CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | carbotricyclic compound |
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Accession: | CHEBI:38032
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browse the term
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Definition: | A carbopolyclic compound comprising of three carbocyclic rings. |
Synonyms: | related_synonym: | carbotricyclic compounds |
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Ephx1 |
epoxide hydrolase 1 |
increases metabolic processing |
ISO |
EPHX1 protein mutant form results in increased metabolism of 9,10-epoxy-9,10-dihydrophenanthrene |
CTD |
PMID:26838043 |
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NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Abca13 |
ATP binding cassette subfamily A member 13 |
affects response to substance |
ISO |
ABCA13 gene SNP affects the susceptibility to Colchicine |
CTD |
PMID:25622337 |
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NCBI chr14:83,873,397...84,376,138
Ensembl chr14:83,873,940...84,375,075
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Abcb11 |
ATP binding cassette subfamily B member 11 |
affects localization |
EXP |
Colchicine affects the localization of ABCB11 protein |
CTD |
PMID:12702492 PMID:15304119 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a |
ATP binding cassette subfamily B member 1A |
affects transport increases export increases expression multiple interactions decreases response to substance |
ISO |
ABCB1 protein affects the transport of Colchicine ABCB1 protein results in increased export of Colchicine Colchicine results in increased expression of ABCB1; Colchicine results in increased expression of ABCB1 mRNA [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form] ABCB1 protein results in decreased susceptibility to Colchicine |
CTD |
PMID:7905786 PMID:11792417 PMID:12711602 PMID:15112361 PMID:15342794 PMID:15725475 PMID:16007523 PMID:24759273 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases response to substance |
ISO |
ABCC1 protein results in decreased susceptibility to Colchicine |
CTD |
PMID:12067707 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
EXP |
[Colchicine co-treated with JTE 013] inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein] |
CTD |
PMID:31300867 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3 |
ATP binding cassette subfamily C member 3 |
affects localization |
EXP |
Colchicine affects the localization of ABCC3 protein |
CTD |
PMID:12702492 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Acetaminophen results in increased expression of ABCC4 protein] |
CTD |
PMID:18468992 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Ace |
angiotensin I converting enzyme |
multiple interactions decreases activity decreases expression |
EXP |
carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Quercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein]; resveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein] |
CTD |
PMID:17135773 PMID:17652827 PMID:18980205 PMID:18992766 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2 |
angiotensin converting enzyme 2 |
decreases expression |
EXP ISO |
Colchicine results in decreased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Ache |
acetylcholinesterase |
increases activity multiple interactions |
ISO |
Colchicine results in increased activity of ACHE protein amyloid beta-protein (25-35) inhibits the reaction [Colchicine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of ACHE protein] |
CTD |
PMID:33617922 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP ISO |
Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:14726149 PMID:22446813 PMID:37573684 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ahr |
aryl hydrocarbon receptor |
decreases activity |
ISO EXP |
Colchicine results in decreased activity of AHR protein |
CTD |
PMID:16611024 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Aif1 |
allograft inflammatory factor 1 |
decreases expression |
EXP |
Colchicine results in decreased expression of AIF1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Ak1 |
adenylate kinase 1 |
decreases expression |
EXP |
Colchicine results in decreased expression of AK1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:38348705 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb |
albumin |
affects expression multiple interactions |
ISO EXP |
Colchicine affects the expression of ALB protein Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein] |
CTD |
PMID:8574231 PMID:23146695 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein] |
CTD |
PMID:37573684 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Apln |
apelin |
decreases expression |
EXP |
Colchicine results in decreased expression of APLN mRNA |
CTD |
PMID:20624997 |
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NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391
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Arg1 |
arginase 1 |
multiple interactions |
EXP |
Colchicine promotes the reaction [Uric Acid results in increased expression of ARG1 protein] |
CTD |
PMID:33894285 |
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NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Atxn1 |
ataxin 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of ATXN1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
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Aurkb |
aurora kinase B |
increases expression |
ISO |
Colchicine results in increased expression of AURKB mRNA |
CTD |
PMID:21472861 |
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NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Avp |
arginine vasopressin |
decreases transport |
EXP |
Colchicine results in decreased transport of AVP protein |
CTD |
PMID:2453250 |
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NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Colchicine results in increased expression of BAX protein dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of BAX protein] |
CTD |
PMID:22342440 PMID:33617922 PMID:33684465 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
Colchicine inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] dihydroactinidiolide inhibits the reaction [Colchicine results in decreased expression of BCL2 protein] |
CTD |
PMID:22342440 PMID:22446813 PMID:33617922 PMID:33684465 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Colchicine] results in decreased expression of BCL2L1 protein |
CTD |
PMID:11749691 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bdnf |
brain-derived neurotrophic factor |
decreases transport |
EXP |
Colchicine results in decreased transport of BDNF protein |
CTD |
PMID:21310905 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Blm |
BLM RecQ like helicase |
decreases expression |
ISO |
Colchicine results in decreased expression of BLM mRNA |
CTD |
PMID:24211769 |
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NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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Btg1 |
BTG anti-proliferation factor 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of BTG1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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Btg2 |
BTG anti-proliferation factor 2 |
decreases expression |
ISO |
Colchicine results in decreased expression of BTG2 mRNA |
CTD |
PMID:24211769 |
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NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Btg3 |
BTG anti-proliferation factor 3 |
decreases expression |
ISO |
Colchicine results in decreased expression of BTG3 mRNA |
CTD |
PMID:24211769 |
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NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
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C1qb |
complement C1q B chain |
increases expression |
EXP |
Colchicine results in increased expression of C1QB mRNA |
CTD |
PMID:7870303 |
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NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
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C3 |
complement C3 |
increases expression |
EXP |
Colchicine results in increased expression of C3 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Capn1 |
calpain 1 |
decreases expression |
EXP |
Colchicine results in decreased expression of CAPN1 mRNA |
CTD |
PMID:18255150 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Casp3 |
caspase 3 |
multiple interactions increases expression increases cleavage increases activity |
EXP ISO |
alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; Lithium inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; SB 216763 inhibits the reaction [Colchicine results in increased activity of CASP3 protein] Colchicine results in increased expression of CASP3 protein dihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of CASP3 protein] Colchicine results in increased cleavage of CASP3 protein Colchicine results in increased expression of CASP3 mRNA |
CTD |
PMID:12941380 PMID:15005753 PMID:16478524 PMID:18255150 PMID:19815060 PMID:20300959 PMID:20624997 PMID:22342440 PMID:33617922 PMID:33684465 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8 |
caspase 8 |
increases expression |
EXP |
Colchicine results in increased expression of CASP8 mRNA |
CTD |
PMID:18255150 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9 |
caspase 9 |
increases activity |
ISO |
Colchicine results in increased activity of CASP9 protein |
CTD |
PMID:22342440 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat |
catalase |
increases expression |
EXP |
Colchicine results in increased expression of CAT mRNA |
CTD |
PMID:18255150 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccdc51 |
coiled-coil domain containing 51 |
decreases expression |
ISO |
Colchicine results in decreased expression of CCDC51 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 8:109,722,595...109,741,478
Ensembl chr 8:109,722,557...109,741,472
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Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
EXP |
Colchicine results in increased expression of CCL2 mRNA |
CTD |
PMID:3119359 PMID:20624997 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnb1 |
cyclin B1 |
increases expression |
ISO |
Colchicine results in increased expression of CCNB1 mRNA; Colchicine results in increased expression of CCNB1 protein |
CTD |
PMID:21472861 PMID:27769712 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnd1 |
cyclin D1 |
increases expression |
ISO EXP |
Colchicine results in increased expression of CCND1 protein Colchicine results in increased expression of CCND1 mRNA |
CTD |
PMID:16495211 PMID:18255150 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne2 |
cyclin E2 |
decreases expression |
ISO |
Colchicine results in decreased expression of CCNE2 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cd14 |
CD14 molecule |
increases expression |
EXP |
Colchicine results in increased expression of CD14 mRNA |
CTD |
PMID:20624997 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd44 |
CD44 molecule |
increases expression |
EXP |
Colchicine results in increased expression of CD44 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cd59b |
CD59b molecule |
increases mutagenesis |
ISO |
Colchicine results in increased mutagenesis of CD59 protein |
CTD |
PMID:17045307 |
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NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
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Cdc25a |
cell division cycle 25A |
decreases expression |
ISO |
Colchicine results in decreased expression of CDC25A mRNA |
CTD |
PMID:24211769 |
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NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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Cdc6 |
cell division cycle 6 |
decreases expression |
ISO |
Colchicine results in decreased expression of CDC6 mRNA |
CTD |
PMID:24211769 |
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NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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Cdh1 |
cadherin 1 |
affects activity |
ISO |
Colchicine affects the activity of CDH1 protein |
CTD |
PMID:10413674 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk2 |
cyclin dependent kinase 2 |
increases expression |
EXP |
Colchicine results in increased expression of CDK2 mRNA |
CTD |
PMID:18255150 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk5 |
cyclin-dependent kinase 5 |
increases expression multiple interactions |
EXP |
Colchicine results in increased expression of CDK5 protein alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein] |
CTD |
PMID:12941380 |
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NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression decreases expression |
EXP ISO |
Colchicine results in increased expression of CDKN1A mRNA Colchicine results in increased expression of CDKN1A protein Colchicine results in decreased expression of CDKN1A mRNA |
CTD |
PMID:20624997 PMID:24211769 PMID:27358234 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn3 |
cyclin-dependent kinase inhibitor 3 |
decreases expression |
EXP |
Colchicine results in decreased expression of CDKN3 mRNA |
CTD |
PMID:20624997 |
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NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Celf2 |
CUGBP, Elav-like family member 2 |
multiple interactions increases expression |
ISO |
2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased expression of CELF2 mRNA] |
CTD |
PMID:11478917 |
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NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333
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Chaf1a |
chromatin assembly factor 1 subunit A |
decreases expression |
ISO |
Colchicine results in decreased expression of CHAF1A mRNA |
CTD |
PMID:24211769 |
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NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
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Chaf1b |
chromatin assembly factor 1 subunit B |
decreases expression |
ISO |
Colchicine results in decreased expression of CHAF1B mRNA |
CTD |
PMID:24211769 |
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NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070
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Cldn1 |
claudin 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of CLDN1 mRNA |
CTD |
PMID:33002524 |
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NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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Cln8 |
CLN8, transmembrane ER and ERGIC protein |
decreases expression |
ISO |
Colchicine results in decreased expression of CLN8 mRNA |
CTD |
PMID:24211769 |
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NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774
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Clu |
clusterin |
increases expression |
EXP |
Colchicine results in increased expression of CLU mRNA; Colchicine results in increased expression of CLU protein |
CTD |
PMID:7870303 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Coa7 |
cytochrome c oxidase assembly factor 7 |
decreases expression |
ISO |
Colchicine results in decreased expression of COA7 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 5:123,069,356...123,080,942
Ensembl chr 5:123,069,371...123,080,199
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Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] |
CTD |
PMID:37573684 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased secretion of COL3A1 protein]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] |
CTD |
PMID:37573684 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Cp |
ceruloplasmin |
increases expression |
EXP |
Colchicine results in increased expression of CP mRNA |
CTD |
PMID:20624997 |
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NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Cpt2 |
carnitine palmitoyltransferase 2 |
decreases expression |
ISO |
Colchicine results in decreased expression of CPT2 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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Crh |
corticotropin releasing hormone |
decreases expression increases expression |
EXP |
Colchicine results in decreased expression of CRH protein Colchicine results in increased expression of CRH mRNA |
CTD |
PMID:1850078 PMID:2453250 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] |
CTD |
PMID:18346843 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
EXP |
Colchicine results in increased expression of CXCL1 mRNA |
CTD |
PMID:3119359 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO EXP |
Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] |
CTD |
PMID:16611024 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects metabolic processing |
ISO |
CYP3A4 protein affects the metabolism of Colchicine |
CTD |
PMID:15914514 PMID:16007523 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Colchicine results in increased expression of DDIT3 protein |
CTD |
PMID:27358234 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
decreases expression |
ISO |
Colchicine results in decreased expression of DDIT4 mRNA |
CTD |
PMID:24211769 |
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NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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G |
Drd3 |
dopamine receptor D3 |
decreases expression |
EXP |
Colchicine results in decreased expression of DRD3 mRNA |
CTD |
PMID:7878047 |
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NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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G |
Dusp14 |
dual specificity phosphatase 14 |
decreases expression |
ISO |
Colchicine results in decreased expression of DUSP14 mRNA |
CTD |
PMID:24211769 |
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NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of E2F1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Ednrb |
endothelin receptor type B |
increases expression |
EXP |
Colchicine results in increased expression of EDNRB mRNA |
CTD |
PMID:20624997 |
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NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Enc1 |
ectodermal-neural cortex 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of ENC1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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G |
Eprs1 |
glutamyl-prolyl-tRNA synthetase 1 |
increases expression |
EXP |
Colchicine results in increased expression of EPRS1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
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G |
Esm1 |
endothelial cell-specific molecule 1 |
decreases expression |
EXP |
Colchicine results in decreased expression of ESM1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Colchicine binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:25752796 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
F2 |
coagulation factor II, thrombin |
affects activity |
ISO |
Colchicine affects the activity of F2 protein |
CTD |
PMID:8574231 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F3 |
coagulation factor III, tissue factor |
increases expression |
EXP |
Colchicine results in increased expression of F3 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fas |
Fas cell surface death receptor |
increases expression decreases expression |
ISO |
Colchicine results in increased expression of FAS mRNA Colchicine results in decreased expression of FAS protein |
CTD |
PMID:10675359 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fcgr2b |
Fc gamma receptor 2B |
increases expression |
EXP |
Colchicine results in increased expression of FCGR2B mRNA |
CTD |
PMID:20624997 |
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NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
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G |
Fdxr |
ferredoxin reductase |
decreases expression |
ISO |
Colchicine results in decreased expression of FDXR mRNA |
CTD |
PMID:24211769 |
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NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
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G |
Fgf2 |
fibroblast growth factor 2 |
affects expression |
EXP |
Colchicine affects the expression of FGF2 protein |
CTD |
PMID:7714246 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA] |
CTD |
PMID:37573684 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
EXP |
Colchicine results in increased expression of and affects the localization of FOS protein Colchicine results in increased expression of FOS mRNA |
CTD |
PMID:3119359 PMID:7537689 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Foxj2 |
forkhead box J2 |
decreases expression |
ISO |
Colchicine results in decreased expression of FOXJ2 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 4:156,047,043...156,073,540
Ensembl chr 4:156,046,969...156,073,518
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G |
Fzd1 |
frizzled class receptor 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of FZD1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643 Ensembl chr 4:29,310,091...29,312,643
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP |
Colchicine results in increased expression of GADD45A mRNA |
CTD |
PMID:20624997 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
increases expression |
EXP |
Colchicine results in increased expression of GADD45B mRNA |
CTD |
PMID:20624997 |
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NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression |
EXP |
Colchicine results in increased expression of GADD45G mRNA |
CTD |
PMID:20624997 |
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NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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G |
Gas7 |
growth arrest specific 7 |
decreases expression |
EXP |
Colchicine results in decreased expression of GAS7 mRNA |
CTD |
PMID:20624997 |
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NCBI chr10:52,152,718...52,383,283
Ensembl chr10:52,152,493...52,383,276
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G |
Gch1 |
GTP cyclohydrolase 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of GCH1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] |
CTD |
PMID:37573684 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA] |
CTD |
PMID:37573684 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gdf15 |
growth differentiation factor 15 |
decreases expression |
ISO |
Colchicine results in decreased expression of GDF15 mRNA |
CTD |
PMID:24211769 |
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NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein] |
CTD |
PMID:38348705 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
EXP |
Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form] |
CTD |
PMID:8824497 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of GOT1 protein] |
CTD |
PMID:37573684 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] |
CTD |
PMID:37573684 PMID:38348705 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression |
EXP |
Colchicine results in increased expression of GPX1 mRNA |
CTD |
PMID:18255150 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of GRIN1 mRNA |
CTD |
PMID:34748853 |
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NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grpel1 |
GrpE-like 1, mitochondrial |
decreases expression |
ISO |
Colchicine results in decreased expression of GRPEL1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression |
EXP |
Colchicine results in decreased expression of GSK3B mRNA |
CTD |
PMID:18255150 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein] |
CTD |
PMID:37573684 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hal |
histidine ammonia lyase |
decreases expression |
EXP |
Colchicine results in decreased expression of HAL mRNA |
CTD |
PMID:32741898 |
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NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions affects expression |
EXP ISO |
Colchicine results in increased expression of HMOX1 mRNA Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein] [dihydroactinidiolide co-treated with Colchicine] results in increased expression of HMOX1 mRNA Colchicine affects the expression of HMOX1 mRNA |
CTD |
PMID:20624997 PMID:22954530 PMID:33617922 PMID:38348705 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Colchicine results in increased expression of HSPA5 protein |
CTD |
PMID:27358234 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
EXP |
Colchicine results in increased expression of ICAM1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id3 |
inhibitor of DNA binding 3 |
decreases expression |
ISO |
Colchicine results in decreased expression of ID3 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein] |
CTD |
PMID:29594315 PMID:37573684 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
increases phosphorylation affects response to substance multiple interactions |
ISO |
Colchicine results in increased phosphorylation of IKBKB protein IKBKB protein affects the susceptibility to Colchicine Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein] |
CTD |
PMID:17029595 PMID:20159942 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
[Colchicine co-treated with Uric Acid] results in increased expression of IL10 protein |
CTD |
PMID:33894285 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] |
CTD |
PMID:11154858 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions decreases expression |
EXP ISO |
Colchicine results in increased expression of IL1B mRNA Colchicine inhibits the reaction [Uric Acid results in increased expression of IL1B protein] Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] Colchicine results in increased expression of IL1B protein Colchicine results in decreased expression of IL1B mRNA |
CTD |
PMID:20624997 PMID:29594315 PMID:33002524 PMID:33894285 PMID:34453961 PMID:37573684 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
decreases expression multiple interactions |
ISO |
Colchicine results in decreased expression of IL2 protein [Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA |
CTD |
PMID:1553933 PMID:29594315 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions decreases expression |
EXP ISO |
Colchicine results in increased expression of IL6 mRNA Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] Colchicine results in increased expression of IL6 protein Colchicine results in decreased expression of IL6 mRNA Colchicine inhibits the reaction [Ethanol results in increased expression of IL6 protein] |
CTD |
PMID:20624997 PMID:22446813 PMID:33002524 PMID:34453961 PMID:37573684 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Inha |
inhibin subunit alpha |
decreases expression |
EXP |
Colchicine results in decreased expression of INHA mRNA |
CTD |
PMID:20624997 |
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NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
Colchicine inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]] |
CTD |
PMID:19070612 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ints15 |
integrator complex subunit 15 |
decreases expression |
ISO |
Colchicine results in decreased expression of INTS15 mRNA |
CTD |
PMID:24211769 |
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NCBI chr12:11,245,045...11,260,170
Ensembl chr12:11,245,842...11,260,166
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G |
Isg20l2 |
interferon stimulated exonuclease gene 20-like 2 |
decreases expression |
ISO |
Colchicine results in decreased expression of ISG20L2 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
Colchicine promotes the reaction [Uric Acid results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:33894285 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation multiple interactions increases activity |
ISO EXP |
Colchicine results in increased phosphorylation of JUN protein 3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased phosphorylation of JUN protein]; Colchicine results in increased expression of and results in increased phosphorylation of JUN protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein] 3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased activity of JUN protein]; Colchicine results in increased phosphorylation of and results in increased localization of JUN protein |
CTD |
PMID:12221076 PMID:16478524 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kif20a |
kinesin family member 20A |
decreases expression |
ISO |
Colchicine results in decreased expression of KIF20A mRNA |
CTD |
PMID:24211769 |
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NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
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G |
Klf6 |
KLF transcription factor 6 |
increases expression |
ISO |
Colchicine results in increased expression of KLF6 mRNA |
CTD |
PMID:24211769 |
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NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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G |
Kras |
KRAS proto-oncogene, GTPase |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of KRAS protein] |
CTD |
PMID:38348705 |
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NCBI chr 4:178,185,418...178,218,484
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G |
Krt18 |
keratin 18 |
decreases expression |
ISO |
Colchicine results in decreased expression of KRT18 protein |
CTD |
PMID:11259854 |
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NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions increases secretion |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of LDHA protein] Colchicine results in increased secretion of LDHA protein |
CTD |
PMID:37573684 PMID:37660997 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Lhx2 |
LIM homeobox 2 |
decreases expression |
ISO |
Colchicine results in decreased expression of LHX2 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908
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G |
Lpo |
lactoperoxidase |
decreases expression |
ISO |
Colchicine results in decreased expression of LPO mRNA |
CTD |
PMID:34748853 |
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NCBI chr10:72,606,950...72,626,220
Ensembl chr10:72,606,944...72,626,535
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G |
Lrp2 |
LDL receptor related protein 2 |
affects localization |
EXP |
Colchicine affects the localization of LRP2 protein |
CTD |
PMID:25588984 |
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NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
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G |
Lrrc47 |
leucine rich repeat containing 47 |
decreases expression |
ISO |
Colchicine results in decreased expression of LRRC47 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 5:164,570,539...164,580,174
Ensembl chr 5:164,570,435...164,580,174
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G |
Map2 |
microtubule-associated protein 2 |
decreases expression |
ISO |
Colchicine results in decreased expression of MAP2 mRNA |
CTD |
PMID:34748853 |
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NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO |
Colchicine results in increased phosphorylation of MAPK8 protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:12221076 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation multiple interactions |
ISO |
Colchicine results in increased phosphorylation of MAPK9 protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:12221076 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mapt |
microtubule-associated protein tau |
decreases expression |
ISO |
Colchicine results in decreased expression of MAPT protein |
CTD |
PMID:16930453 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mcm10 |
minichromosome maintenance 10 replication initiation factor |
decreases expression |
ISO |
Colchicine results in decreased expression of MCM10 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
multiple interactions |
ISO |
[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine |
CTD |
PMID:11792417 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mir130b |
microRNA 130b |
decreases expression |
ISO |
Colchicine results in decreased expression of MIR130B |
CTD |
PMID:35134991 |
|
NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244
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G |
Mir185 |
microRNA 185 |
decreases expression |
ISO |
Colchicine results in decreased expression of MIR185 |
CTD |
PMID:35134991 |
|
NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
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G |
Mir190b |
microRNA 190b |
increases expression |
ISO |
Colchicine results in increased expression of MIR190B |
CTD |
PMID:35134991 |
|
NCBI chr 2:175,514,800...175,514,877
Ensembl chr 2:175,514,800...175,514,877
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G |
Mir20a |
microRNA 20a |
decreases expression |
ISO |
Colchicine results in decreased expression of MIR20A |
CTD |
PMID:35134991 |
|
NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
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G |
Mir9-3 |
microRNA 9-3 |
decreases expression |
ISO |
Colchicine results in decreased expression of MIR9-3 |
CTD |
PMID:35134991 |
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NCBI chr 1:133,440,049...133,440,138
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G |
Mirlet7d |
microRNA let-7d |
decreases expression |
ISO |
Colchicine results in decreased expression of MIRLET7D |
CTD |
PMID:35134991 |
|
NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
Colchicine results in decreased expression of MMP9 mRNA |
CTD |
PMID:33684465 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Colchicine inhibits the reaction [Ethanol results in increased activity of MPO protein] |
CTD |
PMID:22446813 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mrm2 |
mitochondrial rRNA methyltransferase 2 |
decreases expression |
ISO |
Colchicine results in decreased expression of MRM2 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118
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G |
Msh6 |
mutS homolog 6 |
decreases expression |
ISO |
Colchicine results in decreased expression of MSH6 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases expression |
ISO |
Colchicine results in decreased expression of MTOR mRNA |
CTD |
PMID:34748853 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
EXP |
Colchicine results in increased expression of MYC mRNA |
CTD |
PMID:3119359 PMID:20624997 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myt1 |
myelin transcription factor 1 |
increases phosphorylation |
ISO |
Colchicine results in increased phosphorylation of MYT1 protein |
CTD |
PMID:16611024 |
|
NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341
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G |
Nbn |
nibrin |
increases expression |
EXP |
Colchicine results in increased expression of NBN mRNA |
CTD |
PMID:20624997 |
|
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] |
CTD |
PMID:25257666 |
|
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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G |
Ndufs4 |
NADH:ubiquinone oxidoreductase subunit S4 |
affects response to substance |
ISO |
NDUFS4 protein affects the susceptibility to Colchicine |
CTD |
PMID:21383081 |
|
NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
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G |
Nfatc4 |
nuclear factor of activated T-cells 4 |
decreases localization |
ISO |
Colchicine results in decreased localization of NFATC4 protein |
CTD |
PMID:17044076 |
|
NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[dihydroactinidiolide co-treated with Colchicine] results in increased expression of NFE2L2 mRNA Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein] |
CTD |
PMID:33617922 PMID:37573684 PMID:38348705 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation multiple interactions |
ISO EXP |
Colchicine results in increased phosphorylation of NFKBIA protein Colchicine inhibits the reaction [Uric Acid results in decreased expression of NFKBIA protein] Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein] |
CTD |
PMID:17029595 PMID:33894285 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos1 |
nitric oxide synthase 1 |
increases expression |
EXP |
Colchicine results in increased expression of NOS1 protein |
CTD |
PMID:7537689 |
|
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Colchicine inhibits the reaction [Uric Acid results in increased expression of NOS2 protein] |
CTD |
PMID:23146695 PMID:33894285 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nptx1 |
neuronal pentraxin 1 |
increases expression |
EXP |
Colchicine results in increased expression of NPTX1 mRNA |
CTD |
PMID:18255150 |
|
NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Colchicine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] |
CTD |
PMID:25257666 |
|
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions increases degradation increases activity |
ISO |
Colchicine results in decreased localization of and results in decreased activity of NR3C1 protein Colchicine results in increased degradation of NR3C1 protein Colchicine results in increased activity of NR3C1 protein |
CTD |
PMID:15744361 PMID:20448266 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nts |
neurotensin |
increases expression |
EXP |
Colchicine results in increased expression of NTS mRNA |
CTD |
PMID:1850078 |
|
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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G |
Ocln |
occludin |
decreases expression |
ISO |
Colchicine results in decreased expression of OCLN mRNA |
CTD |
PMID:33002524 |
|
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions increases expression |
ISO EXP |
Colchicine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] Colchicine results in increased expression of ODC1 mRNA |
CTD |
PMID:3119359 PMID:9270009 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Olig2 |
oligodendrocyte transcription factor 2 |
decreases expression |
ISO |
Colchicine results in decreased expression of OLIG2 mRNA |
CTD |
PMID:34748853 |
|
NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
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G |
Orai3 |
ORAI calcium release-activated calcium modulator 3 |
decreases expression |
ISO |
Colchicine results in decreased expression of ORAI3 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052
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G |
Palb2 |
partner and localizer of BRCA2 |
decreases expression |
ISO |
Colchicine results in decreased expression of PALB2 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
Colchicine results in increased cleavage of PARP1 protein |
CTD |
PMID:33684465 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pawr |
pro-apoptotic WT1 regulator |
increases expression multiple interactions |
EXP |
Colchicine results in increased expression of PAWR protein alvocidib inhibits the reaction [Colchicine results in increased expression of PAWR protein] |
CTD |
PMID:12941380 |
|
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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G |
Pax6 |
paired box 6 |
multiple interactions |
ISO |
Colchicine promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] |
CTD |
PMID:32949729 |
|
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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G |
Pelo |
pelota mRNA surveillance and ribosome rescue factor |
decreases expression |
ISO |
Colchicine results in decreased expression of PELO mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746
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G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
decreases expression |
ISO |
Colchicine results in decreased expression of PHLDA3 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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G |
Pidd1 |
p53-induced death domain protein 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of PIDD1 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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G |
Plagl1 |
PLAG1 like zinc finger 1 |
increases expression |
EXP |
Colchicine results in increased expression of PLAGL1 mRNA |
CTD |
PMID:20624997 |
|
NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228
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G |
Plat |
plasminogen activator, tissue type |
increases expression |
EXP |
Colchicine results in increased expression of PLAT mRNA |
CTD |
PMID:20624997 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Plaur |
plasminogen activator, urokinase receptor |
increases expression |
EXP |
Colchicine results in increased expression of PLAUR mRNA |
CTD |
PMID:20624997 |
|
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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G |
Plekhf1 |
pleckstrin homology and FYVE domain containing 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of PLEKHF1 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820
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G |
Plxnb2 |
plexin B2 |
decreases expression |
ISO |
Colchicine results in decreased expression of PLXNB2 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330
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G |
Pomc |
proopiomelanocortin |
increases secretion |
EXP |
Colchicine results in increased secretion of POMC protein |
CTD |
PMID:2453250 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Ppm1d |
protein phosphatase, Mg2+/Mn2+ dependent, 1D |
decreases expression |
ISO |
Colchicine results in decreased expression of PPM1D mRNA |
CTD |
PMID:24211769 |
|
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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G |
Ppp1ca |
protein phosphatase 1 catalytic subunit alpha |
increases expression |
ISO |
Colchicine results in increased expression of PPP1CA protein |
CTD |
PMID:16495211 |
|
NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
EXP |
Colchicine results in increased expression of PPP1R15A mRNA |
CTD |
PMID:20624997 |
|
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Prkab1 |
protein kinase AMP-activated non-catalytic subunit beta 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of PRKAB1 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
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G |
Psmc3ip |
PSMC3 interacting protein |
decreases expression |
ISO |
Colchicine results in decreased expression of PSMC3IP mRNA |
CTD |
PMID:24211769 |
|
NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] |
CTD |
PMID:37573684 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2b |
protein tyrosine kinase 2 beta |
multiple interactions increases phosphorylation |
ISO |
2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein] |
CTD |
PMID:11478917 |
|
NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
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G |
Ptp4a1 |
protein tyrosine phosphatase 4A1 |
decreases expression |
ISO |
Colchicine results in decreased expression of PTP4A1 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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G |
Pus3 |
pseudouridine synthase 3 |
decreases expression |
ISO |
Colchicine results in decreased expression of PUS3 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 8:33,910,461...33,918,716
Ensembl chr 8:33,911,357...33,918,714
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G |
Rad51c |
RAD51 paralog C |
decreases expression |
ISO |
Colchicine results in decreased expression of RAD51C mRNA |
CTD |
PMID:24211769 |
|
NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
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G |
Ralbp1 |
ralA binding protein 1 |
multiple interactions affects transport |
ISO |
Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4] RALBP1 protein affects the transport of Colchicine |
CTD |
PMID:15386349 |
|
NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
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G |
Rap2b |
RAP2B, member of RAS oncogene family |
decreases expression |
ISO |
Colchicine results in decreased expression of RAP2B mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069
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G |
Rassf1 |
Ras association domain family member 1 |
increases expression |
EXP |
Colchicine results in increased expression of RASSF1 mRNA |
CTD |
PMID:20624997 |
|
NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
Colchicine results in decreased phosphorylation of and results in decreased activity of RB1 protein |
CTD |
PMID:16495211 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rbm34 |
RNA binding motif protein 34 |
decreases expression |
ISO |
Colchicine results in decreased expression of RBM34 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr19:54,936,516...54,956,810
Ensembl chr19:54,936,531...54,956,715
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Colchicine inhibits the reaction [Uric Acid results in increased phosphorylation of RELA protein] |
CTD |
PMID:33894285 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rfc1 |
replication factor C subunit 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of RFC1 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
|
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G |
Rgs16 |
regulator of G-protein signaling 16 |
decreases expression |
ISO |
Colchicine results in decreased expression of RGS16 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
|
|
G |
Rnf113a1 |
ring finger protein 113A1 |
decreases expression |
ISO |
Colchicine results in decreased expression of RNF113A mRNA |
CTD |
PMID:24211769 |
|
NCBI chr X:116,427,941...116,429,164
Ensembl chr X:116,427,684...116,433,762
|
|
G |
Rnf19b |
ring finger protein 19B |
decreases expression |
ISO |
Colchicine results in decreased expression of RNF19B mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380
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G |
S100a8 |
S100 calcium binding protein A8 |
increases expression |
EXP |
Colchicine results in increased expression of S100A8 mRNA |
CTD |
PMID:20624997 |
|
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
|
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G |
S100a9 |
S100 calcium binding protein A9 |
increases expression |
EXP |
Colchicine results in increased expression of S100A9 mRNA |
CTD |
PMID:20624997 |
|
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
|
|
G |
Sac3d1 |
SAC3 domain containing 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of SAC3D1 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 1:203,414,184...203,416,563
Ensembl chr 1:203,414,187...203,416,604
|
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G |
Sct |
secretin |
multiple interactions |
EXP |
Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Colchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT] |
CTD |
PMID:22194894 |
|
NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
|
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G |
Sdc1 |
syndecan 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of SDC1 mRNA |
CTD |
PMID:24211769 |
|
NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
|
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G |
Sdhaf1 |
succinate dehydrogenase complex assembly factor 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of SDHAF1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 1:85,576,207...85,577,156
Ensembl chr 1:85,576,041...85,577,366 Ensembl chr 1:85,576,041...85,577,366
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Sele |
selectin E |
increases expression |
EXP |
Colchicine results in increased expression of SELE mRNA |
CTD |
PMID:20624997 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Serpina6 |
serpin family A member 6 |
decreases transport |
EXP |
Colchicine results in decreased transport of SERPINA6 protein |
CTD |
PMID:16700006 |
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NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349
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Serpine1 |
serpin family E member 1 |
increases expression |
EXP |
Colchicine results in increased expression of SERPINE1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sesn1 |
sestrin 1 |
increases expression decreases expression |
EXP ISO |
Colchicine results in increased expression of SESN1 mRNA Colchicine results in decreased expression of SESN1 mRNA |
CTD |
PMID:20624997 PMID:24211769 |
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NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of SGK1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Shank2 |
SH3 and multiple ankyrin repeat domains 2 |
decreases expression |
ISO |
Colchicine results in decreased expression of SHANK2 mRNA |
CTD |
PMID:34748853 |
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NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
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G |
Slbp |
stem-loop histone mRNA binding protein |
decreases expression |
ISO |
Colchicine results in decreased expression of SLBP mRNA |
CTD |
PMID:24211769 |
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NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906
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Slc1a5 |
solute carrier family 1 member 5 |
decreases expression |
ISO |
Colchicine results in decreased expression of SLC1A5 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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G |
Slc6a4 |
solute carrier family 6 member 4 |
decreases expression |
ISO |
Colchicine results in decreased expression of SLC6A4 mRNA |
CTD |
PMID:34748853 |
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NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein] |
CTD |
PMID:37573684 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Spon1 |
spondin 1 |
increases expression |
EXP |
Colchicine results in increased expression of SPON1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
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G |
Sptan1 |
spectrin, alpha, non-erythrocytic 1 |
multiple interactions increases cleavage |
ISO |
3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased cleavage of SPTAN1 protein] |
CTD |
PMID:16478524 |
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NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
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G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
ISO |
Colchicine results in increased expression of SRXN1 protein |
CTD |
PMID:27358234 |
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NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
Colchicine deficiency results in decreased activity of and affects the localization of STAT1 protein |
CTD |
PMID:28086195 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
Colchicine promotes the reaction [Uric Acid results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:33894285 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tat |
tyrosine aminotransferase |
multiple interactions decreases expression |
ISO |
pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA] |
CTD |
PMID:15744361 |
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NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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G |
Tbc1d4 |
TBC1 domain family, member 4 |
multiple interactions affects phosphorylation |
EXP |
Colchicine inhibits the reaction [Oligomycins results in increased phosphorylation of TBC1D4 protein] Colchicine affects the phosphorylation of TBC1D4 protein |
CTD |
PMID:18063688 |
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NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
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G |
Tfpi2 |
tissue factor pathway inhibitor 2 |
increases expression |
EXP |
Colchicine results in increased expression of TFPI2 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] |
CTD |
PMID:14726149 PMID:22446813 PMID:23146695 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thbd |
thrombomodulin |
increases expression |
EXP |
Colchicine results in increased expression of THBD mRNA |
CTD |
PMID:20624997 |
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NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
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G |
Thbs1 |
thrombospondin 1 |
increases expression |
EXP |
Colchicine results in increased expression of THBS1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
Colchicine binds to and results in decreased activity of THRA protein |
CTD |
PMID:25752796 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions |
ISO |
Colchicine binds to and results in decreased activity of THRB protein |
CTD |
PMID:25752796 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Tigar |
TP53 induced glycolysis regulatory phosphatase |
decreases expression |
ISO |
Colchicine results in decreased expression of TIGAR mRNA |
CTD |
PMID:24211769 |
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NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
EXP |
Colchicine results in increased expression of TIMP1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tipin |
timeless interacting protein |
decreases expression |
ISO |
Colchicine results in decreased expression of TIPIN mRNA |
CTD |
PMID:24211769 |
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NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352
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G |
Tjp1 |
tight junction protein 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of TJP1 mRNA |
CTD |
PMID:33002524 |
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NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tmem185b |
transmembrane protein 185B |
decreases expression |
ISO |
Colchicine results in decreased expression of TMEM185B mRNA |
CTD |
PMID:24211769 |
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NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858
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G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions increases expression |
ISO EXP |
Colchicine results in decreased expression of TNF protein Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] Colchicine results in increased expression of TNF protein Colchicine results in decreased expression of TNF mRNA Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TNF protein] |
CTD |
PMID:1553933 PMID:11154858 PMID:22446813 PMID:23146695 PMID:33002524 PMID:34453961 PMID:37573684 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
affects response to substance |
ISO |
TNFRSF1A protein affects the susceptibility to Colchicine |
CTD |
PMID:20159942 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfsf9 |
TNF superfamily member 9 |
decreases expression |
ISO |
Colchicine results in decreased expression of TNFSF9 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
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G |
Tnni3 |
troponin I3, cardiac type |
increases expression |
EXP |
Colchicine results in increased expression of TNNI3 protein |
CTD |
PMID:20624997 |
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NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G |
Top3a |
DNA topoisomerase III alpha |
decreases expression |
ISO |
Colchicine results in decreased expression of TOP3A mRNA |
CTD |
PMID:24211769 |
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NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559
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G |
Tor1a |
torsin family 1, member A |
decreases expression |
ISO |
Colchicine results in decreased expression of TOR1A mRNA |
CTD |
PMID:24211769 |
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NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:12221076 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tpd52l1 |
TPD52 like 1 |
increases expression |
EXP |
Colchicine results in increased expression of TPD52L1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
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G |
Traf2 |
Tnf receptor-associated factor 2 |
affects response to substance |
ISO |
TRAF2 protein affects the susceptibility to Colchicine |
CTD |
PMID:20159942 |
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NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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G |
Triap1 |
TP53 regulated inhibitor of apoptosis 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of TRIAP1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
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G |
Trim26 |
tripartite motif-containing 26 |
decreases expression |
ISO |
Colchicine results in decreased expression of TRIM26 mRNA |
CTD |
PMID:24211769 |
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NCBI chr20:1,708,297...1,731,176
Ensembl chr20:1,709,788...1,731,120
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G |
Trim32 |
tripartite motif-containing 32 |
decreases expression |
ISO |
Colchicine results in decreased expression of TRIM32 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018
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G |
Trim38 |
tripartite motif containing 38 |
decreases expression |
ISO |
Colchicine results in decreased expression of TRIM38 mRNA |
CTD |
PMID:24211769 |
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NCBI chr17:41,351,857...41,365,021
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G |
Tuba1b |
tubulin, alpha 1B |
decreases expression |
EXP |
Colchicine results in decreased expression of TUBA1B mRNA |
CTD |
PMID:20624997 |
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NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186
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G |
Tuba4a |
tubulin, alpha 4A |
decreases expression |
EXP |
Colchicine results in decreased expression of TUBA4A mRNA |
CTD |
PMID:20624997 |
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NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
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G |
Tubb4b |
tubulin, beta 4B class IVb |
decreases expression |
EXP |
Colchicine results in decreased expression of TUBB4B mRNA |
CTD |
PMID:20624997 |
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NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296
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G |
Tubb5 |
tubulin, beta 5 class I |
decreases expression |
EXP |
Colchicine results in decreased expression of TUBB5 mRNA |
CTD |
PMID:20624997 |
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NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
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G |
Tubg1 |
tubulin, gamma 1 |
decreases expression |
EXP |
Colchicine results in decreased expression of TUBG1 mRNA |
CTD |
PMID:20624997 |
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NCBI chr10:86,052,845...86,059,436
Ensembl chr10:86,052,743...86,059,433
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G |
Utp3 |
UTP3, small subunit processome component |
decreases expression |
ISO |
Colchicine results in decreased expression of UTP3 mRNA |
CTD |
PMID:24211769 |
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NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression multiple interactions |
EXP ISO |
Colchicine results in increased expression of VCAM1 mRNA Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]; Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] |
CTD |
PMID:11154858 PMID:20624997 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vip |
vasoactive intestinal peptide |
increases expression |
EXP |
Colchicine results in increased expression of VIP mRNA; Colchicine results in increased expression of VIP protein |
CTD |
PMID:1850078 PMID:8837219 |
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NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
decreases expression |
ISO |
Colchicine results in decreased expression of XPC mRNA |
CTD |
PMID:24211769 |
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NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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G |
Zbtb24 |
zinc finger and BTB domain containing 24 |
decreases expression |
ISO |
Colchicine results in decreased expression of ZBTB24 mRNA |
CTD |
PMID:24211769 |
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NCBI chr20:44,943,302...44,965,329
Ensembl chr20:44,947,297...44,963,963
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G |
Zfp202 |
zinc finger protein 202 |
decreases expression |
ISO |
Colchicine results in decreased expression of ZNF202 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 8:40,542,665...40,567,397
Ensembl chr 8:40,542,701...40,563,118
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G |
Zfp36l1 |
zinc finger protein 36, C3H type-like 1 |
decreases expression |
ISO |
Colchicine results in decreased expression of ZFP36L1 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
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G |
Zfp94 |
zinc finger protein 94 |
decreases expression |
ISO |
Colchicine results in decreased expression of ZNF45 mRNA |
CTD |
PMID:24211769 |
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NCBI chr 1:79,858,188...79,879,702
Ensembl chr 1:79,859,180...79,879,612
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
1-amino-2,4-dibromoanthraquinone binds to and results in increased activity of ESR1 protein |
CTD |
PMID:20707409 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Hras |
HRas proto-oncogene, GTPase |
increases mutagenesis |
ISO |
1-amino-2,4-dibromoanthraquinone results in increased mutagenesis of HRAS gene |
CTD |
PMID:11560247 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases activity |
ISO |
1-amino-2,4-dibromoanthraquinone results in increased activity of NFE2L2 protein |
CTD |
PMID:30203046 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
1-amino-2,4-dibromoanthraquinone results in increased activity of NR1I3 protein |
CTD |
PMID:30203046 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
1-hydroxy-1-norresistomycin results in increased expression of BAX protein |
CTD |
PMID:29596799 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Casp3 |
caspase 3 |
increases expression |
ISO |
1-hydroxy-1-norresistomycin results in increased expression of CASP3 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CASP3 protein |
CTD |
PMID:29596799 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases expression |
ISO |
1-hydroxy-1-norresistomycin results in increased expression of CASP9 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CASP9 protein |
CTD |
PMID:29596799 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
1-hydroxy-1-norresistomycin results in increased expression of CDKN1A mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CDKN1A protein |
CTD |
PMID:29596799 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
1-hydroxy-1-norresistomycin results in decreased expression of MMP2 mRNA; 1-hydroxy-1-norresistomycin results in decreased expression of MMP2 protein |
CTD |
PMID:29596799 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
1-hydroxy-1-norresistomycin results in decreased expression of MMP9 mRNA; 1-hydroxy-1-norresistomycin results in decreased expression of MMP9 protein |
CTD |
PMID:29596799 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Smim10l2a |
small integral membrane protein 10 like 2A |
increases expression |
ISO |
1-hydroxy-1-norresistomycin results in increased expression of SMIM10L2A mRNA |
CTD |
PMID:29596799 |
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NCBI chr X:134,151,325...134,154,647
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G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
1-hydroxy-1-norresistomycin results in decreased expression of TNF mRNA |
CTD |
PMID:29596799 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
1-hydroxy-1-norresistomycin results in increased expression of TP53 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of TP53 protein |
CTD |
PMID:29596799 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
1-hydroxyanthraquinone results in decreased activity of CYP1A2 protein |
CTD |
PMID:33438235 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Ahr |
aryl hydrocarbon receptor |
affects binding |
EXP |
1-methylfluorene binds to AHR protein |
CTD |
PMID:3024361 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
A2m |
alpha-2-macroglobulin |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of A2M mRNA |
CTD |
PMID:17690111 |
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NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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G |
Ahr |
aryl hydrocarbon receptor |
increases activity multiple interactions |
EXP |
1-methylphenanthrene results in increased activity of AHR protein [1-methylphenanthrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA |
CTD |
PMID:11339718 PMID:17941746 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aldob |
aldolase, fructose-bisphosphate B |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of ALDOB mRNA |
CTD |
PMID:17690111 |
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NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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G |
Amacr |
alpha-methylacyl-CoA racemase |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of AMACR mRNA |
CTD |
PMID:17690111 |
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NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
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G |
Apoc3 |
apolipoprotein C3 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of APOC3 mRNA |
CTD |
PMID:17690111 |
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NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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G |
Ar |
androgen receptor |
multiple interactions |
EXP |
1-methylphenanthrene inhibits the reaction [Metribolone binds to AR protein] |
CTD |
PMID:3695475 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CDKN1A mRNA |
CTD |
PMID:17690111 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Ceacam6 |
CEA cell adhesion molecule 6 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CEACAM6 mRNA |
CTD |
PMID:17690111 |
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NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression affects expression multiple interactions |
EXP ISO |
1-methylphenanthrene results in increased expression of CYP1A1 protein 1-methylphenanthrene affects the expression of CYP1A1 mRNA 1-methylphenanthrene affects the reaction [Benzo(a)pyrene affects the expression of CYP1A1 mRNA]; [1-methylphenanthrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CYP1A1 mRNA |
CTD |
PMID:11339718 PMID:17690111 PMID:17941746 PMID:27099206 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
affects expression multiple interactions |
EXP |
1-methylphenanthrene affects the expression of CYP1B1 mRNA 1-methylphenanthrene affects the reaction [Benzo(a)pyrene affects the expression of CYP1B1 mRNA] |
CTD |
PMID:27099206 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Ece1 |
endothelin converting enzyme 1 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of ECE1 mRNA |
CTD |
PMID:17690111 |
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NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of G6PD mRNA |
CTD |
PMID:17690111 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of GADD45A mRNA |
CTD |
PMID:17690111 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gck |
glucokinase |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of GCK mRNA |
CTD |
PMID:17690111 |
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NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of HIF1A mRNA |
CTD |
PMID:17690111 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGF1 mRNA |
CTD |
PMID:17690111 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGFBP1 mRNA |
CTD |
PMID:17690111 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Klf6 |
KLF transcription factor 6 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of KLF6 mRNA |
CTD |
PMID:17690111 |
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NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of MCL1 mRNA |
CTD |
PMID:17690111 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mt1-ps3 |
metallothionein 1, pseudogene 3 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of MT1E mRNA |
CTD |
PMID:17690111 |
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NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
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G |
Sat1 |
spermidine/spermine N1-acetyl transferase 1 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SAT1 mRNA |
CTD |
PMID:17690111 |
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NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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G |
Serpina3n |
serpin family A member 3N |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SERPINA3 mRNA |
CTD |
PMID:17690111 |
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NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SPP1 mRNA |
CTD |
PMID:17690111 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Tp53 |
tumor protein p53 |
increases phosphorylation |
EXP |
1-methylphenanthrene results in increased phosphorylation of TP53 protein |
CTD |
PMID:17941746 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Xrcc1 |
X-ray repair cross complementing 1 |
multiple interactions |
ISO |
[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of XRCC1 mRNA |
CTD |
PMID:17690111 |
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NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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G |
Aaas |
aladin WD repeat nucleoporin |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of AAAS mRNA |
CTD |
PMID:21607683 |
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NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression increases expression multiple interactions increases activity |
ISO EXP |
2-Acetylaminofluorene results in decreased expression of ABCB1 mRNA 2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1A mRNA lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1A mRNA] 2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1 protein Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 protein] 2-Acetylaminofluorene results in increased activity of ABCB1 protein [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA; [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA; [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA] |
CTD |
PMID:11170838 PMID:11960367 PMID:12387747 PMID:17303067 PMID:17669244 PMID:21784091 PMID:22213190 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of ABCB1B mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1B protein [2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased expression of ABCB1B mRNA; lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA] |
CTD |
PMID:11020383 PMID:11170838 PMID:12801967 PMID:17070881 PMID:22084566 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ABCC1 mRNA |
CTD |
PMID:12801967 PMID:17669244 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc10 |
ATP binding cassette subfamily C member 10 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ABCC10 mRNA |
CTD |
PMID:12566991 |
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NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of ABCC2 mRNA 2-Acetylaminofluorene results in increased expression of ABCC2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA] |
CTD |
PMID:10691972 PMID:16381673 PMID:16426233 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of ABCC3 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC3 protein |
CTD |
PMID:10691972 PMID:12801967 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression increases activity multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of ABCG2 mRNA 2-Acetylaminofluorene results in increased activity of ABCG2 protein 2-Acetylaminofluorene results in increased expression of ABCG2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCG2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA] |
CTD |
PMID:12819005 PMID:16381673 PMID:17538966 PMID:17669244 PMID:27475308 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Acaa2 |
acetyl-CoA acyltransferase 2 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ACAA2 mRNA |
CTD |
PMID:14656948 |
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NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
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G |
Acmsd |
aminocarboxymuconate semialdehyde decarboxylase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ACMSD mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
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G |
Acot9 |
acyl-CoA thioesterase 9 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ACOT9 mRNA |
CTD |
PMID:21784091 |
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NCBI chr X:40,073,197...40,123,573
Ensembl chr X:40,064,810...40,123,559
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G |
Acsl3 |
acyl-CoA synthetase long-chain family member 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ACSL3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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G |
Aen |
apoptosis enhancing nuclease |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of AEN mRNA |
CTD |
PMID:17070881 PMID:21607683 PMID:22584684 |
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NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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G |
Afp |
alpha-fetoprotein |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein; [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP protein 2-Acetylaminofluorene results in increased expression of AFP mRNA; 2-Acetylaminofluorene results in increased expression of AFP protein |
CTD |
PMID:6187438 PMID:11350689 PMID:11813887 PMID:15133858 PMID:17538966 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of AHR mRNA |
CTD |
PMID:25224404 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ak1 |
adenylate kinase 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of AK1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of AKR1B1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
multiple interactions increases expression |
EXP ISO |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1B10 mRNA 2-Acetylaminofluorene results in increased expression of AKR1B10 mRNA |
CTD |
PMID:14656948 PMID:26198647 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr1c12 |
aldo-keto reductase family 1, member C12 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AKR1C12 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1C12 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr17:66,045,376...66,061,496
Ensembl chr17:66,045,378...66,108,329
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G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of AKR7A3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA 2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:11960367 PMID:17303067 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of ALB protein 2-Acetylaminofluorene results in increased expression of ALB protein |
CTD |
PMID:6187438 PMID:15133858 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ALDH1A1 mRNA; 2-Acetylaminofluorene results in increased expression of ALDH1A1 protein |
CTD |
PMID:17070881 PMID:22584684 PMID:33211169 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1a3 |
aldehyde dehydrogenase 1 family, member A3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ALDH1A3 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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G |
Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein] |
CTD |
PMID:15548946 PMID:15554553 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Anapc11 |
anaphase promoting complex subunit 11 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ANAPC11 mRNA |
CTD |
PMID:22584684 |
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NCBI chr10:105,875,209...105,886,307
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G |
Anxa3 |
annexin A3 |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of ANXA3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA] [Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of ANXA3 mRNA |
CTD |
PMID:17317680 PMID:18071240 |
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NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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G |
Anxa8 |
annexin A8 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ANXA8 mRNA |
CTD |
PMID:17317680 |
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NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043
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G |
Aox1 |
aldehyde oxidase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AOX1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AOX1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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G |
Apoa2 |
apolipoprotein A2 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of APOA2 mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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G |
Apoa4 |
apolipoprotein A4 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of APOA4 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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G |
Apoc3 |
apolipoprotein C3 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of APOC3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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G |
Apod |
apolipoprotein D |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of APOD mRNA |
CTD |
PMID:20713471 |
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NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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G |
Aqp5 |
aquaporin 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of AQP5 mRNA |
CTD |
PMID:17187413 |
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NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
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G |
Areg |
amphiregulin |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of AREG mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA] |
CTD |
PMID:17317680 |
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NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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G |
Asgr1 |
asialoglycoprotein receptor 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ASGR1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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G |
Atp6v1d |
ATPase H+ transporting V1 subunit D |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ATP6V1D mRNA |
CTD |
PMID:17070881 |
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NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO EXP |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA] 2-Acetylaminofluorene results in increased expression of BAX mRNA [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein] |
CTD |
PMID:11915028 PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein] 2-Acetylaminofluorene results in increased expression of BCL2 mRNA |
CTD |
PMID:11915028 PMID:19167416 PMID:22213190 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions increases expression |
EXP ISO |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein] 2-Acetylaminofluorene results in increased expression of BCL2L1 mRNA |
CTD |
PMID:11915028 PMID:21607683 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of BIRC5 mRNA |
CTD |
PMID:19167416 PMID:22213190 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Brca1 |
BRCA1, DNA repair associated |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of BRCA1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Btg2 |
BTG anti-proliferation factor 2 |
increases expression |
EXP ISO |
2-Acetylaminofluorene results in increased expression of BTG2 mRNA |
CTD |
PMID:17070881 PMID:21607683 |
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NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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G |
Bzw1 |
basic leucine zipper and W2 domains 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of BZW1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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G |
C4bpa |
complement component 4 binding protein, alpha |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of C4BPA mRNA |
CTD |
PMID:16510358 |
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NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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G |
C6 |
complement C6 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of C6 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
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G |
C7 |
complement C7 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of C7 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
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G |
Cacna2d1 |
calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CACNA2D1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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G |
Cadm1 |
cell adhesion molecule 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CADM1 protein |
CTD |
PMID:17326163 |
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NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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G |
Car2 |
carbonic anhydrase 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CAR2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAR2 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity |
EXP |
2-Acetylaminofluorene inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased cleavage of CASP3 protein]; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP3 protein] |
CTD |
PMID:12907702 PMID:23665045 PMID:26364502 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] |
CTD |
PMID:23665045 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp9 |
caspase 9 |
increases activity increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased activity of CASP9 protein 2-Acetylaminofluorene results in increased expression of CASP9 protein Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP9 protein] |
CTD |
PMID:23665045 PMID:26364502 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases activity decreases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of CAT protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of CAT protein] |
CTD |
PMID:17761372 PMID:23665045 PMID:26364502 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cavin3 |
caveolae associated protein 3 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAVIN3 mRNA |
CTD |
PMID:14656948 |
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NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
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G |
Cblc |
Cbl proto-oncogene C |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CBLC mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
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G |
Cbr1 |
carbonyl reductase 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CBR1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Cck |
cholecystokinin |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CCK mRNA |
CTD |
PMID:22584684 |
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NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of CCL2 mRNA; 2-Acetylaminofluorene affects the expression of CCL2 protein |
CTD |
PMID:25051504 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CCL7 protein |
CTD |
PMID:25051504 |
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NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of CCN2 mRNA; 2-Acetylaminofluorene results in increased expression of CCN2 protein Iloprost inhibits the reaction [2-Acetylaminofluorene results in increased expression of CCN2 mRNA] |
CTD |
PMID:15940639 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CCNA2 protein |
CTD |
PMID:15158336 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression increases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CCNB1 protein 2-Acetylaminofluorene results in increased expression of CCNB1 mRNA |
CTD |
PMID:15158336 PMID:22584684 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnb2 |
cyclin B2 |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of CCNB2 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA] |
CTD |
PMID:17317680 PMID:19167416 PMID:22584684 |
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NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA] 2-Acetylaminofluorene results in increased expression of CCND1 mRNA |
CTD |
PMID:14633663 PMID:22584684 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
multiple interactions decreases activity |
EXP |
2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA] 2-Acetylaminofluorene results in decreased activity of CCNE1 protein |
CTD |
PMID:10708481 PMID:14633663 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccng1 |
cyclin G1 |
decreases expression increases expression |
EXP ISO |
2-Acetylaminofluorene results in decreased expression of CCNG1 mRNA 2-Acetylaminofluorene results in increased expression of CCNG1 mRNA |
CTD |
PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684 |
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NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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G |
Cd276 |
Cd276 molecule |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CD276 mRNA |
CTD |
PMID:17070881 PMID:21784091 |
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NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
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G |
Cd44 |
CD44 molecule |
increases expression |
EXP IEP |
2-Acetylaminofluorene results in increased expression of CD44 mRNA; 2-Acetylaminofluorene results in increased expression of CD44 protein 2-Fluorenylacetamide increases CD44 mRNA in liver, and protein in liver and serum |
CTD RGD |
PMID:17187413 PMID:22584684 PMID:33211169 PMID:31966914 |
RGD:25823185 |
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cdc37 |
cell division cycle 37, HSP90 cochaperone |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 protein |
CTD |
PMID:16317707 |
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NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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G |
Cdca3 |
cell division cycle associated 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDCA3 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
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G |
Cdh13 |
cadherin 13 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDH13 mRNA |
CTD |
PMID:21784091 |
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NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
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G |
Cdh22 |
cadherin 22 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDH22 mRNA |
CTD |
PMID:17187413 |
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NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588
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G |
Cdh3 |
cadherin 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDH3 mRNA |
CTD |
PMID:17187413 |
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NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDK1 mRNA |
CTD |
PMID:19167416 PMID:22584684 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions decreases activity |
EXP |
2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; 2-Acetylaminofluorene results in decreased localization of and results in decreased phosphorylation of and results in decreased activity of CDK2 protein 2-Acetylaminofluorene results in decreased activity of CDK2 protein |
CTD |
PMID:10708481 PMID:15158336 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases activity |
EXP |
2-Acetylaminofluorene results in increased activity of CDK4 protein |
CTD |
PMID:15158336 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
EXP ISO |
2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of CDKN1A protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; pioglitazone inhibits the reaction [2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]] 2-Acetylaminofluorene results in increased expression of CDKN1A mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA] 2-Acetylaminofluorene results in increased expression of CDKN1A mRNA; 2-Acetylaminofluorene results in increased expression of CDKN1A protein |
CTD |
PMID:10708481 PMID:11003613 PMID:14633663 PMID:17070881 PMID:17317680 PMID:17582756 PMID:19167416 PMID:21607683 PMID:22213190 PMID:22584684 More...
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions |
EXP |
2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]; Pioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]] |
CTD |
PMID:17582756 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions increases expression increases methylation |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A protein 2-Acetylaminofluorene results in increased expression of CDKN2A mRNA 2-Acetylaminofluorene results in increased methylation of CDKN2A gene; 2-Acetylaminofluorene results in increased methylation of CDKN2A promoter |
CTD |
PMID:16317707 PMID:18204080 PMID:19167416 PMID:20188851 PMID:22213190 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cdkn2b |
cyclin-dependent kinase inhibitor 2B |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of CDKN2B mRNA |
CTD |
PMID:17317680 PMID:22213190 |
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NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
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G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDKN2C mRNA |
CTD |
PMID:22584684 |
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NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
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G |
Cdkn3 |
cyclin-dependent kinase inhibitor 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDKN3 mRNA |
CTD |
PMID:22213190 PMID:22584684 |
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NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CEBPA protein |
CTD |
PMID:20188851 PMID:21785164 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions decreases expression |
EXP |
2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter] 2-Acetylaminofluorene results in decreased expression of CEBPB protein |
CTD |
PMID:21785164 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Ces2e |
carboxylesterase 2E |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CES2E mRNA |
CTD |
PMID:21607683 |
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NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856
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G |
Ces3a |
carboxylesterase 3a |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CES3 mRNA |
CTD |
PMID:20713471 |
|
NCBI chr19:32,992,386...33,000,562
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G |
Ckmt1 |
creatine kinase, mitochondrial 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CKMT1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
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G |
Cldn4 |
claudin 4 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CLDN4 mRNA |
CTD |
PMID:17187413 |
|
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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G |
Cldn7 |
claudin 7 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CLDN7 mRNA |
CTD |
PMID:17187413 |
|
NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
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G |
Clu |
clusterin |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CLU mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CLU mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Cmas |
cytidine monophosphate N-acetylneuraminic acid synthetase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CMAS protein |
CTD |
PMID:6331524 |
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NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125
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G |
Col17a1 |
collagen type XVII alpha 1 chain |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632
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G |
Commd3 |
COMM domain containing 3 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of COMMD3 mRNA |
CTD |
PMID:17317680 |
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NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177
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G |
Coq6 |
coenzyme Q6 monooxygenase |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of COQ6 mRNA |
CTD |
PMID:16158176 |
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NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
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G |
Cpq |
carboxypeptidase Q |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CPQ mRNA |
CTD |
PMID:17070881 |
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NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
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G |
Cps1 |
carbamoyl-phosphate synthase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of CPS1 protein |
CTD |
PMID:11813887 |
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NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
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G |
Crebbp |
CREB binding protein |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CREBBP mRNA |
CTD |
PMID:22213190 |
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NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Cryab |
crystallin, alpha B |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CRYAB mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Cryl1 |
crystallin, lambda 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CRYL1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CRYL1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
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G |
Csta |
cystatin A |
affects expression |
ISO |
2-Acetylaminofluorene affects the expression of CSTA mRNA |
CTD |
PMID:27825931 |
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NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CX3CL1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of CXCL1 protein |
CTD |
PMID:25051504 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of CXCL10 protein |
CTD |
PMID:25051504 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCL12 protein 2-Acetylaminofluorene results in increased expression of CXCL12 mRNA; 2-Acetylaminofluorene results in increased expression of CXCL12 protein |
CTD |
PMID:12626097 PMID:15579440 |
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NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of CXCL2 protein |
CTD |
PMID:25051504 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of CXCR4 mRNA [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 protein |
CTD |
PMID:12626097 PMID:15579440 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases hydrolysis multiple interactions increases expression |
ISO EXP |
CYP1A1 results in increased hydrolysis of 2-Acetylaminofluorene 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA] 2-Acetylaminofluorene analog results in increased expression of CYP1A1 protein; 2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP1A1 protein |
CTD |
PMID:2334931 PMID:10445401 PMID:11888708 PMID:15916741 PMID:20713471 PMID:25224404 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects metabolic processing increases expression decreases expression multiple interactions increases hydrolysis increases activity |
ISO EXP |
CYP1A2 protein affects the metabolism of 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of CYP1A2 protein 2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA 2-Acetylaminofluorene analog results in decreased expression of CYP1A2 protein; 2-Acetylaminofluorene results in decreased expression of CYP1A2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA] CYP1A2 results in increased hydrolysis of 2-Acetylaminofluorene CYP1A2 protein results in increased activity of 2-Acetylaminofluorene |
CTD |
PMID:2334931 PMID:2655891 PMID:15450435 PMID:15916741 PMID:16381673 PMID:28245158 More...
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:17317680 PMID:20713471 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CYP2A22 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases expression increases expression |
EXP |
2-Acetylaminofluorene analog results in decreased expression of CYP2B1 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B1 protein 2-Acetylaminofluorene results in increased expression of CYP2B1 protein |
CTD |
PMID:10445401 PMID:15916741 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
decreases expression |
EXP |
2-Acetylaminofluorene analog results in decreased expression of CYP2B2 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B2 protein |
CTD |
PMID:15916741 |
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NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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G |
Cyp2c13 |
cytochrome P450, family 2, subfamily c, polypeptide 13 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CYP2C13 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CYP2E1 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] 2-Acetylaminofluorene analog results in increased expression of CYP2E1 protein; 2-Acetylaminofluorene results in increased expression of CYP2E1 protein |
CTD |
PMID:14656948 PMID:15916741 PMID:16158176 PMID:17393424 PMID:23665045 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CYP3A2 protein |
CTD |
PMID:10445401 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 protein [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP3A23-3A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP3A23-3A1 mRNA; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]; Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA] |
CTD |
PMID:12504080 PMID:14656948 PMID:16158176 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp4f5 |
cytochrome P450, family 4, subfamily f, polypeptide 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CYP4F5 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Dap |
death-associated protein |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of DAP mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of DAP mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Ddah1 |
dimethylarginine dimethylaminohydrolase 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of DDAH1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
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G |
Ddit4l |
DNA-damage-inducible transcript 4-like |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of DDIT4L mRNA |
CTD |
PMID:21607683 |
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NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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G |
Ddr1 |
discoidin domain receptor tyrosine kinase 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of DDR1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
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G |
Des |
desmin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of DES mRNA |
CTD |
PMID:17187413 |
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NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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G |
Dhodh |
dihydroorotate dehydrogenase (quinone) |
decreases activity |
EXP |
2-Acetylaminofluorene results in decreased activity of DHODH protein |
CTD |
PMID:6331524 |
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NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of DLK1 mRNA; 2-Acetylaminofluorene results in increased expression of DLK1 protein |
CTD |
PMID:15567716 PMID:17187413 PMID:17538966 |
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NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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G |
Dmp1 |
dentin matrix acidic phosphoprotein 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of DMP1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression increases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of E2F1 protein 2-Acetylaminofluorene results in increased expression of E2F1 mRNA |
CTD |
PMID:15158336 PMID:19167416 PMID:22213190 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f3 |
E2F transcription factor 3 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of E2F3 protein |
CTD |
PMID:15158336 PMID:19167416 |
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NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
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G |
E2f4 |
E2F transcription factor 4 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of E2F4 protein |
CTD |
PMID:15158336 |
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NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
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G |
Eda2r |
ectodysplasin A2 receptor |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of EDA2R mRNA |
CTD |
PMID:21607683 |
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NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268
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G |
Egf |
epidermal growth factor |
decreases localization multiple interactions |
EXP |
2-Acetylaminofluorene results in decreased localization of EGF protein 2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein] |
CTD |
PMID:10900465 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases expression |
EXP |
2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein] 2-Acetylaminofluorene results in decreased expression of EGFR mRNA |
CTD |
PMID:10900465 PMID:22213190 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of EGR1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Ei24 |
EI24, autophagy associated transmembrane protein |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
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G |
Emp2 |
epithelial membrane protein 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of EMP2 mRNA |
CTD |
PMID:21607683 |
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NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733
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G |
Enc1 |
ectodermal-neural cortex 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ENC1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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G |
Eno1 |
enolase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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G |
Epcam |
epithelial cell adhesion molecule |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of EPCAM mRNA |
CTD |
PMID:17070881 PMID:17187413 |
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NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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G |
Epha1 |
Eph receptor A1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of EPHA1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP ISO |
2-Acetylaminofluorene results in increased expression of EPHX1 mRNA |
CTD |
PMID:17070881 PMID:17317680 PMID:21607683 |
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NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ERBB2 protein |
CTD |
PMID:11350689 |
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ESR1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Exoc4 |
exocyst complex component 4 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of EXOC4 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723
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G |
Fam110a |
family with sequence similarity 110, member A |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of FAM110A mRNA |
CTD |
PMID:21607683 |
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NCBI chr 3:140,474,484...140,485,074
Ensembl chr 3:140,474,249...140,485,093
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G |
Fas |
Fas cell surface death receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of FAS mRNA |
CTD |
PMID:17070881 PMID:22584684 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fbxw9 |
F-box and WD repeat domain containing 9 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of FBXW9 mRNA |
CTD |
PMID:21607683 |
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NCBI chr19:23,090,534...23,097,439
Ensembl chr19:23,090,534...23,097,439
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G |
Fhit |
fragile histidine triad diadenosine triphosphatase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of FHIT mRNA |
CTD |
PMID:17070881 |
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NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
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G |
Flt3 |
Fms related receptor tyrosine kinase 3 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of FLT3 mRNA |
CTD |
PMID:18031378 |
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NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474
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G |
Fn1 |
fibronectin 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of FN1 mRNA |
CTD |
PMID:15940639 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein] |
CTD |
PMID:17696247 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fth1 |
ferritin heavy chain 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of FTH1 protein |
CTD |
PMID:21785164 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein] |
CTD |
PMID:15554553 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Gaa |
alpha glucosidase |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GAA mRNA |
CTD |
PMID:17317680 |
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NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836
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G |
Gas2l3 |
growth arrest-specific 2 like 3 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of GAS2L3 mRNA |
CTD |
PMID:20713471 |
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NCBI chr 7:23,803,578...23,836,816
Ensembl chr 7:23,806,310...23,836,411
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G |
Gcgr |
glucagon receptor |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCGR mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCGR mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of GCLC mRNA [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA |
CTD |
PMID:14656948 PMID:16158176 PMID:16426233 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLM mRNA |
CTD |
PMID:16158176 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GDF15 mRNA |
CTD |
PMID:21607683 |
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NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of GGT1 mRNA [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein] |
CTD |
PMID:15554553 PMID:17187413 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Gja1 |
gap junction protein, alpha 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of GJA1 mRNA; 2-Acetylaminofluorene results in increased expression of GJA1 protein |
CTD |
PMID:15133858 PMID:17187413 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gjb1 |
gap junction protein, beta 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of GJB1 mRNA |
CTD |
PMID:2559087 |
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NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
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G |
Gjb2 |
gap junction protein, beta 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of GJB2 mRNA |
CTD |
PMID:22213190 |
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NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
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G |
Glrx3 |
glutaredoxin 3 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GLRX3 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
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G |
Gpc3 |
glypican 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of GPC3 mRNA |
CTD |
PMID:17187413 |
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NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798
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G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GPX2 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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G |
Gria3 |
glutamate ionotropic receptor AMPA type subunit 3 |
increases expression |
EXP ISO |
2-Acetylaminofluorene results in increased expression of GRIA3 mRNA |
CTD |
PMID:17070881 PMID:21607683 |
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NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
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G |
Grina |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GRINA mRNA |
CTD |
PMID:21607683 |
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NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases activity decreases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSR mRNA; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of GSR protein] |
CTD |
PMID:16158176 PMID:23665045 PMID:26364502 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gss |
glutathione synthetase |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GSS mRNA |
CTD |
PMID:17317680 |
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NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions increases expression |
EXP ISO |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTA2 mRNA 2-Acetylaminofluorene results in increased expression of GSTA2 mRNA |
CTD |
PMID:14656948 PMID:16158176 PMID:17317680 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of GSTM1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein] 2-Acetylaminofluorene results in increased expression of GSTP1 mRNA; 2-Acetylaminofluorene results in increased expression of GSTP1 protein |
CTD |
PMID:12497209 PMID:12781041 PMID:12907702 PMID:15554553 PMID:17393424 PMID:18271918 PMID:21785164 PMID:22213190 More...
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gtse1 |
G-2 and S-phase expressed 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GTSE1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
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G |
H2ax |
H2A.X variant histone |
increases expression increases phosphorylation |
EXP ISO |
2-Acetylaminofluorene results in increased expression of H2AX protein 2-Acetylaminofluorene results in increased phosphorylation of H2AX protein |
CTD |
PMID:26338220 PMID:34510228 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of HADHA mRNA |
CTD |
PMID:16158176 |
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NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions decreases expression |
EXP |
2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter] 2-Acetylaminofluorene results in decreased expression of HAMP mRNA |
CTD |
PMID:21785164 |
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NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hebp2 |
heme binding protein 2 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA; beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] |
CTD |
PMID:20435455 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmox1 |
heme oxygenase 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of HMOX1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hras |
HRas proto-oncogene, GTPase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of HRAS protein |
CTD |
PMID:11350689 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsd17b6 |
hydroxysteroid (17-beta) dehydrogenase 6 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of HSD17B6 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425
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G |
Ica1 |
islet cell autoantigen 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ICA1 mRNA |
CTD |
PMID:21784091 |
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NCBI chr 4:36,656,475...36,804,705
Ensembl chr 4:36,656,475...36,804,298
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G |
Id1 |
inhibitor of DNA binding 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ID1 mRNA |
CTD |
PMID:15120964 |
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NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Ifna1 |
interferon, alpha 1 |
multiple interactions |
EXP |
IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA] |
CTD |
PMID:14633663 |
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NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
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G |
Ifna2 |
interferon alpha 2 |
multiple interactions |
EXP |
IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:11915028 PMID:15368444 |
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NCBI chr 5:103,258,617...103,259,195
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G |
Ifng |
interferon gamma |
multiple interactions |
EXP |
2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein] |
CTD |
PMID:14736494 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf2 |
insulin-like growth factor 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of IGF2 mRNA |
CTD |
PMID:22213190 |
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NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Igfals |
insulin-like growth factor binding protein, acid labile subunit |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of IGFALS mRNA |
CTD |
PMID:21607683 |
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NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
increases activity |
ISO |
2-Acetylaminofluorene results in increased activity of IKBKB protein |
CTD |
PMID:11960367 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of IL10 protein |
CTD |
PMID:25051504 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of IL12B protein |
CTD |
PMID:25051504 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il1b |
interleukin 1 beta |
multiple interactions affects expression increases expression |
ISO EXP |
2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] 2-Acetylaminofluorene affects the expression of IL1B mRNA 2-Acetylaminofluorene results in increased expression of IL1B protein |
CTD |
PMID:14670622 PMID:25051504 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of IL2RA mRNA |
CTD |
PMID:17070881 |
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NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il33 |
interleukin 33 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of IL33 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il5 |
interleukin 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of IL5 protein |
CTD |
PMID:25051504 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of IL6 protein |
CTD |
PMID:25051504 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgb4 |
integrin subunit beta 4 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ITGB4 mRNA |
CTD |
PMID:17317680 |
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NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein] |
CTD |
PMID:17696247 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kdm6a |
lysine demethylase 6A |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of KDM6A mRNA |
CTD |
PMID:22213190 |
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NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062
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G |
Kif11 |
kinesin family member 11 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of KIF11 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
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G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of KIT protein |
CTD |
PMID:15133858 |
|
NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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G |
Krt14 |
keratin 14 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of KRT14 protein |
CTD |
PMID:33211169 |
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NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799
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G |
Krt15 |
keratin 15 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of KRT15 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
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G |
Krt19 |
keratin 19 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of KRT19 mRNA; 2-Acetylaminofluorene results in increased expression of KRT19 protein [Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of KRT19 protein |
CTD |
PMID:15133858 PMID:17187413 PMID:17661067 |
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NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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G |
Krt20 |
keratin 20 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of KRT20 mRNA |
CTD |
PMID:17317680 |
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NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107
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G |
Krt23 |
keratin 23 |
multiple interactions increases expression |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr10:84,434,445...84,450,773
Ensembl chr10:84,434,380...84,450,983
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G |
Krt4 |
keratin 4 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of KRT4 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 7:133,046,067...133,052,027
Ensembl chr 7:133,046,515...133,052,019
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G |
Krt8 |
keratin 8 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of KRT8 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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G |
Lep |
leptin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of LEP protein |
CTD |
PMID:25051504 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lig4 |
DNA ligase 4 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of LIG4 mRNA |
CTD |
PMID:19167416 |
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NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
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G |
Ly6d |
lymphocyte antigen 6 family member D |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of LY6D mRNA |
CTD |
PMID:17317680 |
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NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733
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G |
Ly6e |
lymphocyte antigen 6 family member E |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of LY6E mRNA |
CTD |
PMID:21607683 |
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NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
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G |
Lypd3 |
Ly6/Plaur domain containing 3 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901
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G |
Lzic |
leucine zipper and CTNNBIP1 domain containing |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of LZIC mRNA |
CTD |
PMID:21607683 |
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NCBI chr 5:159,928,260...159,941,512
Ensembl chr 5:159,920,439...159,939,685
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G |
Mal |
mal, T-cell differentiation protein |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of MAL mRNA |
CTD |
PMID:17317680 |
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NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
2-Acetylaminofluorene affects the phosphorylation of and affects the activity of MAPK8 protein |
CTD |
PMID:17546627 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mat1a |
methionine adenosyltransferase 1A |
affects acetylation decreases expression affects methylation |
EXP |
2-Acetylaminofluorene affects the acetylation of MAT1A exon; 2-Acetylaminofluorene affects the acetylation of MAT1A promoter 2-Acetylaminofluorene results in decreased expression of MAT1A mRNA 2-Acetylaminofluorene affects the methylation of MAT1A exon; 2-Acetylaminofluorene affects the methylation of MAT1A promoter |
CTD |
PMID:22213190 |
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NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274
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G |
Matn2 |
matrilin 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MATN2 mRNA; 2-Acetylaminofluorene results in increased expression of MATN2 protein |
CTD |
PMID:17513098 |
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NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113
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G |
Mbl2 |
mannose binding lectin 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of MBL2 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 1:228,016,439...228,024,736
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G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions increases expression |
EXP ISO |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein 2-Acetylaminofluorene results in increased expression of MDM2 mRNA; 2-Acetylaminofluorene results in increased expression of MDM2 protein |
CTD |
PMID:11003613 PMID:19167416 PMID:21607683 PMID:22213190 PMID:22584684 |
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NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Meg3 |
maternally expressed 3 |
decreases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in decreased expression of MEG3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 6:128,491,808...128,524,010
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases expression decreases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MGMT mRNA 2-Acetylaminofluorene results in decreased expression of MGMT mRNA |
CTD |
PMID:17070881 PMID:22213190 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mgst2 |
microsomal glutathione S-transferase 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MGST2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MGST2 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
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G |
Mir106b |
microRNA 106b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR106B mRNA |
CTD |
PMID:19167416 |
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NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425
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G |
Mir125b1 |
microRNA 125b-1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR125B-1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052
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G |
Mir130b |
microRNA 130b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR130B mRNA |
CTD |
PMID:19167416 |
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NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244
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G |
Mir132 |
microRNA 132 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR132 mRNA |
CTD |
PMID:19167416 |
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NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
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G |
Mir146b |
microRNA 146b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR146B mRNA |
CTD |
PMID:19167416 |
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NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525
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G |
Mir155 |
microRNA 155 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR155 mRNA |
CTD |
PMID:19167416 |
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NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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G |
Mir17 |
microRNA 17 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR17; 2-Acetylaminofluorene results in increased expression of MIR17 mRNA |
CTD |
PMID:19167416 PMID:20188851 |
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NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
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G |
Mir181b2 |
microRNA 181b-2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR181B-2 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035
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G |
Mir181c |
microRNA 181c |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR181C mRNA |
CTD |
PMID:19167416 |
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NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628
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G |
Mir185 |
microRNA 185 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR185 mRNA |
CTD |
PMID:19167416 |
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NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
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G |
Mir18a |
microRNA 18a |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR18A; 2-Acetylaminofluorene results in increased expression of MIR18A mRNA |
CTD |
PMID:19167416 PMID:20188851 |
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NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
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G |
Mir200a |
microRNA 200a |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR200A mRNA |
CTD |
PMID:19167416 PMID:22584684 |
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NCBI chr 5:166,648,494...166,648,582
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G |
Mir200b |
microRNA 200b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR200B mRNA |
CTD |
PMID:19167416 PMID:22584684 |
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NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
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G |
Mir200c |
microRNA 200c |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR200C mRNA |
CTD |
PMID:19167416 |
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NCBI chr 4:157,523,679...157,523,747
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G |
Mir202 |
microRNA 202 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR202 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 1:194,754,730...194,754,801
Ensembl chr 1:194,754,730...194,754,801
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G |
Mir204 |
microRNA 204 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR204 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040
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G |
Mir205 |
microRNA 205 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR205 mRNA |
CTD |
PMID:19167416 |
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NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985
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G |
Mir20a |
microRNA 20a |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR20A; 2-Acetylaminofluorene results in increased expression of MIR20A mRNA |
CTD |
PMID:19167416 PMID:20188851 |
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NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
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G |
Mir21 |
microRNA 21 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR21 mRNA |
CTD |
PMID:19167416 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir214 |
microRNA 214 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR214 mRNA |
CTD |
PMID:19167416 |
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NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
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G |
Mir22 |
microRNA 22 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR22 mRNA |
CTD |
PMID:22213190 |
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NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
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G |
Mir221 |
microRNA 221 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR221 mRNA |
CTD |
PMID:19167416 |
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NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573
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G |
Mir293 |
microRNA 293 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR293 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 1:65,963,050...65,963,121
Ensembl chr 1:65,963,050...65,963,121
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G |
Mir31 |
microRNA 31 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR31; 2-Acetylaminofluorene results in increased expression of MIR31 mRNA |
CTD |
PMID:19167416 PMID:20188851 |
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NCBI chr 5:103,599,038...103,599,143
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G |
Mir34a |
microRNA 34a |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR34A mRNA |
CTD |
PMID:19167416 PMID:22584684 |
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NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
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G |
Mir3545 |
microRNA 3545 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR203 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656
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G |
Mir410 |
microRNA 410 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR410 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
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G |
Mir429 |
microRNA 429 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR429 mRNA |
CTD |
PMID:19167416 PMID:22584684 |
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NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543
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G |
Mir490 |
microRNA 490 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR490 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 4:65,047,548...65,047,631
Ensembl chr 4:65,047,548...65,047,631
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G |
Mir93 |
microRNA 93 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR93; 2-Acetylaminofluorene results in increased expression of MIR93 mRNA |
CTD |
PMID:19167416 PMID:20188851 |
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NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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G |
Mir96 |
microRNA 96 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR96 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
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G |
Mir99a |
microRNA 99a |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR99A mRNA |
CTD |
PMID:19167416 PMID:22584684 |
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NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
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G |
Mirlet7b |
microRNA let-7b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIRLET7B mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
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G |
Mirlet7c1 |
microRNA let-7c-1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIRLET7C-1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
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G |
Mirlet7i |
microRNA let-7i |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIRLET7I mRNA |
CTD |
PMID:19167416 |
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NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions increases expression |
EXP ISO |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein] 2-Acetylaminofluorene results in increased expression of MKI67 mRNA |
CTD |
PMID:15565650 PMID:17317680 PMID:17393424 PMID:23665045 PMID:26338220 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp2 |
matrix metallopeptidase 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MMP2 mRNA |
CTD |
PMID:18678246 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MMP9 mRNA |
CTD |
PMID:18678246 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mt1 |
metallothionein 1 |
multiple interactions increases expression |
EXP |
Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MT1A protein] |
CTD |
PMID:15565650 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Mthfr |
methylenetetrahydrofolate reductase |
decreases expression decreases methylation |
EXP |
2-Acetylaminofluorene results in decreased expression of MTHFR mRNA 2-Acetylaminofluorene results in decreased methylation of MTHFR promoter |
CTD |
PMID:22213190 |
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NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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G |
Muc1 |
mucin 1, cell surface associated |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MUC1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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G |
Mybl1 |
MYB proto-oncogene like 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of MYBL1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions increases mutagenesis increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein] 2-Acetylaminofluorene results in increased mutagenesis of MYC gene 2-Acetylaminofluorene results in increased expression of MYC protein |
CTD |
PMID:11350689 PMID:17696247 PMID:19167416 PMID:20188851 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nampt |
nicotinamide phosphoribosyltransferase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of NAMPT mRNA |
CTD |
PMID:22584684 |
|
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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G |
Nat1 |
N-acetyltransferase 1 |
increases activity |
ISO |
NAT1 protein results in increased activity of 2-Acetylaminofluorene |
CTD |
PMID:15450435 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
increases activity |
ISO |
NAT2 protein results in increased activity of 2-Acetylaminofluorene |
CTD |
PMID:15450435 |
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Nek6 |
NIMA-related kinase 6 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of NEK6 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression increases activity |
ISO |
2-Acetylaminofluorene results in increased expression of NFE2L2 mRNA 2-Acetylaminofluorene results in increased activity of NFE2L2 protein |
CTD |
PMID:21607683 PMID:30114225 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions increases localization |
ISO |
[RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA] 2-Acetylaminofluorene results in increased localization of NFKB1 protein Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of NFKB1 protein] |
CTD |
PMID:11960367 PMID:17303067 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein; Acetylcysteine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]; S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:18404532 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions increases degradation |
EXP |
[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased degradation of NFKBIB protein 2-Acetylaminofluorene results in increased degradation of NFKBIB protein |
CTD |
PMID:11020383 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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G |
Ngfr |
nerve growth factor receptor |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of TNFRSF10B mRNA |
CTD |
PMID:21607683 |
|
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Ninj1 |
ninjurin 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of NINJ1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NINJ1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of NOS2 protein] |
CTD |
PMID:23665045 PMID:26364502 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of NOS3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Notch1 |
notch receptor 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of NOTCH1 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Nprl2 |
NPR2-like, GATOR1 complex subunit |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of NPRL2 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of NQO1 mRNA |
CTD |
PMID:21607683 PMID:22213190 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of NR1I2 mRNA NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA] NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A11 mRNA] |
CTD |
PMID:12504080 PMID:16381673 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nudcd2 |
NudC domain containing 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of NUDCD2 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr10:25,163,247...25,168,738
Ensembl chr10:25,163,220...25,168,738
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G |
Nudt7 |
nudix hydrolase 7 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of NUDT7 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081
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G |
Nup50-ps1 |
nucleoporin 50, pseudogene 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SPG7 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SPG7 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr 4:128,787,567...128,789,296
Ensembl chr 4:128,787,100...128,789,312
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G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of NUPR1 mRNA |
CTD |
PMID:17070881 PMID:22584684 |
|
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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G |
Nusap1 |
nucleolar and spindle associated protein 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of NUSAP1 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
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G |
Ociad2 |
OCIA domain containing 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of OCIAD2 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr14:34,873,668...34,889,276
Ensembl chr14:34,873,820...34,889,265
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G |
Olfm1 |
olfactomedin 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of OLFM1 mRNA |
CTD |
PMID:20713471 |
|
NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239
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G |
Osm |
oncostatin M |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of OSM mRNA |
CTD |
PMID:15743783 PMID:18678246 |
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NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
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G |
Osmr |
oncostatin M receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of OSMR mRNA |
CTD |
PMID:15743783 |
|
NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
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G |
Padi2 |
peptidyl arginine deiminase 2 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 5:153,209,053...153,251,632
Ensembl chr 5:153,209,053...153,251,632
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of PCK1 mRNA |
CTD |
PMID:16510358 |
|
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein] |
CTD |
PMID:16352317 PMID:17393424 PMID:19167416 PMID:23665045 PMID:26364502 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdia3 |
protein disulfide isomerase family A, member 3 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PECAM1 mRNA |
CTD |
PMID:17187413 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Perp |
p53 apoptosis effector related to PMP22 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
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G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of PHLDA3 mRNA |
CTD |
PMID:17070881 PMID:21607683 PMID:22584684 |
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NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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G |
Phyh |
phytanoyl-CoA 2-hydroxylase |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of PHYH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of PHYH mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
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G |
Piga |
phosphatidylinositol glycan anchor biosynthesis, class A |
increases mutagenesis |
EXP |
2-Acetylaminofluorene results in increased mutagenesis of PIGA |
CTD |
PMID:22923490 |
|
NCBI chr X:30,043,033...30,055,861
Ensembl chr X:30,042,343...30,055,804
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G |
Pkd1 |
polycystin 1, transient receptor potential channel interacting |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of PKD1 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128
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G |
Pkm |
pyruvate kinase M1/2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PKM mRNA; 2-Acetylaminofluorene results in increased expression of PKM protein |
CTD |
PMID:17538966 |
|
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pkp1 |
plakophilin 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PKP1 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465
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G |
Plk2 |
polo-like kinase 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PLK2 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA] |
CTD |
PMID:17317680 PMID:19167416 |
|
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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G |
Polk |
DNA polymerase kappa |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of POLK mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
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G |
Por |
cytochrome p450 oxidoreductase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of POR mRNA |
CTD |
PMID:15089088 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Prc1 |
protein regulator of cytokinesis 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PRC1 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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G |
Prkch |
protein kinase C, eta |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
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G |
Prom1 |
prominin 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PROM1 mRNA |
CTD |
PMID:17187413 |
|
NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
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G |
Prox1 |
prospero homeobox 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of PROX1 mRNA |
CTD |
PMID:22213190 |
|
NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
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G |
Psmd10 |
proteasome 26S subunit, non-ATPase 10 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of PSMD10 protein RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein] |
CTD |
PMID:16448463 |
|
NCBI chr X:104,656,809...104,665,122
Ensembl chr X:104,656,812...104,665,097
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G |
Psrc1 |
proline and serine rich coiled-coil 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PSRC1 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874
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G |
Pten |
phosphatase and tensin homolog |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of PTEN protein |
CTD |
PMID:19167416 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptgr1 |
prostaglandin reductase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNA |
CTD |
PMID:16158176 |
|
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PTGS2 protein] |
CTD |
PMID:23665045 PMID:26364502 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptn |
pleiotrophin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PTN mRNA |
CTD |
PMID:12057922 |
|
NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456
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G |
Ptp4a3 |
protein tyrosine phosphatase 4A3 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PTP4A3 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 7:105,650,640...105,660,921
Ensembl chr 7:105,628,029...105,660,919
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G |
Ptprc |
protein tyrosine phosphatase, receptor type, C |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PTPRC mRNA |
CTD |
PMID:17187413 |
|
NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
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G |
Pttg1 |
PTTG1 regulator of sister chromatid separation, securin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PTTG1 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
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G |
Pvt1 |
Pvt1 oncogene |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PVT1 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 7:93,656,528...93,879,938
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G |
Rac1 |
Rac family small GTPase 1 |
increases activity multiple interactions |
ISO |
2-Acetylaminofluorene results in increased activity of RAC1 protein [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA |
CTD |
PMID:11960367 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Rassf1 |
Ras association domain family member 1 |
increases methylation |
EXP |
2-Acetylaminofluorene results in increased methylation of RASSF1 promoter |
CTD |
PMID:20188851 |
|
NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
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G |
Rb1 |
RB transcriptional corepressor 1 |
affects phosphorylation multiple interactions |
EXP |
2-Acetylaminofluorene affects the phosphorylation of RB1 protein 2-Acetylaminofluorene results in increased expression of and results in increased phosphorylation of RB1 protein; RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein] |
CTD |
PMID:15158336 PMID:16448463 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rbx1 |
ring-box 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RBX1 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases activity increases expression multiple interactions increases localization |
ISO EXP |
2-Acetylaminofluorene results in increased activity of RELA protein 2-Acetylaminofluorene results in increased expression of RELA protein geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of RELA protein]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA] 2-Acetylaminofluorene results in increased localization of RELA protein [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA] 2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of RELA protein] |
CTD |
PMID:11020383 PMID:11960367 PMID:14670622 PMID:17303067 PMID:26364502 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rgn |
regucalcin |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of RGN mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of RGN mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450
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G |
Rgs2 |
regulator of G-protein signaling 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of RGS2 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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G |
Rhbdf2 |
rhomboid 5 homolog 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RHBDF2 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283
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G |
Rhob |
ras homolog family member B |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of RHOB mRNA |
CTD |
PMID:22584684 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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G |
Rhobtb2 |
Rho-related BTB domain containing 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of RHOBTB2 mRNA |
CTD |
PMID:17070881 |
|
NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651
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G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of RIPK1 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
|
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RIPK3 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
|
|
G |
Ripk4 |
receptor-interacting serine-threonine kinase 4 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RIPK4 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr11:37,122,555...37,144,799
Ensembl chr11:37,122,565...37,144,799
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G |
Ros1 |
ROS proto-oncogene 1 , receptor tyrosine kinase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ROS1 mRNA |
CTD |
PMID:17187413 |
|
NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865
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|
G |
Rplp0 |
ribosomal protein lateral stalk subunit P0 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of RPLP0 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of RPLP0 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
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G |
Rprm |
reprimo, TP53 dependent G2 arrest mediator homolog |
multiple interactions increases expression decreases expression |
ISO EXP |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA] 2-Acetylaminofluorene results in increased expression of RPRM mRNA 2-Acetylaminofluorene results in decreased expression of RPRM mRNA |
CTD |
PMID:17317680 PMID:19167416 PMID:22584684 |
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NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998
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G |
Rps27l |
ribosomal protein S27-like |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RPS27L mRNA |
CTD |
PMID:17317680 |
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NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
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G |
Rrm1 |
ribonucleotide reductase catalytic subunit M1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RRM1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
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G |
Rrm2b |
ribonucleotide reductase regulatory TP53 inducible subunit M2B |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RRM2B mRNA |
CTD |
PMID:21704725 |
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NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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G |
Rsad2 |
radical S-adenosyl methionine domain containing 2 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of RSAD2 mRNA |
CTD |
PMID:20713471 |
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NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
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G |
S100a11 |
S100 calcium binding protein A11 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of S100A11 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044
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G |
S100a14 |
S100 calcium binding protein A14 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of S100A14 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 2:176,008,395...176,010,423
Ensembl chr 2:176,008,395...176,010,423
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G |
Scarb2 |
scavenger receptor class B, member 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of SCARB2 mRNA |
CTD |
PMID:17317680 |
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NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
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G |
Scpep1 |
serine carboxypeptidase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SCPEP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SCPEP1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr10:73,703,275...73,732,892
Ensembl chr10:73,703,278...73,732,850
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G |
Sctr |
secretin receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SCTR mRNA |
CTD |
PMID:17187413 |
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NCBI chr13:31,127,781...31,190,162
Ensembl chr13:31,127,858...31,180,189
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G |
Serpina7 |
serpin family A member 7 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SERPINA7 mRNA |
CTD |
PMID:17070881 |
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NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
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G |
Serpinb5 |
serpin family B member 5 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of SERPINB5 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
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G |
Serpinf1 |
serpin family F member 1 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of SERPINF1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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G |
Sesn2 |
sestrin 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of SESN2 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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G |
Sfn |
stratifin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SFN mRNA |
CTD |
PMID:19167416 PMID:22213190 |
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NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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G |
Sirt1 |
sirtuin 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SIRT1 protein |
CTD |
PMID:19167416 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Slc15a5 |
solute carrier family 15, member 5 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of SLC15A5 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 4:170,878,021...170,971,620
Ensembl chr 4:170,878,021...170,971,620
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G |
Slc16a10 |
solute carrier family 16 member 10 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of SLC16A10 mRNA |
CTD |
PMID:17070881 |
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NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
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G |
Slc25a4 |
solute carrier family 25 member 4 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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G |
Slc2a8 |
solute carrier family 2 member 8 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464
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G |
Slc40a1 |
solute carrier family 40 member 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SLC40A1 mRNA |
CTD |
PMID:21785164 |
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NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1A4 mRNA |
CTD |
PMID:16158176 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1B2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SLCO1B2 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:15368444 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:15368444 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Smad4 |
SMAD family member 4 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of SMAD4 mRNA |
CTD |
PMID:22213190 |
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NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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G |
Smo |
smoothened, frizzled class receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SMO mRNA |
CTD |
PMID:17187413 |
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NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
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G |
Sncg |
synuclein, gamma |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SNCG mRNA |
CTD |
PMID:22213190 |
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NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
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G |
Sntg2 |
syntrophin, gamma 2 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of SNTG2 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 6:46,801,893...47,003,390
Ensembl chr 6:46,801,377...47,003,372
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G |
Socs1 |
suppressor of cytokine signaling 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SOCS1 mRNA |
CTD |
PMID:22213190 |
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NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of SOD1 protein |
CTD |
PMID:17761372 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein; O-(Chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] |
CTD |
PMID:17761372 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sox4 |
SRY-box transcription factor 4 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SOX4 mRNA |
CTD |
PMID:22584684 |
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NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665
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G |
Spink1 |
serine peptidase inhibitor, Kazal type 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of SPINK1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
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G |
Sprr1a |
small proline-rich protein 1A |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of SPRR1A mRNA |
CTD |
PMID:17317680 |
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NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063
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G |
Sprr2f |
small proline rich protein 2F |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of SPRR2F mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 2:177,989,974...177,990,204
Ensembl chr 2:177,989,974...177,990,204
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G |
Sptlc2 |
serine palmitoyltransferase, long chain base subunit 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of SPTLC2 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542
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G |
Sst |
somatostatin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SST protein |
CTD |
PMID:16534498 |
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NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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G |
St3gal3 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of ST3GAL3 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810
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G |
St3gal5 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ST3GAL5 protein |
CTD |
PMID:6331524 |
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NCBI chr 4:104,134,613...104,192,558
Ensembl chr 4:104,134,613...104,192,558
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein; Dexamethasone inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein] |
CTD |
PMID:12957465 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Steap3 |
STEAP3 metalloreductase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of STEAP3 mRNA |
CTD |
PMID:22584684 |
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NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519
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