Adam8 (a disintegrin and metallopeptidase domain 8) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Adam8 (a disintegrin and metallopeptidase domain 8) Mus musculus
Analyze
Symbol: Adam8
Name: a disintegrin and metallopeptidase domain 8
RGD ID: 1320020
MGI Page MGI
Description: Enables cell adhesion molecule binding activity; metal ion binding activity; and metallopeptidase activity. Involved in several processes, including positive regulation of defense response; positive regulation of intracellular signal transduction; and positive regulation of leukocyte migration. Acts upstream of or within cell-cell adhesion. Located in plasma membrane. Part of alpha9-beta1 integrin-ADAM8 complex. Is expressed in several structures, including alimentary system; hindlimb cartilage condensation; reproductive system; respiratory system; and venous system. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metalloprotease domain (ADAM) 8; a disintegrin and metalloprotease domain 8; ADAM 8; CD156; CD156a; cell surface antigen MS2; disintegrin and metalloproteinase domain-containing protein 8; E430039A18Rik; macrophage cysteine-rich glycoprotein; MS; MS2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,558,845 - 139,573,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,558,845 - 139,572,475 (-)EnsemblGRCm39 Ensembl
GRCm387139,978,932 - 139,995,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7139,978,932 - 139,992,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv377147,164,840 - 147,178,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,830,261 - 139,843,808 (-)NCBIMGSCv36mm8
Celera7139,782,797 - 139,796,305 (-)NCBICelera
Cytogenetic Map7F4NCBI
cM Map784.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
anthracen-2-amine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
choline  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
D-glucose  (EXP)
deguelin  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
folic acid  (EXP)
fructose  (EXP)
glucose  (EXP)
Heliotrine  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lipopolysaccharide  (EXP)
methotrexate  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
Phenelzine  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picoxystrobin  (ISO)
progesterone  (EXP)
rotenone  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (EXP)
sulforaphane  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
XL147  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IDA)
blood vessel endothelial cell migration  (NAS)
canonical NF-kappaB signal transduction  (IDA)
cell morphogenesis  (IMP)
cell-cell adhesion  (IDA)
cell-matrix adhesion  (TAS)
cellular response to hypoxia  (ISO,ISS)
inflammatory response  (IBA,ISO)
leukocyte migration involved in inflammatory response  (IMP)
lymphocyte chemotaxis  (IDA)
membrane fusion  (TAS)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of thymocyte aggregation  (NAS)
osteoclast fusion  (TAS)
positive regulation of acute inflammatory response  (IMP)
positive regulation of bone resorption  (IDA,IMP)
positive regulation of cell adhesion  (IDA)
positive regulation of cellular extravasation  (IBA,IMP)
positive regulation of eosinophil migration  (IMP)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of fibronectin-dependent thymocyte migration  (IMP)
positive regulation of inflammatory response  (IDA)
positive regulation of innate immune response  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of membrane protein ectodomain proteolysis  (IBA,IDA,ISO)
positive regulation of neutrophil extravasation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA)
positive regulation of T cell differentiation in thymus  (IDA)
positive regulation of T cell migration  (IMP)
positive regulation of thymocyte apoptotic process  (IMP)
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  (IMP)
proteolysis  (IBA,IEA)
regulation of cell-cell adhesion  (IBA,ISO,ISS)
regulation of osteoclast differentiation  (NAS)
signal release  (IEA,ISO)
tissue morphogenesis  (TAS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Upregulation of ADAM8 in the airways of mice with allergic bronchial asthma. Chiba Y, etal., Lung. 2009 May-Jun;187(3):179-85. Epub 2009 Apr 17.
2. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. Foley SC, etal., J Allergy Clin Immunol. 2007 Apr;119(4):863-71. Epub 2007 Mar 6.
3. Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. Matsuno O, etal., Respir Med. 2010 Jan;104(1):34-9. Epub 2009 Jul 21.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma. Naus S, etal., Am J Respir Crit Care Med. 2010 Jun 15;181(12):1318-28. Epub 2010 Mar 1.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The disintegrin domain of ADAM 8 enhances protection against rat experimental autoimmune encephalomyelitis, neuritis and uveitis by a polyvalent autoantigen vaccine. Schluesener HJ J Neuroimmunol. 1998 Jul 1;87(1-2):197-202.
12. ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer. Valkovskaya N, etal., J Cell Mol Med. 2007 Sep-Oct;11(5):1162-74.
13. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. Yoshiyama K, etal., Genomics 1997 Apr 1;41(1):56-62.
Additional References at PubMed
PMID:1318459   PMID:1982220   PMID:8163572   PMID:9218457   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11050116   PMID:11076861   PMID:11217851   PMID:11341326   PMID:12135759  
PMID:12372841   PMID:12477932   PMID:12777399   PMID:14756057   PMID:14761956   PMID:15087305   PMID:15580619   PMID:15907280   PMID:16141072   PMID:16141073   PMID:16154205   PMID:16452166  
PMID:16602821   PMID:16831910   PMID:16967505   PMID:16995821   PMID:17072319   PMID:17344430   PMID:18287572   PMID:18397961   PMID:19003792   PMID:19397475   PMID:19574220   PMID:19737139  
PMID:20119708   PMID:20220092   PMID:20605457   PMID:20660068   PMID:20683884   PMID:20826683   PMID:20856819   PMID:21077325   PMID:21205794   PMID:21268008   PMID:21282332   PMID:21308776  
PMID:21873635   PMID:22447932   PMID:22844512   PMID:23670189   PMID:23833070   PMID:24194600   PMID:25511460   PMID:25585999   PMID:27626380   PMID:28358362   PMID:28596294   PMID:28863006  
PMID:28916789   PMID:28973166   PMID:29750543   PMID:32325033   PMID:32554809   PMID:33314720   PMID:33469101   PMID:33568475   PMID:33814981   PMID:34615811   PMID:35132956   PMID:35247391  
PMID:37992987   PMID:37995078   PMID:38355793   PMID:39221886  


Genomics

Comparative Map Data
Adam8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,558,845 - 139,573,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,558,845 - 139,572,475 (-)EnsemblGRCm39 Ensembl
GRCm387139,978,932 - 139,995,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7139,978,932 - 139,992,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv377147,164,840 - 147,178,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,830,261 - 139,843,808 (-)NCBIMGSCv36mm8
Celera7139,782,797 - 139,796,305 (-)NCBICelera
Cytogenetic Map7F4NCBI
cM Map784.96NCBI
ADAM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,262,423 - 133,276,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,262,420 - 133,276,868 (-)EnsemblGRCh38hg38GRCh38
GRCh3710135,075,927 - 135,090,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610134,925,911 - 134,940,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410134,964,788 - 134,979,211NCBI
Celera10128,426,024 - 128,440,474 (+)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,622,621 - 128,637,236 (-)NCBIHuRef
CHM1_110135,357,756 - 135,372,278 (-)NCBICHM1_1
T2T-CHM13v2.010134,218,053 - 134,232,489 (-)NCBIT2T-CHM13v2.0
Adam8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,206,206 - 204,218,988 (-)NCBIGRCr8
mRatBN7.21194,776,559 - 194,789,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,770,060 - 194,788,801 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01212,317,510 - 212,332,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,317,848 - 212,330,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,236,436 - 219,251,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41199,780,772 - 199,791,855 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1192,454,105 - 192,468,808 (-)NCBICelera
Cytogenetic Map1q41NCBI
Adam8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547710,895,446 - 10,907,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547710,894,288 - 10,906,961 (-)NCBIChiLan1.0ChiLan1.0
ADAM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,386,583 - 145,400,948 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,391,940 - 145,406,305 (-)NCBINHGRI_mPanPan1
PanPan1.110134,171,986 - 134,186,221 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,172,724 - 134,186,227 (-)Ensemblpanpan1.1panPan2
ADAM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,853,665 - 40,865,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2840,909,672 - 40,921,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,490,792 - 41,502,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,973,551 - 40,985,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,962,945 - 40,974,543 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,365,582 - 41,377,170 (-)NCBIUU_Cfam_GSD_1.0
Adam8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,156,736 - 6,171,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,391,324 - 19,402,332 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,389,925 - 19,403,577 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,221,198 - 141,232,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,221,177 - 141,233,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,183,627 - 153,194,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,114,184 - 53,129,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,114,924 - 53,126,900 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605441,248,757 - 41,264,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473713,459,274 - 13,474,686 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam8
869 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1423
Count of miRNA genes:594
Interacting mature miRNAs:706
Transcripts:ENSMUST00000026546, ENSMUST00000106069, ENSMUST00000128332, ENSMUST00000132903, ENSMUST00000148670, ENSMUST00000149915, ENSMUST00000156647, ENSMUST00000173209
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse

Markers in Region
X13335  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387139,979,172 - 139,979,369UniSTSGRCm38
MGSCv377147,165,071 - 147,165,268UniSTSGRCm37
Celera7139,783,028 - 139,783,225UniSTS
Cytogenetic Map7F4UniSTS
Cytogenetic Map7F3-F5UniSTS
Whitehead/MRC_RH71425.23UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006536151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY523626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE634944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000026546   ⟹   ENSMUSP00000026546
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,558,845 - 139,572,461 (-)Ensembl
GRCm38.p6 Ensembl7139,978,932 - 139,992,548 (-)Ensembl
Ensembl Acc Id: ENSMUST00000106069   ⟹   ENSMUSP00000101684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,558,845 - 139,572,475 (-)Ensembl
GRCm38.p6 Ensembl7139,978,932 - 139,992,562 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128332
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,558,845 - 139,572,475 (-)Ensembl
GRCm38.p6 Ensembl7139,978,932 - 139,992,562 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132903
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,559,307 - 139,560,281 (-)Ensembl
GRCm38.p6 Ensembl7139,979,394 - 139,980,368 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148670   ⟹   ENSMUSP00000117858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,563,767 - 139,572,475 (-)Ensembl
GRCm38.p6 Ensembl7139,983,854 - 139,992,562 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,567,567 - 139,568,343 (-)Ensembl
GRCm38.p6 Ensembl7139,987,654 - 139,988,430 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156647
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,558,845 - 139,568,347 (-)Ensembl
GRCm38.p6 Ensembl7139,978,932 - 139,988,434 (-)Ensembl
Ensembl Acc Id: ENSMUST00000173209   ⟹   ENSMUSP00000133673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,569,332 - 139,572,421 (-)Ensembl
GRCm38.p6 Ensembl7139,989,419 - 139,992,508 (-)Ensembl
RefSeq Acc Id: NM_001291066   ⟹   NP_001277995
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,558,850 - 139,572,426 (-)NCBI
GRCm387139,978,932 - 139,992,562 (-)NCBI
Celera7139,782,794 - 139,796,326 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007403   ⟹   NP_031429
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,558,850 - 139,572,426 (-)NCBI
GRCm387139,978,932 - 139,992,562 (-)NCBI
MGSCv377147,164,840 - 147,178,387 (-)RGD
Celera7139,782,794 - 139,796,326 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006536151   ⟹   XP_006536214
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,558,845 - 139,573,016 (-)NCBI
GRCm387139,978,932 - 139,995,207 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017321932   ⟹   XP_017177421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,558,845 - 139,573,016 (-)NCBI
GRCm387139,978,932 - 139,995,207 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017321933   ⟹   XP_017177422
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,558,845 - 139,573,016 (-)NCBI
GRCm387139,978,932 - 139,995,207 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017321934   ⟹   XP_017177423
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,563,293 - 139,573,016 (-)NCBI
GRCm387139,983,380 - 139,995,207 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001277995 (Get FASTA)   NCBI Sequence Viewer  
  NP_031429 (Get FASTA)   NCBI Sequence Viewer  
  XP_006536214 (Get FASTA)   NCBI Sequence Viewer  
  XP_017177421 (Get FASTA)   NCBI Sequence Viewer  
  XP_017177422 (Get FASTA)   NCBI Sequence Viewer  
  XP_017177423 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH25584 (Get FASTA)   NCBI Sequence Viewer  
  AAS90834 (Get FASTA)   NCBI Sequence Viewer  
  BAA21771 (Get FASTA)   NCBI Sequence Viewer  
  BAC40743 (Get FASTA)   NCBI Sequence Viewer  
  BAC40775 (Get FASTA)   NCBI Sequence Viewer  
  BAE29535 (Get FASTA)   NCBI Sequence Viewer  
  BAE30482 (Get FASTA)   NCBI Sequence Viewer  
  BAE31407 (Get FASTA)   NCBI Sequence Viewer  
  BAE31481 (Get FASTA)   NCBI Sequence Viewer  
  BAE31691 (Get FASTA)   NCBI Sequence Viewer  
  BAE33430 (Get FASTA)   NCBI Sequence Viewer  
  BAE33500 (Get FASTA)   NCBI Sequence Viewer  
  BAE35583 (Get FASTA)   NCBI Sequence Viewer  
  BAE42219 (Get FASTA)   NCBI Sequence Viewer  
  CAA31712 (Get FASTA)   NCBI Sequence Viewer  
  EDL17877 (Get FASTA)   NCBI Sequence Viewer  
  EDL17878 (Get FASTA)   NCBI Sequence Viewer  
  EDL17879 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000026546
  ENSMUSP00000026546.10
  ENSMUSP00000101684
  ENSMUSP00000101684.3
  ENSMUSP00000117858
  ENSMUSP00000117858.2
  ENSMUSP00000133673.2
GenBank Protein Q05910 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031429   ⟸   NM_007403
- Peptide Label: isoform 1 precursor
- UniProtKB: Q05910 (UniProtKB/Swiss-Prot),   Q3U1J7 (UniProtKB/TrEMBL),   Q3TVN5 (UniProtKB/TrEMBL),   Q3U1R3 (UniProtKB/TrEMBL),   Q3U6N3 (UniProtKB/TrEMBL),   Q8R3D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006536214   ⟸   XM_006536151
- Peptide Label: isoform X3
- UniProtKB: Q3TVN5 (UniProtKB/TrEMBL),   Q3U1R3 (UniProtKB/TrEMBL),   Q3U6N3 (UniProtKB/TrEMBL),   Q8R3D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277995   ⟸   NM_001291066
- Peptide Label: isoform 2 precursor
- UniProtKB: Q3U7G2 (UniProtKB/TrEMBL),   Q3TVN5 (UniProtKB/TrEMBL),   Q3U1R3 (UniProtKB/TrEMBL),   Q3U6N3 (UniProtKB/TrEMBL),   Q8R3D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177422   ⟸   XM_017321933
- Peptide Label: isoform X2
- UniProtKB: Q3TVN5 (UniProtKB/TrEMBL),   Q3U1R3 (UniProtKB/TrEMBL),   Q3U6N3 (UniProtKB/TrEMBL),   Q8R3D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177421   ⟸   XM_017321932
- Peptide Label: isoform X1
- UniProtKB: Q3TVN5 (UniProtKB/TrEMBL),   Q3U1R3 (UniProtKB/TrEMBL),   Q3U6N3 (UniProtKB/TrEMBL),   Q8R3D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177423   ⟸   XM_017321934
- Peptide Label: isoform X4
- UniProtKB: E9Q359 (UniProtKB/TrEMBL),   Q8C269 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000026546   ⟸   ENSMUST00000026546
Ensembl Acc Id: ENSMUSP00000101684   ⟸   ENSMUST00000106069
Ensembl Acc Id: ENSMUSP00000133673   ⟸   ENSMUST00000173209
Ensembl Acc Id: ENSMUSP00000117858   ⟸   ENSMUST00000148670
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05910-F1-model_v2 AlphaFold Q05910 1-826 view protein structure

Promoters
RGD ID:8665983
Promoter ID:EPDNEW_M11023
Type:initiation region
Name:Adam8_1
Description:Mus musculus a disintegrin and metallopeptidase domain 8 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387139,992,513 - 139,992,573EPDNEW
RGD ID:6840496
Promoter ID:MM_KWN:53137
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000050404
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367147,165,956 - 147,167,157 (-)MPROMDB
RGD ID:6840494
Promoter ID:MM_KWN:53138
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000050400,   OTTMUST00000050403
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367147,174,061 - 147,175,107 (-)MPROMDB
RGD ID:6848062
Promoter ID:MM_ACW:46457
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain
Transcripts:ADAM8AND6430531B16RIK.HSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367147,176,056 - 147,177,237 (-)MPROMDB
RGD ID:6840493
Promoter ID:MM_KWN:53139
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   MEF_B4
Transcripts:ENSMUST00000106069,   ENSMUST00000106070,   OTTMUST00000050398,   OTTMUST00000050401,   OTTMUST00000050402
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367147,178,366 - 147,179,437 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107825 AgrOrtholog
Ensembl Genes ENSMUSG00000025473 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026546 ENTREZGENE
  ENSMUST00000026546.16 UniProtKB/TrEMBL
  ENSMUST00000106069 ENTREZGENE
  ENSMUST00000106069.9 UniProtKB/Swiss-Prot
  ENSMUST00000148670 ENTREZGENE
  ENSMUST00000148670.8 UniProtKB/TrEMBL
  ENSMUST00000173209.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1620.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107825 ENTREZGENE
NCBI Gene 11501 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam8 PhenoGen
PRINTS DISINTEGRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADAM8_MOUSE UniProtKB/Swiss-Prot
  E9Q359 ENTREZGENE, UniProtKB/TrEMBL
  G3UXF8_MOUSE UniProtKB/TrEMBL
  Q05910 ENTREZGENE
  Q3TVN5 ENTREZGENE, UniProtKB/TrEMBL
  Q3U1J7 ENTREZGENE, UniProtKB/TrEMBL
  Q3U1R3 ENTREZGENE, UniProtKB/TrEMBL
  Q3U6N3 ENTREZGENE, UniProtKB/TrEMBL
  Q3U7G2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UA33_MOUSE UniProtKB/TrEMBL
  Q5VCS5_MOUSE UniProtKB/TrEMBL
  Q8C269 ENTREZGENE, UniProtKB/TrEMBL
  Q8R3D3 ENTREZGENE, UniProtKB/TrEMBL