, etal., Brain Res. 2008 Jul 11;1219:103-10. Epub 2008 May 17.
3. Brain monoaminergic neurotransmission parameters in weanling rats after perinatal exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153). Castoldi AF, etal., Brain Res. 2006 Sep 27;1112(1):91-8. Epub 2006 Aug 10.
4. Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease. Costa P, etal., Am J Med Genet 1997 Apr 18;74(2):154-6.
5. Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. Ekuni D, etal., Am J Pathol. 2009 Oct;175(4):1398-409. Epub 2009 Sep 24.
6. An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Falk EM, etal., Pharmacol Biochem Behav. 2002 Jun;72(3):617-22.
7. Modification of L-DOPA pharmacological activity by MAO inhibitors. Finberg JP and Sader-Mazbar O, J Neural Transm. 2007;114(6):801-5. Epub 2007 Apr 10.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Immunocytochemical localization of monoamine oxidase type B in rat liver. Huang YH, etal., Eur J Histochem. 2008 Jan-Mar;52(1):11-8.
11. Molecular cloning of a cDNA for rat liver monoamine oxidase B. Ito A, etal., Biochem Biophys Res Commun 1988 Dec 30;157(3):970-6.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Structural, functional, and biochemical changes in the brain during modeling of dopamine system disturbances in rats. Khudoerkov RM, etal., Bull Exp Biol Med. 2007 Jul;144(1):36-8.
14. Monoamine oxidase and catechol-o-methyltransferase enzyme activity and gene expression in response to sustained glucocorticoids. Lindley SE, etal., Psychoneuroendocrinology. 2005 Sep;30(8):785-90.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. The oxidation of adrenaline and noradrenaline by the two forms of monoamine oxidase from human and rat brain. O'Carroll AM, etal., Neurochem Int. 1986;8(4):493-500. doi: 10.1016/0197-0186(86)90182-8.
18. A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase and Monoamine Oxidase B Cascade in Ethanol-Induced Cellular Damage. Ou XM, etal., Biol Psychiatry. 2009 Dec 18.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease. Sherif F, etal., J Neural Transm Park Dis Dement Sect. 1992;4(3):227-40.
25. Both inorganic and organic selenium supplements can decrease brain monoamine oxidase B enzyme activity in adult rats. Tang YL, etal., Br J Nutr. 2008 Sep;100(3):660-5. Epub 2008 Feb 28.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Characterization of detergent purified recombinant rat liver monoamine oxidase B expressed in Pichia pastoris. Upadhyay AK and Edmondson DE, Protein Expr Purif. 2008 Jun;59(2):349-56. Epub 2008 Mar 10.
28. Determination of the oligomeric states of human and rat monoamine oxidases in the outer mitochondrial membrane and octyl beta-D-glucopyranoside micelles using pulsed dipolar electron spin resonance spectroscopy. Upadhyay AK, etal., Biochemistry. 2008 Feb 12;47(6):1554-66. Epub 2008 Jan 17.
29. Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease. Zhang J, etal., Saudi Med J. 2009 Jun;30(6):760-6.
30. Metabolic changes in rat brain histaminergic neurons during subhepatic cholestasis. Zimatkin SM, etal., Neurosci Behav Physiol. 2008 Oct;38(8):807-10. Epub 2008 Sep 18.
Additional References at PubMed
PMID:9162023   PMID:12477932   PMID:12865426   PMID:14697889   PMID:14986002   PMID:15489334   PMID:15526171   PMID:16098487   PMID:18092818   PMID:18614015   PMID:19909795   PMID:20204567  
PMID:20547771   PMID:20833797   PMID:21341713   PMID:21700703   PMID:22926577   PMID:23376485   PMID:27503749   PMID:34244591   PMID:34290084   PMID:35723772  


Genomics

Comparative Map Data
Maob
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X8,490,405 - 8,594,065 (+)NCBIGRCr8
mRatBN7.2X5,907,327 - 6,010,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX5,907,266 - 6,011,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX5,962,563 - 6,066,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X9,438,380 - 9,542,028 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X5,758,453 - 5,862,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X6,430,694 - 6,533,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,430,594 - 6,533,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X7,249,779 - 7,352,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,553,529 - 17,657,852 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X17,606,846 - 17,711,170 (+)NCBI
CeleraX6,397,919 - 6,500,914 (+)NCBICelera
Cytogenetic MapXq11NCBI
MAOB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X43,766,610 - 43,882,450 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX43,766,610 - 43,882,450 (-)EnsemblGRCh38hg38GRCh38
GRCh37X43,625,857 - 43,741,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X43,510,801 - 43,626,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X43,382,111 - 43,497,935NCBI
CeleraX47,765,631 - 47,881,481 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX41,355,388 - 41,470,732 (-)NCBIHuRef
CHM1_1X43,659,020 - 43,774,882 (-)NCBICHM1_1
T2T-CHM13v2.0X43,172,827 - 43,288,647 (-)NCBIT2T-CHM13v2.0
Maob
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X16,575,520 - 16,683,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX16,575,521 - 16,683,605 (-)EnsemblGRCm39 Ensembl
GRCm38X16,709,281 - 16,817,366 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX16,709,282 - 16,817,366 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X16,286,407 - 16,394,492 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X15,866,241 - 15,974,323 (-)NCBIMGSCv36mm8
CeleraX14,324,831 - 14,433,074 (-)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX11.88NCBI
Maob
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555164,328,476 - 4,472,593 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555164,328,286 - 4,473,419 (+)NCBIChiLan1.0ChiLan1.0
MAOB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X45,416,758 - 45,532,609 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X45,420,131 - 45,535,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X36,217,710 - 36,333,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X44,042,000 - 44,157,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX44,042,000 - 44,157,941 (-)Ensemblpanpan1.1panPan2
MAOB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X37,765,810 - 37,883,955 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX37,765,813 - 37,883,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX24,993,868 - 25,112,008 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X37,854,043 - 37,972,251 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX37,854,043 - 37,972,306 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X37,895,301 - 38,013,405 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X37,878,280 - 37,996,408 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X37,973,208 - 38,091,371 (-)NCBIUU_Cfam_GSD_1.0
Maob
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X30,066,432 - 30,229,771 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365029,907,180 - 10,014,773 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365029,907,181 - 10,014,756 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAOB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX39,025,970 - 39,144,345 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X39,025,973 - 39,144,389 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X43,355,507 - 43,474,320 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAOB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X40,936,789 - 41,054,547 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX40,936,711 - 41,054,641 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660766,156,035 - 6,274,102 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Maob
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476211,584,825 - 11,720,506 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476211,584,925 - 11,720,273 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Maob
152 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:158
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000044009
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat

Markers in Region
RH129056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X6,010,770 - 6,010,952 (+)MAPPERmRatBN7.2
Rnor_6.0X6,533,295 - 6,533,476NCBIRnor6.0
Rnor_5.0X7,352,045 - 7,352,226UniSTSRnor5.0
RGSC_v3.4X17,657,627 - 17,657,808UniSTSRGSC3.4
CeleraX6,500,689 - 6,500,870UniSTS
Cytogenetic MapXq12UniSTS
RH142419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X6,010,684 - 6,010,885 (+)MAPPERmRatBN7.2
Rnor_6.0X6,533,209 - 6,533,409NCBIRnor6.0
Rnor_5.0X7,351,959 - 7,352,159UniSTSRnor5.0
RGSC_v3.4X17,657,541 - 17,657,741UniSTSRGSC3.4
CeleraX6,500,603 - 6,500,803UniSTS
Cytogenetic MapXq12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000044009   ⟹   ENSRNOP00000043466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX5,907,266 - 6,011,003 (+)Ensembl
Rnor_6.0 EnsemblX6,430,594 - 6,533,534 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106616   ⟹   ENSRNOP00000087850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX5,949,728 - 6,011,003 (+)Ensembl
RefSeq Acc Id: NM_013198   ⟹   NP_037330
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X8,490,405 - 8,594,065 (+)NCBI
mRatBN7.2X5,907,327 - 6,010,996 (+)NCBI
Rnor_6.0X6,430,694 - 6,533,520 (+)NCBI
Rnor_5.0X7,249,779 - 7,352,270 (+)NCBI
RGSC_v3.4X17,553,529 - 17,657,852 (+)RGD
CeleraX6,397,919 - 6,500,914 (+)RGD
Sequence:
RefSeq Acc Id: NP_037330   ⟸   NM_013198
- UniProtKB: Q5EBB5 (UniProtKB/Swiss-Prot),   P19643 (UniProtKB/Swiss-Prot),   A6JZX1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043466   ⟸   ENSRNOT00000044009
Ensembl Acc Id: ENSRNOP00000087850   ⟸   ENSRNOT00000106616
Protein Domains
Amine oxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19643-F1-model_v2 AlphaFold P19643 1-520 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701704
Promoter ID:EPDNEW_R12227
Type:initiation region
Name:Maob_1
Description:monoamine oxidase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X6,430,684 - 6,430,744EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3041 AgrOrtholog
BioCyc Gene G2FUF-3113 BioCyc
BioCyc Pathway PWY-0 [putrescine degradation III] BioCyc
  PWY-6307 [L-tryptophan degradation X (mammalian, via tryptamine)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6318 [L-phenylalanine degradation IV (mammalian, via side chain)] BioCyc
  PWY-6342 [noradrenaline and adrenaline degradation] BioCyc
  PWY-6399 [melatonin degradation II] BioCyc
  PWY6666-2 [dopamine degradation] BioCyc
BioCyc Pathway Image PWY-0 BioCyc
  PWY-6307 BioCyc
  PWY-6313 BioCyc
  PWY-6318 BioCyc
  PWY-6342 BioCyc
  PWY-6399 BioCyc
  PWY6666-2 BioCyc
Ensembl Genes ENSRNOG00000029778 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055016304 UniProtKB/Swiss-Prot
  ENSRNOG00060018700 UniProtKB/Swiss-Prot
  ENSRNOG00065021133 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044009.6 UniProtKB/Swiss-Prot
  ENSRNOT00000106616.1 UniProtKB/TrEMBL
  ENSRNOT00055027658 UniProtKB/Swiss-Prot
  ENSRNOT00060032306 UniProtKB/Swiss-Prot
  ENSRNOT00065035977 UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.660.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanine Nucleotide Dissociation Inhibitor, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122068 IMAGE-MGC_LOAD
  IMAGE:7323595 IMAGE-MGC_LOAD
InterPro Amino_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_amine_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_MAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25750 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108745 IMAGE-MGC_LOAD
  MGC:93583 IMAGE-MGC_LOAD
NCBI Gene 25750 ENTREZGENE
PANTHER AMINE OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMINE OXIDASE [FLAVIN-CONTAINING] B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Amino_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAOB RGD
PhenoGen Maob PhenoGen
PRINTS AMINEOXDASEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029778 RatGTEx
  ENSRNOG00055016304 RatGTEx
  ENSRNOG00060018700 RatGTEx
  ENSRNOG00065021133 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228489
UniProt A0A8I6A9K2_RAT UniProtKB/TrEMBL
  A6JZX1 ENTREZGENE, UniProtKB/TrEMBL
  AOFB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBB5 ENTREZGENE
  Q99PC8_RAT UniProtKB/TrEMBL
UniProt Secondary Q5EBB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Maob  Monoamine oxidase B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression abundant in serotonergic neurons and astrocytes 633242