Mgmt (O-6-methylguanine-DNA methyltransferase) - Rat Genome Database

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Gene: Mgmt (O-6-methylguanine-DNA methyltransferase) Rattus norvegicus
Analyze
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
RGD ID: 3087
Description: Enables calcium ion binding activity and methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in several processes, including DNA dealkylation involved in DNA repair; cellular response to ionizing radiation; and response to folic acid. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Biomarker of colon adenocarcinoma and melanoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase); INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 1,4-dioxane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 0-6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase; O(6)-alkylguanine-DNA alkyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-alkylguanine-DNA alkyltransferase; O6-methylguanine-DNA methyltranferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21191,710,980 - 191,937,760 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1191,710,930 - 191,937,756 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1200,080,430 - 200,306,973 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01207,225,081 - 207,457,730 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01199,898,541 - 200,131,185 (+)NCBIRnor_WKY
Rnor_6.01209,237,255 - 209,464,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1209,237,233 - 209,464,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01216,161,345 - 216,388,311 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41196,629,366 - 196,866,937 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11196,779,357 - 197,016,929 (+)NCBI
Celera1189,418,812 - 189,644,779 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dioxane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropropane  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2'-deoxyguanosine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-dipyridyl disulfide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alpha-carotene  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
anthracen-2-amine  (EXP)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-carotene  (ISO)
bezafibrate  (ISO)
Biflorin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carmustine  (EXP,ISO)
chloroacetaldehyde  (ISO)
chloroethene  (EXP)
chloroform  (EXP)
chlorohydrocarbon  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dacarbazine  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dichlorine  (EXP)
dichlorvos  (EXP)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfate  (ISO)
disulfiram  (EXP,ISO)
doxorubicin  (ISO)
Echimidine  (EXP)
emodin  (EXP)
fenofibrate  (EXP)
finasteride  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fotemustine  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallic acid  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (ISO)
glycidol  (EXP)
guanine  (ISO)
Heliotrine  (EXP)
hydralazine  (ISO)
hydroxyurea  (ISO)
inulin  (ISO)
iodomethane  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
Lasiocarpine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lomustine  (ISO)
manganese(II) chloride  (EXP,ISO)
methapyrilene  (EXP,ISO)
methyl isocyanate  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
mifepristone  (ISO)
mitomycin C  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethyl-4-nitrosoaniline  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nimustine  (ISO)
nitrogen mustard  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oltipraz  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramide mustard  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
procarbazine  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silibinin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
topotecan  (EXP,ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Methylguanine methyltransferase activity deficiency in immature rat mammary epithelial cells parallels increased carcinogenic susceptibility. Ariazi JL, etal., Mol Carcinog. 2005 Nov;44(3):193-201.
2. Analysis of molecular pathways in sporadic neuroendocrine tumors of the gastro-entero-pancreatic system. Arnold CN, etal., Int J Cancer. 2007 May 15;120(10):2157-64.
3. Formation of DNA adducts and induction of lacI mutations in Big Blue Rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric brain tumors. Bodell WJ, etal., Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):545-51.
4. CpG island methylation in carcinoid and pancreatic endocrine tumors. Chan AO, etal., Oncogene. 2003 Feb 13;22(6):924-34.
5. Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. Chang HJ, etal., Pathol Oncol Res. 2007;13(4):326-35. Epub 2007 Dec 25.
6. Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma. Choy KW, etal., Neoplasia. 2005 Mar;7(3):200-6.
7. Morphologic analysis correlates with gene expression changes in cultured F344 rat mesothelial cells. Crosby LM, etal., Toxicol Appl Pharmacol. 2000 Dec 15;169(3):205-21.
8. Promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin. Dhillon VS, etal., Br J Cancer. 2004 Feb 23;90(4):874-81.
9. Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Duthie SJ, etal., Cancer Prev Res (Phila Pa). 2010 Jan;3(1):92-100.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents. Grombacher T, etal., Oncogene. 1998 Aug 20;17(7):845-51.
13. Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. House MG, etal., Ann Surg. 2003 Sep;238(3):423-31; discussion 431-2.
14. Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Huang J, etal., Carcinogenesis. 2007 Jun;28(6):1314-22. Epub 2007 Jan 18.
15. Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism. Huber WW, etal., Mutat Res. 2003 Jan 28;522(1-2):57-68.
16. Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors. Ingold B, etal., PLoS One. 2009;4(3):e4775. Epub 2009 Mar 10.
17. A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma. Inoue R, etal., Neurol Res. 2003 Dec;25(8):875-9.
18. Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. Jiao L, etal., Cancer Detect Prev. 2006;30(3):284-91. Epub 2006 Jul 17.
19. Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas. Kim BH, etal., Arch Pathol Lab Med. 2007 Jun;131(6):923-30.
20. Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors. Kinjo T, etal., Anticancer Res. 2006 Jul-Aug;26(4B):2829-32.
21. Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. Kohya N, etal., Ann Surg Oncol. 2002 May;9(4):371-9.
22. Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents. Kokkinakis DM, etal., Cancer Res. 1997 Dec 1;57(23):5360-8.
23. O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors. Kulke MH, etal., Clin Cancer Res. 2009 Jan 1;15(1):338-45.
24. Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival. Kuo TC, etal., J Pharmacol Exp Ther. 2009 Sep;330(3):736-44. Epub 2009 Jun 23.
25. Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis. Li C, etal., Cancer Lett. 2005 Sep 8;227(1):49-57.
26. Aberrant methylation of different DNA repair genes demonstrates distinct prognostic value for esophageal cancer. Ling ZQ, etal., Dig Dis Sci. 2011 Oct;56(10):2992-3004. doi: 10.1007/s10620-011-1774-z. Epub 2011 Jun 15.
27. Discrimination of Carcinogens by Hepatic Transcript Profiling in Rats Following 28-day Administration. Matsumoto H, etal., Cancer Inform. ;7:253-69.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants. Mijal RS, etal., Chem Res Toxicol. 2004 Mar;17(3):424-34.
30. Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Mollemann M, etal., Int J Cancer. 2005 Jan 20;113(3):379-85.
31. Ethanol modulates rat hepatic DNA repair functions. Navasumrit P, etal., Alcohol Alcohol. 2001 Sep-Oct;36(5):369-76.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Inverse correlation between the expression of O6-methylguanine-DNA methyl transferase (MGMT) and p53 in breast cancer. Osanai T, etal., Jpn J Clin Oncol. 2005 Mar;35(3):121-5.
34. Induction of thermal and chemical stability of O6-methylguanine-DNA methyltransferase by Ca2+. Park TJ, etal., Biochim Biophys Acta 2002 Sep 23;1599(1-2):36-44.
35. Ribozyme-mediated modulation of human O6-methylguanine-DNA methyltransferase expression. Potter PM, etal., Cancer Res 1993 Apr 15;53(8):1731-4.
36. cDNA cloning of the rat O6-methylguanine-DNA-methyltransferase. Rahden-Staron I and Laval F, Biochem Biophys Res Commun 1991 Jun 14;177(2):597-602.
37. GOA pipeline RGD automated data pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Cloning and expresion of cDNA for rat O6-methylguanine-DNA methyltransferase. Sakumi K, etal., Nucleic Acids Res 1991 Oct 25;19(20):5597-601.
41. MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk. Shen J, etal., Carcinogenesis. 2005 Dec;26(12):2131-7. Epub 2005 Jul 13.
42. Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer. Smith-Sorensen B, etal., Oncogene. 2002 Dec 12;21(57):8878-84.
43. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
44. Inhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma. Toshimitsu H, etal., Ann Surg Oncol. 2010 Feb 24.
45. Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China. Zhang M, etal., Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2123-7.
46. Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells. Zheng LT, etal., J Neurochem. 2009 Dec;111(5):1238-51. Epub 2009 Oct 5.
Additional References at PubMed
PMID:1554415   PMID:2013136   PMID:8202360   PMID:9560238   PMID:10657972   PMID:13679151   PMID:19946888   PMID:24147153   PMID:32433023  


Genomics

Comparative Map Data
Mgmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21191,710,980 - 191,937,760 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1191,710,930 - 191,937,756 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1200,080,430 - 200,306,973 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01207,225,081 - 207,457,730 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01199,898,541 - 200,131,185 (+)NCBIRnor_WKY
Rnor_6.01209,237,255 - 209,464,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1209,237,233 - 209,464,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01216,161,345 - 216,388,311 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41196,629,366 - 196,866,937 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11196,779,357 - 197,016,929 (+)NCBI
Celera1189,418,812 - 189,644,779 (+)NCBICelera
Cytogenetic Map1q41NCBI
MGMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810129,467,241 - 129,770,983 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10129,467,190 - 129,770,983 (+)EnsemblGRCh38hg38GRCh38
GRCh3710131,265,505 - 131,569,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610131,155,456 - 131,455,358 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410131,155,455 - 131,455,358NCBI
Celera10124,937,282 - 125,237,646 (+)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10124,842,441 - 125,144,551 (+)NCBIHuRef
CHM1_110131,547,584 - 131,847,911 (+)NCBICHM1_1
T2T-CHM13v2.010130,392,352 - 130,697,970 (+)NCBIT2T-CHM13v2.0
Mgmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397136,496,315 - 136,732,001 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7136,496,343 - 136,731,995 (+)EnsemblGRCm39 Ensembl
GRCm387136,894,463 - 137,128,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7136,894,614 - 137,130,266 (+)EnsemblGRCm38mm10GRCm38
MGSCv377144,086,294 - 144,319,871 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367136,789,611 - 136,966,732 (+)NCBIMGSCv36mm8
Celera7136,716,995 - 136,951,061 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map782.07NCBI
Mgmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554777,102,977 - 7,376,530 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554777,103,035 - 7,375,073 (+)NCBIChiLan1.0ChiLan1.0
MGMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan110141,361,768 - 141,667,738 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010126,059,701 - 126,365,850 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110130,305,459 - 130,609,532 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10130,305,485 - 130,609,422 (+)Ensemblpanpan1.1panPan2
MGMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12838,204,611 - 38,427,482 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2838,204,610 - 38,427,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2838,200,970 - 38,481,621 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02838,778,341 - 39,060,486 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2838,778,349 - 39,060,187 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12838,267,067 - 38,546,986 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02838,254,871 - 38,535,366 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02838,508,988 - 38,789,325 (+)NCBIUU_Cfam_GSD_1.0
Mgmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072138,634,604 - 8,867,176 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648616,744,570 - 16,923,543 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648616,744,607 - 16,923,209 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14138,499,309 - 138,771,540 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114138,502,005 - 138,771,543 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214150,607,175 - 150,887,520 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MGMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19122,089,768 - 122,376,320 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604883,466,550 - 83,760,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473717,271,992 - 17,528,889 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473717,271,881 - 17,619,123 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mgmt
1212 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000021537
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383635Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383635Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat

Markers in Region
M84524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21191,937,838 - 191,937,937 (+)MAPPERmRatBN7.2
Rnor_6.01209,464,271 - 209,464,369NCBIRnor6.0
Rnor_5.01216,388,392 - 216,388,490UniSTSRnor5.0
RGSC_v3.41196,867,019 - 196,867,117UniSTSRGSC3.4
Celera1189,644,861 - 189,644,959UniSTS
Cytogenetic Map1q41UniSTS
RH130883  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21191,937,586 - 191,937,756 (+)MAPPERmRatBN7.2
Rnor_6.01209,464,019 - 209,464,188NCBIRnor6.0
Rnor_5.01216,388,140 - 216,388,309UniSTSRnor5.0
RGSC_v3.41196,866,767 - 196,866,936UniSTSRGSC3.4
Celera1189,644,609 - 189,644,778UniSTS
RH 3.4 Map11422.2UniSTS
Cytogenetic Map1q41UniSTS
D1Bda40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21191,937,623 - 191,937,725 (+)MAPPERmRatBN7.2
Rnor_6.01209,464,056 - 209,464,157NCBIRnor6.0
Rnor_5.01216,388,177 - 216,388,278UniSTSRnor5.0
RGSC_v3.41196,866,804 - 196,866,905UniSTSRGSC3.4
Celera1189,644,646 - 189,644,747UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:224822  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21191,937,768 - 191,937,937 (+)MAPPERmRatBN7.2
Rnor_6.01209,464,201 - 209,464,369NCBIRnor6.0
Rnor_5.01216,388,322 - 216,388,490UniSTSRnor5.0
RGSC_v3.41196,866,949 - 196,867,117UniSTSRGSC3.4
Celera1189,644,791 - 189,644,959UniSTS
Cytogenetic Map1q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 19 53 41 19 41 6 31 34 11
Low 1 24 4 8 11 68 4 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021537   ⟹   ENSRNOP00000021537
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1191,711,105 - 191,937,738 (+)Ensembl
Rnor_6.0 Ensembl1209,237,233 - 209,464,190 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093786   ⟹   ENSRNOP00000084903
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1191,710,930 - 191,937,734 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119456   ⟹   ENSRNOP00000079311
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1191,711,113 - 191,937,756 (+)Ensembl
RefSeq Acc Id: NM_012861   ⟹   NP_036993
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21191,711,096 - 191,937,757 (+)NCBI
Rnor_6.01209,237,255 - 209,464,189 (+)NCBI
Rnor_5.01216,161,345 - 216,388,311 (+)NCBI
RGSC_v3.41196,629,366 - 196,866,937 (+)RGD
Celera1189,418,812 - 189,644,779 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101590   ⟹   XP_038957518
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21191,841,555 - 191,937,760 (+)NCBI
RefSeq Acc Id: XM_039101594   ⟹   XP_038957522
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21191,710,980 - 191,937,760 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036993   ⟸   NM_012861
- UniProtKB: P24528 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021537   ⟸   ENSRNOT00000021537
RefSeq Acc Id: XP_038957522   ⟸   XM_039101594
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957518   ⟸   XM_039101590
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000084903   ⟸   ENSRNOT00000093786
RefSeq Acc Id: ENSRNOP00000079311   ⟸   ENSRNOT00000119456
Protein Domains
Methylated-DNA-[protein]-cysteine S-   Methylguanine DNA methyltransferase ribonuclease-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24528-F1-model_v2 AlphaFold P24528 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690496
Promoter ID:EPDNEW_R1021
Type:initiation region
Name:Mgmt_1
Description:O-6-methylguanine-DNA methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01209,237,258 - 209,237,318EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3087 AgrOrtholog
BioCyc Gene G2FUF-57131 BioCyc
Ensembl Genes ENSRNOG00000016038 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021537.3 UniProtKB/TrEMBL
  ENSRNOP00000079311 ENTREZGENE
  ENSRNOP00000079311.1 UniProtKB/Swiss-Prot
  ENSRNOP00000084903.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021537.5 UniProtKB/TrEMBL
  ENSRNOT00000093786.1 UniProtKB/TrEMBL
  ENSRNOT00000119456 ENTREZGENE
  ENSRNOT00000119456.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methylated DNA-protein cysteine methyltransferase domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MethylDNA_cys_MeTrfase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MethylDNA_cys_MeTrfase_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MethylDNA_cys_MeTrfase_DNAb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MethylG_MeTrfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGMT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25332 UniProtKB/Swiss-Prot
NCBI Gene 25332 ENTREZGENE
PANTHER METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE UniProtKB/Swiss-Prot
  METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE UniProtKB/Swiss-Prot
  METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE UniProtKB/TrEMBL
  METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE UniProtKB/TrEMBL
Pfam DNA_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyltransf_1N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MGMT RGD
PhenoGen Mgmt PhenoGen
PROSITE MGMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53155 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207308
TIGRFAMs ogt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GB83_RAT UniProtKB/TrEMBL
  A0A8L2QAS3_RAT UniProtKB/TrEMBL
  MGMT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mgmt  O-6-methylguanine-DNA methyltransferase    0-6-methylguanine-DNA methyltransferase  Name updated 1299863 APPROVED
2002-06-10 Mgmt  O6-methylguanine-DNA methyltranferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 68% homology with the human transferase 729380
gene_protein 209 amino acid residues 729332