Akap9 (A-kinase anchoring protein 9) - Rat Genome Database

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Gene: Akap9 (A-kinase anchoring protein 9) Rattus norvegicus
Analyze
Symbol: Akap9
Name: A-kinase anchoring protein 9
RGD ID: 620833
Description: Enables protein kinase A regulatory subunit binding activity. Involved in negative regulation of adenylate cyclase activity and response to electrical stimulus. Located in dendritic branch; neuronal cell body; and synaptic membrane. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in long QT syndrome 11. Orthologous to human AKAP9 (A-kinase anchoring protein 9); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A kinase (PRKA) anchor protein (yotiao); A kinase (PRKA) anchor protein (yotiao) 9; A kinase (PRKA) anchor protein 9; A-kinase anchor protein 9; CG-NAP; GABA-B receptor-interacting scaffolding protein; Gisp; Yotiao
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,011,475 - 31,147,338 (-)NCBIGRCr8
mRatBN7.2430,056,738 - 30,192,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,056,738 - 30,192,606 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,029,487 - 35,165,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,955,579 - 31,091,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,351,555 - 29,487,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,195,346 - 27,331,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,195,346 - 27,331,582 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,098,572 - 27,234,808 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,772,929 - 26,803,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,883,982 - 26,885,323 (-)NCBI
Celera425,482,592 - 25,617,928 (-)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3-chloropropane-1,2-diol  (EXP)
8-Br-cAMP  (ISO)
acetazolamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin 460  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
emetine  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
ketamine  (EXP)
menadione  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulindac  (EXP)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2. Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1). Feliciello A, etal., FEBS Lett 1999 Dec 31;464(3):174-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling. Hur EM, etal., J Cell Biol. 2005 May 23;169(4):657-67.
5. Repeated electroconvulsive shock treatment increases the expression of A kinase anchoring proteins in the rat hippocampus. Lee YI, etal., Neurosci Lett 2004 Jan 30;355(3):213-6.
6. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. Lin JW, etal., J Neurosci 1998 Mar 15;18(6):2017-27.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Piggott LA, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13835-40. Epub 2008 Sep 4.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
15. Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area. Tasken KA, etal., J Biol Chem. 2001 Jun 22;276(25):21999-2002. Epub 2001 Apr 2.
Additional References at PubMed
PMID:10390370   PMID:11799244   PMID:12036294   PMID:12163479   PMID:12477932   PMID:12840069   PMID:16002409   PMID:17241134   PMID:17911601   PMID:18093912   PMID:18643869   PMID:19154774  
PMID:19236309   PMID:19242490   PMID:20096683   PMID:21399614   PMID:21502359   PMID:21616059   PMID:22031837   PMID:23608191   PMID:24648492   PMID:25657325   PMID:27666745   PMID:29162697  
PMID:29891944   PMID:34569663  


Genomics

Comparative Map Data
Akap9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,011,475 - 31,147,338 (-)NCBIGRCr8
mRatBN7.2430,056,738 - 30,192,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,056,738 - 30,192,606 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,029,487 - 35,165,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,955,579 - 31,091,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,351,555 - 29,487,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,195,346 - 27,331,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,195,346 - 27,331,582 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,098,572 - 27,234,808 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,772,929 - 26,803,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,883,982 - 26,885,323 (-)NCBI
Celera425,482,592 - 25,617,928 (-)NCBICelera
Cytogenetic Map4q13NCBI
AKAP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38791,940,862 - 92,110,673 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl791,940,840 - 92,110,673 (+)EnsemblGRCh38hg38GRCh38
GRCh37791,570,176 - 91,739,987 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,408,128 - 91,577,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 34791,214,842 - 91,384,640NCBI
Celera786,274,770 - 86,444,535 (+)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,177,732 - 86,347,418 (+)NCBIHuRef
CHM1_1791,500,226 - 91,670,057 (+)NCBICHM1_1
T2T-CHM13v2.0793,182,145 - 93,351,954 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2790,900,316 - 91,069,225 (+)NCBI
Akap9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3953,977,410 - 4,130,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl53,978,054 - 4,131,310 (+)EnsemblGRCm39 Ensembl
GRCm3853,927,736 - 4,080,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl53,928,054 - 4,081,310 (+)EnsemblGRCm38mm10GRCm38
MGSCv3753,928,186 - 4,080,204 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3653,934,296 - 4,086,209 (+)NCBIMGSCv36mm8
Celera53,864,493 - 4,010,277 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.26NCBI
Akap9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554328,932,952 - 9,095,065 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554328,933,037 - 9,090,872 (+)NCBIChiLan1.0ChiLan1.0
AKAP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26109,829,810 - 109,996,208 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,094,445 - 158,260,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0783,942,590 - 84,108,648 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1797,540,080 - 97,706,122 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl797,540,356 - 97,705,608 (+)Ensemblpanpan1.1panPan2
AKAP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,590,256 - 17,743,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,590,772 - 17,740,294 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,151,819 - 17,305,050 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,396,944 - 17,550,371 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,397,094 - 17,550,290 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,555,293 - 17,708,724 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,269,978 - 17,423,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,543,776 - 17,697,085 (+)NCBIUU_Cfam_GSD_1.0
Akap9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511830,994,258 - 31,121,581 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,246,179 - 2,374,454 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,247,082 - 2,374,407 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl971,895,635 - 72,054,897 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1971,895,615 - 72,054,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2978,631,028 - 78,790,295 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,889,669 - 57,061,526 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,890,183 - 57,061,232 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604247,204,451 - 47,376,002 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248091,103,538 - 1,257,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248091,101,941 - 1,258,402 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap9
270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:457
Count of miRNA genes:222
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000010118
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat

Markers in Region
RH133605  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,161,601 - 30,161,819 (+)MAPPERmRatBN7.2
Rnor_6.0427,300,585 - 27,300,802NCBIRnor6.0
Rnor_5.0427,203,811 - 27,204,028UniSTSRnor5.0
RGSC_v3.4426,877,317 - 26,877,534UniSTSRGSC3.4
Celera425,587,138 - 25,587,355UniSTS
RH 3.4 Map4168.9UniSTS
Cytogenetic Map4q13UniSTS
RH137133  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q13UniSTS
RH140917  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001037093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB071391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC079436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC079990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF133906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ228948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010118   ⟹   ENSRNOP00000010118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,056,738 - 30,192,606 (-)Ensembl
Rnor_6.0 Ensembl427,195,346 - 27,331,582 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090751   ⟹   ENSRNOP00000073290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,056,738 - 30,192,606 (-)Ensembl
Rnor_6.0 Ensembl427,195,650 - 27,331,508 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102882   ⟹   ENSRNOP00000078270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,056,743 - 30,192,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104260   ⟹   ENSRNOP00000094800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,058,844 - 30,173,015 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111753   ⟹   ENSRNOP00000089245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,056,738 - 30,192,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114783   ⟹   ENSRNOP00000084102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,056,738 - 30,192,606 (-)Ensembl
RefSeq Acc Id: NM_001037093   ⟹   NP_001032170
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,338 (-)NCBI
mRatBN7.2430,056,738 - 30,192,606 (-)NCBI
Rnor_6.0427,195,346 - 27,331,582 (-)NCBI
Rnor_5.0427,098,572 - 27,234,808 (-)NCBI
RGSC_v3.4426,772,929 - 26,803,149 (-)RGD
Celera425,482,592 - 25,617,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236023   ⟹   XP_006236085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,177 (-)NCBI
mRatBN7.2430,056,738 - 30,192,714 (-)NCBI
Rnor_6.0427,195,348 - 27,331,484 (-)NCBI
Rnor_5.0427,098,572 - 27,234,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236025   ⟹   XP_006236087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,247 (-)NCBI
mRatBN7.2430,056,738 - 30,192,715 (-)NCBI
Rnor_6.0427,195,348 - 27,331,577 (-)NCBI
Rnor_5.0427,098,572 - 27,234,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762685   ⟹   XP_008760907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,177 (-)NCBI
mRatBN7.2430,056,738 - 30,192,715 (-)NCBI
Rnor_6.0427,195,348 - 27,331,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762686   ⟹   XP_008760908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,177 (-)NCBI
mRatBN7.2430,056,738 - 30,192,715 (-)NCBI
Rnor_6.0427,195,348 - 27,331,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592446   ⟹   XP_017447935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,247 (-)NCBI
mRatBN7.2430,056,738 - 30,192,715 (-)NCBI
Rnor_6.0427,195,348 - 27,331,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592447   ⟹   XP_017447936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,177 (-)NCBI
mRatBN7.2430,056,738 - 30,192,715 (-)NCBI
Rnor_6.0427,195,348 - 27,331,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592448   ⟹   XP_017447937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,177 (-)NCBI
mRatBN7.2430,056,738 - 30,192,716 (-)NCBI
Rnor_6.0427,195,348 - 27,331,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285527   ⟹   XP_063141597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,247 (-)NCBI
RefSeq Acc Id: XM_063285528   ⟹   XP_063141598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,177 (-)NCBI
RefSeq Acc Id: XM_063285530   ⟹   XP_063141600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,177 (-)NCBI
RefSeq Acc Id: XM_063285531   ⟹   XP_063141601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,177 (-)NCBI
RefSeq Acc Id: XM_063285532   ⟹   XP_063141602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,147,247 (-)NCBI
RefSeq Acc Id: XM_063285533   ⟹   XP_063141603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,011,475 - 31,094,058 (-)NCBI
RefSeq Acc Id: NP_001032170   ⟸   NM_001037093
- UniProtKB: F1LPB4 (UniProtKB/TrEMBL),   A0A8I6AIG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236087   ⟸   XM_006236025
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GHX5 (UniProtKB/TrEMBL),   A0A8I6AIG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236085   ⟸   XM_006236023
- Peptide Label: isoform X5
- UniProtKB: A6K272 (UniProtKB/TrEMBL),   A0A8I6AIG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760908   ⟸   XM_008762686
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AIG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760907   ⟸   XM_008762685
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447935   ⟸   XM_017592446
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AIG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447936   ⟸   XM_017592447
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K548 (UniProtKB/TrEMBL),   A0A8I6AIG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447937   ⟸   XM_017592448
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AIG6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010118   ⟸   ENSRNOT00000010118
Ensembl Acc Id: ENSRNOP00000073290   ⟸   ENSRNOT00000090751
Ensembl Acc Id: ENSRNOP00000089245   ⟸   ENSRNOT00000111753
Ensembl Acc Id: ENSRNOP00000094800   ⟸   ENSRNOT00000104260
Ensembl Acc Id: ENSRNOP00000078270   ⟸   ENSRNOT00000102882
Ensembl Acc Id: ENSRNOP00000084102   ⟸   ENSRNOT00000114783
RefSeq Acc Id: XP_063141602   ⟸   XM_063285532
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063141597   ⟸   XM_063285527
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063141601   ⟸   XM_063285531
- Peptide Label: isoform X11
- UniProtKB: A0A8I5ZWI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141600   ⟸   XM_063285530
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063141598   ⟸   XM_063285528
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063141603   ⟸   XM_063285533
- Peptide Label: isoform X13
Protein Domains
Pericentrin/AKAP-450 centrosomal targeting

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692849
Promoter ID:EPDNEW_R3367
Type:multiple initiation site
Name:Akap9_1
Description:A-kinase anchoring protein 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0427,331,490 - 27,331,550EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620833 AgrOrtholog
BioCyc Gene G2FUF-45772 BioCyc
Ensembl Genes ENSRNOG00000026319 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010118.7 UniProtKB/TrEMBL
  ENSRNOT00000090751.2 UniProtKB/TrEMBL
  ENSRNOT00000102882.1 UniProtKB/TrEMBL
  ENSRNOT00000104260.1 UniProtKB/TrEMBL
  ENSRNOT00000111753.1 UniProtKB/TrEMBL
  ENSRNOT00000114783.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7371023 IMAGE-MGC_LOAD
InterPro AKAP9 UniProtKB/TrEMBL
  PACT_domain UniProtKB/TrEMBL
KEGG Report rno:246150 UniProtKB/TrEMBL
MGC_CLONE MGC:112786 IMAGE-MGC_LOAD
NCBI Gene 246150 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 9 UniProtKB/TrEMBL
  PTHR44981 UniProtKB/TrEMBL
Pfam PACT_coil_coil UniProtKB/TrEMBL
PhenoGen Akap9 PhenoGen
RatGTEx ENSRNOG00000026319 RatGTEx
UniProt A0A0G2K548 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZKK3_RAT UniProtKB/TrEMBL
  A0A8I5ZWI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHX5 ENTREZGENE, UniProtKB/TrEMBL
  A6K272 ENTREZGENE, UniProtKB/TrEMBL
  F1LPB4 ENTREZGENE, UniProtKB/TrEMBL
  Q4G046_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap9  A-kinase anchoring protein 9  Akap9  A kinase (PRKA) anchor protein 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-11 Akap9  A kinase (PRKA) anchor protein 9  Akap9  A kinase (PRKA) anchor protein (yotiao) 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Akap9  A kinase (PRKA) anchor protein (yotiao) 9    A kinase (PRKA) anchor protein (yotiao)  Name updated 1299863 APPROVED
2002-08-07 Akap9  A kinase (PRKA) anchor protein (yotiao)      Symbol and Name status set to provisional 70820 PROVISIONAL