Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tnks | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Tnks (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TNKS mRNA | CTD | PMID:22206623 | Tnks | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of TNKS mRNA | CTD | PMID:29097150 | Tnks | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of TNKS mRNA | CTD | PMID:32145629 | Tnks | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tnks (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TNKS mRNA | CTD | PMID:21570461 | Tnks | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TNKS mRNA | CTD | PMID:33387578 | Tnks | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TNKS mRNA | CTD | PMID:22298810 | Tnks | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Tnks | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | TNKS (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of TNKS mRNA | CTD | PMID:30851411 | Tnks | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of TNKS mRNA | CTD | PMID:28628672 | Tnks | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of TNKS mRNA | CTD | PMID:28628672 | Tnks | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Tnks (Mus musculus) | 6480464 | Fenretinide results in decreased expression of TNKS mRNA | CTD | PMID:28973697 | Tnks | Rat | acrolein | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of TNKS mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Tnks | Rat | alpha-pinene | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of TNKS mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of TNKS mRNA | CTD | PMID:32699268 | Tnks | Rat | antirheumatic drug | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of TNKS mRNA | CTD | PMID:24449571 | Tnks | Rat | arsenite(3-) | increases methylation | ISO | TNKS (Homo sapiens) | 6480464 | arsenite results in increased methylation of TNKS promoter | CTD | PMID:23974009 | Tnks | Rat | arsenite(3-) | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to TNKS mRNA] | CTD | PMID:32406909 | Tnks | Rat | bisphenol A | increases expression | ISO | Tnks (Mus musculus) | 6480464 | bisphenol A results in increased expression of TNKS mRNA | CTD | PMID:26063408 | Tnks | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TNKS mRNA | CTD | PMID:30816183 | Tnks | Rat | bisphenol A | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | bisphenol A results in increased expression of TNKS mRNA | CTD | PMID:29275510 | Tnks | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TNKS mRNA | CTD | PMID:29097150 | Tnks | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of TNKS mRNA | CTD | PMID:25181051 and PMID:32145629 | Tnks | Rat | bortezomib | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of TNKS mRNA | CTD | PMID:25522274 | Tnks | Rat | butanal | decreases expression | ISO | TNKS (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of TNKS mRNA | CTD | PMID:26079696 | Tnks | Rat | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of TNKS promoter | CTD | PMID:22457795 | Tnks | Rat | CGP 52608 | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TNKS gene] | CTD | PMID:28238834 | Tnks | Rat | chlordecone | increases expression | ISO | Tnks (Mus musculus) | 6480464 | Chlordecone results in increased expression of TNKS mRNA | CTD | PMID:33711761 | Tnks | Rat | chlordecone | decreases expression | ISO | Tnks (Mus musculus) | 6480464 | Chlordecone results in decreased expression of TNKS mRNA | CTD | PMID:29980752 | Tnks | Rat | cobalt dichloride | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of TNKS mRNA | CTD | PMID:19320972 | Tnks | Rat | copper(II) sulfate | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of TNKS mRNA | CTD | PMID:19549813 | Tnks | Rat | crocidolite asbestos | decreases expression | ISO | Tnks (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of TNKS mRNA | CTD | PMID:29279043 | Tnks | Rat | curcumin | decreases expression | ISO | TNKS (Homo sapiens) | 6480464 | Curcumin analog results in decreased expression of TNKS mRNA | CTD | PMID:26409325 | Tnks | Rat | cyclosporin A | decreases expression | ISO | TNKS (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TNKS mRNA | CTD | PMID:25562108 | Tnks | Rat | dexamethasone | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of TNKS mRNA | CTD | PMID:28628672 | Tnks | Rat | Dibutyl phosphate | affects expression | ISO | TNKS (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of TNKS mRNA | CTD | PMID:37042841 | Tnks | Rat | dorsomorphin | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNKS mRNA | CTD | PMID:27188386 | Tnks | Rat | doxorubicin | decreases expression | ISO | TNKS (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of TNKS mRNA | CTD | PMID:29803840 | Tnks | Rat | ethyl methanesulfonate | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of TNKS mRNA | CTD | PMID:23649840 | Tnks | Rat | etoposide | affects response to substance | ISO | TNKS (Homo sapiens) | 6480464 | TNKS protein affects the susceptibility to Etoposide | CTD | PMID:16217747 | Tnks | Rat | fenthion | decreases expression | ISO | Tnks (Mus musculus) | 6480464 | Fenthion results in decreased expression of TNKS mRNA | CTD | PMID:34813904 | Tnks | Rat | folic acid | decreases expression | ISO | Tnks (Mus musculus) | 6480464 | Folic Acid results in decreased expression of TNKS mRNA | CTD | PMID:25629700 | Tnks | Rat | indometacin | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of TNKS mRNA | CTD | PMID:28628672 | Tnks | Rat | isoprenaline | increases expression | ISO | Tnks (Mus musculus) | 6480464 | Isoproterenol results in increased expression of TNKS mRNA | CTD | PMID:20003209 | Tnks | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of TNKS gene | CTD | PMID:35440735 | Tnks | Rat | methyl methanesulfonate | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of TNKS mRNA | CTD | PMID:23649840 | Tnks | Rat | mitoxantrone | affects response to substance | ISO | TNKS (Homo sapiens) | 6480464 | TNKS protein affects the susceptibility to Mitoxantrone | CTD | PMID:16217747 | Tnks | Rat | omethoate | increases response to substance | ISO | TNKS (Homo sapiens) | 6480464 | TNKS 3' UTR SNP results in increased susceptibility to dimethoxon | CTD | PMID:31551201 | Tnks | Rat | ozone | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of TNKS mRNA more ... | CTD | PMID:32699268 more ... | Tnks | Rat | perfluorohexanesulfonic acid | decreases expression | ISO | Tnks (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of TNKS mRNA | CTD | PMID:37995155 | Tnks | Rat | quercetin | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Quercetin results in increased expression of TNKS mRNA | CTD | PMID:21632981 | Tnks | Rat | rac-lactic acid | decreases expression | ISO | TNKS (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of TNKS mRNA | CTD | PMID:30851411 | Tnks | Rat | resveratrol | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of TNKS mRNA | CTD | PMID:23557933 | Tnks | Rat | SB 431542 | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNKS mRNA | CTD | PMID:27188386 | Tnks | Rat | sodium arsenite | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of TNKS mRNA | CTD | PMID:38568856 | Tnks | Rat | sunitinib | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Sunitinib results in increased expression of TNKS mRNA | CTD | PMID:31533062 | Tnks | Rat | thiram | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Thiram results in increased expression of TNKS mRNA | CTD | PMID:38568856 | Tnks | Rat | titanium dioxide | increases expression | ISO | Tnks (Mus musculus) | 6480464 | titanium dioxide results in increased expression of TNKS mRNA | CTD | PMID:29264374 | Tnks | Rat | titanium dioxide | increases methylation | ISO | Tnks (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of TNKS gene | CTD | PMID:35295148 | Tnks | Rat | titanium dioxide | decreases methylation | ISO | Tnks (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of TNKS gene | CTD | PMID:35295148 | Tnks | Rat | triphenyl phosphate | affects expression | ISO | TNKS (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of TNKS mRNA | CTD | PMID:37042841 | Tnks | Rat | triticonazole | decreases expression | EXP | | 6480464 | triticonazole results in decreased expression of TNKS mRNA | CTD | PMID:36084822 | Tnks | Rat | tungsten | decreases expression | ISO | Tnks (Mus musculus) | 6480464 | Tungsten results in decreased expression of TNKS mRNA | CTD | PMID:30912803 | Tnks | Rat | urethane | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Urethane results in increased expression of TNKS mRNA | CTD | PMID:28818685 | Tnks | Rat | valproic acid | decreases methylation | ISO | TNKS (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of TNKS gene | CTD | PMID:29154799 | Tnks | Rat | valproic acid | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNKS mRNA | CTD | PMID:27188386 | Tnks | Rat | valproic acid | decreases expression | ISO | TNKS (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of TNKS mRNA | CTD | PMID:23179753 more ... | Tnks | Rat | valproic acid | affects expression | ISO | TNKS (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TNKS mRNA | CTD | PMID:25979313 | Tnks | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of TNKS mRNA | CTD | PMID:19015723 | Tnks | Rat | XAV939 | multiple interactions | ISO | TNKS (Homo sapiens) | 6480464 | XAV939 inhibits the reaction [N-(oxo-5 more ... | CTD | PMID:22297980 | Tnks | Rat | XAV939 | decreases activity | ISO | TNKS (Homo sapiens) | 6480464 | XAV939 results in decreased activity of TNKS protein | CTD | PMID:28001384 | Tnks | Rat | XAV939 | affects binding | ISO | TNKS (Homo sapiens) | 6480464 | XAV939 binds to TNKS protein | CTD | PMID:22297980 | Tnks | Rat | xylitol | increases expression | ISO | TNKS (Homo sapiens) | 6480464 | Xylitol results in increased expression of TNKS mRNA | CTD | PMID:32275922 | |