Tgfb2 (transforming growth factor, beta 2) - Rat Genome Database

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Gene: Tgfb2 (transforming growth factor, beta 2) Rattus norvegicus
Analyze
Symbol: Tgfb2
Name: transforming growth factor, beta 2
RGD ID: 70491
Description: Exhibits identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of release of sequestered calcium ion into cytosol; and regulation of apoptotic process. Localizes to several cellular components, including basement membrane; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: TGF beta 2 protein; TGF-B2; TGF-beta-2; transforming growth factor beta-2; transforming growth factor beta-2 proprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21398,160,075 - 98,261,771 (-)NCBI
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
astemizole  (EXP)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brevetoxin B  (ISO)
bromochloroacetic acid  (EXP)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbaryl  (ISO)
carbofuran  (EXP)
chloroform  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
diclofenac  (ISO)
diethyl malate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dobutamine  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
enalapril  (EXP)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
ethanol  (ISO)
fenamic acid  (EXP)
fenamidone  (ISO)
flusilazole  (ISO)
fructose  (ISO)
furan  (EXP)
furosemide  (EXP)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycine betaine  (EXP)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (EXP)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leptomycin B  (ISO)
linuron  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
metaproterenol  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
minocycline  (ISO)
mitoxantrone  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naproxen  (EXP)
neomycin  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nitrates  (EXP)
nitrofurantoin  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleic acid  (ISO)
orciprenaline  (EXP)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentane-2,3-dione  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylbutazone  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
prazosin  (EXP)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium tungstate  (ISO)
sphingosine 1-phosphate  (ISO)
styrene  (ISO)
styrene oxide  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
tranexamic acid  (ISO)
triadimefon  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO,ISS)
aging  (IEP)
ascending aorta morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrial septum primum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
axon guidance  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (IBA)
cardiac epithelial to mesenchymal transition  (ISO,ISS)
cardiac muscle cell proliferation  (ISO,ISS)
cardiac right ventricle morphogenesis  (ISO)
cardioblast differentiation  (ISO,ISS)
cartilage condensation  (ISO)
cell death  (ISO,ISS)
cell migration  (ISO,ISS)
cell morphogenesis  (ISO,ISS)
cell-cell junction organization  (ISO,ISS)
collagen fibril organization  (ISO,ISS)
cranial skeletal system development  (ISO)
digestive tract development  (IEP)
dopamine biosynthetic process  (ISO,ISS)
embryonic digestive tract development  (ISO,ISS)
embryonic limb morphogenesis  (ISO)
embryonic neurocranium morphogenesis  (IDA)
endocardial cushion fusion  (ISO)
endocardial cushion morphogenesis  (ISO)
epithelial to mesenchymal transition  (ISO,ISS)
extracellular matrix organization  (ISO)
extrinsic apoptotic signaling pathway  (ISO,ISS)
eye development  (ISO,ISS)
face morphogenesis  (ISO)
female pregnancy  (IEP)
frontal suture morphogenesis  (IEP)
glial cell migration  (ISO,ISS)
hair follicle development  (ISO,ISS)
hair follicle morphogenesis  (ISO,ISS)
heart development  (ISO,ISS)
heart morphogenesis  (ISO,ISS)
heart valve morphogenesis  (ISO)
hemopoiesis  (ISO,ISS)
hindbrain development  (IEP)
inner ear development  (IEP,ISO)
kidney development  (IEP,ISO)
lung development  (TAS)
male gonad development  (ISO)
membranous septum morphogenesis  (ISO)
negative regulation of alkaline phosphatase activity  (ISO,ISS)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of cartilage development  (ISO)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (IMP,ISO,ISS)
negative regulation of epithelial cell proliferation  (ISO,ISS)
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of immune response  (IDA)
negative regulation of macrophage cytokine production  (ISO,ISS)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of release of sequestered calcium ion into cytosol  (IDA)
neural retina development  (ISO)
neural tube closure  (ISO)
neuron development  (ISO,ISS)
neuron fate commitment  (ISO)
neutrophil chemotaxis  (ISO,ISS)
outflow tract septum morphogenesis  (ISO)
pancreas development  (IEP)
pathway-restricted SMAD protein phosphorylation  (ISO,ISS)
pericyte cell differentiation  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
positive regulation of activation-induced cell death of T cells  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cardioblast differentiation  (ISO,ISS)
positive regulation of cell adhesion mediated by integrin  (ISO,ISS)
positive regulation of cell cycle  (ISO,ISS)
positive regulation of cell division  (IEA)
positive regulation of cell growth  (ISO,ISS)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA,ISO,ISS)
positive regulation of epithelial cell migration  (ISO,ISS)
positive regulation of epithelial to mesenchymal transition  (ISO,ISS)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of extracellular matrix disassembly  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of GTP binding  (ISO)
positive regulation of heart contraction  (ISO,ISS)
positive regulation of immune response  (ISO,ISS)
positive regulation of integrin biosynthetic process  (ISO,ISS)
positive regulation of neuron apoptotic process  (ISO,ISS)
positive regulation of Notch signaling pathway  (IEA,ISO)
positive regulation of ossification  (ISO,ISS)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO,ISS)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA,ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein secretion  (ISO,ISS)
positive regulation of stress-activated MAPK cascade  (ISO,ISS)
positive regulation of timing of catagen  (ISO,ISS)
protein phosphorylation  (ISO,ISS)
pulmonary valve morphogenesis  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of apoptotic process  (ISO)
regulation of apoptotic process involved in outflow tract morphogenesis  (ISO)
regulation of cell cycle  (ISO,ISS)
regulation of cell growth  (TAS)
regulation of cell population proliferation  (IBA,TAS)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of extracellular matrix organization  (ISO)
regulation of timing of catagen  (ISO,ISS)
regulation of transforming growth factor beta2 production  (ISO,ISS)
response to cold  (IEP)
response to cytokine  (IEP)
response to drug  (IEP,ISO,ISS)
response to estradiol  (IEP)
response to estrogen  (IDA)
response to hypoxia  (IEA,ISO,ISS)
response to laminar fluid shear stress  (IEP)
response to organonitrogen compound  (IEP)
response to progesterone  (ISO,ISS)
response to radiation  (IEP)
response to retinoic acid  (IEP)
response to vitamin D  (IEP)
response to wounding  (ISO,ISS)
salivary gland morphogenesis  (ISO,ISS)
secondary palate development  (ISO)
signal transduction  (ISS)
skeletal muscle tissue development  (IEP)
skeletal system development  (ISO)
SMAD protein signal transduction  (IBA,ISO,ISS)
somatic stem cell division  (ISO,ISS)
substantia propria of cornea development  (ISO)
thyroid gland development  (IEP)
transforming growth factor beta receptor signaling pathway  (IBA,ISO,ISS)
uterus development  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)
wound healing  (IEP,IMP,ISS)

Cellular Component

References

References - curated
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2. Alvarez J, etal., Development. 2002 Apr;129(8):1913-24.
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5. Azuara D, etal., Inflamm Bowel Dis. 2013 Jan;19(1):165-73. doi: 10.1002/ibd.22994.
6. Bellone G, etal., Eur J Cancer. 2001 Jan;37(2):224-33.
7. Boyer AS and Runyan RB, Dev Dyn. 2001 Aug;221(4):454-9.
8. Chan KM, etal., Wound Repair Regen. 2008 May-Jun;16(3):399-407.
9. Close JL, etal., Development. 2005 Jul;132(13):3015-26.
10. Colakoglu N, etal., J Mol Histol. 2005 Sep;36(6-7):413-8. Epub 2006 Feb 15.
11. de Andrade Sa ER, etal., Dev Dyn. 2003 Jul;227(3):450-7.
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13. Dhandapani KM, etal., Endocrinology. 2005 Jun;146(6):2749-59. Epub 2005 Mar 3.
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15. Engle SJ, etal., Cancer Res. 1999 Jul 15;59(14):3379-86.
16. Fong KD, etal., Plast Reconstr Surg. 2005 Oct;116(5):1393-404; discussion 1405-6.
17. Frazier K, etal., Toxicol Pathol. 2007;35(2):284-95.
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19. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
20. Hashimoto Y, etal., Mol Cell Biol. 2005 Nov;25(21):9304-17.
21. Jamora C, etal., PLoS Biol. 2005 Jan;3(1):e11. Epub 2004 Dec 28.
22. Javelaud D and Mauviel A, Int J Biochem Cell Biol. 2004 Jul;36(7):1161-5.
23. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
24. Kaltschmidt B and Kaltschmidt C, Mech Dev. 2001 Mar;101(1-2):11-9.
25. Kerola A, etal., Surgery. 2019 May;165(5):905-911. doi: 10.1016/j.surg.2018.12.003. Epub 2019 Jan 25.
26. Kim HJ, etal., J Korean Med Sci. 2006 Feb;21(1):136-42.
27. Kim JC, etal., Anticancer Res. 2009 Aug;29(8):3115-23.
28. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
29. King VR, etal., Neuroscience. 2004;126(1):173-83.
30. Konrad L, etal., Apoptosis. 2006 May;11(5):739-48.
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32. Lamers ML, etal., Matrix Biol. 2007 Sep;26(7):572-82. Epub 2007 May 16.
33. Lopez-Casillas F, etal., J Cell Biol. 1994 Feb;124(4):557-68.
34. Marks G, etal., Acta Cir Bras. 2006;21 Suppl 4:51-6.
35. MGD data from the GO Consortium
36. Muller R, etal., Reprod Fertil Dev. 2005;17(4):435-8.
37. NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. OMIM Disease Annotation Pipeline
39. Opperman LA, etal., Dev Dyn. 2000 Oct;219(2):237-47.
40. Peleg S, etal., Endocrinology. 2002 May;143(5):1625-36.
41. Pipeline to import KEGG annotations from KEGG into RGD
42. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. Plisov SY, etal., Development. 2001 Apr;128(7):1045-57.
44. Raju J, etal., Int J Cancer 2002 Aug 20;100(6):635-41.
45. Renner U, etal., Endocrinology 2002 Oct;143(10):3759-65.
46. RGD automated data pipeline
47. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. RGD automated import pipeline for gene-chemical interactions
49. Schultze-Mosgau S, etal., Head Neck. 2002 Jan;24(1):33-41.
50. Sharma K, etal., Am J Physiol Renal Physiol 2003 Dec;285(6):F1258-70.
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Additional References at PubMed
PMID:1333888   PMID:2119582   PMID:7852346   PMID:8133057   PMID:8164195   PMID:8167376   PMID:8206089   PMID:8486763   PMID:8509457   PMID:8565825   PMID:9217007   PMID:10092230  
PMID:10433821   PMID:10899565   PMID:11157754   PMID:11390347   PMID:11784073   PMID:12393102   PMID:12411310   PMID:12477932   PMID:12646048   PMID:12733949   PMID:12773577   PMID:14707111  
PMID:14717916   PMID:14960316   PMID:15122060   PMID:15375625   PMID:15528466   PMID:15531369   PMID:15744664   PMID:15896309   PMID:15955085   PMID:16034134   PMID:16257223   PMID:16891397  
PMID:16943770   PMID:17068209   PMID:17192487   PMID:17217916   PMID:17401695   PMID:17516499   PMID:17960115   PMID:17999987   PMID:18039789   PMID:18040277   PMID:18049952   PMID:18080134  
PMID:18223299   PMID:18358889   PMID:18378961   PMID:18391505   PMID:18431253   PMID:18498113   PMID:18505915   PMID:18597229   PMID:18790002   PMID:19161227   PMID:19200954   PMID:19342245  
PMID:19434765   PMID:19457129   PMID:19567205   PMID:19656380   PMID:20573232   PMID:20653032   PMID:20875417   PMID:21266196   PMID:21780244   PMID:21865583   PMID:21984612   PMID:24006456  
PMID:24263861   PMID:24838936   PMID:25217442   PMID:25448845   PMID:25639665   PMID:26637070   PMID:26957638   PMID:27049496   PMID:27855367   PMID:28361415   PMID:28694529   PMID:28977001  
PMID:31835434  


Genomics

Comparative Map Data
Tgfb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21398,160,075 - 98,261,771 (-)NCBI
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
TGFB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1218,345,336 - 218,444,619 (+)EnsemblGRCh38hg38GRCh38
GRCh381218,345,336 - 218,444,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371218,518,678 - 218,617,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,586,491 - 216,681,596 (+)NCBINCBI36hg18NCBI36
Build 341214,908,262 - 215,003,365NCBI
Celera1191,735,848 - 191,834,418 (+)NCBI
Cytogenetic Map1q41NCBI
HuRef1189,186,842 - 189,286,057 (+)NCBIHuRef
CHM1_11219,791,024 - 219,890,484 (+)NCBICHM1_1
Tgfb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,354,984 - 186,441,504 (-)NCBIGRCm39mm39
GRCm39 Ensembl1186,354,989 - 186,438,186 (-)Ensembl
GRCm381186,622,787 - 186,709,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,622,792 - 186,705,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,447,065 - 188,529,871 (-)NCBIGRCm37mm9NCBIm37
MGSCv361188,324,430 - 188,406,777 (-)NCBImm8
Celera1193,563,609 - 193,649,724 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.95NCBI
Tgfb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955406172,814 - 249,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955406174,949 - 249,248 (-)NCBIChiLan1.0ChiLan1.0
TGFB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11198,758,718 - 198,856,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1198,758,751 - 198,859,041 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01193,907,398 - 194,005,800 (+)NCBIMhudiblu_PPA_v0panPan3
TGFB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13813,430,832 - 13,511,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3813,429,148 - 13,510,242 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3813,472,728 - 13,552,654 (+)NCBI
ROS_Cfam_1.03813,464,207 - 13,544,357 (+)NCBI
UMICH_Zoey_3.13813,473,487 - 13,553,481 (+)NCBI
UNSW_CanFamBas_1.03813,819,811 - 13,899,809 (+)NCBI
UU_Cfam_GSD_1.03814,128,921 - 14,209,014 (+)NCBI
Tgfb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934458,300,141 - 58,383,975 (-)NCBI
SpeTri2.0NW_004936628310,720 - 394,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl108,305,424 - 8,405,771 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1108,306,136 - 8,435,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21010,353,794 - 10,476,143 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16NCBI
TGFB2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12511,163,651 - 11,259,868 (-)NCBI
ChlSab1.1 Ensembl2511,163,100 - 11,258,470 (-)Ensembl
Vero_WHO_p1.0NW_02366605511,574,533 - 11,672,282 (-)NCBI
Tgfb2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248352,363,059 - 2,436,536 (+)NCBI

Position Markers
RH135195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,260,777 - 98,260,958 (+)MAPPER
Rnor_6.013105,140,324 - 105,140,504NCBIRnor6.0
Rnor_5.013109,791,120 - 109,791,300UniSTSRnor5.0
RGSC_v3.413102,818,312 - 102,818,492UniSTSRGSC3.4
Celera1397,768,970 - 97,769,150UniSTS
RH 3.4 Map13666.0UniSTS
Cytogenetic Map13q26UniSTS
G39607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,231,469 - 98,231,772 (+)MAPPER
Rnor_6.013105,111,026 - 105,111,328NCBIRnor6.0
Rnor_5.013109,761,807 - 109,762,109UniSTSRnor5.0
RGSC_v3.413102,788,984 - 102,789,286UniSTSRGSC3.4
Celera1397,739,652 - 97,739,954UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:224971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,261,133 - 98,261,281 (+)MAPPER
Rnor_6.013105,140,680 - 105,140,827NCBIRnor6.0
Rnor_5.013109,791,476 - 109,791,623UniSTSRnor5.0
RGSC_v3.413102,818,668 - 102,818,815UniSTSRGSC3.4
Celera1397,769,326 - 97,769,473UniSTS
Cytogenetic Map13q26UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:89
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000003313
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 6 6 6 4 6 45 10 31 11 4
Low 3 15 50 34 19 34 4 5 29 25 8 4
Below cutoff 1 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003313   ⟹   ENSRNOP00000003313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087023   ⟹   ENSRNOP00000074059
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13105,042,274 - 105,140,473 (-)Ensembl
RefSeq Acc Id: NM_031131   ⟹   NP_112393
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21398,161,488 - 98,261,234 (-)NCBI
Rnor_6.013105,041,052 - 105,140,780 (-)NCBI
Rnor_5.013109,679,866 - 109,792,609 (-)NCBI
RGSC_v3.413102,718,703 - 102,818,768 (-)RGD
Celera1397,669,691 - 97,769,426 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250448   ⟹   XP_006250510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21398,160,075 - 98,261,771 (-)NCBI
Rnor_6.013105,039,639 - 105,142,010 (-)NCBI
Rnor_5.013109,679,866 - 109,792,609 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112393   ⟸   NM_031131
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006250510   ⟸   XM_006250448
- Peptide Label: isoform X1
- UniProtKB: Q07257 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074059   ⟸   ENSRNOT00000087023
RefSeq Acc Id: ENSRNOP00000003313   ⟸   ENSRNOT00000003313
Protein Domains
TGF_BETA_2   TGFb_propeptide

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699097
Promoter ID:EPDNEW_R9622
Type:multiple initiation site
Name:Tgfb2_1
Description:transforming growth factor, beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013105,140,964 - 105,141,024EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70491 AgrOrtholog
Ensembl Genes ENSRNOG00000002418 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003313 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000074059 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003313 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000087023 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81809 UniProtKB/Swiss-Prot
NCBI Gene 81809 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfb2 PhenoGen
PIRSF TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TGFBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFBETA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V6B1_RAT UniProtKB/TrEMBL
  Q07257 ENTREZGENE
  Q496Y8_RAT UniProtKB/TrEMBL
  TGFB2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63574 UniProtKB/Swiss-Prot
  Q9QW26 UniProtKB/Swiss-Prot
  Q9R281 UniProtKB/Swiss-Prot
  Q9R298 UniProtKB/Swiss-Prot
  Q9R2B8 UniProtKB/Swiss-Prot
  Q9WUQ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Tgfb2  transforming growth factor, beta 2      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Tgfb2  transforming growth factor, beta 2      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression lacking in young rat prostates but present in both the stroma and epithelium of aging prostates 70812
gene_process stimulates proliferation of fetal lung epithelial cells 70317
gene_process stimulates proliferation of fetal lung epithelial cells 70812
gene_process stimulates cell growth 70317
gene_process stimulates cell growth 70812
gene_process stimulates lactotroph cell growth possibly by enhancing prolactin secretion through increased number of lactotroph cells and stimulates vascular endothelial growth factor (Vegf) in pituitary cells 625677
gene_process may modulate growth and function of endocrine pituitary cells including intrapituitary vascular permeablility, intergrity and angiogenesis 625677
gene_product member of Tgf beta superfamily 625677