Bid (BH3 interacting domain death agonist) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Bid (BH3 interacting domain death agonist) Rattus norvegicus
Symbol: Bid
Name: BH3 interacting domain death agonist
RGD ID: 620160
Description: Predicted to enable ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of autophagy in response to ER overload; release of cytochrome c from mitochondria; and response to ischemia. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Used to study pre-malignant neoplasm. Biomarker of bronchopulmonary dysplasia. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human BID (BH3 interacting domain death agonist); PARTICIPATES IN FasL mediated signaling pathway; intrinsic apoptotic pathway; ceramide signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: apoptotic death agonist BID; BH3-interacting domain death agonist; desmocollin type 4; p22 BID
RGD Orthologs
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84155,785,366 - 155,808,775 (-)NCBIGRCr8
mRatBN7.24154,113,198 - 154,136,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,113,198 - 154,134,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4160,379,868 - 160,401,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,163,607 - 156,185,558 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04154,786,934 - 154,808,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04153,439,812 - 153,465,247 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4153,442,218 - 153,465,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04220,531,866 - 220,554,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44157,296,383 - 157,318,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14157,541,223 - 157,563,322 (-)NCBI
Celera4142,956,454 - 142,978,221 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-Dinitropyrene  (ISO)
1,8-Dinitropyrene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-deoxy-D-glucose  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-formylpterin  (ISO)
6-O-methylguanine  (ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (EXP)
ABT-737  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alantolactone  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-mangostin  (ISO)
alpha-Zearalanol  (EXP)
alpinumisoflavone  (ISO)
alvocidib  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
andrographolide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP)
aprepitant  (ISO)
arachidonic acid  (ISO)
arecoline  (EXP)
aripiprazole  (ISO)
arjunolic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
azadirachtin A  (ISO)
bafilomycin A1  (EXP,ISO)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
Berbamine  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chalcones  (ISO)
chrysazin  (ISO)
ciglitazone  (ISO)
cilostazol  (EXP)
Cinobufotalin  (ISO)
cisplatin  (EXP,ISO)
clavulone II  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
dieldrin  (EXP)
Dimethyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echinocystic acid  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
esculetin  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farrerol  (ISO)
fenvalerate  (ISO)
fisetin  (ISO)
flavonols  (ISO)
flufenamic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
Garcinol  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
idelalisib  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
juglone  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lonidamine  (ISO)
Lupiwighteone  (ISO)
Luteolin 7-methyl ether  (EXP)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
masoprocol  (ISO)
melatonin  (ISO)
methamphetamine  (ISO)
methoxychlor  (ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (EXP)
mifepristone  (ISO)
minocycline  (EXP,ISO)
Mitotane  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
Myrtucommulone A  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
Niflumic acid  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitroprusside  (EXP)
Nonidet P-40  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
osthole  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
patulin  (ISO)
PD 0325901  (ISO)
pemetrexed  (ISO)
Pendulone  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (ISO)
pepstatin A  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
phenylmercury acetate  (ISO)
phylloquinone  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium iodide  (EXP)
Pramanicin  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
pterostilbene  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
safrole  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
Sesamol  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
SM-164  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
Spiruchostatin A  (ISO)
spiruchostatin B  (ISO)
staurosporine  (ISO)
Suillin  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tebufenpyrad  (ISO)
thapsigargin  (ISO)
thiazoles  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
topotecan  (ISO)
triamcinolone acetonide  (EXP)
Tributyltin oxide  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (EXP,ISO)
zearalenone  (EXP)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zingerone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic mitochondrial changes  (IBA)
establishment of protein localization to membrane  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
glial cell apoptotic process  (IEP)
hepatocyte apoptotic process  (IEA,ISO,ISS)
mitochondrial ATP synthesis coupled electron transport  (IEA,ISO)
mitochondrial outer membrane permeabilization  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of autophagy in response to ER overload  (IMP)
positive regulation of extrinsic apoptotic signaling pathway  (IBA,IEA,ISO)
positive regulation of fibroblast apoptotic process  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IBA,IEA,ISO)
positive regulation of mitochondrial membrane potential  (IEA,ISO)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of release of cytochrome c from mitochondria  (IBA,IEA,ISO,ISS)
protein targeting to mitochondrion  (IEA,ISO)
protein-containing complex assembly  (IEA,ISO)
regulation of apoptotic process  (ISO)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
regulation of T cell proliferation  (IEA,ISO)
release of cytochrome c from mitochondria  (IDA,IEA,ISO)
response to estradiol  (IEP)
response to ischemia  (IEP)
supramolecular fiber organization  (IEA,ISO)

Cellular Component
cytosol  (IBA,IEA,ISO)
membrane  (ISO)
mitochondrial membrane  (ISO)
mitochondrial outer membrane  (IEA,ISO,ISS)
mitochondrion  (IBA,ISO)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
2. Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/reperfusion injury. Collino M, etal., Thromb Haemost. 2009 Nov;102(5):837-45.
3. The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. Duval N, etal., Front Cell Neurosci. 2018 Jan 30;12:15. doi: 10.3389/fncel.2018.00015. eCollection 2018.
4. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
5. Temporal and spatial profile of Bid cleavage after experimental traumatic brain injury. Franz G, etal., J Cereb Blood Flow Metab 2002 Aug;22(8):951-8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release. Gillick K and Crompton M, J Cell Sci. 2008 Mar 1;121(Pt 5):618-26. Epub 2008 Feb 5.
8. The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice. Hylander BL, etal., J Transl Med. 2005 May 19;3(1):22.
9. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
10. The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells. Kim KW, etal., Spine (Phila Pa 1976). 2007 Oct 15;32(22):2443-8.
11. Effects of 17beta-estradiol on cardiac apoptosis in ovariectomized rats. Liou CM, etal., Cell Biochem Funct. 2010 Aug;28(6):521-8.
12. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein. Roucou X, etal., Biochem J 2002 Dec 15;368(Pt 3):915-21.
22. Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Scarabelli TM, etal., Circ Res. 2002 Apr 5;90(6):745-8.
23. Interaction of 14-3-3 with Bid during seizure-induced neuronal death. Shinoda S, etal., J Neurochem. 2003 Jul;86(2):460-9.
24. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
25. The many roles of FAS receptor signaling in the immune system. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
26. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. Wang J, etal., J Biol Chem. 2004 May 7;279(19):19948-54. Epub 2004 Mar 5.
27. Bid activation in kidney cells following ATP depletion in vitro and ischemia in vivo. Wei Q, etal., Am J Physiol Renal Physiol. 2004 Apr;286(4):F803-9. Epub 2003 Dec 16.
28. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-¿B/p53/Ki67 signaling pathway. Xu B, etal., Biosci Rep. 2018 Jun 12;38(3). pii: BSR20171529. doi: 10.1042/BSR20171529. Print 2018 Jun 29.
29. Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1alpha and p53 pathways. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
30. Inhibition of cytochrome c release by 10-N-nonyl acridine orange, a cardiolipin-specific dye, during myocardial ischemia-reperfusion in the rat. Zhang GX, etal., Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H433-9. Epub 2009 Nov 25.
31. Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression. Zhang J, etal., J Surg Res. 2015 May 15;195(2):588-95. doi: 10.1016/j.jss.2015.01.039. Epub 2015 Jan 28.
Additional References at PubMed
PMID:7774948   PMID:7929347   PMID:8918887   PMID:9727492   PMID:9873064   PMID:10476969   PMID:10950869   PMID:11369777   PMID:11980919   PMID:12011074   PMID:14701745   PMID:14729675  
PMID:14963330   PMID:15138279   PMID:15351738   PMID:15855651   PMID:16446153   PMID:17005564   PMID:17052454   PMID:17289999   PMID:17326836   PMID:18038901   PMID:18084238   PMID:18195012  
PMID:18614015   PMID:19074440   PMID:20392206   PMID:20436477   PMID:20850011   PMID:21041309   PMID:21262771   PMID:21459798   PMID:21525171   PMID:23376485   PMID:23744079   PMID:24616078  
PMID:26219591   PMID:27584794   PMID:29531808   PMID:31533600  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84155,785,366 - 155,808,775 (-)NCBIGRCr8
mRatBN7.24154,113,198 - 154,136,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,113,198 - 154,134,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4160,379,868 - 160,401,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,163,607 - 156,185,558 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04154,786,934 - 154,808,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04153,439,812 - 153,465,247 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4153,442,218 - 153,465,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04220,531,866 - 220,554,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44157,296,383 - 157,318,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14157,541,223 - 157,563,322 (-)NCBI
Celera4142,956,454 - 142,978,221 (-)NCBICelera
Cytogenetic Map4q42NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382217,734,138 - 17,774,665 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2217,734,138 - 17,774,770 (-)EnsemblGRCh38hg38GRCh38
GRCh372218,216,904 - 18,257,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362216,596,906 - 16,637,258 (-)NCBINCBI36Build 36hg18NCBI36
Build 342216,591,459 - 16,631,812NCBI
Celera221,836,614 - 1,876,916 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef222,030,888 - 2,070,940 (-)NCBIHuRef
CHM1_12218,216,448 - 18,257,021 (-)NCBICHM1_1
T2T-CHM13v2.02218,401,873 - 18,442,340 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396120,870,080 - 120,894,074 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6120,868,891 - 120,893,814 (-)EnsemblGRCm39 Ensembl
GRCm386120,893,119 - 120,917,062 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6120,891,930 - 120,916,853 (-)EnsemblGRCm38mm10GRCm38
MGSCv376120,843,137 - 120,866,838 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366120,858,738 - 120,882,439 (-)NCBIMGSCv36mm8
Celera6122,736,915 - 122,760,652 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.02NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554545,777,667 - 5,783,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554545,776,656 - 5,785,500 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22328,052,191 - 28,092,158 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12230,600,920 - 30,639,767 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0221,164,787 - 1,205,051 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12216,594,186 - 16,633,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2216,594,186 - 16,632,844 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12745,344,304 - 45,355,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2745,337,145 - 45,384,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha271,299,470 - 1,338,997 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02745,714,410 - 45,753,866 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2745,714,410 - 45,753,879 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12745,642,533 - 45,681,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02745,615,826 - 45,655,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.027652,469 - 692,311 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404945110,195,950 - 110,237,745 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936807708,276 - 750,093 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936807708,340 - 750,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl569,849,002 - 69,875,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1569,849,007 - 69,874,647 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2572,118,716 - 72,143,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247359,579,979 - 9,589,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247359,557,732 - 9,590,862 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Bid
85 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:124
Interacting mature miRNAs:144
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 4 49 41 19 41 59 35 32 7
Low 39 8 8 11 15 9 4 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000016776   ⟹   ENSRNOP00000016776
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4154,113,198 - 154,134,720 (-)Ensembl
Rnor_6.0 Ensembl4153,442,218 - 153,465,203 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096502   ⟹   ENSRNOP00000078364
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4154,115,605 - 154,122,257 (-)Ensembl
RefSeq Acc Id: NM_022684   ⟹   NP_073175
Rat AssemblyChrPosition (strand)Source
GRCr84155,786,379 - 155,808,319 (-)NCBI
mRatBN7.24154,114,211 - 154,136,153 (-)NCBI
Rnor_6.04153,443,220 - 153,465,247 (-)NCBI
Rnor_5.04220,531,866 - 220,554,360 (-)NCBI
RGSC_v3.44157,296,383 - 157,318,481 (-)RGD
Celera4142,956,454 - 142,978,221 (-)RGD
RefSeq Acc Id: XM_017592880   ⟹   XP_017448369
Rat AssemblyChrPosition (strand)Source
GRCr84155,785,366 - 155,806,890 (-)NCBI
mRatBN7.24154,113,198 - 154,134,700 (-)NCBI
Rnor_6.04153,439,812 - 153,465,055 (-)NCBI
RefSeq Acc Id: XM_039108322   ⟹   XP_038964250
Rat AssemblyChrPosition (strand)Source
GRCr84155,785,366 - 155,808,282 (-)NCBI
mRatBN7.24154,113,198 - 154,136,004 (-)NCBI
RefSeq Acc Id: XM_039108323   ⟹   XP_038964251
Rat AssemblyChrPosition (strand)Source
GRCr84155,785,366 - 155,808,775 (-)NCBI
mRatBN7.24154,113,198 - 154,136,353 (-)NCBI
RefSeq Acc Id: XM_063286667   ⟹   XP_063142737
Rat AssemblyChrPosition (strand)Source
GRCr84155,785,366 - 155,808,473 (-)NCBI
RefSeq Acc Id: NP_073175   ⟸   NM_022684
- UniProtKB: Q9JK60 (UniProtKB/Swiss-Prot),   Q9JLT6 (UniProtKB/Swiss-Prot),   A8ASI9 (UniProtKB/TrEMBL),   A0A8I5ZKS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448369   ⟸   XM_017592880
- Peptide Label: isoform X2
- UniProtKB: Q9JK60 (UniProtKB/Swiss-Prot),   Q9JLT6 (UniProtKB/Swiss-Prot),   A8ASI9 (UniProtKB/TrEMBL),   A0A8I5ZKS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016776   ⟸   ENSRNOT00000016776
RefSeq Acc Id: XP_038964251   ⟸   XM_039108323
- Peptide Label: isoform X2
- UniProtKB: Q9JLT6 (UniProtKB/Swiss-Prot),   Q9JK60 (UniProtKB/Swiss-Prot),   A8ASI9 (UniProtKB/TrEMBL),   A0A8I5ZKS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964250   ⟸   XM_039108322
- Peptide Label: isoform X2
- UniProtKB: Q9JLT6 (UniProtKB/Swiss-Prot),   Q9JK60 (UniProtKB/Swiss-Prot),   A8ASI9 (UniProtKB/TrEMBL),   A0A8I5ZKS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078364   ⟸   ENSRNOT00000096502
RefSeq Acc Id: XP_063142737   ⟸   XM_063286667
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZKS3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLT6-F1-model_v2 AlphaFold Q9JLT6 1-196 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693360
Promoter ID:EPDNEW_R3884
Type:initiation region
Description:BH3 interacting domain death agonist
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.04153,465,247 - 153,465,307EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620160 AgrOrtholog
BioCyc Gene G2FUF-43188 BioCyc
Ensembl Genes ENSRNOG00000012439 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010823 UniProtKB/Swiss-Prot
  ENSRNOG00060025803 UniProtKB/Swiss-Prot
  ENSRNOG00065029226 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016776.3 UniProtKB/Swiss-Prot
  ENSRNOT00000096502.1 UniProtKB/TrEMBL
  ENSRNOT00055018321 UniProtKB/Swiss-Prot
  ENSRNOT00060044691 UniProtKB/Swiss-Prot
  ENSRNOT00065050513 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64625 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR35447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bid PhenoGen
PIRSF BID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012439 RatGTEx
  ENSRNOG00055010823 RatGTEx
  ENSRNOG00060025803 RatGTEx
  ENSRNOG00065029226 RatGTEx
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BID_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9JK60 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Bid  BH3 interacting domain death agonist    apoptotic death agonist BID  Name updated 1299863 APPROVED
2002-08-07 Bid  apoptotic death agonist BID      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process necessary but not sufficient for Bax oligomerization with a mitochondrial protein is also required for proper oligomerization