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Gene: Pde4d (phosphodiesterase 4D) Rattus norvegicus
Symbol: Pde4d
Name: phosphodiesterase 4D
Description: Exhibits beta-2 adrenergic receptor binding activity; cyclic-nucleotide phosphodiesterase activity; and enzyme binding activity. Involved in several processes, including positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; and regulation of signal transduction. Localizes to several cellular components, including Golgi apparatus; centrosome; and myofibril. Used to study mental depression. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D); PARTICIPATES IN protein kinase A (PKA) signaling pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3',5'-cyclic AMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase splice variant PDE4D8; DPDE3; PDE3/IVd; Phosphodiesterase 4D cAMP-specific (dunce; Phosphodiesterase 4D cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3); phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Homo sapiens (human) : PDE4D (phosphodiesterase 4D)  HGNC  Alliance
Mus musculus (house mouse) : Pde4d (phosphodiesterase 4D, cAMP specific)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde4d (phosphodiesterase 4D)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE4D (phosphodiesterase 4D)
Canis lupus familiaris (dog) : PDE4D (phosphodiesterase 4D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde4d (phosphodiesterase 4D)
Sus scrofa (pig) : PDE4D (phosphodiesterase 4D)
Chlorocebus sabaeus (African green monkey) : PDE4D (phosphodiesterase 4D)
more info ...
Allele / Splice: Pde4dTn(sb-T2/Bart3)2.285Mcwi  
Genetic Models: F344-Pde4dTn(sb-T2/Bart3)2.285Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0240,219,999 - 41,468,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl240,554,146 - 41,464,264 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0260,035,104 - 60,521,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0259,292,847 - 59,860,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4240,196,097 - 41,311,012 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1241,035,303 - 41,231,381NCBI
Celera236,258,764 - 37,353,786 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pde4d
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3281
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.