Symbol:
Adam8
Name:
ADAM metallopeptidase domain 8
RGD ID:
1566394
Description:
Predicted to enable several functions, including metal ion binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of defense response; positive regulation of intracellular signal transduction; and positive regulation of leukocyte migration. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and podosome. Predicted to be part of alpha9-beta1 integrin-ADAM8 complex. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
a disintegrin and metallopeptidase domain 8; disintegrin and metalloproteinase domain-containing protein 8; LOC499285; RGD1566394; similar to cysteine-rich glycoprotein
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 204,206,206 - 204,218,988 (-) NCBI GRCr8 mRatBN7.2 1 194,776,559 - 194,789,330 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 194,770,060 - 194,788,801 (-) Ensembl mRatBN7.2 Ensembl Rnor_6.0 1 212,317,510 - 212,332,895 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 212,317,848 - 212,330,349 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 219,236,436 - 219,251,059 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 199,780,772 - 199,791,855 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 1 192,454,105 - 192,468,808 (-) NCBI Celera Cytogenetic Map 1 q41 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Adam8 Rat (1->4)-beta-D-glucan multiple interactions ISO Adam8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ADAM8 mRNA CTD PMID:36331819 Adam8 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Adam8 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 Adam8 Rat 1,2-dimethylhydrazine increases expression EXP 6480464 1 and 2-Dimethylhydrazine results in increased expression of ADAM8 mRNA CTD PMID:27840820 Adam8 Rat 1,2-dimethylhydrazine increases expression ISO Adam8 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of ADAM8 mRNA CTD PMID:22206623 Adam8 Rat 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of ADAM8 mRNA CTD PMID:30723492 Adam8 Rat 17alpha-ethynylestradiol increases expression ISO Adam8 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of ADAM8 mRNA CTD PMID:17942748 Adam8 Rat 17alpha-ethynylestradiol multiple interactions ISO Adam8 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM8 mRNA CTD PMID:17942748 Adam8 Rat 17beta-estradiol multiple interactions ISO Adam8 (Mus musculus) 6480464 [Polyphenols co-treated with Estradiol] results in increased expression of ADAM8 mRNA CTD PMID:30077407 Adam8 Rat 17beta-estradiol multiple interactions ISO ADAM8 (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of ADAM8 mRNA CTD PMID:30165855 Adam8 Rat 17beta-estradiol increases expression ISO Adam8 (Mus musculus) 6480464 Estradiol results in increased expression of ADAM8 mRNA CTD PMID:30077407 Adam8 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Adam8 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 Adam8 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Adam8 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 Adam8 Rat 2,2',5,5'-tetrachlorobiphenyl decreases expression ISO ADAM8 (Homo sapiens) 6480464 2 more ... CTD PMID:36804509 Adam8 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Adam8 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM8 mRNA CTD PMID:17942748 Adam8 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ADAM8 mRNA CTD PMID:33387578 Adam8 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ADAM8 mRNA CTD PMID:34747641 Adam8 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Adam8 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of ADAM8 mRNA CTD PMID:29673856 Adam8 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Adam8 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 Adam8 Rat 2,4-diaminotoluene increases expression ISO Adam8 (Mus musculus) 6480464 2 and 4-diaminotoluene results in increased expression of ADAM8 mRNA CTD PMID:20713471 Adam8 Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Adam8 (Mus musculus) 6480464 2 more ... CTD PMID:38648751 Adam8 Rat 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of ADAM8 mRNA CTD PMID:21346803 Adam8 Rat 3-methylcholanthrene increases expression ISO Adam8 (Mus musculus) 6480464 Methylcholanthrene results in increased expression of ADAM8 mRNA CTD PMID:20713471 Adam8 Rat 4,4'-sulfonyldiphenol increases expression ISO Adam8 (Mus musculus) 6480464 bisphenol S results in increased expression of ADAM8 mRNA CTD PMID:30951980 Adam8 Rat 4,4'-sulfonyldiphenol affects methylation ISO Adam8 (Mus musculus) 6480464 bisphenol S affects the methylation of ADAM8 gene CTD PMID:31683443 Adam8 Rat 4,4'-sulfonyldiphenol increases methylation ISO Adam8 (Mus musculus) 6480464 bisphenol S results in increased methylation of ADAM8 exon CTD PMID:33297965 Adam8 Rat aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of ADAM8 mRNA CTD PMID:22545673 more ... Adam8 Rat aldehydo-D-glucose increases expression ISO Adam8 (Mus musculus) 6480464 Glucose results in increased expression of ADAM8 mRNA CTD PMID:17178593 Adam8 Rat aldehydo-D-glucose multiple interactions ISO Adam8 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of ADAM8 mRNA CTD PMID:37567420 Adam8 Rat all-trans-retinoic acid increases expression ISO ADAM8 (Homo sapiens) 6480464 Tretinoin results in increased expression of ADAM8 mRNA CTD PMID:23724009 Adam8 Rat amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of ADAM8 mRNA CTD PMID:30779732 Adam8 Rat anthracen-2-amine increases expression EXP 6480464 2-anthramine results in increased expression of ADAM8 mRNA CTD PMID:23038007 Adam8 Rat antirheumatic drug decreases expression ISO ADAM8 (Homo sapiens) 6480464 Antirheumatic Agents results in decreased expression of ADAM8 mRNA CTD PMID:24449571 Adam8 Rat aristolochic acid A increases expression ISO ADAM8 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of ADAM8 mRNA CTD PMID:33212167 Adam8 Rat azoxystrobin decreases expression ISO ADAM8 (Homo sapiens) 6480464 azoxystrobin results in decreased expression of ADAM8 mRNA CTD PMID:33512557 Adam8 Rat benzo[a]pyrene decreases expression ISO Adam8 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of ADAM8 mRNA CTD PMID:25908611 and PMID:27195522 Adam8 Rat benzo[a]pyrene decreases methylation ISO ADAM8 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of ADAM8 exon and Benzo(a)pyrene results in decreased methylation of ADAM8 promoter CTD PMID:27901495 Adam8 Rat benzo[a]pyrene increases expression ISO Adam8 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of ADAM8 mRNA CTD PMID:32417428 Adam8 Rat bisphenol A increases expression ISO Adam8 (Mus musculus) 6480464 bisphenol A results in increased expression of ADAM8 mRNA CTD PMID:26063408 and PMID:29165653 Adam8 Rat bisphenol A decreases methylation ISO ADAM8 (Homo sapiens) 6480464 bisphenol A results in decreased methylation of ADAM8 gene CTD PMID:31601247 Adam8 Rat bisphenol A decreases expression ISO Adam8 (Mus musculus) 6480464 bisphenol A results in decreased expression of ADAM8 mRNA CTD PMID:25594700 Adam8 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ADAM8 mRNA CTD PMID:25181051 Adam8 Rat bisphenol F increases expression ISO Adam8 (Mus musculus) 6480464 bisphenol F results in increased expression of ADAM8 mRNA CTD PMID:30951980 Adam8 Rat C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of ADAM8 mRNA CTD PMID:19167457 Adam8 Rat cadmium dichloride multiple interactions ISO ADAM8 (Homo sapiens) 6480464 TNF affects the reaction [Cadmium Chloride results in increased expression of ADAM8 mRNA] CTD PMID:18560533 Adam8 Rat cadmium dichloride increases expression ISO ADAM8 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of ADAM8 mRNA CTD PMID:18560533 Adam8 Rat calciol decreases expression ISO Adam8 (Mus musculus) 6480464 Cholecalciferol results in decreased expression of ADAM8 mRNA CTD PMID:16508948 Adam8 Rat calcitriol decreases expression ISO ADAM8 (Homo sapiens) 6480464 Calcitriol results in decreased expression of ADAM8 mRNA CTD PMID:26485663 Adam8 Rat carbofuran increases expression EXP 6480464 Carbofuran results in increased expression of ADAM8 mRNA CTD PMID:20211217 Adam8 Rat carbon nanotube increases expression ISO Adam8 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 Adam8 Rat cefaloridine decreases expression EXP 6480464 Cephaloridine results in decreased expression of ADAM8 mRNA CTD PMID:18500788 Adam8 Rat choline multiple interactions ISO Adam8 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM8 mRNA CTD PMID:20938992 Adam8 Rat cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of ADAM8 mRNA CTD PMID:22023808 Adam8 Rat copper(II) sulfate increases expression ISO ADAM8 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of ADAM8 mRNA CTD PMID:19549813 Adam8 Rat D-glucose increases expression ISO Adam8 (Mus musculus) 6480464 Glucose results in increased expression of ADAM8 mRNA CTD PMID:17178593 Adam8 Rat D-glucose multiple interactions ISO Adam8 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of ADAM8 mRNA CTD PMID:37567420 Adam8 Rat deguelin decreases expression ISO ADAM8 (Homo sapiens) 6480464 deguelin results in decreased expression of ADAM8 mRNA CTD PMID:33512557 Adam8 Rat Dibutyl phosphate affects expression ISO ADAM8 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of ADAM8 mRNA CTD PMID:37042841 Adam8 Rat dioxygen multiple interactions ISO Adam8 (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ADAM8 mRNA CTD PMID:30529165 Adam8 Rat diuron increases expression EXP 6480464 Diuron results in increased expression of ADAM8 mRNA CTD PMID:25152437 Adam8 Rat doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of ADAM8 mRNA CTD PMID:20211217 Adam8 Rat Echimidine increases expression EXP 6480464 echimidine results in increased expression of ADAM8 mRNA CTD PMID:32419051 Adam8 Rat endosulfan increases expression ISO ADAM8 (Homo sapiens) 6480464 Endosulfan results in increased expression of ADAM8 mRNA CTD PMID:26615145 Adam8 Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of ADAM8 mRNA CTD PMID:29391264 Adam8 Rat entinostat increases expression ISO ADAM8 (Homo sapiens) 6480464 entinostat results in increased expression of ADAM8 mRNA CTD PMID:32870474 Adam8 Rat ethanol multiple interactions ISO Adam8 (Mus musculus) 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of ADAM8 mRNA CTD PMID:30517762 Adam8 Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of ADAM8 mRNA CTD PMID:30307764 Adam8 Rat folic acid multiple interactions ISO Adam8 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM8 mRNA CTD PMID:20938992 Adam8 Rat fructose multiple interactions ISO Adam8 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of ADAM8 mRNA CTD PMID:37567420 Adam8 Rat glucose increases expression ISO Adam8 (Mus musculus) 6480464 Glucose results in increased expression of ADAM8 mRNA CTD PMID:17178593 Adam8 Rat glucose multiple interactions ISO Adam8 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of ADAM8 mRNA CTD PMID:37567420 Adam8 Rat Heliotrine increases expression EXP 6480464 heliotrine results in increased expression of ADAM8 mRNA CTD PMID:32419051 Adam8 Rat iron dichloride decreases expression ISO ADAM8 (Homo sapiens) 6480464 ferrous chloride results in decreased expression of ADAM8 mRNA CTD PMID:35984750 Adam8 Rat isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of ADAM8 mRNA CTD PMID:20211217 Adam8 Rat L-methionine multiple interactions ISO Adam8 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM8 mRNA CTD PMID:20938992 Adam8 Rat Lasiocarpine increases expression EXP 6480464 lasiocarpine results in increased expression of ADAM8 mRNA CTD PMID:32419051 Adam8 Rat lipopolysaccharide decreases expression ISO Adam8 (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of ADAM8 mRNA CTD PMID:12057914 Adam8 Rat methotrexate decreases expression ISO ADAM8 (Homo sapiens) 6480464 Methotrexate results in decreased expression of ADAM8 mRNA CTD PMID:24449571 Adam8 Rat microcystin-LR increases expression EXP 6480464 cyanoginosin LR results in increased expression of ADAM8 mRNA CTD PMID:34740672 Adam8 Rat N-methyl-4-phenylpyridinium increases expression ISO ADAM8 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of ADAM8 mRNA CTD PMID:32870474 Adam8 Rat nickel atom increases expression ISO ADAM8 (Homo sapiens) 6480464 Nickel results in increased expression of ADAM8 mRNA CTD PMID:25583101 Adam8 Rat nickel sulfate increases expression ISO Adam8 (Mus musculus) 6480464 nickel sulfate results in increased expression of ADAM8 mRNA CTD PMID:16166746 Adam8 Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of ADAM8 mRNA CTD PMID:25729387 Adam8 Rat oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of ADAM8 mRNA CTD PMID:25729387 Adam8 Rat ozone increases expression ISO ADAM8 (Homo sapiens) 6480464 Ozone results in increased expression of ADAM8 mRNA CTD PMID:23033980 Adam8 Rat ozone multiple interactions ISO ADAM8 (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of ADAM8 mRNA CTD PMID:35430440 Adam8 Rat paracetamol affects expression ISO Adam8 (Mus musculus) 6480464 Acetaminophen affects the expression of ADAM8 mRNA CTD PMID:17562736 Adam8 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of ADAM8 mRNA CTD PMID:33387578 Adam8 Rat PCB138 multiple interactions ISO Adam8 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 Adam8 Rat pentane-2,3-dione decreases expression EXP 6480464 2 and 3-pentanedione results in decreased expression of ADAM8 mRNA CTD PMID:25710175 Adam8 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Adam8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ADAM8 mRNA CTD PMID:36331819 Adam8 Rat Phenelzine increases expression ISO Adam8 (Mus musculus) 6480464 Phenelzine results in increased expression of ADAM8 mRNA CTD PMID:31249575 Adam8 Rat phenytoin decreases expression ISO ADAM8 (Homo sapiens) 6480464 Phenytoin results in decreased expression of ADAM8 mRNA CTD PMID:14741686 Adam8 Rat phorbol 13-acetate 12-myristate multiple interactions ISO ADAM8 (Homo sapiens) 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM8 mRNA CTD PMID:16979875 Adam8 Rat phorbol 13-acetate 12-myristate increases expression ISO Adam8 (Mus musculus) 6480464 Tetradecanoylphorbol Acetate results in increased expression of ADAM8 mRNA CTD PMID:19945525 Adam8 Rat picoxystrobin decreases expression ISO ADAM8 (Homo sapiens) 6480464 picoxystrobin results in decreased expression of ADAM8 mRNA CTD PMID:33512557 Adam8 Rat progesterone decreases expression ISO Adam8 (Mus musculus) 6480464 Progesterone results in decreased expression of ADAM8 mRNA CTD PMID:22238285 Adam8 Rat rotenone decreases expression ISO ADAM8 (Homo sapiens) 6480464 Rotenone results in decreased expression of ADAM8 mRNA CTD PMID:33512557 Adam8 Rat rotenone increases expression ISO ADAM8 (Homo sapiens) 6480464 Rotenone results in increased expression of ADAM8 mRNA CTD PMID:32870474 Adam8 Rat senecionine increases expression EXP 6480464 senecionine results in increased expression of ADAM8 mRNA CTD PMID:32419051 Adam8 Rat Senkirkine increases expression EXP 6480464 senkirkine results in increased expression of ADAM8 mRNA CTD PMID:32419051 Adam8 Rat silicon dioxide increases expression ISO ADAM8 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of ADAM8 mRNA and Silicon Dioxide results in increased expression of ADAM8 mRNA CTD PMID:22300531 more ... Adam8 Rat silver atom affects expression ISO Adam8 (Mus musculus) 6480464 Silver affects the expression of ADAM8 mRNA CTD PMID:27131904 Adam8 Rat silver(0) affects expression ISO Adam8 (Mus musculus) 6480464 Silver affects the expression of ADAM8 mRNA CTD PMID:27131904 Adam8 Rat sodium arsenite decreases expression ISO ADAM8 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of ADAM8 mRNA CTD PMID:38568856 Adam8 Rat sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of ADAM8 mRNA CTD PMID:22561333 and PMID:25993096 Adam8 Rat succimer multiple interactions ISO Adam8 (Mus musculus) 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ADAM8 mRNA CTD PMID:26378955 Adam8 Rat sulforaphane increases expression ISO Adam8 (Mus musculus) 6480464 sulforaphane results in increased expression of ADAM8 mRNA CTD PMID:30529165 Adam8 Rat tebufenpyrad decreases expression ISO ADAM8 (Homo sapiens) 6480464 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of ADAM8 mRNA CTD PMID:33512557 Adam8 Rat temozolomide decreases expression ISO ADAM8 (Homo sapiens) 6480464 Temozolomide results in decreased expression of ADAM8 mRNA CTD PMID:31758290 Adam8 Rat tert-butyl hydroperoxide increases expression ISO Adam8 (Mus musculus) 6480464 tert-Butylhydroperoxide results in increased expression of ADAM8 mRNA CTD PMID:15003993 Adam8 Rat tetrachloromethane increases expression ISO Adam8 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of ADAM8 mRNA and Carbon Tetrachloride results in increased expression of ADAM8 protein CTD PMID:24646716 more ... Adam8 Rat tetrachloromethane multiple interactions ISO Adam8 (Mus musculus) 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of ADAM8 mRNA more ... CTD PMID:24646716 and PMID:30517762 Adam8 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of ADAM8 mRNA CTD PMID:23411599 and PMID:34492290 Adam8 Rat titanium dioxide increases expression ISO Adam8 (Mus musculus) 6480464 titanium dioxide results in increased expression of ADAM8 mRNA CTD PMID:27760801 Adam8 Rat titanium dioxide affects expression ISO Adam8 (Mus musculus) 6480464 titanium dioxide affects the expression of ADAM8 mRNA CTD PMID:23557971 Adam8 Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of ADAM8 mRNA CTD PMID:25729387 Adam8 Rat topotecan increases expression EXP 6480464 Topotecan results in increased expression of ADAM8 mRNA CTD PMID:25729387 Adam8 Rat tremolite asbestos increases expression ISO Adam8 (Mus musculus) 6480464 tremolite results in increased expression of ADAM8 mRNA CTD PMID:29279043 Adam8 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of ADAM8 mRNA CTD PMID:33387578 Adam8 Rat triphenyl phosphate affects expression ISO ADAM8 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of ADAM8 mRNA CTD PMID:37042841 Adam8 Rat triptonide increases expression ISO Adam8 (Mus musculus) 6480464 triptonide results in increased expression of ADAM8 mRNA CTD PMID:33045310 Adam8 Rat tris(2-butoxyethyl) phosphate affects expression ISO ADAM8 (Homo sapiens) 6480464 tris(2-butoxyethyl) phosphate affects the expression of ADAM8 mRNA CTD PMID:29024780 Adam8 Rat trovafloxacin increases expression ISO Adam8 (Mus musculus) 6480464 trovafloxacin results in increased expression of ADAM8 mRNA CTD PMID:35537566 Adam8 Rat valproic acid increases methylation ISO ADAM8 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of ADAM8 gene CTD PMID:29154799 Adam8 Rat vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of ADAM8 mRNA CTD PMID:19015723 Adam8 Rat XL147 multiple interactions ISO Adam8 (Mus musculus) 6480464 [N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ADAM8 mRNA CTD PMID:27935865 Adam8 Rat zinc atom multiple interactions ISO ADAM8 (Homo sapiens) 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM8 mRNA CTD PMID:16979875 Adam8 Rat zinc(0) multiple interactions ISO ADAM8 (Homo sapiens) 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM8 mRNA CTD PMID:16979875
(1->4)-beta-D-glucan (ISO) 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO) 1,2-dimethylhydrazine (EXP,ISO) 1-naphthyl isothiocyanate (EXP) 17alpha-ethynylestradiol (ISO) 17beta-estradiol (ISO) 2,2',4,4',5,5'-hexachlorobiphenyl (ISO) 2,2',5,5'-tetrachlorobiphenyl (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,4,4'-trichlorobiphenyl (ISO) 2,4-diaminotoluene (ISO) 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO) 2,6-dinitrotoluene (EXP) 3-methylcholanthrene (ISO) 4,4'-sulfonyldiphenol (ISO) aflatoxin B1 (EXP) aldehydo-D-glucose (ISO) all-trans-retinoic acid (ISO) amphetamine (EXP) anthracen-2-amine (EXP) antirheumatic drug (ISO) aristolochic acid A (ISO) azoxystrobin (ISO) benzo[a]pyrene (ISO) bisphenol A (EXP,ISO) bisphenol F (ISO) C60 fullerene (EXP) cadmium dichloride (ISO) calciol (ISO) calcitriol (ISO) carbofuran (EXP) carbon nanotube (ISO) cefaloridine (EXP) choline (ISO) cisplatin (EXP) copper(II) sulfate (ISO) D-glucose (ISO) deguelin (ISO) Dibutyl phosphate (ISO) dioxygen (ISO) diuron (EXP) doxorubicin (EXP) Echimidine (EXP) endosulfan (EXP,ISO) entinostat (ISO) ethanol (ISO) fenvalerate (EXP) folic acid (ISO) fructose (ISO) glucose (ISO) Heliotrine (EXP) iron dichloride (ISO) isoprenaline (EXP) L-methionine (ISO) Lasiocarpine (EXP) lipopolysaccharide (ISO) methotrexate (ISO) microcystin-LR (EXP) N-methyl-4-phenylpyridinium (ISO) nickel atom (ISO) nickel sulfate (ISO) oxaliplatin (EXP) ozone (ISO) paracetamol (EXP,ISO) PCB138 (ISO) pentane-2,3-dione (EXP) perfluorooctane-1-sulfonic acid (ISO) Phenelzine (ISO) phenytoin (ISO) phorbol 13-acetate 12-myristate (ISO) picoxystrobin (ISO) progesterone (ISO) rotenone (ISO) senecionine (EXP) Senkirkine (EXP) silicon dioxide (ISO) silver atom (ISO) silver(0) (ISO) sodium arsenite (ISO) sodium dichromate (EXP) succimer (ISO) sulforaphane (ISO) tebufenpyrad (ISO) temozolomide (ISO) tert-butyl hydroperoxide (ISO) tetrachloromethane (ISO) thioacetamide (EXP) titanium dioxide (ISO) topotecan (EXP) tremolite asbestos (ISO) trichloroethene (EXP) triphenyl phosphate (ISO) triptonide (ISO) tris(2-butoxyethyl) phosphate (ISO) trovafloxacin (ISO) valproic acid (ISO) vinclozolin (EXP) XL147 (ISO) zinc atom (ISO) zinc(0) (ISO)
Biological Process
angiogenesis (IEA,ISO) biological_process (ND) canonical NF-kappaB signal transduction (IEA,ISO) cell morphogenesis (IEA,ISO) cell-cell adhesion (IEA,ISO) cellular response to hypoxia (IEA,ISO) inflammatory response (IBA,IEA,ISO) leukocyte migration involved in inflammatory response (IEA,ISO) lymphocyte chemotaxis (IEA,ISO) negative regulation of neuron apoptotic process (IEA,ISO) positive regulation of acute inflammatory response (IEA,ISO) positive regulation of bone resorption (IEA,ISO) positive regulation of cell adhesion (IEA,ISO) positive regulation of cellular extravasation (IBA,IEA,ISO) positive regulation of eosinophil migration (IEA,ISO) positive regulation of epithelial to mesenchymal transition (IEA,ISO) positive regulation of fibronectin-dependent thymocyte migration (IEA,ISO) positive regulation of inflammatory response (IEA,ISO) positive regulation of innate immune response (IEA,ISO) positive regulation of MAPK cascade (IEA,ISO) positive regulation of membrane protein ectodomain proteolysis (IBA,IEA,ISO) positive regulation of neutrophil extravasation (IEA,ISO) positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO) positive regulation of T cell differentiation in thymus (IEA,ISO) positive regulation of T cell migration (IEA,ISO) positive regulation of thymocyte apoptotic process (IEA,ISO) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production (IEA,ISO) proteolysis (IBA,IEA) regulation of cell-cell adhesion (IBA,IEA,ISO) signal release (IEA,ISO)
1.
Upregulation of ADAM8 in the airways of mice with allergic bronchial asthma.
Chiba Y, etal., Lung. 2009 May-Jun;187(3):179-85. Epub 2009 Apr 17.
2.
Increased expression of ADAM33 and ADAM8 with disease progression in asthma.
Foley SC, etal., J Allergy Clin Immunol. 2007 Apr;119(4):863-71. Epub 2007 Mar 6.
3.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.
Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry.
Matsuno O, etal., Respir Med. 2010 Jan;104(1):34-9. Epub 2009 Jul 21.
5.
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.
Naus S, etal., Am J Respir Crit Care Med. 2010 Jun 15;181(12):1318-28. Epub 2010 Mar 1.
6.
GOA pipeline
RGD automated data pipeline
7.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
9.
Comprehensive gene review and curation
RGD comprehensive gene curation
10.
The disintegrin domain of ADAM 8 enhances protection against rat experimental autoimmune encephalomyelitis, neuritis and uveitis by a polyvalent autoantigen vaccine.
Schluesener HJ J Neuroimmunol. 1998 Jul 1;87(1-2):197-202.
11.
ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer.
Valkovskaya N, etal., J Cell Mol Med. 2007 Sep-Oct;11(5):1162-74.
Adam8 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 204,206,206 - 204,218,988 (-) NCBI GRCr8 mRatBN7.2 1 194,776,559 - 194,789,330 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 194,770,060 - 194,788,801 (-) Ensembl mRatBN7.2 Ensembl Rnor_6.0 1 212,317,510 - 212,332,895 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 212,317,848 - 212,330,349 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 219,236,436 - 219,251,059 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 199,780,772 - 199,791,855 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 1 192,454,105 - 192,468,808 (-) NCBI Celera Cytogenetic Map 1 q41 NCBI
ADAM8 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 10 133,262,423 - 133,276,868 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 10 133,262,420 - 133,276,868 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 10 135,075,927 - 135,090,372 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 10 134,925,911 - 134,940,362 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 10 134,964,788 - 134,979,211 NCBI Celera 10 128,426,024 - 128,440,474 (+) NCBI Celera Cytogenetic Map 10 q26.3 NCBI HuRef 10 128,622,621 - 128,637,236 (-) NCBI HuRef CHM1_1 10 135,357,756 - 135,372,278 (-) NCBI CHM1_1 T2T-CHM13v2.0 10 134,218,053 - 134,232,489 (-) NCBI T2T-CHM13v2.0
Adam8 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 7 139,558,845 - 139,573,016 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 7 139,558,845 - 139,572,475 (-) Ensembl GRCm39 Ensembl GRCm38 7 139,978,932 - 139,995,207 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 7 139,978,932 - 139,992,562 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 7 147,164,840 - 147,178,387 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 7 139,830,261 - 139,843,808 (-) NCBI MGSCv36 mm8 Celera 7 139,782,797 - 139,796,305 (-) NCBI Celera Cytogenetic Map 7 F4 NCBI cM Map 7 84.96 NCBI
Adam8 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955477 10,895,446 - 10,907,215 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955477 10,894,288 - 10,906,961 (-) NCBI ChiLan1.0 ChiLan1.0
ADAM8 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 8 145,386,583 - 145,400,948 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 10 145,391,940 - 145,406,305 (-) NCBI NHGRI_mPanPan1 PanPan1.1 10 134,171,986 - 134,186,221 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 10 134,172,724 - 134,186,227 (-) Ensembl panpan1.1 panPan2
ADAM8 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 28 40,853,665 - 40,865,604 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 28 40,855,509 - 40,863,747 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 28 40,909,672 - 40,921,207 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 28 41,490,792 - 41,502,283 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 28 41,490,100 - 41,500,790 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 28 40,973,551 - 40,985,028 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 28 40,962,945 - 40,974,543 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 28 41,365,582 - 41,377,170 (-) NCBI UU_Cfam_GSD_1.0
Adam8 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024407213 6,156,736 - 6,171,452 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936486 19,391,324 - 19,402,332 (-) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936486 19,389,925 - 19,403,577 (-) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
ADAM8 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 14 141,221,198 - 141,232,306 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 14 141,221,177 - 141,233,728 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 14 153,183,627 - 153,194,348 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
ADAM8 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 26 53,114,184 - 53,129,650 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 26 53,114,924 - 53,126,900 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666054 41,248,757 - 41,264,128 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Adam8
.
Predicted Target Of
Count of predictions: 95 Count of miRNA genes: 81 Interacting mature miRNAs: 84 Transcripts: ENSRNOT00000024369 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction
1578778 Pur4 Proteinuria QTL 4 3.3 0.003 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 1 150700247 252085048 Rat 1354646 Kidm18 Kidney mass QTL 18 5.7 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) 1 151162512 256448636 Rat 1578780 Cm52 Cardiac mass QTL 52 3.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 1 81591954 219808434 Rat 1354652 Kidm20 Kidney mass QTL 20 4.3 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) 1 177227632 256448636 Rat 2302378 Insul11 Insulin level QTL 11 3.25 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) 1 144267353 251128347 Rat 1354653 Despr9 Despair related QTL 9 0.00019 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 1 167909849 212909849 Rat 2293673 Bss27 Bone structure and strength QTL 27 18.63 0.0001 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 1 171629477 216629477 Rat 2293677 Bss41 Bone structure and strength QTL 41 9.38 0.0001 lumbar vertebra size trait (VT:0010518) lumbar vertebra cross-sectional area (CMO:0001689) 1 171629477 216629477 Rat 1302787 Stl25 Serum triglyceride level QTL 25 2.7 0.0073 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 1 180359209 210702199 Rat 70160 Bw18 Body weight QTL 18 5.7 body mass (VT:0001259) body weight (CMO:0000012) 1 144267353 196383668 Rat 1549830 Bss1 Bone structure and strength QTL 1 4.8 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) 1 172609619 217609619 Rat 7794788 Mcs32 Mammary carcinoma susceptibility QTL 32 2.61 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) 1 115540693 238914717 Rat 70163 Bw20 Body weight QTL 20 5.1 body mass (VT:0001259) body weight (CMO:0000012) 1 174133260 219133260 Rat 1578763 Kidm29 Kidney mass QTL 29 3.3 0.0001 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 1 179567751 260522016 Rat 1354624 Cm35 Cardiac mass QTL35 5.7 heart left ventricle mass (VT:0007031) calculated heart weight (CMO:0000073) 1 177227632 256448636 Rat 1558658 Bw59 Body weight QTL 59 3.5 0.0003 body mass (VT:0001259) body weight (CMO:0000012) 1 178784622 223784622 Rat 631838 Niddm36 Non-insulin dependent diabetes mellitus QTL 36 0.01 insulin secretion trait (VT:0003564) calculated pancreatic islet insulin release measurement (CMO:0001217) 1 184550676 229550676 Rat 1354636 Lmblg1 Limb length QTL 1 6.4 tibia length (VT:0004357) tibia length (CMO:0000450) 1 151162512 201278233 Rat 1549837 Hcar15 Hepatocarcinoma resistance QTL 15 0.05 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) 1 153136852 260522016 Rat 2293689 Bss47 Bone structure and strength QTL 47 7.25 0.0001 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) 1 171629477 216629477 Rat 152025235 Bw194 Body weight QTL 194 4.86 body mass (VT:0001259) 1 123556856 242907031 Rat 1598853 Memor3 Memory QTL 3 4.5 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) 1 143506580 212458660 Rat 61341 Bp26 Blood pressure QTL 26 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 169537671 214537671 Rat 1354634 Kidm12 Kidney mass QTL 12 3.9 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) 1 151162512 201278233 Rat 4889428 Stresp24 Stress response QTL 24 0.05 heart pumping trait (VT:2000009) absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162) 1 155866514 200866514 Rat 152025232 Bw192 Body weight QTL 192 3.93 body mass (VT:0001259) 1 117917486 196963478 Rat 1578759 Uae30 Urinary albumin excretion QTL 30 3.3 0.003 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 1 150700247 252085048 Rat 61343 Bp28 Blood pressure QTL 28 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 151646613 196646613 Rat 2293693 Bss22 Bone structure and strength QTL 22 33.52 0.0001 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) 1 171629477 216629477 Rat 2300161 Bmd43 Bone mineral density QTL 43 8.4 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 1 171629477 216629477 Rat 1300145 Rf7 Renal function QTL 7 2.96 urine creatinine amount (VT:0010540) urine creatinine level (CMO:0000125) 1 185145134 221264292 Rat 61347 Bp197 Blood pressure QTL 197 4.2 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 1 158633083 203633083 Rat 8655655 Arrd2 Age-related retinal degeneration QTL 2 7.79 retinal layer morphology trait (VT:0003727) percentage of study population developing retinopathy during a period of time (CMO:0002453) 1 183970203 243914901 Rat 61348 Bp30 Blood pressure QTL 30 2.4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 144017057 197814409 Rat 2303622 Vencon6 Ventilatory control QTL 6 0.001 respiration trait (VT:0001943) respiration rate (CMO:0000289) 1 154561505 199561505 Rat 1358898 Bp255 Blood pressure QTL 255 3.6 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 191019702 246062233 Rat 631214 Bw61 Body weight QTL61 3.4 0.0001 intramuscular adipose amount (VT:0010044) intramuscular fat area (CMO:0001162) 1 173108781 218108781 Rat 7771612 Cm80 Cardiac mass QTL 80 8.4 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) 1 149448574 221264292 Rat 731168 Bp154 Blood pressure QTL 154 3.4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 94642644 214537671 Rat 631205 Bp196 Blood pressure QTL 196 4 0.0001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 118944897 199050459 Rat 2300174 Bmd42 Bone mineral density QTL 42 8.4 0.0001 lumbar vertebra mineral mass (VT:0010511) bone mineral density (CMO:0001226) 1 171629477 216629477 Rat 737828 Hcas3 Hepatocarcinoma susceptibility QTL 3 4.9 liver integrity trait (VT:0010547) liver tumorous lesion volume to total liver volume ratio (CMO:0001082) 1 144267353 222987745 Rat 1331749 Hrtrt11 Heart rate QTL 11 2.973 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 1 94494440 198211706 Rat 1354661 Bw33 Body weight QTL 33 5.2 body mass (VT:0001259) body weight (CMO:0000012) 1 151162512 256448636 Rat 1358886 Bp260 Blood pressure QTL 260 3.67 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 151162766 225824951 Rat 737977 Bp160 Blood pressure QTL 160 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 181133855 226133855 Rat 2293654 Bss30 Bone structure and strength QTL 30 32.65 0.0001 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 1 171629477 216629477 Rat 724531 Uae5 Urinary albumin excretion QTL 5 4 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 1 150700142 252085212 Rat 2300187 Bmd41 Bone mineral density QTL 41 8.9 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 1 171629477 216629477 Rat 8552891 Epfw5 Epididymal fat weight QTL 5 4.4 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 1 193113876 238113876 Rat 1359018 Hrtrt20 Heart rate QTL 20 3.08 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 1 185356336 202902618 Rat 70209 Niddm23 Non-insulin dependent diabetes mellitus QTL 23 2.82 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 94494440 198324465 Rat 1354580 Scort1 Serum corticosterone level QTL 1 3.4 blood corticosterone amount (VT:0005345) blood corticosterone level (CMO:0001172) 1 156677124 256448636 Rat 634312 Bp143 Blood pressure QTL 143 3 0.0002 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 182623426 219932796 Rat 1358294 Bw37 Body weight QTL 37 5 0.000011 body mass (VT:0001259) body weight (CMO:0000012) 1 171310381 216310381 Rat 61378 Bp43 Blood pressure QTL 43 22.6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 181746937 196383668 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 49393289 199050459 Rat 724559 Pancm1 Pancreatic morphology QTL 1 7.1 islet of Langerhans morphology trait (VT:0005215) pancreatic islet damage composite score (CMO:0001156) 1 181759564 214537555 Rat 2312420 Pur17 Proteinuria QTL 17 7.1 0.0001 urine protein amount (VT:0005160) urine total protein excretion rate (CMO:0000756) 1 156677124 218753816 Rat 10059600 Bp378 Blood pressure QTL 378 3.08 0.05 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 176869060 221869060 Rat 1354591 Cm36 Cardiac mass QTL 36 4.1 heart left ventricle mass (VT:0007031) calculated heart weight (CMO:0000073) 1 102813953 201278233 Rat 7421630 Bp362 Blood pressure QTL 362 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 118608292 241799120 Rat 10059597 Bp377 Blood pressure QTL 377 3.42 0.025 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 32737458 199368955 Rat 619613 Bp77 Blood pressure QTL 77 0.01 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 1 164747424 209747424 Rat 631260 Tcas2 Tongue tumor susceptibility QTL 2 4.93 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 1 192485903 199050587 Rat 619614 Bp78 Blood pressure QTL 78 0.001 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 1 169112897 197261052 Rat 2312564 Glom18 Glomerulus QTL 18 2.4 0.003 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 1 185356336 231689108 Rat 634321 Hc1 Hypercalciuria QTL 1 2.91 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) 1 178810256 240830002 Rat 724562 Rends1 Renal damage susceptibility QTL 1 0.05 kidney glomerulus integrity trait (VT:0010546) index of glomerular damage (CMO:0001135) 1 169537671 214537671 Rat 2292222 Bp307 Blood pressure QTL 307 3.06 0.0014 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 164310393 213533942 Rat 2292220 Bp306 Blood pressure QTL 306 3.47 0.00087 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 164310393 243914901 Rat 10059590 Kidm44 Kidney mass QTL 44 3.42 0.025 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 1 191033875 236033875 Rat 1354615 Cm32 Cardiac mass QTL 32 5.2 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) 1 102813953 201278233 Rat 1600380 Niddm70 Non-insulin dependent diabetes mellitus QTL 70 3.1 0.0008 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 1 176550523 221550523 Rat 1354610 Bw34 Body weight QTL 34 4.1 body mass (VT:0001259) body weight (CMO:0000012) 1 151162512 256448636 Rat 1582206 Kidm33 Kidney mass QTL 33 6.9 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 1 188377360 224054420 Rat 1354620 Kidm19 Kidney mass QTL 19 4 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) 1 151162512 201278233 Rat 8655855 Arrd3 Age-related retinal degeneration QTL 3 3.07 lens clarity trait (VT:0001304) cataract incidence/prevalence measurement (CMO:0001585) 1 183970203 243914901 Rat 634338 Hcar4 Hepatocarcinoma resistance QTL 4 4.6 liver integrity trait (VT:0010547) liver tumorous lesion number to liver area ratio (CMO:0001210) 1 193422268 214537671 Rat 1354618 Kidm15 Kidney mass QTL 15 5 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 1 156677124 201278233 Rat 6903303 Scl34 Serum cholesterol QTL 34 2.5 0.0033 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 180359209 218108781 Rat 6480780 Insul18 Insulin level QTL 18 4.11 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 1 189607473 200611765 Rat 152025212 Bw190 Body weight QTL 190 5.7 body mass (VT:0001259) 1 123556856 196963478 Rat 631549 Bp89 Blood pressure QTL 89 5.7 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 123350581 201284552 Rat 2293083 Iddm25 Insulin dependent diabetes mellitus QTL 25 4.18 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 181829673 224569684 Rat 1354606 Bp246 Blood pressure QTL 246 3.6 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) 1 102813953 218753816 Rat 738032 Hcas5 Hepatocarcinoma susceptibility QTL 5 3.12 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) 1 176426412 257976495 Rat 1358191 Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 3.8 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) 1 192825253 243914732 Rat 1354602 Bw35 Body weight QTL 35 12.2 body mass (VT:0001259) body weight (CMO:0000012) 1 151162512 201278233 Rat 631670 Iddm10 Insulin dependent diabetes mellitus QTL 10 1.9 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 1 174133260 196383668 Rat
RH132117
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 1 194,776,629 - 194,776,843 (+) MAPPER mRatBN7.2 Rnor_6.0 1 212,317,569 - 212,317,782 NCBI Rnor6.0 Rnor_5.0 1 219,236,514 - 219,236,727 UniSTS Rnor5.0 RGSC_v3.4 1 199,780,070 - 199,780,283 UniSTS RGSC3.4 Celera 1 192,454,164 - 192,454,377 UniSTS RH 3.4 Map 1 1437.21 UniSTS Cytogenetic Map 1 q41 UniSTS
AW528396
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 1 194,789,543 - 194,789,724 (+) MAPPER mRatBN7.2 Rnor_6.0 1 212,331,143 - 212,331,323 NCBI Rnor6.0 Rnor_5.0 1 219,249,314 - 219,249,494 UniSTS Rnor5.0 RGSC_v3.4 1 199,793,637 - 199,793,817 UniSTS RGSC3.4 Celera 1 192,467,056 - 192,467,236 UniSTS RH 3.4 Map 1 1437.6 UniSTS Cytogenetic Map 1 q41 UniSTS
RH131378
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 1 194,778,389 - 194,778,596 (+) MAPPER mRatBN7.2 Rnor_6.0 1 212,319,329 - 212,319,535 NCBI Rnor6.0 Rnor_5.0 1 219,238,274 - 219,238,480 UniSTS Rnor5.0 RGSC_v3.4 1 199,781,829 - 199,782,035 UniSTS RGSC3.4 Celera 1 192,455,924 - 192,456,130 UniSTS Cytogenetic Map 1 q41 UniSTS
BF399127
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 1 194,789,457 - 194,789,612 (+) MAPPER mRatBN7.2 Rnor_6.0 1 212,331,057 - 212,331,211 NCBI Rnor6.0 Rnor_5.0 1 219,249,228 - 219,249,382 UniSTS Rnor5.0 RGSC_v3.4 1 199,793,551 - 199,793,705 UniSTS RGSC3.4 Celera 1 192,466,970 - 192,467,124 UniSTS RH 3.4 Map 1 1437.21 UniSTS Cytogenetic Map 1 q41 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000024369 ⟹ ENSRNOP00000024369
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 1 194,770,060 - 194,788,801 (-) Ensembl Rnor_6.0 Ensembl 1 212,317,848 - 212,330,349 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000103573 ⟹ ENSRNOP00000077537
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 1 194,770,089 - 194,788,801 (-) Ensembl
RefSeq Acc Id:
NM_001427124 ⟹ NP_001414053
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 204,206,213 - 204,218,322 (-) NCBI
RefSeq Acc Id:
XM_006230499 ⟹ XP_006230561
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 204,206,206 - 204,218,988 (-) NCBI mRatBN7.2 1 194,776,559 - 194,789,330 (-) NCBI Rnor_6.0 1 212,317,510 - 212,332,895 (-) NCBI Rnor_5.0 1 219,236,436 - 219,251,059 (-) NCBI
Sequence:
GCACAAGGCCCTGGGTTTGGTCCCCAGCTCCGGAAAAAAAATAAATAAAATAAAATAAATAAATAAAAAAGAAGGTGGAGAGTAATTGAGGATATTATCTGGTGTCAGTCTCAGCTCCACATGCACAA
hide sequence
RefSeq Acc Id:
XM_006230500 ⟹ XP_006230562
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 204,206,206 - 204,218,988 (-) NCBI mRatBN7.2 1 194,776,559 - 194,789,330 (-) NCBI Rnor_6.0 1 212,317,510 - 212,332,895 (-) NCBI Rnor_5.0 1 219,236,436 - 219,251,059 (-) NCBI
Sequence:
GCACAAGGCCCTGGGTTTGGTCCCCAGCTCCGGAAAAAAAATAAATAAAATAAAATAAATAAAT
hide sequence
RefSeq Acc Id:
XM_006230501 ⟹ XP_006230563
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 204,206,206 - 204,218,988 (-) NCBI mRatBN7.2 1 194,776,559 - 194,789,330 (-) NCBI Rnor_6.0 1 212,317,510 - 212,332,895 (-) NCBI Rnor_5.0 1 219,236,436 - 219,251,059 (-) NCBI
Sequence:
GCACAAGGCCCTGGGTTTGGTCCCCAGCTCCGGAAAAAAAATAAATAAAATAAAATAAATAAATAAAAAAGAAGGTGGAGAGTAATTGAGGATATTATCTGGTGTCAGTCTCAGCTCCACATGCACAA
hide sequence
RefSeq Acc Id:
XM_017590243 ⟹ XP_017445732
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 204,207,331 - 204,218,988 (-) NCBI mRatBN7.2 1 194,777,648 - 194,789,330 (-) NCBI Rnor_6.0 1 212,318,583 - 212,332,895 (-) NCBI
Sequence:
GCACAAGGCCCTGGGTTTGGTCCCCAGCTCCGGAAAAAAAATAAATAAAATAAAATAAATAAAT
hide sequence
RefSeq Acc Id:
XM_039101260 ⟹ XP_038957188
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 204,206,206 - 204,218,988 (-) NCBI mRatBN7.2 1 194,776,559 - 194,789,330 (-) NCBI
RefSeq Acc Id:
XM_039101261 ⟹ XP_038957189
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 204,206,206 - 204,218,988 (-) NCBI mRatBN7.2 1 194,776,559 - 194,789,330 (-) NCBI
RefSeq Acc Id:
XM_063271567 ⟹ XP_063127637
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 204,206,206 - 204,218,988 (-) NCBI
RefSeq Acc Id:
XP_006230563 ⟸ XM_006230501
- Peptide Label:
isoform X6
- UniProtKB:
A0A8I5Y1P5 (UniProtKB/TrEMBL)
- Sequence:
MLGLWLLSILWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRSLPSQWGLYPESLSYALGTSEQVFTLHLRKNRDLLGSSYTETYSAANGSEVKEQLHEQDHCLYQGHVEGYEGSAASISTCAGLSGF
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RefSeq Acc Id:
XP_006230562 ⟸ XM_006230500
- Peptide Label:
isoform X2
- Sequence:
MLGLWLLSILWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRSLPSQWGLYPESLSYALGTSEQ
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RefSeq Acc Id:
XP_006230561 ⟸ XM_006230499
- Peptide Label:
isoform X1
- UniProtKB:
D3ZB52 (UniProtKB/TrEMBL)
- Sequence:
MLGLWLLSILWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRSLPSQWGLYPESLSYALGTSEQ
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RefSeq Acc Id:
XP_017445732 ⟸ XM_017590243
- Peptide Label:
isoform X5
- Sequence:
MLGLWLLSILWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRSLPSQWGLYPESLSYALGTSEQ
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Ensembl Acc Id:
ENSRNOP00000024369 ⟸ ENSRNOT00000024369
RefSeq Acc Id:
XP_038957189 ⟸ XM_039101261
- Peptide Label:
isoform X4
RefSeq Acc Id:
XP_038957188 ⟸ XM_039101260
- Peptide Label:
isoform X3
Ensembl Acc Id:
ENSRNOP00000077537 ⟸ ENSRNOT00000103573
RefSeq Acc Id:
XP_063127637 ⟸ XM_063271567
- Peptide Label:
isoform X7
RefSeq Acc Id:
NP_001414053 ⟸ NM_001427124
- Peptide Label:
precursor
RGD ID: 13690512 Promoter ID: EPDNEW_R1032 Type: single initiation site Name: Adam8_1 Description: ADAM metallopeptidase domain 8 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 1 212,330,279 - 212,330,339 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2008-09-18
Adam8
ADAM metallopeptidase domain 8
Adam8
a disintegrin and metallopeptidase domain 8
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-03-07
Adam8
a disintegrin and metallopeptidase domain 8
RGD1566394_predicted
similar to cysteine-rich glycoprotein (predicted)
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2006-03-07
RGD1566394_predicted
similar to cysteine-rich glycoprotein (predicted)
LOC499285
similar to cysteine-rich glycoprotein
Symbol and Name status set to approved
1299863 APPROVED
2006-02-09
LOC499285
similar to cysteine-rich glycoprotein
Symbol and Name status set to provisional
70820 PROVISIONAL
