Car2 (carbonic anhydrase 2) - Rat Genome Database

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Gene: Car2 (carbonic anhydrase 2) Rattus norvegicus
Analyze
Symbol: Car2
Name: carbonic anhydrase 2
RGD ID: 2240
Description: Enables carbonate dehydratase activity. Involved in several processes, including estrous cycle; positive regulation of bone resorption; and positive regulation of osteoclast differentiation. Located in several cellular components, including apical part of cell; basolateral plasma membrane; and microvillus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (carbonic anhydrase 2); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CA-II; Ca2; carbonate dehydratase II; carbonic anhydrase II; cyanamide hydratase CA2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2286,741,625 - 86,756,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,741,626 - 86,756,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx293,060,690 - 93,075,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,181,691 - 91,196,793 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,238,526 - 86,253,627 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,097,740 - 88,112,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,097,720 - 88,113,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02107,871,654 - 107,886,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,077,095 - 88,092,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1288,022,060 - 88,037,185 (-)NCBI
Celera282,339,410 - 82,354,537 (-)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-1,2,4-triazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-di-tert-butylphenol  (ISO)
2,6-Dimethylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenyl acetate  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
aconitine  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
anthocyanin  (ISO)
anthracen-2-amine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azathioprine  (EXP)
benomyl  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
brinzolamide  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
captopril  (ISO)
carbonates  (ISO)
carnosic acid  (ISO)
celecoxib  (ISO)
chalcone  (ISO)
chlordecone  (ISO)
chloric acid  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP,ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenamide  (ISO)
diethylstilbestrol  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
dorzolamide hydrochloride  (ISO)
enalapril  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethoxzolamide  (ISO)
famotidine  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP,ISO)
furosemide  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
guaiacol  (ISO)
hydrazinecarbothioamide  (ISO)
hydrogencarbonate  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
malvidin 3-O-beta-D-glucoside  (ISO)
malvin  (ISO)
medroxyprogesterone acetate  (ISO)
merbromin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Methazolamide  (ISO)
methylamines  (ISO)
methylglyoxal  (ISO)
methylisothiazolinone  (ISO)
molybdate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-phenylthiourea  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric acid  (ISO)
nitrofen  (EXP)
omeprazole  (EXP)
orphenadrine  (EXP)
oryzalin  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pelargonidin 3-O-beta-D-glucoside  (ISO)
pelargonidin 3-O-beta-D-glucoside chloride  (ISO)
pentachlorophenol  (ISO)
perchlorate  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
prontosil  (ISO)
propofol  (ISO)
pyrimidines  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
rubiadin  (EXP)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silychristin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium hydrogencarbonate  (EXP)
sulfamic acid  (ISO)
sulfates  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
synephrine  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiazolidines  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thiourea  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
tioxolone  (ISO)
titanium dioxide  (ISO)
topiramate  (ISO)
topotecan  (EXP)
trans-chalcone  (ISO)
triazoles  (ISO)
trichloroethene  (EXP)
tungstate  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
voriconazole  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical part of cell  (IBA,IDA,ISO)
axon  (IDA)
basolateral plasma membrane  (IDA)
cytoplasm  (IBA,IDA,ISO)
cytosol  (ISO)
extracellular space  (IDA)
microvillus  (IDA)
myelin sheath  (ISO)
plasma membrane  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effect of phytoestrogens on gene expression of carbonic anhydrase II in rat uterus and liver. Caldarelli A, etal., J Steroid Biochem Mol Biol. 2005 Nov;97(3):251-6. Epub 2005 Sep 26.
2. Immunocytochemical localization of carbonic anhydrase in myelinated fibers in peripheral nerves of rat and mouse. Cammer W and Tansey FA, J Histochem Cytochem. 1987 Aug;35(8):865-70.
3. Role of macrophages in nephrolithiasis in rats: an analysis of the renal interstitium. de Water R, etal., Am J Kidney Dis. 2000 Sep;36(3):615-25.
4. Purification and characterization of carbonic anhydrase from the saliva of the rat. Feldstein JB and Silverman DN, J Biol Chem. 1984 May 10;259(9):5447-53.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. In-vivo functional study on the involvement of CFTR, SLC26A6, NHE-1 and CA isoenzymes II and XII in uterine fluid pH, volume and electrolyte regulation in rats under different sex-steroid influence. Gholami K, etal., Int J Med Sci. 2013 Jul 5;10(9):1121-34. doi: 10.7150/ijms.5918. Print 2013.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Differential regulation of carbonic anhydrase II by androgen and estrogen in dorsal and lateral prostate of the rat. Harkonen PL, etal., Endocrinology. 1991 Jun;128(6):3219-27.
9. A splice junction mutation in intron 2 of the carbonic anhydrase II gene of osteopetrosis patients from Arabic countries. Hu PY, etal., Hum Mutat. 1992;1(4):288-92.
10. Developmental changes in carbonic anhydrase II in the rat kidney. Karashima S, etal., Pediatr Nephrol. 1998 May;12(4):263-8.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Ultrastructural localization of carbonic anhydrase II in subpopulations of intercalated cells of the rat kidney. Kim J, etal., J Am Soc Nephrol. 1990 Sep;1(3):245-56.
13. Inhibition of intravacuolar acidification by antisense RNA decreases osteoclast differentiation and bone resorption in vitro. Laitala-Leinonen T, etal., J Cell Sci. 1999 Nov;112 ( Pt 21):3657-66.
14. Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+. Lehenkari P, etal., Exp Cell Res 1998 Jul 10;242(1):128-37.
15. Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. Liu CG, etal., Cancer Res. 2005 Sep 1;65(17):7790-9.
16. Characterization of the rat carbonic anhydrase II gene structure: sequence analysis of the 5' flanking region and 3' UTR. McGowan MH, etal., Gene 1997 Feb 28;186(2):181-8.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Niemelä AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. doi: 10.1158/1055-9965.EPI-07-0080.
20. Bicarbonate secretion by rat bile duct brush cells indicated by immunohistochemical localization of CFTR, anion exchanger AE2, Na+/HCO3 -cotransporter, carbonic anhydrase II, Na+/H+ exchangers NHE1 and NHE3, H+/K+-ATPase, and Na+/K+-ATPase. Ogata T Med Mol Morphol. 2006 Mar;39(1):44-8.
21. Inhibitory mechanisms of H(+)-ATPase inhibitor bafilomycin A1 and carbonic anhydrase II inhibitor acetazolamide on experimental bone resorption. Ohba Y, etal., FEBS Lett. 1996 Jun 3;387(2-3):175-8.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Demonstration of a specific localization of carbonic anhydrase C in the glial cells of rat CNS by an immunohistochemical method. Roussel G, etal., Brain Res. 1979 Jan 5;160(1):47-55.
27. Low pH enhances expression of carbonic anhydrase II by cultured rat inner medullary collecting duct cells. Schwartz GJ, etal., Am J Physiol. 1994 Feb;266(2 Pt 1):C508-14.
28. Human carbonic anhydrases and carbonic anhydrase deficiencies. Sly WS and Hu PY, Annu Rev Biochem 1995;64:375-401.
29. Nucleotide sequence of a cDNA encoding rat brain carbonic anhydrase II and its deduced amino acid sequence. Stolle CA, etal., Gene 1991 Dec 30;109(2):265-7.
30. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
31. Gene expression profiling in lung tissues from rats exposed to formaldehyde. Sul D, etal., Arch Toxicol. 2007 Feb 7;.
32. Immunohistochemical localization of carbonic anhydrase isozyme II in rat incisor epithelial cells at various stages of amelogenesis. Toyosawa S, etal., Cell Tissue Res. 1996 Aug;285(2):217-25.
33. Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas. Viikilä P, etal., World J Gastroenterol. 2016 Sep 28;22(36):8168-77. doi: 10.3748/wjg.v22.i36.8168.
34. Molecular comparison of apocrine released and cytoplasmic resident carbonic anhydrase II. Wilhelm B, etal., Biochimie 2003 Oct;85(10):939-46.
35. Serum albumin as a potential carrier for the apocrine secretion of proteins in the rat coagulating gland. Wilhelm B, etal., Eur J Cell Biol. 1999 Apr;78(4):256-64.
36. Effects of fluid shear stress on mRNA expression of carbonic anhydrase II in polarized rat osteoclasts. Zhang Q, etal., Cell Biol Int. 2006 Sep;30(9):714-20. Epub 2006 May 12.
Additional References at PubMed
PMID:114507   PMID:3126084   PMID:3151020   PMID:7758465   PMID:14600151   PMID:14660577   PMID:14675051   PMID:15385584   PMID:15489334   PMID:15885224   PMID:15990874   PMID:16217040  
PMID:17634366   PMID:17690328   PMID:19056867   PMID:20150244   PMID:21327437   PMID:22206666   PMID:23376485   PMID:23709596   PMID:23881097   PMID:24297849   PMID:24670789   PMID:24789143  
PMID:31694264  


Genomics

Comparative Map Data
Car2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2286,741,625 - 86,756,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,741,626 - 86,756,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx293,060,690 - 93,075,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,181,691 - 91,196,793 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,238,526 - 86,253,627 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,097,740 - 88,112,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,097,720 - 88,113,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02107,871,654 - 107,886,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,077,095 - 88,092,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1288,022,060 - 88,037,185 (-)NCBI
Celera282,339,410 - 82,354,537 (-)NCBICelera
Cytogenetic Map2q23NCBI
CA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38885,464,007 - 85,481,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl885,463,968 - 85,481,493 (+)EnsemblGRCh38hg38GRCh38
GRCh37886,376,236 - 86,393,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,563,383 - 86,580,973 (+)NCBINCBI36Build 36hg18NCBI36
Build 34886,563,497 - 86,580,973NCBI
Celera882,381,194 - 82,398,781 (+)NCBICelera
Cytogenetic Map8q21.2NCBI
HuRef881,870,322 - 81,887,902 (+)NCBIHuRef
CHM1_1886,427,817 - 86,445,411 (+)NCBICHM1_1
T2T-CHM13v2.0885,902,727 - 85,920,191 (+)NCBIT2T-CHM13v2.0
Car2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,951,329 - 14,965,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,951,333 - 14,965,830 (+)EnsemblGRCm39 Ensembl
GRCm38314,886,269 - 14,900,770 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,886,273 - 14,900,770 (+)EnsemblGRCm38mm10GRCm38
MGSCv37314,886,426 - 14,900,770 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36314,863,469 - 14,877,513 (+)NCBIMGSCv36mm8
Celera314,899,001 - 14,912,886 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.23NCBI
Ca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,386,087 - 3,402,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554173,388,110 - 3,402,798 (+)NCBIChiLan1.0ChiLan1.0
CA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1876,834,337 - 76,852,343 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0881,991,037 - 82,009,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1883,601,163 - 83,618,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl883,597,440 - 83,632,580 (+)Ensemblpanpan1.1panPan2
CA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,959,225 - 31,975,309 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,935,172 - 31,980,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2932,190,440 - 32,197,007 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02932,108,070 - 32,124,176 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2932,107,905 - 32,129,372 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12932,159,433 - 32,175,512 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02932,180,668 - 32,196,793 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02932,567,770 - 32,583,867 (+)NCBIUU_Cfam_GSD_1.0
Ca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,413,843 - 47,429,881 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936544362,591 - 380,223 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936544362,591 - 379,151 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,193,756 - 51,211,259 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1451,194,686 - 51,211,436 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,157,606 - 56,174,354 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,830,963 - 80,848,245 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl880,830,939 - 80,848,707 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603960,251,073 - 60,269,156 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247446,167,606 - 6,183,538 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247446,168,030 - 6,183,407 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Car2
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:383
Count of miRNA genes:202
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000013354
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)27478666494359546Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat

Markers in Region
RH137250  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2286,741,674 - 86,741,924 (+)MAPPERmRatBN7.2
Rnor_6.0288,097,778 - 88,098,027NCBIRnor6.0
Rnor_5.02107,871,692 - 107,871,941UniSTSRnor5.0
RGSC_v3.4288,077,133 - 88,077,382UniSTSRGSC3.4
Celera282,339,448 - 82,339,697UniSTS
RH 3.4 Map2531.1UniSTS
Cytogenetic Map2q23UniSTS
AW533290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2286,755,477 - 86,755,575 (+)MAPPERmRatBN7.2
Rnor_6.0288,111,580 - 88,111,677NCBIRnor6.0
Rnor_5.02107,885,494 - 107,885,591UniSTSRnor5.0
RGSC_v3.4288,090,935 - 88,091,032UniSTSRGSC3.4
Celera282,353,249 - 82,353,346UniSTS
RH 3.4 Map2531.5UniSTS
Cytogenetic Map2q23UniSTS
AA893916  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2286,746,302 - 86,746,469 (+)MAPPERmRatBN7.2
Rnor_6.0288,102,406 - 88,102,572NCBIRnor6.0
Rnor_5.02107,876,320 - 107,876,486UniSTSRnor5.0
RGSC_v3.4288,081,761 - 88,081,927UniSTSRGSC3.4
Celera282,344,076 - 82,344,242UniSTS
RH 3.4 Map2532.3UniSTS
Cytogenetic Map2q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 10 10 1 10
Medium 1 42 38 28 16 28 8 8 70 35 35 11 8
Low 1 1 9 3 2 3 3 4 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH006769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013354   ⟹   ENSRNOP00000013354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl286,741,626 - 86,756,818 (-)Ensembl
Rnor_6.0 Ensembl288,097,720 - 88,113,029 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114144   ⟹   ENSRNOP00000095475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl286,744,261 - 86,756,818 (-)Ensembl
RefSeq Acc Id: NM_019291   ⟹   NP_062164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2286,741,637 - 86,756,766 (-)NCBI
Rnor_6.0288,097,740 - 88,112,868 (-)NCBI
Rnor_5.02107,871,654 - 107,886,782 (-)NCBI
RGSC_v3.4288,077,095 - 88,092,223 (-)RGD
Celera282,339,410 - 82,354,537 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102978   ⟹   XP_038958906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2286,741,625 - 86,755,530 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062164   ⟸   NM_019291
- UniProtKB: P27139 (UniProtKB/Swiss-Prot),   A6IH09 (UniProtKB/TrEMBL),   A0A8I6AMP9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013354   ⟸   ENSRNOT00000013354
RefSeq Acc Id: XP_038958906   ⟸   XM_039102978
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000095475   ⟸   ENSRNOT00000114144
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27139-F1-model_v2 AlphaFold P27139 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691219
Promoter ID:EPDNEW_R1744
Type:single initiation site
Name:Car2_1
Description:carbonic anhydrase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0288,112,920 - 88,112,980EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2240 AgrOrtholog
BioCyc Gene G2FUF-53809 BioCyc
Ensembl Genes ENSRNOG00000009629 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013354 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000114144.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623601 IMAGE-MGC_LOAD
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54231 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72487 IMAGE-MGC_LOAD
NCBI Gene 54231 ENTREZGENE
PANTHER CARBONIC ANHYDRASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Car2 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009629 RatGTEx
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AMP9 ENTREZGENE, UniProtKB/TrEMBL
  A6IH09 ENTREZGENE, UniProtKB/TrEMBL
  CAH2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-18 Car2  carbonic anhydrase 2  Ca2  carbonic anhydrase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-06 Ca2  carbonic anhydrase 2  Car2  carbonic anhydrase II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Car2  carbonic anhydrase II  Ca2  carbonic anhydrase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ca2  carbonic anhydrase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed abundantly in adult male brain and kidney with negligible amounts detected in heart and liver 634675
gene_protein 260 amino acid protein 69786
gene_transcript 15.5 kb mRNA 634675
gene_transcript contain 7 exons and 6 introns 634675