Dync1h1 (dynein cytoplasmic 1 heavy chain 1) - Rat Genome Database

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Gene: Dync1h1 (dynein cytoplasmic 1 heavy chain 1) Rattus norvegicus
Analyze
Symbol: Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
RGD ID: 2511
Description: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in cellular response to 3,3',5-triiodo-L-thyronine; cellular response to nerve growth factor stimulus; and spermatid development. Located in several cellular components, including manchette; neuronal cell body; and nuclear envelope. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant intellectual developmental disorder 13; and spinal muscular atrophy with lower extremity predominant 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1); PARTICIPATES IN mitochondria transport pathway; phagocytosis pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytoplasmic dynein 1 heavy chain 1; cytoplasmic dynein heavy chain 1; DHC1a; Dnch1; Dnchc1; dynein heavy chain, cytosolic; dynein, cytoplasmic, heavy chain 1; MAP 1C; microtubule-associated protein 1 C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86135,436,375 - 135,502,117 (+)NCBIGRCr8
mRatBN7.26129,615,208 - 129,680,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,609,397 - 129,680,883 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6129,792,251 - 129,857,975 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,088,243 - 130,153,968 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06129,452,122 - 129,517,762 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06134,958,854 - 135,085,769 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6134,958,854 - 135,085,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,094,877 - 144,159,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46135,318,083 - 135,391,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16135,324,200 - 135,397,646 (+)NCBI
Celera6127,184,881 - 127,250,555 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
asphyxiating thoracic dystrophy 3  (ISO)
atrophic muscular disease  (ISO)
autism spectrum disorder  (ISO)
autosomal dominant cerebellar ataxia  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
autosomal dominant intellectual developmental disorder 13  (ISO)
cerebellar ataxia  (ISO)
cerebellar hypoplasia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease axonal type 2O  (ISO,ISS)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
Charcot-Marie-Tooth disease type 5  (ISO)
childhood spinal muscular atrophy  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
Developmental Disabilities  (ISO)
epilepsy  (ISO)
fetal akinesia deformation sequence syndrome 1  (ISO)
genetic disease  (ISO)
Herpes Simplex Encephalitis 3  (ISO)
intellectual disability  (ISO)
lissencephaly  (ISO)
microcephaly  (ISO)
motor peripheral neuropathy  (ISO)
Muscle Weakness  (ISO)
myopathy  (ISO)
Nervous System Malformations  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
neuropathy  (ISO)
papillary thyroid carcinoma  (ISO)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
spinal muscular atrophy  (ISO)
spinal muscular atrophy with lower extremity predominant  (ISO)
spinal muscular atrophy with lower extremity predominant 1  (ISO)
Spinocerebellar Ataxias  (ISO)
Talipes Cavus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
torcetrapib  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic dynein. Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
2. Triiodothyronine and nerve growth factor are required to induce cytoplasmic dynein expression in rat dorsal root ganglion cultures. Barakat-Walter I and Riederer BM, Brain Res Dev Brain Res. 1996 Oct 23;96(1-2):109-19.
3. A novel cytoplasmic dynein heavy chain: expression of DHC1b in mammalian ciliated epithelial cells. Criswell PS, etal., J Cell Sci. 1996 Jul;109 ( Pt 7):1891-8.
4. Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues. Eschbach J, etal., Biochim Biophys Acta. 2011 Jan;1812(1):59-69. doi: 10.1016/j.bbadis.2010.09.009. Epub 2010 Sep 29.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Effect of Alzheimer's brain extracts on dynein immunoreactivity in PC12 cells. Kopec K and Chambers JP, Proc Soc Exp Biol Med. 1997 Dec;216(3):429-37.
7. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. Ligon LA, etal., J Biol Chem. 2004 Apr 30;279(18):19201-8. Epub 2004 Feb 24.
8. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C). Mikami A, etal., Neuron 1993 May;10(5):787-96.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Homology of the 74-kD cytoplasmic dynein subunit with a flagellar dynein polypeptide suggests an intracellular targeting function. Paschal BM, etal., J Cell Biol 1992 Sep;118(5):1133-43.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Multiple mouse chromosomal loci for dynein-based motility. Vaughan KT, etal., Genomics 1996 Aug 15;36(1):29-38.
21. Distribution of cytoplasmic and axonemal dyneins in rat tissues. Yoshida T, etal., J Cell Sci. 1992 Mar;101 ( Pt 3):579-87.
22. Association of cytoplasmic dynein with manchette microtubules and spermatid nuclear envelope during spermiogenesis in rats. Yoshida T, etal., J Cell Sci. 1994 Mar;107 ( Pt 3):625-33.
23. The primary structure of rat brain (cytoplasmic) dynein heavy chain, a cytoplasmic motor enzyme. Zhang Z, etal., Proc Natl Acad Sci U S A 1993 Sep 1;90(17):7928-32.
Additional References at PubMed
PMID:14760703   PMID:16449194   PMID:16496424   PMID:16854843   PMID:17110338   PMID:19056867   PMID:19199708   PMID:19825938   PMID:19946888   PMID:20458337   PMID:21362503   PMID:21399614  
PMID:21525035   PMID:21700703   PMID:21723285   PMID:22658674   PMID:22681889   PMID:22871113   PMID:23027904   PMID:23533145   PMID:23979707   PMID:24625528   PMID:25272277   PMID:25670086  
PMID:25931508   PMID:26316108   PMID:26514267   PMID:27462074   PMID:29476059   PMID:30978476   PMID:32357304  


Genomics

Comparative Map Data
Dync1h1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86135,436,375 - 135,502,117 (+)NCBIGRCr8
mRatBN7.26129,615,208 - 129,680,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,609,397 - 129,680,883 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6129,792,251 - 129,857,975 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,088,243 - 130,153,968 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06129,452,122 - 129,517,762 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06134,958,854 - 135,085,769 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6134,958,854 - 135,085,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,094,877 - 144,159,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46135,318,083 - 135,391,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16135,324,200 - 135,397,646 (+)NCBI
Celera6127,184,881 - 127,250,555 (+)NCBICelera
Cytogenetic Map6q32NCBI
DYNC1H1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,964,573 - 102,056,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,964,573 - 102,056,443 (+)EnsemblGRCh38hg38GRCh38
GRCh3714102,430,910 - 102,522,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614101,500,734 - 101,586,888 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414101,500,736 - 101,586,887NCBI
Celera1482,485,364 - 82,571,630 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1482,609,802 - 82,696,060 (+)NCBIHuRef
CHM1_114102,368,694 - 102,454,973 (+)NCBICHM1_1
T2T-CHM13v2.01496,200,188 - 96,292,054 (+)NCBIT2T-CHM13v2.0
Dync1h1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912110,567,829 - 110,633,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12110,567,886 - 110,633,379 (+)EnsemblGRCm39 Ensembl
GRCm3812110,601,395 - 110,666,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12110,601,452 - 110,666,945 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712111,839,605 - 111,905,154 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612111,049,261 - 111,114,731 (+)NCBIMGSCv36mm8
Celera12111,791,744 - 111,857,176 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.7NCBI
Dync1h1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555381,390,137 - 1,458,025 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555381,388,595 - 1,458,166 (+)NCBIChiLan1.0ChiLan1.0
DYNC1H1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215103,116,643 - 103,202,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114102,333,470 - 102,419,449 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01482,584,876 - 82,670,750 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114102,406,807 - 102,489,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14102,406,993 - 102,489,475 (+)Ensemblpanpan1.1panPan2
DYNC1H1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,997,021 - 70,064,886 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl869,997,145 - 70,064,825 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha869,511,720 - 69,579,474 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0870,275,463 - 70,343,231 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl870,275,317 - 70,343,231 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1869,939,596 - 70,007,343 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0870,005,661 - 70,073,498 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0870,405,277 - 70,473,042 (+)NCBIUU_Cfam_GSD_1.0
Dync1h1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086403,905,752 - 3,970,028 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936835225,324 - 289,954 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936835225,879 - 290,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNC1H1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27129,791,255 - 129,832,564 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DYNC1H1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12479,915,719 - 80,008,666 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2479,915,889 - 80,000,099 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605367,092,529 - 67,183,574 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dync1h1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247342,254,085 - 2,311,177 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247342,253,931 - 2,311,341 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dync1h1
252 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:29
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000009377, ENSRNOT00000073950
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat

Markers in Region
D6Wox27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26129,615,264 - 129,615,466 (+)MAPPERmRatBN7.2
Rnor_6.06134,958,883 - 134,959,084NCBIRnor6.0
Rnor_5.06144,094,906 - 144,095,107UniSTSRnor5.0
RGSC_v3.46135,318,112 - 135,318,313UniSTSRGSC3.4
Celera6127,184,910 - 127,185,111UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009377   ⟹   ENSRNOP00000009377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6129,609,397 - 129,680,883 (+)Ensembl
Rnor_6.0 Ensembl6134,958,973 - 135,022,584 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073950   ⟹   ENSRNOP00000066312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6129,615,192 - 129,680,883 (+)Ensembl
Rnor_6.0 Ensembl6134,958,854 - 135,085,769 (+)Ensembl
RefSeq Acc Id: NM_019226   ⟹   NP_062099
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86135,436,478 - 135,502,116 (+)NCBI
mRatBN7.26129,615,236 - 129,680,883 (+)NCBI
Rnor_6.06134,958,854 - 135,085,769 (+)NCBI
Rnor_5.06144,094,877 - 144,159,980 (+)NCBI
RGSC_v3.46135,318,083 - 135,391,459 (+)RGD
Celera6127,184,881 - 127,250,555 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111848   ⟹   XP_038967776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86135,436,375 - 135,502,117 (+)NCBI
mRatBN7.26129,615,208 - 129,680,888 (+)NCBI
Protein Sequences
Protein RefSeqs NP_062099 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967776 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41103 (Get FASTA)   NCBI Sequence Viewer  
  AAC52796 (Get FASTA)   NCBI Sequence Viewer  
  EDL97508 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009377.8
  ENSRNOP00000066312.3
GenBank Protein P38650 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062099   ⟸   NM_019226
- UniProtKB: M0R9X8 (UniProtKB/TrEMBL),   A6KBM1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066312   ⟸   ENSRNOT00000073950
Ensembl Acc Id: ENSRNOP00000009377   ⟸   ENSRNOT00000009377
RefSeq Acc Id: XP_038967776   ⟸   XM_039111848
- Peptide Label: isoform X1
- UniProtKB: M0R9X8 (UniProtKB/TrEMBL)
Protein Domains
AAA+ ATPase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694827
Promoter ID:EPDNEW_R5352
Type:initiation region
Name:Dync1h1_1
Description:dynein cytoplasmic 1 heavy chain 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06134,958,838 - 134,958,898EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2511 AgrOrtholog
BioCyc Gene G2FUF-35877 BioCyc
Ensembl Genes ENSRNOG00000006178 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009377.8 UniProtKB/TrEMBL
  ENSRNOT00000073950.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.472.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.8.1220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.8.710 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.8.720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1270.280 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.140.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.1120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.920.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.920.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.920.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.490.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.180.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.1060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_11_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DYNC2H1-like_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_AAA1S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_AAA5_ext UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_C_barrel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_HC_stalk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_heavy_chain_D4_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_heavy_D6_P-loop UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_heavy_dom-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_heavy_dom-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29489 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29489 ENTREZGENE
PANTHER DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MALE FERTILITY FACTOR KL5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHC_N1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHC_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DYN_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_AAA_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_heavy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF12777 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dync1h1 PhenoGen
RatGTEx ENSRNOG00000006178 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204102
UniProt A6KBM1 ENTREZGENE, UniProtKB/TrEMBL
  DYHC1_RAT UniProtKB/Swiss-Prot
  F1LRT9_RAT UniProtKB/TrEMBL
  M0R9X8 ENTREZGENE, UniProtKB/TrEMBL
  P38650 ENTREZGENE
UniProt Secondary Q63178 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Dync1h1  dynein cytoplasmic 1 heavy chain 1  Dnch1  dynein, cytoplasmic, heavy chain 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Dnch1  dynein, cytoplasmic, heavy chain 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function transports membranous organelles towards minus ends of polarized microtubules via ATP hydrolysis 1298890
gene_physical_interaction interacts with microtubules to generate force 1298890
gene_process may be responsible for retrograde axonal transport, juxtanuclear positioning of various cellular compartments as well as nuclear migration during mitosis 1298890
gene_protein holoprotein is comprised of multiple subunits 1298890