Tnks (tankyrase) - Rat Genome Database

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Gene: Tnks (tankyrase) Rattus norvegicus
Analyze
Symbol: Tnks
Name: tankyrase
RGD ID: 1308784
Description: Predicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in cellular response to nutrient. Predicted to be located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS (tankyrase); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290794; poly [ADP-ribose] polymerase tankyrase-1; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21657,223,174 - 57,370,740 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1657,225,094 - 57,366,260 (+)Ensembl
Rnor_6.01660,925,093 - 61,067,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1660,925,093 - 61,067,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01660,595,492 - 60,747,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41660,953,917 - 61,095,523 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11660,954,529 - 61,095,505 (+)NCBI
Celera1655,274,422 - 55,414,315 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. Zhong L, etal., PLoS One. 2015 Apr 13;10(4):e0122948. doi: 10.1371/journal.pone.0122948. eCollection 2015.
Additional References at PubMed
PMID:9822378   PMID:11739745   PMID:11854288   PMID:12782650   PMID:15133513   PMID:16076287   PMID:16555329   PMID:17026964   PMID:18221737   PMID:18436240   PMID:19245366   PMID:19759537  
PMID:20657601   PMID:21270334   PMID:21478859   PMID:21531765   PMID:22864114   PMID:23791195   PMID:25043379   PMID:25939383   PMID:26373281   PMID:28628258  


Genomics

Comparative Map Data
Tnks
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21657,223,174 - 57,370,740 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1657,225,094 - 57,366,260 (+)Ensembl
Rnor_6.01660,925,093 - 61,067,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1660,925,093 - 61,067,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01660,595,492 - 60,747,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41660,953,917 - 61,095,523 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11660,954,529 - 61,095,505 (+)NCBI
Celera1655,274,422 - 55,414,315 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
TNKS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3889,555,912 - 9,782,346 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl89,555,912 - 9,782,346 (+)EnsemblGRCh38hg38GRCh38
GRCh3789,413,422 - 9,639,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3689,450,855 - 9,677,266 (+)NCBINCBI36hg18NCBI36
Build 3489,450,854 - 9,671,801NCBI
Celera88,541,508 - 8,765,562 (+)NCBI
Cytogenetic Map8p23.1NCBI
HuRef88,339,612 - 8,568,337 (+)NCBIHuRef
CHM1_189,478,677 - 9,705,116 (+)NCBICHM1_1
T2T-CHM13v2.089,959,097 - 10,187,973 (-)NCBI
Tnks
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39835,296,333 - 35,432,844 (-)NCBIGRCm39mm39
GRCm39 Ensembl835,293,614 - 35,432,844 (-)Ensembl
GRCm38834,829,179 - 34,965,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl834,826,460 - 34,965,690 (-)EnsemblGRCm38mm10GRCm38
MGSCv37835,892,233 - 36,028,744 (-)NCBIGRCm37mm9NCBIm37
MGSCv36836,297,696 - 36,434,207 (-)NCBImm8
Celera837,445,126 - 37,580,726 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map821.16NCBI
Tnks
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554635,588,423 - 5,764,581 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554635,589,194 - 5,770,141 (+)NCBIChiLan1.0ChiLan1.0
TNKS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v089,435,412 - 9,654,810 (-)NCBIMhudiblu_PPA_v0panPan3
TNKS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11634,826,248 - 35,040,004 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1634,831,662 - 35,039,946 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1635,288,261 - 35,501,954 (-)NCBI
ROS_Cfam_1.01636,853,307 - 37,067,471 (-)NCBI
ROS_Cfam_1.0 Ensembl1636,857,336 - 37,067,463 (-)Ensembl
UMICH_Zoey_3.11634,954,332 - 35,174,394 (-)NCBI
UNSW_CanFamBas_1.01635,524,234 - 35,737,885 (-)NCBI
UU_Cfam_GSD_1.01635,643,380 - 35,857,095 (-)NCBI
Tnks
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494344,149,106 - 44,353,527 (+)NCBI
SpeTri2.0NW_004936573788,909 - 993,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNKS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1555,514,254 - 55,681,504 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11555,513,874 - 55,681,544 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21562,930,160 - 63,096,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNKS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.189,300,234 - 9,524,350 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl89,305,872 - 9,524,104 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605232,885,368 - 33,110,014 (+)NCBIVero_WHO_p1.0
Tnks
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248395,675,656 - 5,856,787 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248395,675,581 - 5,860,736 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH129333  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21657,370,538 - 57,370,724 (+)MAPPERmRatBN7.2
Rnor_6.01661,071,471 - 61,071,656NCBIRnor6.0
Rnor_5.01660,742,073 - 60,742,258UniSTSRnor5.0
RGSC_v3.41661,100,230 - 61,100,415UniSTSRGSC3.4
Celera1655,418,594 - 55,418,779UniSTS
RH 3.4 Map16544.4UniSTS
Cytogenetic Map16q12.2UniSTS
RH142999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21657,295,077 - 57,295,238 (+)MAPPERmRatBN7.2
Rnor_6.01660,995,250 - 60,995,410NCBIRnor6.0
Rnor_5.01660,665,779 - 60,665,939UniSTSRnor5.0
RGSC_v3.41661,024,414 - 61,024,574UniSTSRGSC3.4
Celera1655,344,377 - 55,344,537UniSTS
RH 3.4 Map16542.51UniSTS
Cytogenetic Map16q12.2UniSTS
RH143994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21657,375,491 - 57,375,620 (+)MAPPERmRatBN7.2
Rnor_6.01661,076,425 - 61,076,553NCBIRnor6.0
Rnor_5.01660,747,027 - 60,747,155UniSTSRnor5.0
RGSC_v3.41661,105,184 - 61,105,312UniSTSRGSC3.4
Celera1655,423,547 - 55,423,675UniSTS
RH 3.4 Map16559.8UniSTS
Cytogenetic Map16q12.2UniSTS
BE111758  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21657,368,550 - 57,368,707 (+)MAPPERmRatBN7.2
Rnor_6.01661,069,483 - 61,069,639NCBIRnor6.0
Rnor_5.01660,740,085 - 60,740,241UniSTSRnor5.0
RGSC_v3.41661,098,242 - 61,098,398UniSTSRGSC3.4
Celera1655,416,606 - 55,416,762UniSTS
RH 3.4 Map16559.8UniSTS
Cytogenetic Map16q12.2UniSTS
BI289331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21657,357,314 - 57,357,597 (+)MAPPERmRatBN7.2
Rnor_6.01661,058,247 - 61,058,529NCBIRnor6.0
Rnor_5.01660,728,849 - 60,729,131UniSTSRnor5.0
RGSC_v3.41661,087,006 - 61,087,288UniSTSRGSC3.4
Celera1655,405,370 - 55,405,652UniSTS
RH 3.4 Map16543.21UniSTS
Cytogenetic Map16q12.2UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:56
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000015813
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 29 13 16 13 4 4 74 31 41 11 4
Low 3 8 28 28 3 28 4 7 4 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015813   ⟹   ENSRNOP00000015813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1657,225,094 - 57,366,260 (+)Ensembl
Rnor_6.0 Ensembl1660,925,093 - 61,067,192 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108961   ⟹   ENSRNOP00000076451
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1657,225,094 - 57,366,260 (+)Ensembl
RefSeq Acc Id: NM_001106084   ⟹   NP_001099554
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21657,225,094 - 57,366,260 (+)NCBI
Rnor_6.01660,925,093 - 61,067,192 (+)NCBI
Rnor_5.01660,595,492 - 60,747,261 (+)NCBI
RGSC_v3.41660,953,917 - 61,095,523 (+)RGD
Celera1655,274,422 - 55,414,315 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094390   ⟹   XP_038950318
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21657,223,174 - 57,370,740 (+)NCBI
RefSeq Acc Id: XM_039094391   ⟹   XP_038950319
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21657,225,354 - 57,370,740 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099554 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950318 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950319 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09189 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099554   ⟸   NM_001106084
- UniProtKB: D3Z8Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015813   ⟸   ENSRNOT00000015813
RefSeq Acc Id: XP_038950318   ⟸   XM_039094390
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038950319   ⟸   XM_039094391
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000076451   ⟸   ENSRNOT00000108961
Protein Domains
PARP catalytic   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8Q6-F1-model_v2 AlphaFold D3Z8Q6 1-1317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700135
Promoter ID:EPDNEW_R10659
Type:multiple initiation site
Name:Tnks_1
Description:tankyrase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01660,925,093 - 60,925,153EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 61023252 61023253 A C snv SR/JrHsd (MCW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 60693854 60693855 A C snv SR/JrHsd (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308784 AgrOrtholog
BioCyc Gene G2FUF-11151 BioCyc
Ensembl Genes ENSRNOG00000011625 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015813 ENTREZGENE
  ENSRNOP00000015813.5 UniProtKB/TrEMBL
  ENSRNOP00000076451.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015813 ENTREZGENE
  ENSRNOT00000015813.7 UniProtKB/TrEMBL
  ENSRNOT00000108961.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
  TNKS UniProtKB/TrEMBL
KEGG Report rno:290794 UniProtKB/TrEMBL
NCBI Gene 290794 ENTREZGENE
PANTHER PTHR24180:SF3 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_3 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Ank_5 UniProtKB/TrEMBL
  PARP UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PhenoGen Tnks PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
  PARP_CATALYTIC UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt A0A8I5YBL7_RAT UniProtKB/TrEMBL
  D3Z8Q6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Tnks  tankyrase  Tnks  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tnks  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase   Tnks_predicted  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tnks_predicted  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (predicted)      Symbol and Name status set to approved 70820 APPROVED