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Gene: Pde4d (phosphodiesterase 4D, cAMP specific) Mus musculus
Symbol: Pde4d
Name: phosphodiesterase 4D, cAMP specific
Description: Exhibits 3',5'-cyclic-AMP phosphodiesterase activity; ATPase binding activity; and ion channel binding activity. Involved in several processes, including cellular response to epinephrine stimulus; regulation of heart contraction; and regulation of release of sequestered calcium ion into cytosol. Localizes to centrosome and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9630011N22Rik; AI452195; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cyclic AMP specific phosphodiesterase PDE4D5A; Dpde3; dunce; expressed sequence AI452195
Homo sapiens (human) : PDE4D (phosphodiesterase 4D)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pde4d (phosphodiesterase 4D)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde4d (phosphodiesterase 4D)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE4D (phosphodiesterase 4D)
Canis lupus familiaris (dog) : PDE4D (phosphodiesterase 4D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde4d (phosphodiesterase 4D)
Sus scrofa (pig) : PDE4D (phosphodiesterase 4D)
Chlorocebus sabaeus (African green monkey) : PDE4D (phosphodiesterase 4D)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl13108,449,948 - 109,953,461 (+)EnsemblGRCm38mm10GRCm38
GRCm3813108,654,177 - 109,955,969 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3713109,444,371 - 110,741,682 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613109,775,041 - 111,072,352 (+)NCBImm8
Celera13112,976,414 - 114,285,878 (+)NCBICelera
Cytogenetic Map13D2.1NCBI
cM Map1359.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Pde4d
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11066
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.