RGD Reference Report - Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. - Rat Genome Database

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Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry.

Authors: Matsuno, O  Ono, E  Ueno, T  Takenaka, R  Nishitake, T  Hiroshige, S  Miyazaki, E  Kumamoto, T  Higuchi, Y 
Citation: Matsuno O, etal., Respir Med. 2010 Jan;104(1):34-9. Epub 2009 Jul 21.
RGD ID: 5128874
Pubmed: PMID:19625177   (View Abstract at PubMed)
DOI: DOI:10.1016/j.rmed.2009.06.018   (Journal Full-text)

BACKGROUND: ADAM8 (a disintegrin and a metalloprotease 8) has been linked to asthma and eosinophilic pneumonia (EP). ADAM8 cleaves a variety of substrates and is a sheddase for CD23, the low affinity IgE receptor. The concentration of soluble ADAM8 (sADAM8) is increased in bronchoalveolar lavage fluid (BALF) from patients with smoking-induced acute eosinophilic pneumonia (AEP) and chronic eosinophilic pneumonia (CEP), but not drug-induced EP (Drug-EP). In AEP, the BALF sADAM8 concentration significantly correlates with the soluble CD23 concentration (sCD23). METHODS: To evaluate the involvement of ADAM8 in the pathogenesis of eosinophilic pneumonia, we measured the concentrations of sADAM8 and its substrate, soluble CD23 (sCD23), in serum from patients with AEP, CEP, and Drug-EP. We also measured the change in the sADAM8 concentration after a provocation test. RESULTS: In contrast to the BALF findings, serum sADAM8 concentrations were increased in Drug-EP (mean+/-SEM; 639.6+/-49.15) and serum ADAM8 levels correlated positively with the serum sCD23 levels in patients with Drug-EP (P=0.0080, R(2)=0.8465). Serum sADAM8 concentrations were also increased in AEP (409+/-76.91) and CEP (644.7+/-87.03). Serum ADAM8 concentrations were also elevated after the provocation test. CONCLUSION: Serum ADAM8 concentrations were elevated in Drug-EP, although the sADAM8 concentrations were not increased in the BALF in Drug-EP. Thus, the pathogenesis of AEP and Drug-EP may be distinct with regard to allergen exposure; AEP may be caused by the inhalation of antigens, whereas Drug-EP may be caused by bloodstream antigens. These findings indicate that ADAM8 levels reflect the route of eosinophilic inflammation in EP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary eosinophilia  IEP 5128874protein:increased expression:serumRGD 
pulmonary eosinophilia  ISOADAM8 (Homo sapiens)5128874; 5128874protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adam8  (ADAM metallopeptidase domain 8)

Genes (Mus musculus)
Adam8  (a disintegrin and metallopeptidase domain 8)

Genes (Homo sapiens)
ADAM8  (ADAM metallopeptidase domain 8)


Additional Information