Tgfb2 (transforming growth factor, beta 2) - Rat Genome Database

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Gene: Tgfb2 (transforming growth factor, beta 2) Rattus norvegicus
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Symbol: Tgfb2
Name: transforming growth factor, beta 2
RGD ID: 70491
Description: Enables identical protein binding activity. Involved in several processes, including negative regulation of release of sequestered calcium ion into cytosol; regulation of apoptotic process; and skeletal system morphogenesis. Located in several cellular components, including cell surface; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4; colorectal cancer; and pancreatic adenosquamous carcinoma. Orthologous to human TGFB2 (transforming growth factor beta 2); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: TGF beta 2 protein; TGF-B2; TGF-beta-2; transforming growth factor beta-2; transforming growth factor beta-2 proprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21398,160,075 - 98,261,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1398,160,087 - 98,261,405 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13100,678,931 - 100,778,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013102,066,560 - 102,165,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01399,261,239 - 99,360,947 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (IEP)
aortic aneurysm  (ISO)
aortic disease  (ISO)
aortic valve insufficiency  (ISO)
atrial heart septal defect 1  (ISO)
autoimmune disease  (ISO)
bone development disease  (ISO)
cholangitis  (ISO)
cleft palate  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
Congenital Limb Deformities  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
Cyanosis  (ISO)
diabetic neuropathy  (IEP)
Ehlers-Danlos syndrome  (ISO)
endometriosis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Eye Abnormalities  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
hepatocellular carcinoma  (ISO)
Hirschsprung Disease 1  (ISO)
Hirschsprung's disease  (ISO)
Holt-Oram syndrome  (ISO)
liver cirrhosis  (ISO)
Loeys-Dietz syndrome  (ISO,ISS)
Loeys-Dietz syndrome 4  (ISO)
lung adenocarcinoma  (ISO)
malignant mesothelioma  (ISO)
Martsolf Syndrome  (ISO)
methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency  (ISO)
Musculoskeletal Abnormalities  (ISO)
myocardial infarction  (IEP)
osteochondrodysplasia  (IEP)
pancreatic adenosquamous carcinoma  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
parathyroid carcinoma  (ISO)
Respiratory System Abnormalities  (ISO)
Spinal Cord Injuries  (IMP)
thoracic aortic aneurysm  (ISO)
ureteral obstruction  (ISO)
Urogenital Abnormalities  (ISO)
Usher syndrome  (ISO)
Wallerian Degeneration  (IEP)
Wounds and Injuries  (IEP,IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
4-tert-Octylphenol  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
Allylamine  (EXP)
AM-251  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
astemizole  (EXP)
atrazine  (EXP)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brevetoxin B  (ISO)
bromochloroacetic acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbaryl  (ISO)
carbofuran  (EXP)
CGP 52608  (ISO)
chloroform  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cordycepin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl malate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
dobutamine  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
fenamic acid  (EXP)
fenamidone  (ISO)
fenvalerate  (EXP)
flusilazole  (ISO)
fructose  (ISO)
furan  (EXP)
furosemide  (EXP)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Glutathione ethyl ester  (ISO)
glycine betaine  (EXP)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (EXP)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leptomycin B  (ISO)
Licochalcone B  (ISO)
linuron  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
metaproterenol  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
minocycline  (ISO)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naproxen  (EXP)
neomycin  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nitrates  (EXP)
nitrofen  (EXP)
nitrofurantoin  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleic acid  (ISO)
orciprenaline  (EXP)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylbutazone  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
prazosin  (EXP)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
sodium tungstate  (ISO)
sphingosine 1-phosphate  (ISO)
styrene  (ISO)
styrene oxide  (ISO)
sulfadimethoxine  (EXP)
sumatriptan  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
tranexamic acid  (ISO)
triadimefon  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (ISO)
animal organ morphogenesis  (IEA)
ascending aorta morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrial septum primum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
axon guidance  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cardiac epithelial to mesenchymal transition  (ISO,ISS)
cardiac muscle cell proliferation  (ISO,ISS)
cardiac right ventricle morphogenesis  (ISO)
cardioblast differentiation  (ISO,ISS)
cartilage condensation  (ISO)
cell migration  (ISO,ISS)
cell morphogenesis  (ISO,ISS)
cell-cell junction organization  (ISO,ISS)
collagen fibril organization  (ISO,ISS)
cranial skeletal system development  (ISO)
digestive tract development  (IEP)
dopamine biosynthetic process  (ISO,ISS)
embryonic digestive tract development  (ISO,ISS)
embryonic limb morphogenesis  (ISO)
embryonic neurocranium morphogenesis  (IDA)
endocardial cushion fusion  (ISO)
endocardial cushion morphogenesis  (ISO)
epithelial cell differentiation  (ISO,ISS)
epithelial to mesenchymal transition  (ISO,ISS)
extracellular matrix organization  (ISO)
extrinsic apoptotic signaling pathway  (ISO,ISS)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
eye development  (ISO,ISS)
face morphogenesis  (ISO)
female pregnancy  (IEP)
frontal suture morphogenesis  (IEP)
glial cell migration  (ISO,ISS)
hair follicle development  (ISO,ISS)
hair follicle morphogenesis  (ISO,ISS)
heart development  (ISO,ISS)
heart morphogenesis  (ISO,ISS)
heart valve morphogenesis  (ISO)
hemopoiesis  (ISO,ISS)
hindbrain development  (IEP)
inner ear development  (IEP,ISO)
kidney development  (IEP,ISO)
lung development  (TAS)
male gonad development  (ISO)
membranous septum morphogenesis  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of cartilage development  (ISO)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (IMP,ISO,ISS)
negative regulation of epithelial cell proliferation  (ISO,ISS)
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of macrophage cytokine production  (ISO,ISS)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of release of sequestered calcium ion into cytosol  (IDA)
neural retina development  (ISO)
neural tube closure  (ISO)
neuron development  (ISO,ISS)
neuron fate commitment  (ISO)
neutrophil chemotaxis  (ISO,ISS)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
pancreas development  (IEP)
pericyte cell differentiation  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
positive regulation of activation-induced cell death of T cells  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of cardioblast differentiation  (ISO,ISS)
positive regulation of cell adhesion mediated by integrin  (ISO,ISS)
positive regulation of cell cycle  (ISO,ISS)
positive regulation of cell division  (IEA)
positive regulation of cell growth  (IEA,ISO,ISS)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA,ISO,ISS)
positive regulation of epithelial cell migration  (ISO,ISS)
positive regulation of epithelial to mesenchymal transition  (ISO,ISS)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of extracellular matrix disassembly  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heart contraction  (ISO,ISS)
positive regulation of immune response  (ISO,ISS)
positive regulation of integrin biosynthetic process  (ISO,ISS)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of neuron apoptotic process  (ISO,ISS)
positive regulation of Notch signaling pathway  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein secretion  (ISO,ISS)
positive regulation of SMAD protein signal transduction  (ISO,ISS)
positive regulation of stress-activated MAPK cascade  (ISO,ISS)
positive regulation of timing of catagen  (ISO,ISS)
pulmonary valve morphogenesis  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of apoptotic process  (ISO)
regulation of apoptotic process involved in outflow tract morphogenesis  (ISO)
regulation of cell growth  (TAS)
regulation of cell population proliferation  (IBA,IEA,ISO,ISS,TAS)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of extracellular matrix organization  (ISO)
regulation of timing of catagen  (ISO,ISS)
regulation of transforming growth factor beta2 production  (ISO,ISS)
response to cytokine  (IEP)
response to estradiol  (IEP)
response to estrogen  (IDA)
response to hypoxia  (IEA,ISO,ISS)
response to laminar fluid shear stress  (IEP)
response to organonitrogen compound  (IEP)
response to progesterone  (ISO,ISS)
response to retinoic acid  (IEP)
response to vitamin D  (IEP)
response to wounding  (ISO,ISS)
response to xenobiotic stimulus  (IEP)
salivary gland morphogenesis  (ISO,ISS)
secondary palate development  (ISO)
signal transduction  (ISS)
signaling  (ISO,ISS)
skeletal muscle tissue development  (IEP)
skeletal system development  (ISO)
somatic stem cell division  (ISO,ISS)
substantia propria of cornea development  (ISO)
system development  (IEA)
thyroid gland development  (IEP)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,ISO,ISS)
tube development  (IEA)
uterus development  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)
wound healing  (ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth. Adab K, etal., Orthod Craniofac Res. 2002 Nov;5(4):227-37.
2. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Alvarez J, etal., Development. 2002 Apr;129(8):1913-24.
3. Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Anjaneyulu M, etal., Exp Neurol. 2008 Jun;211(2):469-79. Epub 2008 Mar 2.
4. The effect of antibodies to TGF-beta1 and TGF-beta2 at a site of sciatic nerve repair. Atkins S, etal., J Peripher Nerv Syst. 2006 Dec;11(4):286-93.
5. Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients. Azuara D, etal., Inflamm Bowel Dis. 2013 Jan;19(1):165-73. doi: 10.1002/ibd.22994.
6. Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinoma. Bellone G, etal., Eur J Cancer. 2001 Jan;37(2):224-33.
7. TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Boyer AS and Runyan RB, Dev Dyn. 2001 Aug;221(4):454-9.
8. Expression of transforming growth factor beta isoforms and their roles in tendon healing. Chan KM, etal., Wound Repair Regen. 2008 May-Jun;16(3):399-407.
9. Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling. Close JL, etal., Development. 2005 Jul;132(13):3015-26.
10. Effects of high dose retinoic acid on TGF-beta2 expression during pancreatic organogenesis. Colakoglu N, etal., J Mol Histol. 2005 Sep;36(6-7):413-8. Epub 2006 Feb 15.
11. Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. de Andrade Sa ER, etal., Dev Dyn. 2003 Jul;227(3):450-7.
12. Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. Deten A, etal., Mol Cell Biochem. 2003 Sep;251(1-2):127-37.
13. Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Dhandapani KM, etal., Endocrinology. 2005 Jun;146(6):2749-59. Epub 2005 Mar 3.
14. The phosphodiesterase inhibitor, pentoxifylline, alters rat intestinal epithelial cell proliferation via changes in the expression of transforming growth factors. Diab-Assef M, etal., Scand J Gastroenterol. 2002 Feb;37(2):206-14.
15. Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Engle SJ, etal., Cancer Res. 1999 Jul 15;59(14):3379-86.
16. Microarray analysis of mechanical shear effects on flexor tendon cells. Fong KD, etal., Plast Reconstr Surg. 2005 Oct;116(5):1393-404; discussion 1405-6.
17. Inhibition of ALK5 signaling induces physeal dysplasia in rats. Frazier K, etal., Toxicol Pathol. 2007;35(2):284-95.
18. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Friess H, etal., Gastroenterology. 1993 Dec;105(6):1846-56. doi: 10.1016/0016-5085(93)91084-u.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
21. Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Hashimoto Y, etal., Mol Cell Biol. 2005 Nov;25(21):9304-17.
22. A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. Jamora C, etal., PLoS Biol. 2005 Jan;3(1):e11. Epub 2004 Dec 28.
23. Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles. Javelaud D and Mauviel A, Int J Biochem Cell Biol. 2004 Jul;36(7):1161-5.
24. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
25. DNA array analysis of the developing rat cerebellum: transforming growth factor-beta2 inhibits constitutively activated NF-kappaB in granule neurons. Kaltschmidt B and Kaltschmidt C, Mech Dev. 2001 Mar;101(1-2):11-9.
26. Divergent expression of liver transforming growth factor superfamily cytokines after successful portoenterostomy in biliary atresia. Kerola A, etal., Surgery. 2019 May;165(5):905-911. doi: 10.1016/j.surg.2018.12.003. Epub 2019 Jan 25.
27. Expression of TGFbeta family in the developing internal ear of rat embryos. Kim HJ, etal., J Korean Med Sci. 2006 Feb;21(1):136-42.
28. Chemoresponsiveness associated with canonical molecular changes in colorectal adenocarcinomas. Kim JC, etal., Anticancer Res. 2009 Aug;29(8):3115-23.
29. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
30. The effects of treatment with antibodies to transforming growth factor beta1 and beta2 following spinal cord damage in the adult rat. King VR, etal., Neuroscience. 2004;126(1):173-83.
31. Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Konrad L, etal., Apoptosis. 2006 May;11(5):739-48.
32. Transforming growth factor-beta2 mediates mesenchymal-epithelial interactions of testicular somatic cells. Konrad L, etal., Endocrinology 2000 Oct;141(10):3679-86.
33. Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland. Lamers ML, etal., Matrix Biol. 2007 Sep;26(7):572-82. Epub 2007 May 16.
34. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
35. Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. Lopez-Casillas F, etal., J Cell Biol. 1994 Feb;124(4):557-68.
36. Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats. Marks G, etal., Acta Cir Bras. 2006;21 Suppl 4:51-6.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Macrophage migration inhibitory factor suppresses transforming growth factor-beta2 secretion in cultured rat testicular peritubular cells. Muller R, etal., Reprod Fertil Dev. 2005;17(4):435-8.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis. Opperman LA, etal., Dev Dyn. 2000 Oct;219(2):237-47.
42. Cellular and molecular events associated with the bone-protecting activity of the noncalcemic vitamin D analog Ro-26-9228 in osteopenic rats. Peleg S, etal., Endocrinology. 2002 May;143(5):1625-36.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis. Plisov SY, etal., Development. 2001 Apr;128(7):1045-57.
46. Steady state levels of transforming growth factor-beta1 and -beta2 mRNA and protein expression are elevated in colonic tumors in vivo irrespective of dietary lipids intervention. Raju J, etal., Int J Cancer 2002 Aug 20;100(6):635-41.
47. Transforming growth factor-beta stimulates vascular endothelial growth factor production by folliculostellate pituitary cells. Renner U, etal., Endocrinology 2002 Oct;143(10):3759-65.
48. GOA pipeline RGD automated data pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer. Schlingensiepen KH, etal., Cancer Sci. 2011 Jun;102(6):1193-200. doi: 10.1111/j.1349-7006.2011.01917.x. Epub 2011 Mar 30.
52. Transforming growth factor beta1 and beta2 (TGFbeta2 / TGFbeta2) profile changes in previously irradiated free flap beds. Schultze-Mosgau S, etal., Head Neck. 2002 Jan;24(1):33-41.
53. Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Sharma K, etal., Am J Physiol Renal Physiol 2003 Dec;285(6):F1258-70.
54. TGF-beta expression during rat pregnancy and activity on decidual cell survival. Shooner C, etal., Reprod Biol Endocrinol. 2005 May 31;3:20.
55. Downregulation of transforming growth factor-beta2 facilitates inflammation in the central nervous system by reciprocal astrocyte/microglia interactions. Siglienti I, etal., J Neuropathol Exp Neurol. 2007 Jan;66(1):47-56.
56. Immunolocalization of TGF-beta2 in the rat thymus during late stages of prenatal development. Sonmez MF, etal., Acta Histochem. 2008 Jun 11.
57. Transforming growth factor beta2 is released from PC12 cells via the regulated pathway of secretion. Specht H, etal., Mol Cell Neurosci. 2003 Jan;22(1):75-86.
58. Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages. Stoll G, etal., Brain Pathol. 2004 Jan;14(1):51-8.
59. Expression of the TGF-beta family of ligands is developmentally regulated in skeletal muscle of neonatal rats. Suryawan A, etal., Pediatr Res. 2006 Feb;59(2):175-9.
60. The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat. Truettner JS, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):124-34.
61. The potential role of TGFbeta1, TGFbeta2 and TGFbeta3 protein expression in colorectal carcinomas. Correlation with classic histopathologic factors and patient survival. Tsamandas AC, etal., Strahlenther Onkol. 2004 Apr;180(4):201-8.
62. Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin. Wagner W and Wehrmann M, J Cell Mol Med. 2007 Nov-Dec;11(6):1342-51.
63. Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. Wang J, etal., J Biol Chem 1995 Feb 10;270(6):2722-8.
64. Quantitative monitoring of the mRNA expression pattern of the TGF-beta-isoforms (beta 1, beta 2, beta 3) during transdifferentiation of hepatic stellate cells using a newly developed real-time SYBR Green PCR. Wickert L, etal., Biochem Biophys Res Commun 2002 Jul 12;295(2):330-5.
65. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
66. Antigen presentation by vaginal cells: role of TGFbeta as a mediator of estradiol inhibition of antigen presentation. Wira CR, etal., Endocrinology 2002 Aug;143(8):2872-9.
67. Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91.
68. Transforming growth factor-beta(s) and their receptors in aging rat prostate. Zhao H, etal., Biochem Biophys Res Commun. 2002 Jun 7;294(2):464-9.
Additional References at PubMed
PMID:1333888   PMID:2119582   PMID:7852346   PMID:8133057   PMID:8164195   PMID:8167376   PMID:8206089   PMID:8486763   PMID:8509457   PMID:8565825   PMID:9217007   PMID:10092230  
PMID:10433821   PMID:10899565   PMID:11157754   PMID:11390347   PMID:11784073   PMID:12393102   PMID:12411310   PMID:12477932   PMID:12646048   PMID:12733949   PMID:12773577   PMID:14707111  
PMID:14717916   PMID:14960316   PMID:15122060   PMID:15375625   PMID:15528466   PMID:15531369   PMID:15744664   PMID:15896309   PMID:15955085   PMID:16034134   PMID:16257223   PMID:16891397  
PMID:16943770   PMID:17068209   PMID:17192487   PMID:17217916   PMID:17401695   PMID:17516499   PMID:17960115   PMID:17999987   PMID:18039789   PMID:18040277   PMID:18049952   PMID:18080134  
PMID:18223299   PMID:18358889   PMID:18378961   PMID:18391505   PMID:18431253   PMID:18498113   PMID:18505915   PMID:18597229   PMID:18790002   PMID:19161227   PMID:19200954   PMID:19342245  
PMID:19434765   PMID:19457129   PMID:19567205   PMID:19656380   PMID:20573232   PMID:20653032   PMID:20875417   PMID:21266196   PMID:21780244   PMID:21865583   PMID:21984612   PMID:24006456  
PMID:24263861   PMID:24838936   PMID:25217442   PMID:25448845   PMID:25639665   PMID:26637070   PMID:26957638   PMID:27049496   PMID:27855367   PMID:28361415   PMID:28694529   PMID:28977001  
PMID:31835434   PMID:34246804   PMID:35028925  


Genomics

Comparative Map Data
Tgfb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21398,160,075 - 98,261,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1398,160,087 - 98,261,405 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13100,678,931 - 100,778,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013102,066,560 - 102,165,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01399,261,239 - 99,360,947 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
TGFB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381218,345,336 - 218,444,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1218,345,336 - 218,444,619 (+)EnsemblGRCh38hg38GRCh38
GRCh371218,518,678 - 218,617,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,586,491 - 216,681,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 341214,908,262 - 215,003,365NCBI
Celera1191,735,848 - 191,834,418 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1189,186,842 - 189,286,057 (+)NCBIHuRef
CHM1_11219,791,024 - 219,890,484 (+)NCBICHM1_1
T2T-CHM13v2.01217,580,100 - 217,679,392 (+)NCBIT2T-CHM13v2.0
Tgfb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,354,984 - 186,441,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,354,989 - 186,438,186 (-)EnsemblGRCm39 Ensembl
GRCm381186,622,787 - 186,709,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,622,792 - 186,705,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,447,065 - 188,529,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361188,324,430 - 188,406,777 (-)NCBIMGSCv36mm8
Celera1193,563,609 - 193,649,724 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.95NCBI
Tgfb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955406172,814 - 249,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955406174,949 - 249,248 (-)NCBIChiLan1.0ChiLan1.0
TGFB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1130,925,280 - 31,023,656 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01193,907,398 - 194,005,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11198,758,718 - 198,856,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1198,758,751 - 198,859,041 (+)Ensemblpanpan1.1panPan2
TGFB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13813,430,832 - 13,511,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3813,429,148 - 13,510,242 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3813,472,728 - 13,552,654 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03813,464,207 - 13,544,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3813,464,807 - 13,545,256 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13813,473,487 - 13,553,481 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03813,819,811 - 13,899,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03814,128,921 - 14,209,014 (+)NCBIUU_Cfam_GSD_1.0
Tgfb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934458,300,141 - 58,383,975 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936628308,691 - 394,007 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936628310,720 - 394,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl108,305,539 - 8,390,341 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1108,306,136 - 8,435,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21010,353,794 - 10,476,143 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16NCBI
TGFB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12511,163,651 - 11,259,868 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2511,163,100 - 11,258,470 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605511,574,533 - 11,672,282 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248352,363,139 - 2,437,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248352,363,059 - 2,436,536 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfb2
485 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:89
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000003313
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH135195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,260,777 - 98,260,958 (+)MAPPERmRatBN7.2
Rnor_6.013105,140,324 - 105,140,504NCBIRnor6.0
Rnor_5.013109,791,120 - 109,791,300UniSTSRnor5.0
RGSC_v3.413102,818,312 - 102,818,492UniSTSRGSC3.4
Celera1397,768,970 - 97,769,150UniSTS
RH 3.4 Map13666.0UniSTS
Cytogenetic Map13q26UniSTS
G39607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,231,469 - 98,231,772 (+)MAPPERmRatBN7.2
Rnor_6.013105,111,026 - 105,111,328NCBIRnor6.0
Rnor_5.013109,761,807 - 109,762,109UniSTSRnor5.0
RGSC_v3.413102,788,984 - 102,789,286UniSTSRGSC3.4
Celera1397,739,652 - 97,739,954UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:224971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,261,133 - 98,261,281 (+)MAPPERmRatBN7.2
Rnor_6.013105,140,680 - 105,140,827NCBIRnor6.0
Rnor_5.013109,791,476 - 109,791,623UniSTSRnor5.0
RGSC_v3.413102,818,668 - 102,818,815UniSTSRGSC3.4
Celera1397,769,326 - 97,769,473UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 6 6 6 4 6 45 10 31 11 4
Low 3 15 50 34 19 34 4 5 29 25 8 4
Below cutoff 1 1 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000003313   ⟹   ENSRNOP00000003313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1398,160,087 - 98,261,191 (-)Ensembl
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087023   ⟹   ENSRNOP00000074059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13105,042,274 - 105,140,473 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111585   ⟹   ENSRNOP00000086888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1398,259,354 - 98,261,405 (-)Ensembl
RefSeq Acc Id: NM_031131   ⟹   NP_112393
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21398,161,488 - 98,261,234 (-)NCBI
Rnor_6.013105,041,052 - 105,140,780 (-)NCBI
Rnor_5.013109,679,866 - 109,792,609 (-)NCBI
RGSC_v3.413102,718,703 - 102,818,768 (-)RGD
Celera1397,669,691 - 97,769,426 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250448   ⟹   XP_006250510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21398,160,075 - 98,261,771 (-)NCBI
Rnor_6.013105,039,639 - 105,142,010 (-)NCBI
Rnor_5.013109,679,866 - 109,792,609 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112393   ⟸   NM_031131
- Peptide Label: precursor
- UniProtKB: Q9WUQ8 (UniProtKB/Swiss-Prot),   Q9R2B8 (UniProtKB/Swiss-Prot),   Q9R298 (UniProtKB/Swiss-Prot),   Q9R281 (UniProtKB/Swiss-Prot),   Q9QW26 (UniProtKB/Swiss-Prot),   Q63574 (UniProtKB/Swiss-Prot),   Q07257 (UniProtKB/Swiss-Prot),   G3V6B1 (UniProtKB/TrEMBL),   A6JGS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250510   ⟸   XM_006250448
- Peptide Label: isoform X1
- UniProtKB: Q9WUQ8 (UniProtKB/Swiss-Prot),   Q9R2B8 (UniProtKB/Swiss-Prot),   Q9R298 (UniProtKB/Swiss-Prot),   Q9R281 (UniProtKB/Swiss-Prot),   Q9QW26 (UniProtKB/Swiss-Prot),   Q63574 (UniProtKB/Swiss-Prot),   Q07257 (UniProtKB/Swiss-Prot),   A6JGS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074059   ⟸   ENSRNOT00000087023
RefSeq Acc Id: ENSRNOP00000003313   ⟸   ENSRNOT00000003313
RefSeq Acc Id: ENSRNOP00000086888   ⟸   ENSRNOT00000111585
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07257-F1-model_v2 AlphaFold Q07257 1-442 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699097
Promoter ID:EPDNEW_R9622
Type:multiple initiation site
Name:Tgfb2_1
Description:transforming growth factor, beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013105,140,964 - 105,141,024EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70491 AgrOrtholog
BioCyc Gene G2FUF-16959 BioCyc
Ensembl Genes ENSRNOG00000002418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003313 ENTREZGENE
  ENSRNOT00000003313.6 UniProtKB/TrEMBL
  ENSRNOT00000111585.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81809 UniProtKB/Swiss-Prot
NCBI Gene 81809 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFORMING GROWTH FACTOR BETA-2 PROPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfb2 PhenoGen
PIRSF TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TGFBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFBETA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002418 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JGS5 ENTREZGENE, UniProtKB/TrEMBL
  A6JGS6 ENTREZGENE, UniProtKB/TrEMBL
  G3V6B1 ENTREZGENE, UniProtKB/TrEMBL
  Q07257 ENTREZGENE
  Q496Y8_RAT UniProtKB/TrEMBL
  Q63574 ENTREZGENE
  Q9QW26 ENTREZGENE
  Q9R281 ENTREZGENE
  Q9R298 ENTREZGENE
  Q9R2B8 ENTREZGENE
  Q9WUQ8 ENTREZGENE
  TGFB2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63574 UniProtKB/Swiss-Prot
  Q9QW26 UniProtKB/Swiss-Prot
  Q9R281 UniProtKB/Swiss-Prot
  Q9R298 UniProtKB/Swiss-Prot
  Q9R2B8 UniProtKB/Swiss-Prot
  Q9WUQ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Tgfb2  transforming growth factor, beta 2      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Tgfb2  transforming growth factor, beta 2      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression lacking in young rat prostates but present in both the stroma and epithelium of aging prostates 70812
gene_process stimulates proliferation of fetal lung epithelial cells 70317
gene_process stimulates proliferation of fetal lung epithelial cells 70812
gene_process stimulates cell growth 70317
gene_process stimulates cell growth 70812
gene_process stimulates lactotroph cell growth possibly by enhancing prolactin secretion through increased number of lactotroph cells and stimulates vascular endothelial growth factor (Vegf) in pituitary cells 625677
gene_process may modulate growth and function of endocrine pituitary cells including intrapituitary vascular permeablility, intergrity and angiogenesis 625677
gene_product member of Tgf beta superfamily 625677