LOC103221883 (uncharacterized LOC103221883) - Rat Genome Database

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Gene: LOC103221883 (uncharacterized LOC103221883) Chlorocebus sabaeus
Analyze
Symbol: LOC103221883 (Ensembl: PDE4D)
Name: uncharacterized LOC103221883 (Ensembl:phosphodiesterase 4D)
RGD ID: 18346925
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-nucleotide phosphodiesterase activity (ortholog); ATPase binding (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acrodysostosis (ortholog); Acrodysostosis 2, with or without Hormone Resistance (ortholog); amphetamine abuse (ortholog); FOUND IN calcium channel complex (ortholog); centrosome (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4D; PDE4D; phosphodiesterase 4D; uncharacterized protein LOC103221883
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1455,148,012 - 56,665,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl455,153,563 - 55,390,027 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660494,132,259 - 4,425,088 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenergic receptor signaling pathway  (ISO)
cAMP/PKA signal transduction  (ISO)
cellular response to cAMP  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
establishment of endothelial barrier  (ISO)
lung development  (ISO)
memory  (ISO)
multicellular organism growth  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of heart contraction  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of relaxation of cardiac muscle  (ISO)
neutrophil chemotaxis  (ISO)
neutrophil migration  (ISO)
ovulation from ovarian follicle  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-5 production  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of type II interferon production  (ISO)
protein-containing complex assembly  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of cAMP/PKA signal transduction  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of cell communication by electrical coupling involved in cardiac conduction  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of heart rate  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
smooth muscle contraction  (ISO)
T cell receptor signaling pathway  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
LOC103221883
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1455,148,012 - 56,665,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl455,153,563 - 55,390,027 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660494,132,259 - 4,425,088 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PDE4D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38558,969,038 - 60,522,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl558,969,038 - 60,522,120 (-)EnsemblGRCh38hg38GRCh38
GRCh37558,264,865 - 59,792,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36558,300,622 - 59,225,378 (-)NCBINCBI36Build 36hg18NCBI36
Build 34558,302,467 - 58,918,032NCBI
Celera555,205,298 - 56,725,032 (-)NCBICelera
Cytogenetic Map5q11.2-q12.1NCBI
HuRef555,222,770 - 56,741,723 (-)ENTREZGENEHuRef
CHM1_1558,265,111 - 59,783,530 (-)NCBICHM1_1
T2T-CHM13v2.0559,787,596 - 61,345,916 (-)NCBIT2T-CHM13v2.0
Pde4d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913108,790,711 - 110,092,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13108,586,482 - 110,089,995 (+)EnsemblGRCm39 Ensembl
GRCm3813108,654,177 - 109,955,969 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13108,449,948 - 109,953,461 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713109,444,371 - 110,741,682 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613109,775,041 - 111,072,352 (+)NCBIMGSCv36mm8
Celera13112,976,414 - 114,285,878 (+)NCBICelera
Cytogenetic Map13D2.1NCBI
cM Map1359.69NCBI
Pde4d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8241,748,337 - 43,262,567 (+)NCBIGRCr8
mRatBN7.2240,014,933 - 41,529,190 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl240,019,933 - 41,525,884 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx247,530,987 - 48,628,657 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0245,589,673 - 46,687,379 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0240,441,484 - 41,540,329 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0240,219,999 - 41,468,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl240,554,146 - 41,464,264 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0259,292,847 - 59,860,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0260,035,104 - 60,521,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4240,196,097 - 41,311,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1241,035,303 - 41,231,381NCBI
Celera236,258,764 - 37,353,786 (+)NCBICelera
Cytogenetic Map2q14NCBI
Pde4d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554468,211,877 - 9,252,653 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554467,914,326 - 9,252,527 (+)NCBIChiLan1.0ChiLan1.0
PDE4D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2453,420,689 - 54,949,638 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1551,574,313 - 53,103,270 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0553,510,287 - 55,039,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1555,749,248 - 56,675,724 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl555,749,214 - 56,670,111 (+)Ensemblpanpan1.1panPan2
PDE4D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1245,843,767 - 47,245,263 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl245,846,294 - 46,949,912 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha242,920,230 - 44,321,074 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0246,331,498 - 47,722,409 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl246,331,504 - 47,770,480 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1243,375,010 - 44,793,218 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0244,204,482 - 45,049,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0245,031,308 - 46,431,653 (-)NCBIUU_Cfam_GSD_1.0
Pde4d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213199,501,304 - 200,299,009 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364808,204,701 - 9,234,865 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364808,123,437 - 9,235,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE4D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1637,897,302 - 39,306,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11637,897,300 - 39,406,534 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21640,637,293 - 40,680,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000014232   ⟹   ENSCSAP00000012210
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl455,153,563 - 55,390,027 (-)Ensembl
RefSeq Acc Id: XM_037982238   ⟹   XP_037838166
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660494,132,259 - 4,425,088 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037838166 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSCSAP00000012210   ⟸   ENSCSAT00000014232
RefSeq Acc Id: XP_037838166   ⟸   XM_037982238


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016138 Ensembl, ENTREZGENE
NCBI Gene PDE4D ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103221883  uncharacterized LOC103221883  PDE4D  phosphodiesterase 4D  Symbol and/or name change 5135510 APPROVED