Adam8 (ADAM metallopeptidase domain 8) - Rat Genome Database

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Gene: Adam8 (ADAM metallopeptidase domain 8) Rattus norvegicus
Analyze
Symbol: Adam8
Name: ADAM metallopeptidase domain 8
RGD ID: 1566394
Description: Predicted to enable several functions, including metal ion binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of defense response; positive regulation of intracellular signal transduction; and positive regulation of leukocyte migration. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and podosome. Predicted to be part of alpha9-beta1 integrin-ADAM8 complex. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 8; disintegrin and metalloproteinase domain-containing protein 8; LOC499285; RGD1566394; similar to cysteine-rich glycoprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,206,206 - 204,218,988 (-)NCBIGRCr8
mRatBN7.21194,776,559 - 194,789,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,770,060 - 194,788,801 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01212,317,510 - 212,332,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,317,848 - 212,330,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,236,436 - 219,251,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41199,780,772 - 199,791,855 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1192,454,105 - 192,468,808 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
anthracen-2-amine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
choline  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (EXP)
Echimidine  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fructose  (ISO)
glucose  (ISO)
Heliotrine  (EXP)
iron dichloride  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
Lasiocarpine  (EXP)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
Phenelzine  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
progesterone  (ISO)
rotenone  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Upregulation of ADAM8 in the airways of mice with allergic bronchial asthma. Chiba Y, etal., Lung. 2009 May-Jun;187(3):179-85. Epub 2009 Apr 17.
2. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. Foley SC, etal., J Allergy Clin Immunol. 2007 Apr;119(4):863-71. Epub 2007 Mar 6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. Matsuno O, etal., Respir Med. 2010 Jan;104(1):34-9. Epub 2009 Jul 21.
5. The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma. Naus S, etal., Am J Respir Crit Care Med. 2010 Jun 15;181(12):1318-28. Epub 2010 Mar 1.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. The disintegrin domain of ADAM 8 enhances protection against rat experimental autoimmune encephalomyelitis, neuritis and uveitis by a polyvalent autoantigen vaccine. Schluesener HJ J Neuroimmunol. 1998 Jul 1;87(1-2):197-202.
11. ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer. Valkovskaya N, etal., J Cell Mol Med. 2007 Sep-Oct;11(5):1162-74.
Additional References at PubMed
PMID:11341326   PMID:12135759   PMID:12372841   PMID:12777399   PMID:14761956   PMID:15220135   PMID:16995821   PMID:17548643   PMID:18397961   PMID:18566576   PMID:19003792   PMID:19397475  
PMID:20683884   PMID:20826683   PMID:20856819   PMID:21268008   PMID:21728900   PMID:31640732   PMID:38218854  


Genomics

Comparative Map Data
Adam8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,206,206 - 204,218,988 (-)NCBIGRCr8
mRatBN7.21194,776,559 - 194,789,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,770,060 - 194,788,801 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01212,317,510 - 212,332,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,317,848 - 212,330,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,236,436 - 219,251,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41199,780,772 - 199,791,855 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1192,454,105 - 192,468,808 (-)NCBICelera
Cytogenetic Map1q41NCBI
ADAM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,262,423 - 133,276,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,262,420 - 133,276,868 (-)EnsemblGRCh38hg38GRCh38
GRCh3710135,075,927 - 135,090,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610134,925,911 - 134,940,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410134,964,788 - 134,979,211NCBI
Celera10128,426,024 - 128,440,474 (+)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,622,621 - 128,637,236 (-)NCBIHuRef
CHM1_110135,357,756 - 135,372,278 (-)NCBICHM1_1
T2T-CHM13v2.010134,218,053 - 134,232,489 (-)NCBIT2T-CHM13v2.0
Adam8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,558,845 - 139,573,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,558,845 - 139,572,475 (-)EnsemblGRCm39 Ensembl
GRCm387139,978,932 - 139,995,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7139,978,932 - 139,992,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv377147,164,840 - 147,178,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,830,261 - 139,843,808 (-)NCBIMGSCv36mm8
Celera7139,782,797 - 139,796,305 (-)NCBICelera
Cytogenetic Map7F4NCBI
cM Map784.96NCBI
Adam8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547710,895,446 - 10,907,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547710,894,288 - 10,906,961 (-)NCBIChiLan1.0ChiLan1.0
ADAM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,386,583 - 145,400,948 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,391,940 - 145,406,305 (-)NCBINHGRI_mPanPan1
PanPan1.110134,171,986 - 134,186,221 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,172,724 - 134,186,227 (-)Ensemblpanpan1.1panPan2
ADAM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,853,665 - 40,865,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2840,909,672 - 40,921,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,490,792 - 41,502,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,973,551 - 40,985,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,962,945 - 40,974,543 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,365,582 - 41,377,170 (-)NCBIUU_Cfam_GSD_1.0
Adam8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,156,736 - 6,171,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,391,324 - 19,402,332 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,389,925 - 19,403,577 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,221,198 - 141,232,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,221,177 - 141,233,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,183,627 - 153,194,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,114,184 - 53,129,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,114,924 - 53,126,900 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605441,248,757 - 41,264,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473713,459,274 - 13,474,686 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:81
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000024369
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512205777982Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
RH132117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21194,776,629 - 194,776,843 (+)MAPPERmRatBN7.2
Rnor_6.01212,317,569 - 212,317,782NCBIRnor6.0
Rnor_5.01219,236,514 - 219,236,727UniSTSRnor5.0
RGSC_v3.41199,780,070 - 199,780,283UniSTSRGSC3.4
Celera1192,454,164 - 192,454,377UniSTS
RH 3.4 Map11437.21UniSTS
Cytogenetic Map1q41UniSTS
AW528396  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21194,789,543 - 194,789,724 (+)MAPPERmRatBN7.2
Rnor_6.01212,331,143 - 212,331,323NCBIRnor6.0
Rnor_5.01219,249,314 - 219,249,494UniSTSRnor5.0
RGSC_v3.41199,793,637 - 199,793,817UniSTSRGSC3.4
Celera1192,467,056 - 192,467,236UniSTS
RH 3.4 Map11437.6UniSTS
Cytogenetic Map1q41UniSTS
RH131378  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21194,778,389 - 194,778,596 (+)MAPPERmRatBN7.2
Rnor_6.01212,319,329 - 212,319,535NCBIRnor6.0
Rnor_5.01219,238,274 - 219,238,480UniSTSRnor5.0
RGSC_v3.41199,781,829 - 199,782,035UniSTSRGSC3.4
Celera1192,455,924 - 192,456,130UniSTS
Cytogenetic Map1q41UniSTS
BF399127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21194,789,457 - 194,789,612 (+)MAPPERmRatBN7.2
Rnor_6.01212,331,057 - 212,331,211NCBIRnor6.0
Rnor_5.01219,249,228 - 219,249,382UniSTSRnor5.0
RGSC_v3.41199,793,551 - 199,793,705UniSTSRGSC3.4
Celera1192,466,970 - 192,467,124UniSTS
RH 3.4 Map11437.21UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024369   ⟹   ENSRNOP00000024369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1194,770,060 - 194,788,801 (-)Ensembl
Rnor_6.0 Ensembl1212,317,848 - 212,330,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103573   ⟹   ENSRNOP00000077537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1194,770,089 - 194,788,801 (-)Ensembl
RefSeq Acc Id: NM_001427124   ⟹   NP_001414053
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,206,213 - 204,218,322 (-)NCBI
RefSeq Acc Id: XM_006230499   ⟹   XP_006230561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,206,206 - 204,218,988 (-)NCBI
mRatBN7.21194,776,559 - 194,789,330 (-)NCBI
Rnor_6.01212,317,510 - 212,332,895 (-)NCBI
Rnor_5.01219,236,436 - 219,251,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230500   ⟹   XP_006230562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,206,206 - 204,218,988 (-)NCBI
mRatBN7.21194,776,559 - 194,789,330 (-)NCBI
Rnor_6.01212,317,510 - 212,332,895 (-)NCBI
Rnor_5.01219,236,436 - 219,251,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230501   ⟹   XP_006230563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,206,206 - 204,218,988 (-)NCBI
mRatBN7.21194,776,559 - 194,789,330 (-)NCBI
Rnor_6.01212,317,510 - 212,332,895 (-)NCBI
Rnor_5.01219,236,436 - 219,251,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590243   ⟹   XP_017445732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,207,331 - 204,218,988 (-)NCBI
mRatBN7.21194,777,648 - 194,789,330 (-)NCBI
Rnor_6.01212,318,583 - 212,332,895 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101260   ⟹   XP_038957188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,206,206 - 204,218,988 (-)NCBI
mRatBN7.21194,776,559 - 194,789,330 (-)NCBI
RefSeq Acc Id: XM_039101261   ⟹   XP_038957189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,206,206 - 204,218,988 (-)NCBI
mRatBN7.21194,776,559 - 194,789,330 (-)NCBI
RefSeq Acc Id: XM_063271567   ⟹   XP_063127637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,206,206 - 204,218,988 (-)NCBI
RefSeq Acc Id: XP_006230563   ⟸   XM_006230501
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y1P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230562   ⟸   XM_006230500
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006230561   ⟸   XM_006230499
- Peptide Label: isoform X1
- UniProtKB: D3ZB52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445732   ⟸   XM_017590243
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSRNOP00000024369   ⟸   ENSRNOT00000024369
RefSeq Acc Id: XP_038957189   ⟸   XM_039101261
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038957188   ⟸   XM_039101260
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000077537   ⟸   ENSRNOT00000103573
RefSeq Acc Id: XP_063127637   ⟸   XM_063271567
- Peptide Label: isoform X7
RefSeq Acc Id: NP_001414053   ⟸   NM_001427124
- Peptide Label: precursor
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZB52-F1-model_v2 AlphaFold D3ZB52 1-823 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690512
Promoter ID:EPDNEW_R1032
Type:single initiation site
Name:Adam8_1
Description:ADAM metallopeptidase domain 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01212,330,279 - 212,330,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566394 AgrOrtholog
BioCyc Gene G2FUF-57070 BioCyc
Ensembl Genes ENSRNOG00000017897 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024369.7 UniProtKB/TrEMBL
  ENSRNOT00000103573.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene 499285 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam8 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017897 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A8I5Y1P5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZB52 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adam8  ADAM metallopeptidase domain 8  Adam8  a disintegrin and metallopeptidase domain 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Adam8  a disintegrin and metallopeptidase domain 8  RGD1566394_predicted  similar to cysteine-rich glycoprotein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566394_predicted  similar to cysteine-rich glycoprotein (predicted)  LOC499285  similar to cysteine-rich glycoprotein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499285  similar to cysteine-rich glycoprotein      Symbol and Name status set to provisional 70820 PROVISIONAL