DYNC1H1 (dynein cytoplasmic 1 heavy chain 1) - Rat Genome Database

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Gene: DYNC1H1 (dynein cytoplasmic 1 heavy chain 1) Pan paniscus
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Symbol: DYNC1H1
Name: dynein cytoplasmic 1 heavy chain 1
RGD ID: 11754867
Description: ENCODES a protein that exhibits ATP binding (inferred); dynein intermediate chain binding (inferred); dynein light intermediate chain binding (inferred); INVOLVED IN cellular response to 3,3',5-triiodo-L-thyronine (ortholog); cellular response to nerve growth factor stimulus (ortholog); spermatid development (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); asphyxiating thoracic dystrophy 3 (ortholog); FOUND IN axon (ortholog); manchette (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytoplasmic dynein 1 heavy chain 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215103,116,643 - 103,202,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114102,333,470 - 102,419,449 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01482,584,876 - 82,670,750 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114102,406,807 - 102,489,678 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14102,406,993 - 102,489,475 (+)EnsemblpanPan2panpan1.1
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
asphyxiating thoracic dystrophy 3  (ISO)
atrophic muscular disease  (ISO)
autism spectrum disorder  (ISO)
autosomal dominant cerebellar ataxia  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
autosomal dominant intellectual developmental disorder 13  (ISO)
cerebellar ataxia  (ISO)
cerebellar hypoplasia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease axonal type 2O  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
Charcot-Marie-Tooth disease type 5  (ISO)
childhood spinal muscular atrophy  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
complex cortical dysplasia with other brain malformations 13  (ISO)
Developmental Disabilities  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
fetal akinesia deformation sequence syndrome 1  (ISO)
genetic disease  (ISO)
immunodeficiency 132A  (ISO)
intellectual disability  (ISO)
lissencephaly  (ISO)
microcephaly  (ISO)
motor peripheral neuropathy  (ISO)
Muscle Weakness  (ISO)
myopathy  (ISO)
Nervous System Malformations  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
neuropathy  (ISO)
papillary thyroid carcinoma  (ISO)
polyneuropathy  (ISO)
rhizomelic chondrodysplasia punctata type 5  (ISO)
spinal muscular atrophy  (ISO)
spinal muscular atrophy with lower extremity predominant  (ISO)
spinal muscular atrophy with lower extremity predominant 1  (ISO)
Spinocerebellar Ataxias  (ISO)
Talipes Cavus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DYNC1H1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215103,116,643 - 103,202,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114102,333,470 - 102,419,449 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01482,584,876 - 82,670,750 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114102,406,807 - 102,489,678 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14102,406,993 - 102,489,475 (+)EnsemblpanPan2panpan1.1
DYNC1H1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,964,573 - 102,056,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,964,573 - 102,056,443 (+)Ensemblhg38GRCh38
GRCh3714102,430,910 - 102,522,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614101,500,734 - 101,586,888 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3414101,500,736 - 101,586,887NCBI
Celera1482,485,364 - 82,571,630 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1482,609,802 - 82,696,060 (+)NCBIHuRef
CHM1_114102,368,694 - 102,454,973 (+)NCBICHM1_1
T2T-CHM13v2.01496,200,188 - 96,292,054 (+)NCBIT2T-CHM13v2.0
Dync1h1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912110,567,829 - 110,633,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12110,567,886 - 110,633,379 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812110,601,395 - 110,666,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12110,601,452 - 110,666,945 (+)Ensemblmm10GRCm38
MGSCv3712111,839,605 - 111,905,154 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612111,049,261 - 111,114,731 (+)NCBIMGSCv36mm8
Celera12111,791,744 - 111,857,176 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.7NCBI
Dync1h1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86135,436,375 - 135,502,117 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6135,430,750 - 135,502,116 (+)EnsemblGRCr8
mRatBN7.26129,615,208 - 129,680,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,609,397 - 129,680,883 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6129,792,251 - 129,857,975 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,088,243 - 130,153,968 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06129,452,122 - 129,517,762 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06134,958,854 - 135,085,769 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6134,958,854 - 135,085,769 (+)Ensemblrn6Rnor6.0
Rnor_5.06144,094,877 - 144,159,980 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46135,318,083 - 135,391,459 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6127,184,881 - 127,250,555 (+)NCBICelera
RGSC_v3.16135,324,200 - 135,397,646 (+)NCBI
Cytogenetic Map6q32NCBI
Dync1h1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555381,390,137 - 1,458,025 (+)Ensembl
ChiLan1.0NW_0049555381,388,595 - 1,458,166 (+)NCBIChiLan1.0ChiLan1.0
DYNC1H1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,997,021 - 70,064,886 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl869,997,145 - 70,064,825 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha869,511,720 - 69,579,474 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0870,275,463 - 70,343,231 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl870,275,317 - 70,343,231 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1869,939,596 - 70,007,343 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0870,005,661 - 70,073,498 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0870,405,277 - 70,473,042 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dync1h1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086403,905,752 - 3,970,028 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936835225,324 - 289,954 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936835225,879 - 290,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNC1H1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27129,791,255 - 129,832,564 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DYNC1H1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12479,915,719 - 80,008,666 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2479,915,889 - 80,000,099 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605367,092,529 - 67,183,574 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dync1h1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247342,254,085 - 2,311,177 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247342,253,931 - 2,311,341 (-)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034938173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000047829   ⟹   ENSPPAP00000025003
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl14102,406,993 - 102,489,449 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000047843   ⟹   ENSPPAP00000025017
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl14102,406,993 - 102,489,449 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000047855   ⟹   ENSPPAP00000025029
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl14102,466,556 - 102,489,475 (+)Ensembl
RefSeq Acc Id: XM_034938173   ⟹   XP_034794064
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v215103,116,643 - 103,202,954 (+)NCBI
NHGRI_mPanPan114102,333,470 - 102,419,449 (+)NCBI
Mhudiblu_PPA_v01482,584,876 - 82,670,750 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034794064 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000025003.1
  ENSPPAP00000025017.1
  ENSPPAP00000025029.1
  ENSPPAP00050039200
RefSeq Acc Id: XP_034794064   ⟸   XM_034938173
- UniProtKB: A0A2R9B5Y7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000025003   ⟸   ENSPPAT00000047829
Ensembl Acc Id: ENSPPAP00000025017   ⟸   ENSPPAT00000047843
Ensembl Acc Id: ENSPPAP00000025029   ⟸   ENSPPAT00000047855
Protein Domains
AAA+ ATPase   Dynein heavy chain AAA module D4   Dynein heavy chain ATP-binding dynein motor region   Dynein heavy chain coiled coil stalk


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035469 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050028027 ENTREZGENE
Ensembl Transcript ENSPPAT00000047829.1 UniProtKB/TrEMBL
  ENSPPAT00000047843.1 UniProtKB/TrEMBL
  ENSPPAT00000047855.1 UniProtKB/TrEMBL
  ENSPPAT00050059952 ENTREZGENE
Gene3D-CATH 1.10.287.2620 UniProtKB/TrEMBL
  1.10.472.130 UniProtKB/TrEMBL
  1.10.8.1220 UniProtKB/TrEMBL
  1.10.8.710 UniProtKB/TrEMBL
  1.10.8.720 UniProtKB/TrEMBL
  1.20.1270.280 UniProtKB/TrEMBL
  1.20.140.100 UniProtKB/TrEMBL
  1.20.58.1120 UniProtKB/TrEMBL
  1.20.920.20 UniProtKB/TrEMBL
  1.20.920.30 UniProtKB/TrEMBL
  1.20.920.60 UniProtKB/TrEMBL
  3.10.490.20 UniProtKB/TrEMBL
  3.20.180.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  6.10.140.1060 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_6 UniProtKB/TrEMBL
  AAA_9 UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/TrEMBL
  AAA_lid_11_sf UniProtKB/TrEMBL
  DHC_fam UniProtKB/TrEMBL
  DYNC2H1-like_lid UniProtKB/TrEMBL
  Dynein_2_N UniProtKB/TrEMBL
  Dynein_AAA1S UniProtKB/TrEMBL
  Dynein_AAA5_ext UniProtKB/TrEMBL
  Dynein_C UniProtKB/TrEMBL
  Dynein_C_barrel UniProtKB/TrEMBL
  Dynein_HC_stalk UniProtKB/TrEMBL
  Dynein_heavy_chain_D4_dom UniProtKB/TrEMBL
  Dynein_heavy_D6_P-loop UniProtKB/TrEMBL
  Dynein_heavy_linker UniProtKB/TrEMBL
  Dynein_heavy_tail UniProtKB/TrEMBL
  Dynein_linker_3 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene DYNC1H1 ENTREZGENE
PANTHER DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1 UniProtKB/TrEMBL
  MALE FERTILITY FACTOR KL5 UniProtKB/TrEMBL
Pfam AAA_6 UniProtKB/TrEMBL
  AAA_7 UniProtKB/TrEMBL
  AAA_8 UniProtKB/TrEMBL
  AAA_9 UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/TrEMBL
  DHC_N1 UniProtKB/TrEMBL
  DHC_N2 UniProtKB/TrEMBL
  DYN_lid UniProtKB/TrEMBL
  Dynein_AAA_lid UniProtKB/TrEMBL
  Dynein_C UniProtKB/TrEMBL
  Dynein_heavy UniProtKB/TrEMBL
  PF12777 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9B5Y7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B5Z5_PANPA UniProtKB/TrEMBL
  A0A2R9BD62_PANPA UniProtKB/TrEMBL